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Austrian company that develops and manufactures high-end laboratory, analytical, and process measurement instruments. Their equipment is widely used in scientific research, quality control, and manufacturing.
Software integrative analysis pipeline for analyzing bulk/single-cell ATAC-seq and RNA-seq data. Integrative multi-omics data analysis framework. It can be used as a standalone pipeline to analyze ATAC-seq, RNA-seq, single cell ATAC-seq or Drop-seq data. Used to integrate diverse datasets and use these information to construct regulatory network and identify candidate driver genes.
This 3,300 square foot clean room is located in the Department of Physics in Regents Hall and includes instrumentation for fabrication and characterization of materials and electronic devices. Users have access to a Scanning Electron Microscope with ebeam lithography and EDS; optical lithography; magnetron sputtering; thermal evaporation; reactive ion etching; atomic layer deposition; chemical vapor deposition; wirebonding; a profilometer and various optical microscopes.
Software R package implementing the UMAP dimensionality reduction method. It also provides means to transform new data and to carry out supervised dimensionality reduction.
Software R package for rich hierarchy of sparse and dense matrix classes, including general, symmetric, triangular, and diagonal matrices with numeric, logical, or pattern entries. Efficient methods for operating on such matrices, often wrapping the 'BLAS', 'LAPACK', and 'SuiteSparse' libraries.
Core offers microscopy services. Provides three offline analysis systems with Intel Xeon-based processors. Two of these are custom-built Origin computers and the third is a Dell Precision computer. All analysis workstations have the most recent versions of the Fiji build of Image J and RStudio.
cGMP facility responsible for the bulk product manufacture, purification, and characterization of clinical-grade materials. Offers vialing of sterile investigational products such as peptides, proteins, carbohydrates, and adjuvants. Service also conducts lot release tests which are required for products release for preclinical and investigational use either in-house or with validated contract vendors.
Core provides services in confocal microscopy (CLSM, including FRET, ion imaging, and colocalization), scanning electron microscopy (SEM, including ESEM for wet samples), SEM prep instrumentation (critical point dryer and sputter coater), epifluorescence microscopy and polarizing microscopy.
Core provides tissue processing, histology and staining services. Services include embedding, sectioning, histochemical staining of mounted slides, immunohistochemical (IHC) staining for paraffin embedded and frozen tissues, immunocytochemical (ICC) staining for cultured cells (as tissue sections or cytospin slides), evaluation of new antibodies for IHC staining, enzyme histochemistry and special staining.Provides defined analyses including RNA / DNA preparation, reverse transcription and cDNA synthesis from total RNA, construction, staining and analysis of tissue microarrays, and construction and analysis of reverse proteomics array from user-defined biospecimens.Core is flexible to accommodate the development of new techniques and expanding its services based on the research requirements of SCC members and other investigators.
Software R package read flat files (csv, tsv, fwf) into R. Used to read rectangular data like 'csv', 'tsv', and 'fwf'. Designed to flexibly parse many types of data found in the wild, while still cleanly failing when data unexpectedly changes.
Contract research organization based in San Leandro, California, that specializes in molecular pathology, genomics, and tissue analysis. Services for drug discovery, biomarker development, and personalized medicine. Provides histopathology and genomic services to the pharmaceutical and biotechnology industries.
Specialty contract research laboratory and biotechnology company that provides stem cell testing and in vitro toxicity screening, particularly for the blood-forming (hematopoietic) system. Provides high-throughput hematotoxicity screening and testing with its proprietary HALO®-Tox HT Platform. Provides the expertise to help in predicting toxicity, risk and safety of a drug or other agent.
Laboratory instrument designed to analyze and quantify ELISpot, FluoroSpot, and FociSpot assays in 96-well plates. Used by immunologists and vaccine researchers to study individual immune cells and detect secretions like antibodies and cytokines. Capable of analyzing up to four analytes simultaneously.
Research-grade upright compound microscope used to visualize fluorescently labeled cells, tissues, and biological markers. Equipped with interchangeable filter cubes (e.g., DAPI, FITC, TRITC), it excites specific fluorophores to study gene expression, protein localization, and cellular dynamics. Beyond fluorescence, it supports brightfield, phase contrast, and Differential Interference Contrast (DIC) for examining unlabeled or transparent specimens. Often fitted with trinocular head and high-resolution digital camera to capture publication quality micrographs and record time-lapse imagery.
Specialized service at Charité – Universitätsmedizin Berlin that provides researchers with fresh, high-quality primary human biospecimens. By bypassing standard supply chains, it connects operating and clinical wards directly to research laboratories, supporting human-based methods to reduce reliance on animal experimentation. Operates as a central contact point, taking care of the logistics from project initiation to sample transfer. It coordinates with surgical clinics, pathology departments, and tissue repositories. Alongside the living biospecimens, the pipeline helps safely transfer relevant, pseudonymized patient data to research groups.
Software application as discrete event simulation model built in the R programming language which simulates individual women through different risk-stratified breast screening programmes. Used to evaluate the costs, outcomes, and cost-effectiveness of different breast cancer screening strategies, particularly risk-stratified approaches in the UK. It helps policymakers determine the best screening intervals for women based on risk rather than just age.
Software tool for rapidly determining the low-resolution three-dimensional shape of biological macromolecules in solution using Small-Angle X-ray Scattering (SAXS) data. Used for rapid ab-initio shape determination in small-angle scattering.
Database of glycans 3D structural data and information that can be downloaded or used with Re-Glyco to rebuild glycoproteins from the RCSB PDB or EMBL-EBI AlphaFold repositories. Glycan structure database and toolbox designed to restore glycoproteins to their native and functional form.
Software program designed for refining atomic models of multidomain proteins or complexes using Small-Angle X-ray Scattering (SAXS) data. It is specifically used in structural biology to help determine the 3D structure of complex molecules in solution.
Software command-line tool designed for hard-filtering variant callsets (VCF files) by applying user-defined criteria to annotate, rather than remove, low-quality variants. It marks fails in the FILTER field (e.g., using JEXL expressions to filter by DP, QD, or FS), making it essential for filtering small datasets, non-model organisms, or whenever Variant Quality Score Recalibration (VQSR) is not feasible