We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Microscopy core managed by Cardiovascular Research Center. Operates as a teach and train service for confocal, slide scanning and general widefield fluorescence imaging.
Flow Cytometry facility provides instrumentation and expertise for cell sorting and analysis.Offers both full-service and self-service facilities, with support and training, as well as cutting-edge research instruments and software resources.
First translational medical research institute dedicated to translating scientific discoveries into applications for medical practice. Australian-first initiative of bench to bedside medical research.
Fully automated spatial proteomics instrument designed to visualize and analyze hundreds of proteins and RNAs within a single tissue section. It maps exactly where cells are and how they interact.
Core provides support for research teams using non-human primate models in scientific projects. It combines specialized biomedical infrastructure, neuroscience expertise, regulatory guidance and qualified technical staff to ensure the housing, monitoring, handling and experimental use of monkeys in accordance with ethical and regulatory standards. It offers technical support for experimental procedures (A2 facility, several imaging techniques), behavioral training, and neurophysiological investigations as well as gene and cell therapy projects (in collaboration with PBI’s TIDU GENOV unit).
Open-source ensemble platform for in silico Phase I and Phase II metabolite prediction with High-Resolution Mass Spectrometry (HRMS) target list generation. Used for Metabolite Identification (MetID) predictions and soft spot analysis.
Software R package for identifying and ranking influential nodes in biological and other complex networks. Implements the Integrated Value of Influence (IVI), Experimental data-based Integrative Ranking (ExIR), SIRIR, and numerous network centrality measures, enabling network topology analysis, influential node detection, feature prioritization, and candidate biomarker discovery. Provides functions for network reconstruction, centrality assessment, visualization, and analysis of relationships between centrality measures. Used for identification and classification of the most influential nodes.
Software R package to generate balancing weights for causal effect estimation in observational studies with binary, multi-category, or continuous point or longitudinal treatments by easing and extending the functionality of several R packages and providing in-house estimation methods. Used for propensity score weighting.
System equipped with DNP (Dynamic Nuclear Polarization) used primarily to dramatically boost the sensitivity of nuclear magnetic resonance (NMR) spectroscopy.It allows researchers to study complex molecular structures, materials, and biological systems that are normally difficult or impossible to observe. Console: Avance III HD; Magnet: Ascend; Field Strength:600 MHz Wide-bore; Software: TopSpin 3.8 on Alma 9.4; Probe: 3.2mm HCN LTMAS for DNP; 3.2mm HX LTMAS for DNP; 1.3mm HCN very-fast MAS.
Highly advanced system used by researchers in chemistry, biology, and materials science to determine the molecular structure, dynamics, and interactions of chemical compounds and biomolecules. Console: Avance III HD; Magnet: Ascend; Field Strength: 600 MHz, Software: TopSpin 3.7 on Windows 10; Probe: 5mm Broadband Observe (BBFO) "Smart" solution iProbe with Z-Gradients.
High-field, ultra-sensitive system used by researchers for deep structural, dynamic, and metabolic analyses of complex molecules. Console: Avance III HD; Magnet: Aeon; Field Strength: 800 MHz Wide-bore; Software: TopSpin 3.8 on Alma 9.4; Probe: 3.2mm Efree HCN MAS; 3.2mm HXY MAS; 1.9mm HCN MAS; 1.3mm HCN MAS; 0.7mm HCND ultra-fast MAS.
Spectrometer represents the pinnacle of commercial nuclear magnetic resonance technology. Operating at 28.2 Tesla, this ultra-high-field system is primarily used for advanced structural biology, pharmaceutical research, and materials science. Delivers the highest commercially available spectral resolution, crucial for investigating complex protein dynamics, functional molecular disorders, and viral structures. Console:Avance Neo; Magnet:Gateway; Field Strength: 1.2 GHz; Software:TopSpin 4.4.1 on CentOS 7; Probes:3mm TCI cryoprobe; 3mm BBI room-temperature; 3.2mm HX low-gamma MAS; 1.9mm HX high-gamma MAS; 1.3mm HCN fast MAS; 0.7mm HCN ultra-fast MAS; Chilled SampleCase (up to 24 samples); Automated Tuning and Matching (ATM); Nitrogen Liquefier.
Spectrometer used for advanced chemical, biological, and materials research. It allows scientists to determine the atomic-level structure, dynamics, and interactions of molecules. Console: Avance Neo; Magnet: Ascend; Field Strength: 800 MHz; software:TopSpin 4.4.1 on CentOS 7; Probe: 5mm QXI-F solution; 5mm TXI solution; 4.0mm gradient hr-MAS; 3.2mm Efree; 2.5mm Tri-gamma MAS; 1.9mm MAS; 1.3mm MAS; 0.7mm ultra-fast MAS.
High-end analytical system used by researchers in chemistry, biology, and materials science. It determines the molecular structure, dynamics, and interactions of organic compounds, proteins, and polymers. Console:Avance III HD; Magnet: Ascend; Field Strength: 700 MHz; Software:TopSpin 3.8 on Alma 9.4; Probe: 5mm Triple-resonance Observe (TXO) cryoprobe with Z-Gradients.
High-resolution Nuclear Magnetic Resonance (NMR) spectrometer. Operating at 14.1 Tesla, it features an ultrashielded magnet for superior stray-field reduction and spatial efficiency. It is widely used for advanced structural analysis of small molecules, proteins, and macromolecules. Console: Avance III HD; Magnet: Ultrashield; Field Strength: 600 MHz; Software:TopSpin 3.8 on Alma 9.4; Probes:5mm Triple-resonance Inverse (TXI) cryoprobe with Z-Gradients.
High-field system powered by an 18.8 Tesla magnet. It is the premier tool for structural biology, metabolomics, and advanced materials research. Console: Avance III HD; Software:TopSpin 3.8 on Alma 9.4; Probe: 5mm Quadruple-resonance Inverse (QCI-P) cryoprobe with Z-Gradients.
Core staff provide expertise and technical support for a wide range of microbiome-focused research. Services and technologies, include initial project consultation, experimental design, sample collection and processing, data analysis and interpretation, grant applications.
Database for residue-level membrane protein-lipid contact annotations derived from experimentally determined Protein Data Bank structures. Includes automated Python pipeline for identifying lipid-containing PDB structures, calculating all-atom heavy-atom residue-lipid contacts using a 4.0 Angstrom distance cutoff, generating cluster-aware train, validation, and test splits, and producing documented dataset files for machine learning and structural bioinformatics. The dataset is deposited on Zenodo under CC0, while the code is released on GitHub under the MIT license. Contains large-scale experimentally-validated dataset of residue-level protein-lipid contacts from membrane protein structures.
Programmable, automated laboratory instrument used for slide based FISH (Fluorescence In Situ Hybridization) and ISH procedures. It is specialized, microprocessor controlled hot plate designed specifically for the denaturation and hybridization of DNA on glass microscope slides.
130-watt programmable sonicator manufactured by Sonics & Materials, Inc. It is commonly used in laboratory settings for processing small volumes of liquid from 150 microliters to 150 milliliters.