Curator Dashboard

Multi-center facility at Columbia University Irving Medical Center, created to help users take advantage of up-to-date resources in the stem cell field in a timely and cost-efficient way. Offered services include giving access to quality-controlled pluripotent stem cells and stem cell-derivatives prepared using standardized approaches; genome editing services for the generation of custom-designed cell lines; training sessions and informal interactions between scientists from multiple laboratories working on different stem cell models. Some reagents commonly used in stem cell labs, as mTeSR1 media and irradiated mouse embryonic fibroblasts, are also available at discounted prices for our users. We are connected to Stem Cell COREdinates(link is external and opens in a new window), a consortium of pluripotent stem cell-focused core facilities, which allows us to take advantage of the sharing of the most updated and efficient protocols, expertise, and reagents.

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• 1 month ago - by Anonymous

Software R package for enhanced visualization of gene set enrichment analysis in biomedicine. Used to visualize Gene Set Enrichment Analysis (GSEA) results.

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• 1 month ago - by Anonymous

Core provides comprehensive preclinical imaging and radiochemistry services. Expertise covers the entire pipeline from study design to data analysis. Services include preclinical research (mice, rats, CAM assay, zebrafish, slugs) using radionuclide imaging via SPECT/CT and PET/CT, as well as 3T MRI, µCT, radiochemistry, tracer biokinetics, and kinetic modeling.

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• 1 month ago - submitted by Edyta Vieth

Real-time live-cell imaging system designed for long-term time-lapse dynamic observation of living cells, including intracellular calcium flux recording, tumor spheroid, organoid 3D growth tracking, cell migration, apoptosis and pharmacodynamic screening. Equipped with multi-channel fluorescence excitation modules, the system supports continuous non-invasive real-time monitoring under physiological culture environment, used in stem cell research, oncology, cardiovascular pharmacology and cell biology experiments.

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• 1 month ago - submitted by Sui Weikai

Core offers solar cell fabrication, characterization and testing capabilities. Additional services include making modules and performing reliability testing. Core is designed with industrial compatibility in mind. Although fabrication on smaller substrates or even pieces is possible, the native substrate form factor is currently 156 mm silicon. New equipment is being selected to maintain compatibility with evolving solar manufacturing sizes (e.g., M12 = 295 mm diagonal). Supported technology thrusts reinforce industry relevance. Considering solely silicon technology, architectures researched include Al BSF, PERC, SHJ and various tandems, predominantly silicon-based with a perovskite top cell.

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• 1 month ago - submitted by CoreFacilities Admin

Software R annotation package for Illumina's EPIC v2.0 methylation arrays. The version 2 covers more than 935K CpG sites in the human genome hg38. It is an update of the original EPIC v1.0 array (i.e., the 850K methylation array).

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• 1 month ago - by Anonymous

Software R package provides functions for estimating mitotic age of tissues from corresponding DNA methylation (DNAm) profile. These functions are epigenetic mitotic clocks, providing separate mitotic age estimates on scales unique to each clock. So each estimate should be interpreted as a relative mitotic age, not an absolute one, except for the epiTOC2 clock which does aim to estimate the total number of stem-cell divisions in a tissue.

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• 1 month ago - by Anonymous

iGenSeq platform offers academic researchers and industry tools and services for genomic analysis: medium, high and very high throughput DNA and RNA sequencing, qPCR and ddPCR.

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• 1 month ago - submitted by Edyta Vieth

Thermionic field emission high-resolution scanning electron microscope designed to make high-performance imaging and analytics. Minimizes user intervention and lab management demands with its SmartAlign Technology, an auto-aligning optics system. Additionally, Thermo Scientific FLASH Technology automates image fine-tuning, correcting lens centering, stigmators, and final focus. Capabilities include 1-nanometer resolution at 10 mm analytical working distance, overcoming the typical trade-off between working distance and image quality.

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• 1 month ago - by Anonymous

Atomic Force Microscope (AFM) designed for bioscience and materials research. It is used to capture high-resolution topographical images and perform precise force measurements on both soft biological samples (like live cells and proteins) and advanced materials at the nanoscale.

