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Established in 1985, LifeLink Tissue Bank is a not-for-profit organization dedicated to serving patients in need of transplantation therapy. It is one of five divisions of the LifeLink Foundation and the largest not-for-profit tissue bank in the Southeast and one of the largest in the United States. LifeLink Tissue Bank is inspected and accredited by The American Association of Tissue Banks (AATB). Our goal is to provide the safest, most clinically effective allografts while remaining cognizant of the rising cost of medical care. Donors and their families are the core of our organization. We treat them with respect, show them compassion, and offer them comfort in knowing that their confidentiality is protected and their gifts optimally utilized. Our allografts are utilized by surgeons and hospitals that trust LifeLink to provide them with safe and clinically effective allografts. Every effort is made to ensure that our allografts are placed back in the hospitals of the communities that we serve with organ and tissue recovery services.

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• SciCrunch
• 16 years ago - by Anonymous

Central repository of information on neuronal cell types mainly accumulating information on: Genetically labeled cell types in mouse brain and genetically engineered mouse lines for cell type research. Mouse lines are annotated with * Atlas for examining transgene expression patterns * Information on construct used to generate transgene * Associated publications * Anatomical regions where transgene is expressed (based on Atlas) * Information on where to obtain the animals Currently, the mouse lines in the database are mostly generated at Cold Spring Harbor Lab, Scripps Research Institute, Baylor College of Medicine and Brandeis University with few other exceptions. In the future, they will incorporate more mouse lines useful for neuronal cell type research. Cell types are annotated with * Anatomical region * Properties (frequently used terms in neuroscience research) * Mouse line used to define the cell type * Genome wide transcriptome data (if available) * Specific (marker) genes (if available) * Marker immunostaining data (if available) * Associated publications * Electrophysiological characterizations (when available) * Morphological characterizations (when available)

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• SciCrunch
• 16 years ago - by Anonymous

A format for efficient storage of multiple tracks of numeric data anchored to a genome. The format allows fast random access to hundreds of gigabytes of data, while retaining a small disk space footprint. They have also developed utilities to load data into this format. Retrieving data from this format is more than 2900 times faster than a naive approach using wiggle files. A reference implementation in Python and C components is available here under the GNU General Public License. The software has only been tested on Linux and Mac systems.

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• SciCrunch
• 16 years ago - by Anonymous

It is the aim of the SepNet initiative to establish a central facility, essential to data and sample quality and homogeneity, that comprises a structured and easily accessible sample bank with probes of homogeneous quality originating from a well-characterized patient population enrolled in independent, innovative and internationally competitive prospective clinical sepsis trials. The SepNetBiobank is a core facility of SepNet. The object of this central sample resource is to organize and handle all relevant aspects of sampling, storage and delivery of samples in the SepNet collaboration to ensure homogeneity of the samples in terms of specimen quality and maintaining sampling standards. This will be achieved through central handling of samples collected in peripheral nationwide 17 regional centers and an additional 36 associated centers according to an agreed sampling scheme and pre-set standards for sample quality, sample handling and banking; quality assurance and all relevant parts of sample handling will be in the hands of the core unit, minimizing pre-analytical steps in the heterogeneous environment of the different regional centers. In the next few months a fully automated sample storage system will be implemented that allows handling of more than 200.000 individual aliquots expected after completion of the different ongoing and planned SepNet Trails. In the next six months a fully automated -80 degree C sample storage system will be implemented. After completion of the plannend and ongoing SepNet trials more than 59.710 expected primary samples (218.040 aliquots) will be stored in this system. This outstanding sample resource will provide the basis for scientific projects aming at improving patient care with sepsis e.g. advancement in diagnostics, risk stratification, therapy and outcome.

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• SciCrunch
• 16 years ago - by Anonymous

Database of positive selection based on a rigorous branch-site specific likelihood test. Positive selection is detected using CODEML on all branches of animal gene trees.

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• SciCrunch
• 17 years ago - by Anonymous

The Michigan Neonatal Biobank (Biobank) is a storage and management facility for The Michigan Department of Community Health''s archive of dried blood spot cards. A 501(c)3 non-profit charitable organization, the Biobank is contracted to serve as the repository for storage and management of the samples in a temperature controlled facility at Wayne State University''s Biobanking Center of Excellence in Tech Town. The Biobank''s roots are planted in the State''s Newborn Screening Program which began in 1965 in the Department of Community Health. Newborn screening is a public health program required by Michigan law to find babies with rare but serious disorders that require early treatment. A few drops of blood taken from the baby''s heel are sent to the State Public Health Laboratory and are tested for 49 disorders. Each year more than 200 Michigan babies are found to have a disorder detected by Newborn Screening. Once screening in the State laboratory is complete, residual dried blood spot samples that are no longer needed for testing are each assigned a unique code which assures anonymity for the sample and its donor. The samples are then sent for storage in the Michigan Neonatal Biobank.

