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Database of glycans 3D structural data and information that can be downloaded or used with Re-Glyco to rebuild glycoproteins from the RCSB PDB or EMBL-EBI AlphaFold repositories. Glycan structure database and toolbox designed to restore glycoproteins to their native and functional form.
Software program designed for refining atomic models of multidomain proteins or complexes using Small-Angle X-ray Scattering (SAXS) data. It is specifically used in structural biology to help determine the 3D structure of complex molecules in solution.
Software command-line tool designed for hard-filtering variant callsets (VCF files) by applying user-defined criteria to annotate, rather than remove, low-quality variants. It marks fails in the FILTER field (e.g., using JEXL expressions to filter by DP, QD, or FS), making it essential for filtering small datasets, non-model organisms, or whenever Variant Quality Score Recalibration (VQSR) is not feasible
Software tool for identifying single nucleotide polymorphisms (SNPs) and insertion/deletion (indels) variants, offering high accuracy via local de-novo assembly of reads. It works by identifying "active regions" with potential variation, reassembling those reads, and calculating genotype likelihoods, making it superior for complex variant detection.
Command-line utility provided by the UCSC Genome Browser to convert text-based bedGraph files into indexed binary bigWig files. It is specifically used in bioinformatics to transform dense, continuous genome coverage data into a format that enables fast visualization and remote viewing in genome browsers like IGV or the UCSC Genome Browser.
The open‑field test system for neurobehavioural analysis is designed to observe and investigate neuropsychiatric changes in experimental animals, as well as their diverse behaviours upon entry into an open environment. Animals typically exhibit fear of novel open spaces, leading them to move predominantly in the peripheral area with limited activity in the central region. Meanwhile, their innate exploratory drive motivates them to venture into the central area, enabling the assessment of anxiety‑related behaviours induced by this conflict.
The open‑field test system for neurobehavioural analysis is designed to observe and investigate neuropsychiatric changes in experimental animals, as well as their diverse behaviours upon entry into an open environment. Animals typically exhibit fear of novel open spaces, leading them to move predominantly in the peripheral area with limited activity in the central region. Meanwhile, their innate exploratory drive motivates them to venture into the central area, enabling the assessment of anxiety‑related behaviours induced by this conflict. brochure pdf needed
Software code and pipelines for the study of pan-cancer myeloid immunosenescence. Analytical framework integrates bulk RNA-seq (GTEx/TCGA) and multi-cohort single-cell RNA sequencing (scRNA-seq) data to construct high-resolution myeloid atlases, cellular communication networks, and clinical prognostic signatures.
Core provides histology, immunohistochemistry, imaging, quantitative image analysis, and pathology consultation services. Offers experience, expertise and instrumentation across all platforms. Through the partnership with the Comparative Pathology Program (CPP), we have board certifies veterinary pathologists on staff who are available for research consultation and collaboration.
Specialized, automated, cyclotron-based system designed for the decentralized, high-volume production of medical radioisotopes, such as Gallium-68,Technetium-99m, and Zirconium-89. It allows hospitals and radiopharmacies to produce PET and SPECT imaging agents locally, bypassing supply chain disruptions and reducing dependence on traditional nuclreactors.
Compact, automated, dual-particle cyclotron system designed for fast, easy and efficient production of PET tracers. It offers the efficiency required to facilitate your clinical schedules, flexibility for research protocols and the performance necessary to meet regional distribution demands. The PETtrace 800 is built around a compact negative ion cyclotron with a vertical mid-plane of proven design, featuring both protons and deuterons allowing maximum flexibility and low-cost isotope production.
Core provides researchers with confocal imaging equipment to enable acquisition of high resolution images (both in vivo and in vitro). Offers training and assistance in the use of confocal microscopes. Optimization of data acquisition and image processing are both part of the training, thus enabling researchers to efficiently design studies, acquire image data and extract relevant data features.
Core enables and promotes responsible research practices to generate trustworthy data, and to safeguard research data. The service is comprised of 4 pillars; governance, good research practice support, stewardship and knowledge exchange.
Facility provides a range of histology and tissue-based molecular services to research scientists within the UCL Cancer Institute and across UCL.The facility also maintains a range of equipment available for use by UCL researchers to support a range of projects involving human and animal samples. We work in close collaboration with the UCL / UCLH Biobank for Studying Health and Disease and the UCL/UCLH Cancer Biomarker Centre (CBC) which provides a framework for the governance of research involving human samples and supports researchers in meeting regulatory standards.
Immune Monitoring and Discovery Platform (IMDP) at the Pelotonia Institute for Immuno-Oncology (PIIO) provides cutting-edge technologies and expertise to accelerate discoveries in cancer immunology and immunotherapy. Our mission is to empower researchers with advanced tools for immune profiling, spatial biology, and translational studies, enabling innovation that drives new therapies for patients.
Software open-source Python/Flask framework for building online behavioral experiments and surveys. You describe your study in plain-text files: a TOML config for settings and page flow, JSON files for questionnaires, and HTML files for custom pages. BOFS handles participant routing, condition assignment, consent forms, data storage, and provides an admin panel for monitoring and export.
Software Jupyter notebook based genomic data visualization toolkit.
Software Python package tool that facilitates the identification of total cis-NATs (cis-natural antisense transcripts) from gene datasets.
Software tool as context-based long-read simulator that models sequence-context-dependent errors from empirical sequencing data, coupled with a Bayesian optimization framework for systematic parameter tuning.
Web open decentralized science platform for peptide sequence analysis and community annotation. Researchers submit amino acid sequences for AI-powered bioactivity scoring, structure prediction, and toxicity assessment. Results are publicly annotated by the community and secured on the Solana blockchain for verifiable, censorship-resistant research records.