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Software R package to run genome-wide association study (GWAS) and genome-wide by environment interaction study (GWEIS) scans using genetic data stored in binary dosage file.
Software Python toolbox for fitting Hierarchical Sequential Sampling Models using Bayesian methods.
Core provides access to technologies and services enabling study of human immune-mediated diseases. Offers expertise in human immunology along with innovative assays and technology. Core specializes in high-parameter single-cell assays utilizing conventional, spectral, and mass cytometry (CyTOF), which can be paired with genomic and bioninformatic analyses through our connections with other outstanding BRI cores. Other services include cell sorting, short-term in vitro assays, DNA/RNA extraction, qPCR, and ELISA or multiplex protein analysis (Luminex), guidance on study design and training on new technologies, execution, data analysis and interpretation.
Interdepartmental, multiuser core facility dedicated to genetic analysis and preservation of the world's biodiversity. Provides equipment used in molecular biology enabling to pursue study of genetic diversity throughout tree of life and at all taxonomic levels, from populations to classes to phyla of organisms.
Advanced microscope systems for multidimensional optical imaging of living and fixed cells and tissues. Microscopy technologies include confocal, super-resolution (Airyscan and SMLM), TIRF, and wide-field microscopy as well as plate reading and laser capture microdissection. Analysis workstation and software are available, with custom pipeline development for processing, analysis, and visualization.
Bioimaging Platform provides access to and support for wide variety of advanced microscopy and flow cytometry instruments, enabling researchers to perform studies from the tissue level and down to sub-cellular scales. Provides access to analytical imaging technologies. As such, the platform comprises of advanced microscopy systems for high resolution studies of fixed and live samples as well as for low-phototoxicity imaging of whole organs and organisms.Bioimaging platform includes seven advanced microscopy systems, two flow cytometers and several high-performance analysis workstations.
AAALAC approved animal research facility to study diverse number of animal species. Core maintains animal housing rooms, observation rooms, and procedure rooms at BSL 1 and 2 containment levels. The ARC is supported by certified veterinarians and animal care technicians who provide technical support and veterinary care.
Web platform for large-scale public data reuse to model immunotherapy response and resistance. Provides integrated large-scale omics data and biomarkers on published ICB trials, non-immunotherapy tumor profiles, and CRISPR screens.
Interactive web-based application to facilitate data integration, discovery, and hypothesis generation across diverse Common Fund programs' datasets, highly processed data can be converted into gene-, metabolite- and drug-set libraries.
Collected, annotated and analyzed cancer scRNA-seq datasets. Data from different studies to reveal patterns of transcriptional ITH across tumour samples.
Standard-sized automated analyzer with its single-channel design, it can run 1~96 samples. Supports various types of applications, including DNA, RNA and protein fragment analyses and high-voltage fast analysis.
Microplate reader can perform wide range of essential cell-based and biochemical assays using included absorbance, fluorescence, and luminescence detection modes.
Facility provides diverse range of equipment, expertise and training in field of biochemistry, molecular, structural and cellular biology. Facility consists of several research laboratories and support areas.
Fully automated and affordable cytometer to simplify and standardize deep single-cell profiling studies.
Core provides equipment to manufacture and test thin-film devices without ever exposing them to air or water, allowing measurements of device performance unaffected by environmental degradation.
Core offers computing and storage resources, along with support and training. Currently, Grex system consists of over 10,000 CPU cores connected via low-latency InfiniBand interconnect, several GPU compute nodes, 2 Petabytes of high-performance Lustre storage, and tape backup system. System also provides for condominium model of hosting researcher-contributed hardware funded by Canada Foundation for Innovation (CFI) and other granting agencies.
Fully automated slide preparation and staining. Processes BD SurePathTM Liquid-based Pap test and Non-Gynaecological samples. Integrates slide creation and staining from enriched cell pellet. Allows for random sample loading.
Core offers automation and screening capabilities. Equipped with environmentally-controlled high-content microscopes, automated liquid handlers, plate washers and readers, and robotic platforms, HTS aims to accelerate experiments from small-scale assays to large screening campaigns.
Software R code for multi-modal analysis to delineate cell types using electrophysiology. Interpretable in vivo neuronal cell type identification using multi-modal analysis of electrophysiological data.
Software application for statistical calculation.