We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Software analysis pipeline for CUT&RUN and CUT&TAG experiments that includes QC, support for spike-ins, IgG controls, peak calling and downstream analysis. Used to process and analyze CUT&RUN, CUT&Tag, and TIP-seq genomic data. It maps protein-DNA interactions and chromatin profiles (similar to ChIP-seq, but with lower background noise) in a reproducible, portable way.
Core provides investigators with access to specialized expertise in primary cell isolation, ex vivo organ function assessment, histology, and advanced tissue imaging. The Core supports cardiovascular, pulmonary, and vascular research through customized experimental services, consultation, and rigorous functional and molecular analyses that accelerate mechanistic discovery and translational research.
Biotechnology company that connects patients and healthy donors directly with medical researchers. It collects human biological samples such as blood, plasma, and immune cells to help pharmaceutical companies develop new drugs, diagnostics, and cell therapies. Human biospecimen provider.
Core translates genomic and molecular discoveries into clinical diagnostic and therapeutic applications, focusing heavily on spatial "omics" and advanced tissue analysis. Services include Spatial Profiling: Houses specialized tools like the NanoString GeoMx® Digital Spatial Profiler to map RNA and proteins inside tissue sections; Multiplex Immunofluorescence: Uses platforms like Akoya Opal™ and Leica Cell DIVE™ to image over 40 custom protein markers on a single tissue sample; Histology and Sample Prep: Provides tissue microarray (TMA) construction, laser capture microdissection, microtomy (sample sectioning), and whole-slide digital scanning; Image Analysis: Uses advanced software (such as HALO) to quantify and evaluate tissue biomarker stains.
Core oversees humane animal care, housing, veterinary oversight, and regulatory compliance for all vertebrate research and teaching facilities across campus, partnering with the Institutional Animal Care and Use Committee (IACUC).
Control and acquisition software package for the Olympus FLUOVIEW FV3000 confocal laser scanning microscope system. File formats; OIR, OIF, OIB and VSI are supported. File exporting function to general file formats (BITMAP, JPEG, PNG, TIFF, WMV, OIF, OIB, FluoView Multi-TIFF) is available.
Software modular Snakemake pipeline for personalised neonatigen discovery and prioritisation using Patient Specific Functional Interaction Networks. Used for identifying and prioritizing personalized tumor neoantigens from DNA and RNA sequencing data. It detects candidate epitopes arising from somatic variants, gene fusions, and alternative-splicing events, and integrates HLA binding, expression, gene essentiality, and patient-specific gene co-expression network features to rank biologically relevant vaccine candidates.
Histology Core specializes in processing, embedding, sectioning, and staining of animal tissues. The core can supply standard hematoxylin-eosin (H&E) staining, and a variety of standard special stains are available. The Histology Core also offers veterinary pathology support through GEMpath Inc.
Core provides Illumina next-generation sequencing and single-cell RNA sequencing to support gene expression and genomic research. Core services include Illumina Sequencing: High-throughput, fast-turnaround genomic sequencing runs; Single-Cell Transcriptomics: Single-cell RNA sequencing (scRNA-seq) chemistries to map gene expression at individual cell resolution; Gene Expression Analysis: Support for studies examining transcriptional changes, host resistance mechanisms, and inflammatory responses.
Standalone, Windows-based software program designed to identify and annotate low-complexity purine and pyrimidine regions as well as user-defined nucleotide sequences within prokaryotic and eukaryotic genomes. It features a graphical user interface and performs rapid "one-go" genome analyses without requiring high-performance computing clusters. Software for detection and annotation of sequence tracks of chosen nucleic acid bases with defined length in genome. Used to identify low-complexity regions containing DNA sequences of selected nucleotide(s) and to annotate the data with the support of NCBI/Genome database.
Software Python framework for analysis of single-molecule FRET data.
Software tool for detection of sample swaps and cross-individual contamination in whole-genome and whole-exome tumor–normal sequencing experiments. Used for human tumor-normal studies to perform concordance verification (= samples coming from the same individual), as well as cross-individual contamination level estimation in whole-genome and whole-exome sequencing experiments.
Software Python package and service for the genome-writing era, the modality that installs new information into genome (inserting genes, flipping or excising kilobases, placing programmable landing pads). Used for verification and grounding layer for AI-driven genome writing: checks proposed genomic edits against validated tools and calibrated models rather than relying on language model outputs alone.
Software application for genome-writing design AI: screens an AI-generated editing plan across five hazard axes and returns allow, flag-for-review, or refuse with cited evidence and a signed design passport. Used to prevent engineered organisms or artificial intelligence DNA designs from causing harm or escaping control.
Core provides centralized services, consultation, training and technical support to advance transgenic animal genotyping and cardiovascular, metabolic and behavioral phenotyping research.
Health care organization in Maine, serving communities across Maine and New Hampshire. Includes MaineHealth Institute for Research to support research at MaineHealth ranging from basic laboratory-based research through translational research, which works to apply basic discoveries to medical problems, to clinical research, which studies the direct application of new drugs, devices and treatment protocols to patients, to health services research which seeks to use research methods to help improve and evaluate health care delivery programs and new technologies.
Core offers a variety of preclinical imaging services. Small animal imaging core facility with high-resolution ultrasound (FujiFilm, Vevo F2, Visual Sonics) and micro CT (SkyScan 1276 (Bruker), micro CT with in vivo and ex vivo capabilities, Caliper IVIS Lumina LT (Revvity). Offers complete services for non-destructive, longitudinal optical imaging with bioluminescence and fluorescence capabilities of mice.
Core facility provides microscopy services including confocals, epifluorescence, 2-photon, lightsheet, superresolution, slide scanning and image analysis.
Core offers integrated biobanking, histology, digital pathology and other advanced tissue analysis services to support basic, translational and clinical research.
Software Python library to manage metabolic networks. Python library for hAndling metaData of METabolism.