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• SciCrunch
• 16 years ago - by Anonymous

The J.P. McCarthy Cord Stem Cell Bank at the Karmanos Cancer Institute is a public, non-profit stem cell bank with over 1,200 umbilical cord blood units in its inventory. The bank was founded in 2001 and is one of only 21 internationally recognized cord stem cell banks affiliated with the National Marrow Donor Program. The only bank of its kind in Michigan, it was created in anticipation of providing life-saving hope to people who have been diagnosed with cancer and serious blood disorders. Karmanos collects, processes and stores donated umbilical cord blood that becomes a readily available source of hematopoietic stem cells for transplant in children and adults with leukemia, lymphoma, sickle cell disease or other life-threatening conditions. The J.P. McCarthy Cord Blood Bank and Carls Processing Laboratory is also accredited by the Foundation for the Accreditation of Cellular Therapy (FACT). The accreditation signifies the highest standards of practice in collection, processing and transplantation. Karmanos is the only FACT accredited cord blood bank in Michigan and one of only nine in the United States. In the Detroit Metropolitan area, the number of hospitals participating in the collection of cord blood is rapidly increasing. Please consider donating your baby''s cord blood if you are delivering at one of our participating hospitals: Henry Ford Wyandotte Hospital in Wyandotte, MI, Providence Park Hospital in Novi, MI, St. Joseph Mercy Hospital in Ann Arbor

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• SciCrunch
• 16 years ago - by Anonymous

A repository of information related to Huntington's disease and its causes, progression, treatments, and possible cures. It stores and accepts data and specimens to accelerate research on Huntington's disease and provides scientists with prospectively collected clinical data and biological specimens. The COHORT sample includes individuals which manifest Huntington's disease (HD), unaffected individuals known to carry the HD gene or who are at risk of carrying the HD gene, and family members who have no risk for HD (control subjects). Clinical data includes demographics, clinical features, family history, and genetic characteristics. Biological specimens include blood with a potential of collecting urine or other samples in the future. The COHORT biological specimen repository will provide research specimens for current and future scientific research aimed at developing useful biomarkers of HD.

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• SciCrunch
• 16 years ago - by Anonymous

Software resource including non-EEG related Matlab functions, Neuron''s simulation files, C/C++ functions, Java, Unix tips, Flash 5 buttons and movies, Publishing photo albums using Linux (external page), and Publishing digital camera movies using Linux (external page). Non-EEG related Matlab functions *Qsubfunc *Gui Matlab functions *Function keyword input/output arguments processing *Web and Matlab help *Others C/C++ functions *Convolution *Chono *Format_biblio *Image processing library *Fusion sort Java *Simple scroll *Rebound scroll *Spiking neurons Unix tips *Send a mail automatically in non-interactive mode *Log in remotely and redirect/assess resources *Schedule automatically a task (for instance to check your quota)

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• SciCrunch
• 16 years ago - by Anonymous

The AIDS And HIV Research Lab Registry is a registry of lab heads ranked by total citation score. You may sort the rankings by total score, mean score, publication number and last 365 days. Results presented are Rank, Name, Affiliation, and Total score/Last 365 days. Clicking on the name of the lab head provides additional information including a picture, affiliation, citations, the researcher''s home page, and collaborative biography.

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• SciCrunch
• 16 years ago - by Anonymous

