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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 23,2022. In this database data can be searched and browsed. Very few SSU rRNA modification maps are believed to be complete, i.e., with all sites and structures of modified nucleosides unambiguously established. The exception is perhaps E. coli, the subject of investigation for many years; Lingering discrepancies were mostly resolved upon completion of the gene sequence, with the final modified residue (Y-516) placed in 1994. When using the present compilation, the reader should be aware of several major sources of incomplete listings for some organisms. The first is that only portions of the rRNA molecule may have been sequenced, thus giving the (possibly incorrect) appearance in comparative alignments that portions of the rRNA are unmodified. For example in the case of B. stearothermophilus only the 52 3'-terminal nucleotides were sequenced, but which produces an incomplete picture when B. stearothermophilus is aligned with the E. coli map, which is complete. An additional source of incomplete listings lies in data derived from RNase T1 catalogs in the earlier literature. Most such studies were made for the purpose of establishing patterns of phylogenetic relatedness. For this reason most reported catalog sequences purposely omitted short sequences, some of which were undoubtedly modified, because they were of less use in establishing unique "signature" sequences. The extent of this problem in judging modification map completeness is difficult to judge unless a total modification assay (as from HPLC or LC/MS analysis of a complete nucleoside digest) has been carried out in order to determine the identities and approximate numbers of modifications. A third source of incompleteness may result from the method used for detection of modification. For instance pseudouridine residues (which are abundant in eukarya) would not be reported if the 14C-methionine method, resulting in labeled methyl groups, were used. Similarly, maps reporting locations of pseudouridine have in recent years often been based on the modification-reverse transcriptase method of Ofengand, and was thus not intended to detect ribose methylation. Reference to the original citations will usually be required to establish whether the methodology used would have influenced the reported modification distribution. Supported by: National Institute of General Medical Sciences, grant GM29812.

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• 14 years ago - by Anonymous

Software for hierarchical Clustering Analysis of Millions of 16S rRNA Pyrosequences in Quasi-linear Time.

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• 13 years ago - by Anonymous

Platform for exploring the anatomic and genetic basis of glioblastoma at the cellular and molecular levels that includes two interactive databases linked together by de-identified tumor specimen numbers to facilitate comparisons across data modalities: * The open public image database, here, providing in situ hybridization data mapping gene expression across the anatomic structures inherent in glioblastoma, as well as associated histological data suitable for neuropathological examination * A companion database (Ivy GAP Clinical and Genomic Database) offering detailed clinical, genomic, and expression array data sets that are designed to elucidate the pathways involved in glioblastoma development and progression. This database requires registration for access. The hope is that researchers all over the world will mine these data and identify trends, correlations, and interesting leads for further studies with significant translational and clinical outcomes. The Ivy Glioblastoma Atlas Project is a collaborative partnership between the Ben and Catherine Ivy Foundation, the Allen Institute for Brain Science and the Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment.

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• 16 years ago - by Anonymous

NDRI actively recovers a diverse range of normal and diseased human tissues for biomedical researchers. We have recently implemented a new program to make human dorsal root ganglia (DRG) available for your research studies. The dorsal root ganglia contain cell bodies of afferent (inbound) neurons, and transmit pain and temperature sensations from the body. DRGs from C5 through L5 regions will be available. DRGs will be recovered under operating room conditions with a low post mortem interval to preservation and can be shipped at 4 degrees C, snap-frozen or fixed. Detailed medical-social history information is provided for each donor. If you are interested in obtaining these specimens, please contact me at your earliest convenience. Current NDRI researchers can immediately request these samples. Non-NDRI researchers need to submit a researcher application. * The program provides a reliable source of human DRG neurons that can be utilized for: Electrophysiology analysis, Live cell imaging studies * Low PMI yields high quality samples that are suitable for rigorous molecular applications: Deep sequencing analysis, In situ hybridization, Micro-array analysis * DRGs from C5 through L5 regions will be available. * The tissue fee for this program is 500 dollars per DRG * Customizable-- the researcher determines the DRG location and quantity that is needed for their research.

