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Specialized laboratory facility at Emory University Winship Cancer Institute. Its primary mission is to assist investigators in developing, characterizing, and analyzing animal models to accelerate translational cancer research. By providing centralized access to advanced engineering technologies and high-end preclinical imaging equipment, the core helps researchers simulate cancer progression and evaluate new therapies efficiently and cost-effectively.
Core provides services in preclinical imaging with an Spectrum IVIS-CT, a Bruker CT, and ultrasound.
Core provides advanced 3 Tesla (3T) magnetic resonance imaging (MRI) capabilities for clinical, translational, and research applications. Facility is equipped with radiofrequency (RF) coils to support high-quality brain, body, and musculoskeletal imaging studies.MRI system features broadband multinuclear imaging and magnetic resonance spectroscopy (MRS) capabilities, enabling the investigation of tissue metabolism, physiology, and molecular pathways beyond conventional proton (1H) imaging. These advanced capabilities support a broad spectrum of research in neuroscience, metabolism, nutrition, aging, oncology, and precision medicine.Facility's 70 cm wide-bore MRI system enhances participant comfort and accessibility, making it well-suited for life-course imaging studies involving pediatric, adult, and elderly populations, as well as individuals who may benefit from a less restrictive scanning environment.Supports translational and technology-development research through the evaluation of medical devices, MRI-compatible robotic systems, and advanced materials.
Nanofabrication facility is part of a network of cleanroom laboratories. Training can be tailored to the specific set of processes or techniques needed to fabricate and test various devices or materials. Films of numerous metals and ceramics can be applied and patterning as small as 10 nm can be accomplished. A wet chemistry area provides a safe environment for the use of a variety of coatings, solvents, and etchants.
Facility is aimed towards developing new research tools for life sciences. In the facility, CMOS processing technologies are utilized to enable personalized healthcare and preemptive medicine via smart and miniature devices, circuits, and systems with biomedical applications. Biosensing, DNA sequencing, and smart implanting are key components of the COREs tasks. Discovery-based research and translational research is supported in this lab as the Device Fabrication facility wishes to promote the development of new research tools for life science applications.
Core provides services in High-throughput (HTCD) and standard circular dichroism (CD), fluorescence and anisotropy, microscale thermophoresis (MST), biacore 8K surface plasmon resonance (SPR), multi-angle (SEC-MALS) and dynamic light scattering (DLS), refractive index detection (RI), isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC).
Core provides services for the assessment of health impacts resulting from inhaled environmental constituents and evaluation of therapeutics for the mitigation of cardiorespiratory disease. Resources include acilities for the generation of precisely controlled atmospheres and delivery to both in vitro and in vivo laboratory animal models.
Core for advanced materials characterization, micro/nanoscale manufacturing, and bioengineering research. NERCF provides open access to more than 20 state-of-the-art research instruments, technical consultation, user training, and collaborative research support for investigators from academia, government laboratories, industry, and external institutions. Major capabilities include scanning electron microscopy, focused ion beam, X-ray computed tomography, metal additive manufacturing, atomic force microscopy, nano-IR spectroscopy, optical profilometry, and mechanical characterization. By integrating advanced manufacturing with multimodal characterization, NERCF supports interdisciplinary research, workforce development, and innovation across Nebraska and beyond.
Shared resource facility housed in five dedicated laboratory rooms (878 sq. feet) within the North Life Sciences building. All services are provided on a fee-for-service, hourly recharge basis and are available for BSL-1 and BSL-2 research activities. Major instrumentation includes a BD Biosciences FACSAria Fusion in a biosafety cabinet and FACSMelody cell sorting systems; two BD LSR II flow cytometric analyzers; an Amnis ImageStreamX Mark II imaging flow cytometer; a PerkinElmer In Vivo Imaging System (IVIS); and a MESO QuickPlex Q 60MM electrochemiluminescence detection platform. The Core provides comprehensive instrumentation, expert technical support, and consultation in experimental design and data analysis that supports high-parameter cellular phenotyping (up to 18 colors), high-speed, multi-population sorting (up to four populations simultaneously) for enrichment or high-purity recovery, 96-well plate single-cell sorting for clonal expansion or downstream single-cell sequencing applications, multi-parameter quantitative imaging (up to six imaging channels), whole-organism fluorescence and bioluminescence imaging, and multiplex biomarker quantification.
High performance benchtop instrument used in research and bioprocessing labs to count cells, measure cell viability, and analyze cell size. Provides 1, 3 and 8-chamber slide options, state of the art optics, dual fluorescent and brightfield detection, precision autofocus, and 21 CFR Part 11 compliance. Has built-in quality control software and new validation slides for monitoring QC and production.