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• 1 month ago - by Anonymous

Core provides light and electron microscopy services.

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• 1 month ago - by Anonymous

Core provides electron microscopy services including Sample preparation from tissues, cell culture, cell suspension; Sample preparation for materials science; Preparation of semi-thin sections; Preparation of ultrathin sections for classical TEM , REM and serial reconstruction;Contrast methods for TEM samples, SEM samples, negative contrast, coating methods for SEM; Classical TEM and REM; Immunogold technique;Tokuyasu freeze-cutting technique; Cryo-substitution; Cryo-electron microscopy; Electron tomography; 3D array tomography; SBF-SEM; Image documentation and digital processing; Technical-preparative adjustments; Provision of infrastructure (sample preparation, electron microscopes, individual user training); Creating image documentation and evaluations; Image processing techniques and quantitative evaluation techniques (Image J, Fiji/TrakEM2, IMOD/3Dmod, Amira 5, ZEN Connect, etc.); Publication consulting.

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• 1 month ago - submitted by Sara Timm

Web tool for prediction of changes in protein-protein binding affinity on mutations. Predictor of changes in binding free energy induced by point mutations. It relies on a set of statistical potentials derived from known protein structures, and combines the effect of the mutation on the strength of the interactions at the interface, and on the overall stability of the complex.

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• 1 month ago - by Anonymous

Electronic Lab Notebook digital platform designed to help researchers organize, store, and share experimental notes, protocols, and data. Acting as a modern replacement for traditional paper lab notebooks, it operates as an institution-wide research data management (RDM) system.

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• 1 month ago - submitted by Rob Day

Spacial neuron gene expression atlas. Interactive, server-free web application and spatial transcriptomics database designed to help researchers map and analyze gene expression within the brain. Mouse whole brain spatial transcriptomic atlas.

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• 1 month ago - submitted by Lindsay Meyerdirk

Facilitates multi‐disciplinary collaboration among imaging scientists and clinicians at academic institutions within the Milwaukee region. Manages MCW research imaging facilities and provides access to MCW faculty imaging specialists. Services include performing mixed research and advanced clinical outpatient imaging to support clinical evaluation trials and basic science/technology research.

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• 1 month ago - by Anonymous

Core is part of the University of Pittsburgh Center for Biologic Imaging. Provides expertise in the design and implementation of experiments that use microscopy techniques and image analysis, including interpretation of morphological data. Services include to prepare, store and optimally analyze tissues and cells via morphological and mRNA and protein localization techniques; provide fixed cell and tissue imaging to Hillman investigators; provide live cell, live tissue, and live animal imaging to Hillman project leaders; perform detailed electron microscopy analysis of tissue structure; provide training related to use of and access to all instrumentation; Assist with experimental design and refinement, and evaluate experimental results including developing and implementing appropriate software algorithms to provide quantitative measurements.

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• SciCrunch
• 1 month ago - submitted by Edyta Vieth

Software R package provides access to the iLINCS (Integrative LINCS) database for drug repurposing and functional genomics research. Enables systematic analysis of gene expression signatures against comprehensive databases of Gene Knockdown signatures, Gene Overexpression signatures, Chemical Perturbagen signatures.

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• 1 month ago - submitted by Ali Sajid Imami

Zeiss Crossbeam 550 (sometimes referred to as the XB 550) is dual-beam system that combines the Gemini 2 SEM with the Ion-sculptor FIB (Focused Ion Beam) for advanced materials analysis and sample preparation. XB 550 combined with the Leica EM VCT 500 is a highly specialized system designed for advanced cryogenic workflows in materials and life sciences. It enables researchers to investigate and prepare samples at ultra-low temperatures without exposing them to air or contamination.

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• 1 month ago - submitted by Danielle Jorgens

Software highly performant messaging and multiprocessing data framework designed for building modular, high-performance signal processing pipelines. It is built in Python with no dependencies, making it easy to install and use.

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• 1 month ago - submitted by Brock Wester