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• 15 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented September 6, 2016. The Allen Institute Neurowiki is a joint project between Vulcan Inc. and the Allen Institute to build a Semantic Wiki mapping genetic instances. It is a finished prototype testing the import pipelines and display componenets for combining 5 major RDF datasets from 4 different sources. Current planning includes mapping complete datasets, curating a better ontology, and creating multiple ontology management for a user class. Biological Linked Data Map: * Open, public online access * Data from multiple RDF data stores * Complete import pipeline using LDIF framework * Outlines of each imported instance embedding inline wiki properties and providing views of imported properties from original RDF datasets * Charting tools that ''''pivot'''' SPARQL queries providing several views of each query * Navigation and composition tools for accessing and mining the data Where did we get the data? * KEGG: Kyoto Encyclopedia of Genes and Genomes: KEGG GENES is a collection of gene catalogs for all complete genomes generated from publicly available resources, mostly NCBI RefSeq * Diseasome: The Diseasome website is a disease / disorder relationships explorer and a sample of an innovative map-oriented scientific work. Built by a team of researchers and engineers, it uses the Human Disease Network dataset. * DrugBank: The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug data with comprehensive drug target information. * Sider: Sider contains information on marketed medicines and their recorded adverse drug reactions. The information is extracted from public documents and package inserts. Every piece of content on every instance page is generated by Semantic Result Formatters interpreting SPARQL results.

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• 15 years ago - by Anonymous

TBI/Tissue Banks International is a non-profit network of medical eye and tissue banks dedicated to the relief of human suffering through transplantation. More than 100,000 patients are treated with TBI tissue annually. TBI is a recognized innovator in the field of eye and tissue banking and has led advancements in recovery, processing, and distribution of allograft tissue. Each person who chooses to become an eye and tissue donor can help more than a dozen people through their gift. Sight can be restored with a cornea, mobility enabled with a ligament, pain eased with a spinal implant made of bone, burns treated with skin, and lives saved with heart valves. The largest provider of ocular tissue in the world, TBI started as a single eye bank in 1962, and has grown to a network that covers the United States and reaches around the globe. Each year, more than 130,000 TBI tissues are used in transplant surgery, with thousands more utilized in research and medical education.

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• 16 years ago - by Anonymous

Percolator post-processes the results of a shotgun proteomics database search program, re-ranking peptide-spectrum matches so that the top of the list is enriched for correct matches. Shotgun proteomics uses liquid chromatography-tandem mass spectrometry to identify proteins in complex biological samples. We describe an algorithm, called Percolator, for improving the rate of peptide identifications from a collection of tandem mass spectra. Percolator uses semi-supervised machine learning to discriminate between correct and decoy spectrum identifications, correctly assigning peptides to 17% more spectra from a tryptic dataset and up to 77% more spectra from non-tryptic digests, relative to a fully supervised approach. The yeast-01 data is available in tab delimetered format. The SEQUEST parameter file and target database for the yeast and worm data are also available.

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• 16 years ago - by Anonymous

An Antibody supplier

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• 17 years ago - by Anonymous

Non-profit organization dedicated exclusively to education and support for the issues of prevention and recovery of brain injury in the state of Utah. The Brain Injury Association of Utah provides Help, Hope and Healing through Education, Facilitation and Advocacy. If you are one of the thousands of people who are faced with traumatic brain injury, you may be scared, and confused. We have resources, connections and programs that can help offer hope, clarity and sense of direction when it comes to living life to the fullest possibilities after traumatic brain injury. You are not alone. Together, we will not only survive, but thrive through the challenges ahead. At the Brain Injury Association of Utah you will find: * What To Expect * Basics of Brain Injury * Continuum of Care * Emotional Stages after Brain Injury * Facts About Brain Injury * Cognitive Brain Skills & Clues About Brain Injury * Glascow and Ranchos Coma Scale * Types and Levels of Brain Injury BIAU has coalitions with major hospitals, governmental agencies, and rehabilitation centers to provide a network of support, information, and help. Your support will strengthen this network and make a significant difference in the lives of those who have suffered a brain injury.