Widefield fluorescence microscope and digital imaging workstation. Fluorescence Imaging: Captures multi-channel fluorescent, brightfield, and DIC (differential interference contrast) images of biological samples. Live-Cell Experiments: Supports long-term time-lapse imaging (hours to days) using environmental chambers, motorized stages, and focus drift control. Multidimensional Data: Handles Z-stacking (3D), multi-position tiling (TileScanning/stitching), and 4D/time-lapse studies. Microscope Base: Typically paired with automated upright/inverted research microscopes (like the Leica DM/DMI series) or stereomicroscopes. Software: Powered by LAS AF (Leica Application Suite AF), sharing a software family with Leica confocal systems. Control & Analysis: Optional modules for 3D visualization, deconvolution, FRET (Förster Resonance Energy Transfer), calcium imaging, and motion analysis.
Core provides computational resources, fast on-premises storage, software deployment, and development consulting. Team of engineers and developers can assist in all stages of High Performance Computing projects. Forecasts system requirements, provision, deploy, and monitor hardware as well as support your software development projects. Enterprise-grade High Performance Computing infrastructure dedicated to WCM researchers and supporting AI workloads.
Enterprise-grade High Performance Computing infrastructure dedicated to WCM researchers and supporting AI workloads.
Software tool as graph self-supervised contrastive learning method that combines graph neural networks with self-supervised contrastive learning for spatial clustering, multi-sample integration, and cell-type deconvolution of spatial transcriptomics data.
Resources to support implementation of BRCA testing through routine oncology appointments.
Software application for opening and reviewing EDF, EDF+, BDF, and BDF+ biomedical-signal recordings in a multi-document Windows x64 workspace. It provides channel organization, navigation and scaling, measurements, annotation browsing and separate sidecars, selected-region frequency inspection, and review exports within documented limits while leaving source recordings unchanged. The current release is a public preview for waveform review, education, software validation, and research support; it makes no diagnostic interpretation claim.
Confocal Raman imaging microscope for automated molecular and chemical characterization and spatially resolved Raman mapping. Supports high-resolution chemical imaging and analysis of heterogeneous samples. Used to map, identify, and visualize the chemical and molecular composition of a sample in real time.
Core provides advanced instrumentation and expertise for the identification, characterization, and quantification of chemical compounds in a wide range of research samples. Instrumentation and capabilities include liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF), gas chromatography-mass spectrometry (GC-MS), high-performance liquid chromatography (HPLC) with diode array, fluorescence, and refractive index detection, inductively coupled plasma-optical emission spectrometry (ICP-OES), Fourier-transform infrared spectroscopy (FTIR), UV-Vis-NIR spectroscopy, and fluorescence spectroscopy. Provides expertise in analytical method development and optimization, sample preparation and analysis, data analysis and interpretation, experimental design, and training in analytical instrumentation and methods.
Functional genomics experiments based on DNA array technologies, either under the platform of cDNA or oligonucleotides, is the dominant technology. Any of the platforms used generates an array of gene expression (GEM). Discounting the laboratory artifacts introduced during the obtention of a GEM, one of the main limitations of these techniques is that the statistical analysis is complex and requires specialized software applications. The Bioconductor project has produced a lot of routines developed in R, which are oriented to analyzing functional genomics experiments. These routines are computationally efficient, are stable and are optimized for the analysis of gene expression arrays. However, its use requires a high level of specialization, which involves handling concepts and object-oriented techniques and be familiar with the syntax of the R programming language. Most biologists and biotechnologists do not have the necessary training to use these routines and this circumstance forces them to rely on data analysis services. Moreover, every analyst knows that the analysis process requires successive approximations and this implies that the researcher has to repeat the analysis from different perspectives or under various scenarios, which is not possible when you depend on a standardized processing service. It is therefore important that researchers could have friendly tools for the analysis of functional genomics data. fgStatistics is a software with a visual interface that takes advantage of the enormous potential of the R platform and packages specifically routines, developed in the framework of Bioconductor, to offer a freeware tool that covers the basic needs of a biologist or biotechnologist for data analysis DNA microarrays. Additionally, for advanced users, offers a programming interface that allows R use the full potential of this language without leaving the workplace and accessing data structures and objects that generate procedures with friendly interfaces.
LinRegPCR is a program for the analysis of quantitative RT-PCR (qPCR) data resulting from monitoring the PCR reaction with SYBR green or similar fluorescent dyes. The program determines a baseline fluorescence and does a baseline subtraction. Then a Window-of-Linearity is set and PCR efficiencies per sample are calculated. With the mean PCR efficiency per amplicon, the Ct value per sample and the fluorescence threshold set to determnine the Ct, the starting concentration per sample, expressed in arbitrary fluorescence units, is calculated