The NEI-AREDS Genetic Repository is a collection of genetic material submitted by participants in the Age-Related Eye Disease Study (AREDS) which was sponsored by the National Eye Institute (NEI). The Repository stores DNA for use by investigators conducting genetics research into the causes of eye disease. The Age-Related Eye Disease Study was designed to learn about macular degeneration and cataract, two leading causes of vision loss in older adults. The study looked at how these two diseases progress and what their causes may be. In addition, the study tested certain vitamins and minerals to find out if they can help to prevent or slow these diseases. Participants in the study did not have to have either disease. (Enrollment was completed in January 1998.) Eleven medical centers in the United States took part in the study, and more than 4,700 people across the country were enrolled in AREDS. The study was supported by the National Eye Institute, part of the Federal government''s National Institutes of Health. The clinical trial portion of the study also received support from Bausch & Lomb Pharmaceuticals and was completed in October 2001. Data from AREDS is publicly available in the Database of Genotypes and Phenotypes (dbGaP). Genetic samples from 600 AREDS participants (200 controls, 200 Neovascular AMD cases, and 200 Geographic Atrophy cases) were selected using data available in March 2005 and then were genotyped using the Illumina 100K and the Affymetrix 100K gene chips. These genotype data are available in the dbGaP. DNA samples are distributed only to qualified professional persons who are associated with recognized research, medical, educational, or industrial organizations engaged in health-related research or health delivery. All orders for DNA samples must be submitted using the online catalog.

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• SciCrunch
• 16 years ago - by Anonymous

SeraCare stores and manages over 19 million samples in our state-of-the-art biobank, and is supported by a range of processing and characterization services. Security. Backup. On-line inventory. Next day sample access. Analysis. Characterization. Anonymization. Transformation. Restoration. Compliance. Coordination. We handle your samples all the way through. SeraCare is well-equipped to perform a wide range of sample storage, management, and processing services. We have longstanding customer relationships with clinical and research laboratories, biopharma, and public health agencies, including the National Institutes of Health, the Centers for Disease Control, and the US Food and Drug Administration. * Our scientists have expertise in virology, immunology, molecular biology, and biochemistry * We have a proven legacy of custom assay design and custom product development to meet your specifications

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• SciCrunch
• 16 years ago - by Anonymous

The Regional Biobank of Central Norway, henceforth called the Biobank, is a research facility which contains a collection of human biological material such as blood, tissue and urine samples, and a database which stores relevant information about the samples and the patients from whom the samples originate, as well as information obtained from analysis of the material. The material is collected as part of medical examinations, diagnosis or treatment. The Biobank is foreseen to give an increased knowledge about causes for diseases and their mechanisms, and thereby contributing to improve prophylactic health work, diagnostics and treatment. The Biobank is owned and operated by official authorities on a no commercial profit basis. The Biobank was established in collaboration between the Central Norwegian Regional Health Authority (data management and administration) and the Faculty of Medicine at the Norwegian University of Science and Technology (economics and personnel). The Biobank is approved by The Data Inspectorate of Norway, and by the Regional Committee for Medical Research Ethics, and all information in the Biobank is handled according to the guidelines of the Data Inspectorate.

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• SciCrunch
• 16 years ago - by Anonymous

Software tool to visualize and edit phylogenetic trees. It combines a browser-based Javascript client with a Python (web2py) server. Trees are rendered in SVG using Raphael.

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• SciCrunch
• 12 years ago - by Anonymous

A searchable public data repository for multi-assay studies in the field of high-throughput biology. Studies are annotated and curated using ontologies and controlled vocabularies according to the recommendations of the OBO foundry (Open Biological and Biomedical Ontologies) and the NCBO bioportal. Each data set is assigned a digital object identifier (DOI) provided by DataCite. In addition, the SIDR team has developed an ISA-XML (ISA-ML) version of the ISA-TAB format and the mapping to the FuGE object model (ISA-TABtoFuGE); these improvements should facilitate further tool integration, including web services. SIDR contributes to the proof-of-concept addressing the critical success factor for data integration. The SIDR team will continue to put in place the building blocks for giving access to interoperable data through a world-wide network of national hubs in the context of the community-based ISA infrastructure.

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• SciCrunch
• 16 years ago - by Anonymous

Recently, our team completed an NINDS-funded, Phase IIa double-blinded, placebo-controlled pilot clinical trial that examined the pharmacokinetics, safety, and activity of progesterone, a steroid found to have powerful neuroprotective effects in multiple animal models of brain injury. Our pilot study demonstrated a 50% reduction in death among severe TBI patients and less disability among moderate TBI patients treated with progesterone. Based on these promising results and supportive preclinical data, we are conducting a large, phase III clinical trial (ProTECT III) to definitively assess the safety and efficacy of this treatment for adults with moderate to severe acute TBI. The study is slated to begin August 2008. WHY Progesterone: Although progresterone is widely considered a sex steroid, it is also a potent neurosteroid. Progesterone is naturally synthesized in the CNS. A large and growing body of animal studies indicate that early administration of progesterone after TBI reduces cerebral edema, neuronal loss, and behavioral deficits in laboratory animals. Certain properties of progesterone make it an ideal therapeutic candidate. First, in contrast to most drugs tested to date, progesterone rapidly enters the brain and reaches equilibrium with the plasma within an hour of administration. Second, unlike other experimental agents, progesterone has a long history of safe use in humans. Finally, the findings of our pilot clinical trial (presented in the Preliminary Data Section, below) indicate that progesterone has consistent and predictable pharmacokinetic properties, is unlikely to produce harm, and may be efficacious for treating acute TBI in humans.