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• 15 years ago - by Anonymous

A biological medical device company that focuses on the development of implantable biological devices, surgical adhesives, and biomaterials for use in cardiac and vascular for patients of all ages. The Company''s research and development efforts are focused on Protein Hydrogel Technologies, such as BioFoam Surgical Matrix for parenchymal organ sealing. The Company is also investigating additional applications for its SynerGraft decellularization technology. CryoLife provides surgeons with multiple tissue options for cardiovascular reconstruction. CryoLife preserved allografts have helped save the lives and limbs of patients for 20 years. CryoLife''s tissue, along with BioGlue and BioFoam offer a wide range of Life Restoring Technologies for cardiac and vascular surgeons. CryoLife provides innovative products that will benefit patients around the world by working with other pioneering companies and by continuous investment in research and development.

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• 16 years ago - by Anonymous

An Antibody supplier

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• 14 years ago - by Anonymous

Software tool to exploit the mate pair/paired-end information for assembly of short reads from high throughput sequencing platforms, e.g. Illumina and SOLiD.

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• 13 years ago - by Anonymous

The South Carolina Biorepository System (SCBS), directed by Dr. Phil Buckhaults, School of Medicine, is a statewide tissue bank working with health care facilities across South Carolina to collect tumor and matched normal tissue samples from patients with cancer, and providing these samples to researchers statewide. All specimens are de-identified to protect patient privacy, but are annotated with essential, detailed clinical data. Currently, the SCBS inventory includes specimens from the leading types of cancers in South Carolina: breast, colorectal, lung, and prostate, as well as many other cancer sites. The ultimate goal is to improve the lives of cancer patients and their families.

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• 16 years ago - by Anonymous

New Mexico Donor Services (NMDS) is committed to saving and improving lives, connecting one life to another through donation and transplantation. NMDS and New Mexico hospitals share responsibility to ensure that an individual''s decision to be a donor is followed or their family is given the option to donate organs and/or tissue. Hospitals identify potential donors, make timely referrals, and manage the patients to allow NMDS to evaluate the patient for donor suitability and check donor status on their driver''s license or ID. Organs are distributed to waiting recipients through the national organ transplant list maintained by the United Network for Organ Sharing (UNOS) based on medical factors such as blood type, size and tissue match. It is illegal to distribute organs based on wealth or celebrity status. Tissue is distributed based on patient need, medical criteria and availability.

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• 16 years ago - by Anonymous

FlyAtlas gives you a quick answer to the question: where is my gene of interest expressed/enriched in the adult fly? For each gene and tissue, you''re given the mRNA SIGNAL (how abundant the mRNA is), the mRNA ENRICHMENT (compared to whole flies), and the Affymetrix PRESENT CALL (out of 4 arrays, how many times it was detectably expressed). The dataset so far comprises 44 Affymetrix Dros2 expression arrays, each mapping the expression of 18770 transcripts - corresponding to the vast majority of known Drosophila genes. The dataset thus contains over 822800 separate datapoints. This website is intended to make the data easily accessible and comprehensible to mere mortals. FlyAtlas provides the most comprehensive view yet of expression in multiple tissues of Drosophila melanogaster. Meta-analysis of the data shows that a significant fraction of the genome is expressed with great tissue specificity in the adult, demonstrating the need for the functional genomic community to embrace a wide range of functional phenotypes. Well-known developmental genes are often reused in surprising tissues in the adult, suggesting new functions. The homologs of many human genetic disease loci show selective expression in the Drosophila tissues analogous to the affected human tissues, providing a useful filter for potential candidate genes. Additionally, the contributions of each tissue to the whole-fly array signal can be calculated, demonstrating the limitations of whole-organism approaches to functional genomics and allowing modeling of a simple tissue fractionation procedure that should improve detection of weak or tissue-specific signals.

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• 16 years ago - by Anonymous

Open platform for analyzing and sharing neuroimaging data from human brain imaging research studies. Brain Imaging Data Structure ( BIDS) compliant database. Formerly known as OpenfMRI. Data archives to hold magnetic resonance imaging data. Platform for sharing MRI, MEG, EEG, iEEG, and ECoG data.

