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Core provides analysis of large and small molecules using several ionization methods, low or high resolution, hyphenated techniques, proteomics, and metabolomics.
Electron microscopy core with both service and individual use options.
Cloud-based high performance computing for specialised analyses on environmental omics.
Software R package to analyse large volumes of data. Extracts structure of data without the need to build any model to represent it. Provides functions for data exploration via PCA, and allows the user to generate publication ready figures.
Software environment for subtomogram averaging of cryo-EM data. Development tool for subtomogram averaging of cryo-EM data in high-performance computing environments.
Core uses mass spectrometry to characterize proteins as well as other biologically-derived molecules. Specializes in characterization of protein post-translational modifications, including glycosylation, phosphorylation, acetylation and persulfidation.Provides identification of protein-interactions including determination of protein-protein crosslinks and quantitative comparisons of complex samples.
Core provides basic husbandry, training, supplies, and specialized service support for medical research at IU School of Medicine.
LAR provides housing, food, water, bedding, enrichment and medical care for animals housed in LAR animal facilities to be used for research.
Core develops and uses gene-targeting technology to investigate pathophysiological roles of genes of blood coagulation, anticoagulation, and fibrinolytic pathways in hemostasis, with associated relevance to embryonic development, cancer, infection, and inflammation.
Offers cryo-electron microscopy, transmission electron microscopy, and scanning electron microscopy. Provides technical services to help design and then implement experiments needing each type of microscopy.
Automated system for comprehensive, label-free analysis and characterization of biomolecular interactions in real-time. Can be used for applications, including structure function studies, pathway analysis, biomarker discovery and validation, drug target identification and validation, and assay development.
Optima XPN generates centrifugal forces for separation of particles.Centrifuge is intended to separate human samples, including blood, urine, and other bodily fluids to prepare samples for downstream in vitro diagnostic procedures, which may include molecular diagnostic, chemistry, immunoassay, and coagulation tests. This centrifuge should be operated by laboratory professionals only.Floor model preparative ultracentrifuge offers temperature from 0 to 40℃, meets environmental protection requirements, adopts microcomputer controlled variable reluctance drive system, vacuum friction reduction system.
Piston fractionation leaves gradient undisturbed while piston descends from the top, displacing layers through centre of its patented trumpet shaped tip, keeping flow smooth and precise. Used to fractionate based on distance rather than drop or time.
Generates linear gradients using process called tilted tube rotation. Process involves layering two end point solutions directly in centrifuge tube, capping it and placing it in magnetic tube holder that adheres to rotary steel plate on instrument. Gradient Master takes over and tilts tube to the proper angle, rotates it for designated time and returns it to its original vertical position, ready to use.
Core to perform novel discovery-based high throughput compound, CRISPR and RNAi screens at any scale in both 2D and 3D formats, using liquid handling instruments, automated high content imaging microscopes, live imaging systems and large reagent libraries.
Software R package to provide ggplot2 implementation of biplot, simultaneous plot of scores for observations and vectors for variables for principal component-like analyses.
NIH-funded resource that provides information about how human genetic variation affects response to medications. PharmGKB collects, curates and disseminates knowledge about clinically actionable gene-drug associations and genotype-phenotype relationships.
Database of Cannabis sativa Single Nucleotide Polymorphisms discovered from NGS sequences and BioSamples available in NCBI. Sequence reads were called against cs10, Purple kush, and Finola reference assemblies using GATK and Parabricks pipelines.
Portal contains information about the geographic locations of dam removals and any associated scientific studies evaluating outcomes to physical, biological, and water quality parameters. Results can be downloaded based on customized search criteria specified by the user.
Software environment to ease task of building macromolecular models into low to medium resolution experimental maps. Physically realistic environment for model building into low-resolution electron-density maps. Can generate maps directly from crystallographic F/sigF data in MTZ format and automatically re-calculate them when model changes, and/or generate "static" maps from pre-calculated F/phi data.