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AI-powered integrated research platform for one-stop analysis of medical images. Provides advanced functionality such as automatic segmentation, registration, and classification for variety of application domains. Has major merits including Advanced built-in algorithms applicable to multiple imaging modalities (i.e., CT, MR, PET, DR), diseases (i.e., tumor, neurodegenerative disease, pneumonia), and applications (i.e., diagnosis, treatment planning, follow-up); Iterative deep learning-based training strategy for fast delineation of ROIs of large-scale datasets, thereby saving clinicians' time and obtaining novel and more robust models; Modular architecture with customization and extensibility, where plugins can be designed for specific purposes.
System for evaluative purposes applies cell stretching and compression force and is operated manually. Has two versions available: 4 cm2 or 10 cm2 stretch chambers. Can mechanically stimulate monolayer and cultured cells and tissue to increase cell growth and shape.
Software graphical application written in Python, to analyze videos and create notes for events in the video. Used to identify animals’ behaviors based on information extracted from video.
Instrument provides automated DNA or RNA purification. Sample lysis and binding to paramagnetic particles is primary separation principle. Up to 16 samples can be prepared in single run. Instrument is controlled through graphical user interface running on Tablet PC and has ability to record and report sample tracking and method run data. Reports can be printed and exported to storage location or USB drive.
Provides genomic technology services and expertise. Services offered include Nanopore PromethION sequencing, Electronic optical mapping on Nabsys, Optical Genome mapping on Bionano Saphyr, NGS (Illumina-based), Sanger Sequencing, Single cell analysis/RNAseq, Transcriptomic spatial profiling, Gene expression analysis , Droplet Digital PCR & qPCR, Microsatellite/fragment analysis, SNP genotyping , Chromosomal microarray analysis, Sample prep and QC, Project consultation, Bioinformatics support.
Microplate Reader measures absorbance, fluorescence, time-resolved fluorescence including HTRF, fluorescence polarization, AlphaScreen, AlphaLISA, and luminescence assays for up to 1536-well plates. Detection cartridge modularity allows for easy addition of new read modes within minutes without requiring service visit, while providing flexibility for future applications.
Software R package for DNA copy number detection from off-target sequence data. Used to extract DNA copy number information from targeted sequencing by utiizing off-target reads.
Web tool for protein structure prediction, leveraging sequence alignment, template-based modeling, deep learning, and validation techniques. With input of either amino acid sequence or FASTA file, ProStruc generates protein structures. ProStruc automates process of blast searches, template selection, structural modeling, and validation, including RMSD, TM-score, and QMEAN.
Core assists investigators to identify and quantify proteins and their modifications that are differentially expressed in cells, tissues or body fluids, to track interactions with binding partners during changes in signal transduction, and to identify proteolytic cleavage sites and map post-translational modifications by providing following proteomic services: Consultation, Sample preparation,Protein Identification,Protein Modifications, Protein Quantification, Targeted Quantification, High Resolution Mass Analysis,Training and Self-Service Equipment. Core offers workshops to use the Core’s MALDI-TOF mass spectrometer, Typhoon gel imaging scanner and 2D gel electrophoresis equipment and proteomic software.
Portal provides access to data set including, for each U.S. census tract (defined using 2010 census tract boundaries), certain social determinants of health data elements, including race/ethnicity, education, poverty, urban/rural, socioeconomic status, and racial residential segregation indices defined using 2008-2012 American Community Survey data and 2010 definitions of rural urban commuting areas.
Core offers services related to cryo electron microscopy. Services include grid preparation, screening and data collection, as well as user training.
BIDMC Bioinformatics Core is Unit of the Precision RNA Medicine Core and provides support for management, integration and contextual analysis of biological high-throughput data, training on tools, databases and best practice.
GetData Graph Digitizer is a program for digitizing graphs and plots. It is often necessary to obtain original (x,y) data from graphs, e.g. from scanned scientific plots, when data values are not available. the URL does not work; the letter sent to the submitter
Collaborative open project of Chan Zuckerberg Initiative and Chan Zuckerberg Biohub. The no-code, cloud-based bioinformatics tool for researchers. Used to analyzing genomic data for free. Hypothesis-free global software platform that helps scientists identify pathogens in metagenomic sequencing data.
Benchtop pH Meter to record accurate and reliable pH, mV, ORP and temperature measurements.
Real-time PCR system that enables precise quantitative real-time PCR results. High-quality qPCR results, 4-color, 96-well PCR instrument.
Software tool for gene fusion detection from RNA-Seq data. Fusion detection algorithm specifically designed to meet demanding requirements of HTS-assisted precision oncology. Capable of detecting aberrant transcripts that are not called by most fusion detection methods but may be clinically relevant. This includes tumor suppressor genes that are occasionally inactivated by rearrangements within the gene or by translocations to introns or intergenic regions.
Software tool to leverage chimeric and discordant read alignments identified by STAR aligner to predict fusions. Component of Trinity Cancer Transcriptome Analysis Toolkit. Used to identify candidate fusion transcripts supported by Illumina reads. Maps junction reads and spanning reads to reference annotation set.
Core provides multidimensional LC-MS/MS analysis including Protein ID, Proteomics Profiling, Targeted Proteomics and Post Translational Modification analysis. Quantitative proteomic services are provided using label free quantitative proteomic (LFQ) profiling, Tandem mass tagging (TMT) or SILAC approaches. Provides support for macromolecular complexes using Nano ESI.
Software tool for fast and accurate alignment of BS-Seq reads using bwa-mem and 3-letter genome.