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• SciCrunch
• 16 years ago - by Anonymous

A biobank of repositories which works to obtain, store, manage and distribute large collections of human biological samples of phenotypes and diseases of marked interest for researchers. The biobank sample collection is made up of three extensive repositories. The Neurological Tissue Biobank is a nervous tissue repository (brain and spinal cord) created from donations from cadavers with or without neurological conditions. It helps facilitate research in neurological illnesses. The Tumour Biobank and Anatomical Pathologies Collections is a repository of tumorous tissue and samples from cancer patients. The Blood and Fluid Biobank is a repository which contains samples of metabolic, inflammatory bowel, hepatic, digestive and maternal and foetal diseases, among others. It houses a large range of samples of scientific interest, primarily DNA, serum and plasma.

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• SciCrunch
• 16 years ago - by Anonymous

Ontology that extends the Ontology for Biomedical Investigations (OBI) to support consistent annotation of Bioinformatics Web services.

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• SciCrunch
• 13 years ago - by Anonymous

DNA samples and cell lines from fifteen populations, including the samples used for the International HapMap Project, the HapMap 3 Project and the 1000 Genomes Project (except for the CEPH samples). All of the samples were contributed with consent to broad data release and to their use in many future studies, including for extensive genotyping and sequencing, gene expression and proteomics studies, and all other types of genetic variation research. NHGRI led the contribution of the NIH to the International HapMap Project, which developed a haplotype map of the human genome. This haplotype map, called the HapMap is a publicly available tool that allows researchers to find genes and genetic variations that affect health and disease. The samples from four populations used to develop the HapMap were initially housed in the Human Genetic Cell Repository of the National Institute of General Medical Sciences (NIGMS). Except for the Utah CEPH samples that were in the NIGMS Repository before the initiation of the HapMap Project and remain there, the NHGRI Repository now houses all of the HapMap samples. The NHGRI repository also houses the extended set of HapMap samples, which includes additional samples from the HapMap populations and samples from seven additional populations. All of the samples were collected with extensive community engagement, including discussions with members of the donor communities about the ethical and social implications of human genetic variation research. These samples were studied as part of the HapMap 3 Project. The NHGRI repository also houses the samples for the International 1000 Genomes Project. This Project is lightly sequencing genome-wide 2500 samples from 27 populations. This project aims to provide a detailed map of human genetic variation, including common and rare SNPs and structural variants. This map will allow more precise localization of genomic regions that contribute to health and disease. The 1000 Genomes Project includes many of the samples from the HapMap and extended set of HapMap samples, as well as samples being collected from additional populations. Currently, samples from five additional populations are available; the others will become available during 2011 and 2012. No identifying or phenotypic information is available for the samples. Donors gave broad consent for use of the samples, including for genotyping, sequencing, and cellular phenotype studies. Samples collected from other populations for the study of human genetic variation may be added to the collection in the future. The NHGRI Repository distributes high quality lymphoblastoid cell lines and DNA from the samples to researchers. DNA is provided in plates or panels of 70 to 100 samples or as individual samples. Cell cultures and DNA samples are distributed only to qualified professional persons who are associated with recognized research, medical, educational, or industrial organizations engaged in health-related research or health delivery.

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• SciCrunch
• 16 years ago - by Anonymous

Immunology is a wikibook with the following contents: * Introduction * Organs of the Immune System * Cells of the Immune System * Antigens * Antibodies * Immune System Genetics * Antibody/Antigen Interactions * Major Histocompatibility Complex * Antigen Processing and Presentation * T Cells * B Cells * Cell-Mediated Immune Response * Cytokines * The Complement System * Inflammation * Hypersensitivity * Infectious Disease * Immunodeficiency * Autoimmunity * Transplants * Cancer * Vaccines * Experimental Methods in Immunology You may download as a PDF or print it.

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• SciCrunch
• 16 years ago - by Anonymous