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• 15 years ago - by Anonymous

The (Clinical) Institute of Neurology (IN) of the Medical University Vienna was founded in 1882 by Heinrich Obersteiner. It is the oldest institution embracing the multidisciplinarity of neurosciences and has served as model for the establishment of similarly designed institutions in many countries. The original location of the then Neurological Institute in Vienna was at Schwarzspanierstrasse. Since 1993, IN is located in the Vienna General Hospital in top-class laboratory facilities. IN is committed to its proud tradition as Obersteiner Institute and to a promising future of a nationally and internationally leading institution in the clinical neurosciences. Our work aims to translate the understanding of nervous diseases to the development of novel therapeutics and diagnostics. IN''''s tasks include diagnostic patient service, research and graduate / postgraduate teaching in neuropathology, neurochemistry, and neuro-molecular biology in an integrated way. Neuropathology is a recognized medical specialty in Austria. It analyzes structural changes of nervous tissues in disease. Diagnostic neuropathology makes use of most modern morphological techniques applied to diseased central, peripheral and vegetative nervous tissues and fluids, and muscle. Neuropathological diagnoses are a basis for disease classification and rational therapies. Neurodegenerative disorders, in particular prion diseases, virus diseases affecting the nervous system, and brain tumors (neuro-oncology) are research priorities. In the highly publicized area of prion diseases, IN has developed into a national and international center of excellence and expertise that leads several European, EU-funded networks in prion research. As an indispensable asset, the IN possesses a large brain bank that has systematically collected neuropathological specimens since 1948. Most samples are fixed and paraffin-embedded tissue only, but in a part of neurosurgical, nerve and muscle biopsies and autopsies, also fresh tissue is obtained, frozen and stored at -80 degrees C. Occasionally blood and CSF are also available. The unique neuropathological collection of histological slides, paraffin blocks and formol-fixed nervous tissues now comprises about 16.000 brain autopsies, 30.000 neurosurgical and 7.500 nerve/muscle biopsies. Also a number of cell cultures have been stored, mainly fibroblasts from patients with rare neurometabolic diseases, and primary cultures of brain tumors. IN participates in the EU-supported European Network of Brain Banks BrainNet Europe.

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• 15 years ago - by Anonymous

Atlas of developing human brain for studying transcriptional mechanisms involved in human brain development. One of the BrainSpan datasets, Exon microarray summarized to genes, is presented. It is a downloadable archive of files containing normalized RNA-Seq expression values for analysis.

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• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on March 19,2024. Brain tissue donation is a valuable contribution to mental health research. It enables scientists to investigate how the normal brain works, and how the brain is disturbed when it is affected by schizophrenia, depression, bipolar (manic depressive) disease or other related disorders. The Department of Psychiatry at the University of Pittsburgh has established a brain tissue bank to which brain tissue can be donated at no expense. The gift of brain tissue enables scientists to conduct research designed to understand causes, to develop new treatments, and ultimately to find cures for diseases that affect the brain. Brain tissue donation is a gift that makes it possible for researchers to study various types of mental disorders. Donations of brain tissue from individuals without these disorders are also needed to establish comparisons with brain samples from individuals who have these disorders. Any legally competent adult or guardian may indicate during life their interest in donating brain tissue after death. Next-of-kin either of healthy individuals or of those with psychiatric disorders may give consent to donate brain tissue following the death of a loved one. Brain tissue is removed during autopsy at a morgue or hospital and is transported to the University of Pittsburgh Medical Center for examination and study.

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• 15 years ago - by Anonymous

An independent, non-profit organization, Lifeline of Ohio (LOOP), promotes and coordinates the donation of human organs and tissue for transplantation. Its mission is to educate and empower central and southeastern Ohioans about organ and tissue donation while also facilitating the donation process. Lifeline of Ohio, a Donate Life Organization, has been approved by the Centers for Medicare and Medicaid Services (CMS) as the designated organ procurement organization (OPO) serving 37 Ohio counties along with Wood and Hancock counties in West Virginia. Accredited by both the Association of Organ Procurement Organizations (AOPO) and the American Association of Tissue Banks (AATB), Lifeline of Ohio provides services to 70 hospitals and the communities they serve through its procurement and tissue coordinators, and other professional staff.

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• 16 years ago - by Anonymous