We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Core offers quantitative and qualitative proteomics services using LC-MS/MS technologies. Servies include sample preparation from harvested cell pellets, elutions post-enrichment or purification, or gel bands through data acquisition, quantification, and statistical analysis.
Guidelines for accessing and sharing data collected by the All of Us Research Program. It aims to ensure responsible data use while promoting transparency and collaboration in research to advance precision medicine.
Software tool for detecting transposon insertions using short-read whole-genome sequencing data. Used to detect germline transposon insertions, estimate number of uninherited/somatic transposon insertions by removing artificial insertion introduced by chimeric reads.
Software package to facilitate microbiome exploration and ensuring nice plotting.
This technology relies on newly described chemical modifications that allow site-specific and multiple-site conjugation of a wide assortment of molecules on both the termini and internal sites of Cas9, creating a platform for endowing Cas9 with diverse functions. Using this platform, Cas9 can be modified to more precisely incorporate exogenously supplied single-stranded oligonucleotide donor (ssODN) at the DNA break site. We demonstrate that the multiple-site conjugation of ssODN to Cas9 significantly increases the efficiency of precision genome editing, and such a platform is compatible with ssODNs of diverse lengths.
Microfluidic systems including housing configured to receive cartridge, housing including channels for loading one or more biological cells within wells of the cartridge. Three-dimensional scaffolds, devices, and systems comprising such scaffolds that mimic the in vivo structure, physical properties, and protein composition of extracellular matrix surrounding pancreatic islet cells and adipocytes, with use for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications. The cartridge including a plurality of wells for receiving one or more biological cells. The microfluidic systems include a structure with channels for introducing a medium into the housing and through channels the cartridge.
Device and system for 3-dimensional adipocyte expansion to produce mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.
Microfluidic cartridge for automatically hydrodynamically loading objects (e.g., cell clusters) into traps in parallel trapping channels with one object per trap. This improves loading of cell clusters compared to well-based systems.
iXon Life Electron Multiplying CCD platform for fluorescence microscopy applications and is engineered to deliver single photon sensitivity.
National research resource within All of Us Research Program which asks about participant’s use of tobacco, alcohol, and recreational drugs.
National research resource within All of Us Research Program which is the core survey and asks basic demographic questions, including questions about a participant’s work and home.
National research resource within All of Us Research Program which asks about social determinants of health, including a participant’s neighborhood, social life, stress, and feelings about everyday life.
American Community Survey is annual demographics survey program conducted by the U.S. Census Bureau. American Community Survey releases new data every year through variety of data tables. This table (B02018) specificially provides data on estimated number of individuals who identified as Asian, including ethnicities.
Software tool as germline small variant caller for long-reads. Symphonizing pileup and full-alignment for high-performance long-read variant calling.
Software tool to discover haplotypes in sequenced data. Colors each individual as hybrid of all other sequences. The "coancestry matrix" exposes ancestral associations among individuals. ChromoPainter algorithm uses Hidden Markov Model and outputs range of features, such as expected number of recombination events and sample haplotypes.
System to automate most aspects of sample preparation prior to liquid chromatography analysis, particularly for use with mass spectrometry, by integrating sample introduction, cleanup, and chromatographic separation on single platform, significantly reducing manual steps and improving sample throughput.
Automated benchtop hematology analyzer for high quality blood cell analysis. Provides testing for up to 80 samples per hour, enabling rapid turnaround time.
Manual high-performance microtome with mechanical precision specimen feed, designed above all for the manual sectioning of biological specimens embedded in paraffin.Can also be used for cutting harder materials. This product has been discontinued and replaced by HistoCore BIOCUT.
Database with products that can serve as alternative for basement membrane extracts (BMEs) for in vitro applications. BME-free database is publicly available and is part of 3Rs Research Tools Programme, which is managed and hosted by 3Rs Centre Utrecht.
Core provides services for advanced imaging and flow cytometry. Equipment, training and services are available for both internal users and external users from other academic institutions and industry.