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Database of predicted three dimensional structures of Human Leukocyte Antigens molecules constructed by using homology modeling. Developed to improve epitope analysis in context of organ transplantation by providing 3D structures of HLA molecules present in current solid-phase assays for serum antibodies screening. Gives crystalographic modeling structure of HLA protein.Provides means to visualize target epitopes recognized by anti-HLA antibodies.

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• RRID
• 2 years ago - submitted by Steven Heron

EMBOSS Water uses Smith-Waterman algorithm to calculate the local alignment of two sequences. Pairwise sequence alignment. Used for determining protein-to-protein homology.

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• 2 years ago - submitted by Steven Heron

Core is self service facility that provides access to specialized instrumentation for phenotyping and genotyping of immune cells. Offers single cell next generation sequencing and quality control technologies. All instruments are located in the laboratories of four different CIIC investigators (KCBD 10220E and 10220C), and are available for use by the larger UChicago community.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Core provides instrumentation and expertise for high-field Preclinical Magnetic Resonance Imaging and Magnetic Resonance Microscopy. Facility has instruments: Bruker 9.4 Tesla/30 cm AVANCE 3 HD scanner and Bruker 11.7 Tesla 89 mm AVANCE 3 HD micro imaging system.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Software R package for calculating Net Reclassification Improvement for risk prediction models with time to event and binary data. NRI for risk prediction models with time to event and binary response data.

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• 2 years ago - by Anonymous

Core provides technical support and expertise to enable measurement based care and compute focused research. Service consists of computing platform, composed of redundant high-capacity storage system, along with compute cluster and workstations, tied together with unified single-sign-on user and group management. Platform has facilities for capturing form-based, interactive testing-based and arbitrary binary (imaging etc.) data. Allows clinical researchers to track the trajectories of participating patients across Douglas clinics.

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• RRID
• 2 years ago - submitted by Edyta Vieth

Facility dedicated to preclinical and clinical research in brain imaging in the field of mental health to foster development of new biomarkers for early diagnosis, treatment and prevention of neuropsychiatric conditions. Instruments include human (3T MRI Siemens Prisma Fit) and animal (7T Bruker Biospec) imaging equipment. Expert staff provides support for project design, acquisition and analysis. Core offers project specific conceptual assistance, 3D printing and prototyping in addition to facilities for equipment production (coil design and production). Team consists of traditional and computational neuroscientists, basic and clinical researchers, image analysts, magnetic resonance imaging physicists, and expert technologists

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• RRID
• 2 years ago - submitted by Edyta Vieth

Core provides access to characterization and process instrumentation. Expert staff provides assistance and guidance. Services include electron microscopy and analysis (SEM, TEM, FIB, EBSD, WDS), microelectronic device fabrication (7000 sq ft cleanroom, Class 100-1000), X-ray computed tomography (CT), particle system characterization (size, zeta potential, surface area, porosity, rheology), X-ray diffraction, surface analysis (AFM, profilometry, XPS, Auger), spectroscopy (UV/Vis with integrating sphere, FTIR/NIR with micro capability and micro-Raman).

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Facility utilizes LabMA system developed by Luminex Co., for protein analysis that permits simultaneous quantitative analysis of up to 100 different proteins, peptides, or RNA molecules in single microtiter well. Commercially available assays from Millipore, R&D Systems, Bio-Rad or Thermofisher are also used for analysis.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Advanced imaging core for multi channel fluorescence imaging,3D imaging, super resolution imaging, scanning, image analysis in cancer research. Technical services are forcused on fluorescent in situ hybridization, immunohistochemistry, and microdissection of biological material.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Core for image based analysis, laser capture microdissection, and live cell fluorescence imaging. Provides range of consultation and laboratory services performed by core staff. Users training is available.Cell and Tissue imaging on confocal microscopes including Zeiss LSM 710, Leical Sp8 and Leica Stellaris.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Spatial biology company, building multiplex immunofluorescence and IHC solutions for discovery and immuno-oncology research.Laboratory equipment supplier in Tolochenaz, Switzerland.

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• 2 years ago - by Anonymous

Caliper provides products and services for life sciences research. The firm, founded in 1995, is based in Hopkinton, Massachusetts with direct sales, service and application support operations in countries around the globe.

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• RRID
• 2 years ago - by Anonymous

Company designs, develops and commercializes molecular pathology systems for tumor diagnosis, prognosis, precision medicine and life science research.

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• RRID
• 2 years ago - by Anonymous

Web tool to detect under- or over-dispersion in a baseline table from baseline table.

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• RRID
• 2 years ago - by Anonymous

Facility maintains large array of instrumentation for production and analysis of complex materials, including nanoparticles, thin films, polymers, ceramics, and molecular electronics.Oversees operations of Department Biological Instrumentation Cluster which provides access to specialized equipment used in molecular biology and biological chemistry.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Facility specializes in training users in both solution phase and solid state NMR across all active nuclei and multiple NMR experients

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

X-Ray Diffraction Facility located in Chemistry Instrumentation Center is equipped with Bruker X8 Prospector Ultra with Copper ImuS micro-focus X-ray source and Bruker D8 Venture Dual source (Molybdenum and Copper micro-focus X-ray tubes) diffractometer with Photon III CPAD detector. Data can be collected at nitrogen-cooled temperatures as low as 90K. Core provides sample submission services for small molecule crystalography.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Core supports fabrication and characterization of nanoscale materials and structures, and integration of devices at all length scales. Houses advanced equipment with core nano-level capability for fabrication and characterization, including electron-beam lithography system, dual-beam system, plasma etching, thin film deposition, TEM, multifunctional scanning probe station, modular XRD, and more.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Core provides mass spectrometry instruments including Bruker Daltonics UltrafleXtreme MALDI TOF-TOF, Shimadzu Instrument LCMS-2020,Shimadzu Instrument QP2010S GCMS,Thermo Fisher Oribtrap Exploris 240,Thermo Scientific Q-Exactive Oribtrap for determining masses of particles, and elemental composition of sample or molecule.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth