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Source BioScience LifeSciences are European leaders in DNA sequencing, genomic services, bioinformatic analyses and offers a comprehensive portfolio of genomic reagents and antibodies. Source BioScience LifeScience is a CPA, GLP/GCP accredited and Illumina NGS CSPro certified genomic service provider and distributes a comprehensive range of biological products to companies and institutions worldwide. Source BioScience is proud to announce that Source BioScience imaGenes has joined it's LifeSciences group. This will enable us to bring our customers one unified website with our complete range of Products, Clones and Services. We have merged our clone libraries together so that can now offer you over 20 million clones! Add to this our excellent sequencing service and our range of over 100,000 antibodies and Source BioScience LifeSciences is your ideal outsourcing partner.

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• SciCrunch
• 16 years ago - by Anonymous

An algorithm for the identification of microRNA targets. Details are provided (3' UTR alignments with predicted sites, links to various public databases etc) regarding: # microRNA target predictions in vertebrates (Krek et al, Nature Genetics 37:495-500 (2005)) # microRNA target predictions in seven Drosophila species (Grn et al, PLoS Comp. Biol. 1:e13 (2005)) # microRNA targets in three nematode species (Lall et al, Current Biology 16, 1-12 (2006)) # human microRNA targets that are not conserved but co-expressed (i.e. the microRNA and mRNA are expressed in the same tissue) (Chen and Rajewsky, Nat Genet 38, 1452-1456 (2006)) co-expressed targets

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• SciCrunch
• 17 years ago - by Anonymous

Department of Pharmacology and Cancer Biology spans two overlapping and broad disciplines, one exploring how chemical agents impact living cells and one seeking to understand how inappropriate responses to environmental molecules and internal cellular cues can lead to development of Cancer. Occupying Levine Science Research Center, Pharmacology and Cancer Biology department is dedicated to mentoring and training of graduate students and postdoctoral fellows.Innovative undergraduate program also allows students majoring in Biology or Chemistry at Duke to complete area specialization in Pharmacology, as well as offering courses in Pharmacology and Neuropharmacology for undergraduates. Department trains also students working towards Ph.D.s in Molecular Cancer Biology. Moreover, students enter our department through several university-wide multi-disciplinary programs including the Toxicology, Cell and Molecular Biology Program and the University Program in Genetics and Genomics. Our 23 faculty members are remarkably diverse and use all of the tools available to biomedical scientists to address questions critical to fundamental biology and human health. The faculty members share the common goal of exploiting cellular signaling pathways to address a myriad of important scientific questions relevant to cancer, metabolism, nervous system function, drugs of abuse and environmental toxicants.

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• SciCrunch
• 17 years ago - by Anonymous

Virtual microscope for viewing in situ images that show where a gene is used in an organism, sometimes down to cellular resolution. The user can examine cell-by-cell as well as tissue-by-tissue expression patterns. Users can retrieve images that meet specific search criteria, then interactively zoom and scroll across the collection. Image set contributions are welcome. The following image collections are currently available for browsing: * High-quality high-resolution images of eight-week-old male mouse sagittal brain slices with reverse-complemented mRNA hybridization probes from the Allen Brain Atlas, courtesy of the Allen Institute for Brain Science * Mouse in situ images from the Jackson Lab Gene Expression Database (GXD) at MGI * Transcription factors in mouse embryos from the Mahoney Center for Neuro-Oncology * Mouse head and brain in situ images from NCBI''''s Gene Expression Nervous System Atlas (GENSAT) database * Xenopus laevis in situ images from the National Institute for Basic Biology (NIBB) XDB project

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• SciCrunch
• 17 years ago - by Anonymous

A structured controlled vocabulary of the anatomy of the Hymenoptera (bees, wasps, sawflies and ants)

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• SciCrunch
• 13 years ago - by Anonymous

It studies epigenetic regulation of the genome and its dysregulation in disease. This lab has a long-standing interest in gene regulatory processes that extend over large regions of the genome and give rise to human diseases. Our major projects are centred on the discovery of DNA sequence characteristics that discriminate genes undergoing genomic imprinting, using these to find new imprinted genes that are candidates for causing human disease.

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• SciCrunch
• 14 years ago - by Anonymous

The Department of Pharmacology and Physiology offers graduate programs leading to the M.S. and the Ph.D. degrees. The programs require independent research under the direction of departmental faculty members who are engaged in highly active research programs involving molecular, cellular, and behavioral approaches to experimental pharmacology and physiology in a strongly collaborative environment. The disciplines of pharmacology and physiology touch on virtually every scientific discipline and clinical area within the biomedical sciences, thereby providing students with a range of opportunities into disease mechanisms and altered physiological processes, new pharmacological tools and new medications. We are unique in offering educational programs not only in the basic sciences of pharmacology and physiology but also in drug discovery and development, which provides students with a wealth of advantages in considering career opportunities within academic, biopharmaceutical, and pharmaceutical settings. Students in both the PhD and MS programs begin their coursework with a core curriculum in biomedical sciences, and immediately start laboratory rotations. Intensive graduate-level pharmacology and physiology courses round out the core programmatic courses. Specialization in ion channel physiology, smooth-muscle physiology, neuropharmacology, behavioral pharmacology, and signal transduction processes may involve the taking of several elective courses. Each program requires the defense of a thesis based on original research. For more information visit, http://www.drexel.edu/catalog/g-about/pharm.htm.

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• SciCrunch
• 17 years ago - by Anonymous

The Department of Neurobiology and Anatomy at the Drexel University College of Medicine provides an outstanding academic environment for pursuing multidisciplinary training and research in neuroscience. The department offers postdoctoral training through a NIH training grants and graduate student training through the Neuroscience program for outstanding individuals preparing for a research career in the biomedical sciences. The Department is also responsible for 3 major courses given to medical students that include Medical Neuroscience, Gross Anatomy and MicroAnatomy. Training can be obtained in all aspects of advanced microscopy and imaging, tissue culture, transplantation techniques, gene therapy and sequencing, behavioral neurobiology, kinematics, intracellular recording, patch clamping, computer modeling of neurobiological processes and robotics. The Department has well equipped shared facilities for confocal microscopy, electron microscopy, image acquisition and processing, small animal surgery, behavioral analysis, biochemistry and molecular biology. Research training is also supplemented by a seminar series featuring faculty, postdoctoral fellows and outside speakers. Journal clubs and discussions of research findings are scheduled regularly and often shared among individual laboratories.

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• SciCrunch
• 17 years ago - by Anonymous

Online educational tool that brings challenging clinical practice to your computer, providing medical education that is engaging, challenging and interactive. While there is no substitute for real-life direct contact with patients or colleagues, research has shown that interactive online education can be a highly effective and enjoyable method of learning many components of clinical medicine, including ethics, clinical management, epidemiology and communication skills. eDoctoring offers 25 simulated clinical cases, 15 interactive tutorials and a virtual library containing numerous articles, fast facts and video clips. Their learning material is arranged in the following content areas: * Ethical, Legal and Social Implications of Genetic Testing * Palliative and End-of-Life Care * Prostate Cancer Screening and Shared Decision-Making

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 16,2023. Software application (entry from Genetic Analysis Software).

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• SciCrunch
• 14 years ago - by Anonymous

A biopharmaceutical company applying its discoveries in human genetics to develop drugs and diagnostics for common diseases. They specialize in gene discovery - their population approach and resources have enabled them to isolate key genes contributing to major public health challenges from cardiovascular disease to cancer. The company's genotyping capacity is now one of the highest in the world. They have a large population-based biobank containing whole blood and DNA samples with extensive relevant phenotypic information from around 120.000 Icelanders. In the company's work in more than 50 disease projects, their statistical and informatics departments have established themselves in data processing and analysis. deCODE genetics is widely recognized as a center of excellence in genetic research.

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• SciCrunch
• 12 years ago - by Anonymous

The primary instructional mission of the Department is to provide professional students with an understanding of the pharmacological basis of therapeutics. In addition to instruction of students in the medical, dental, pharmacy and nursing programs at Creighton, faculty are actively involved in both teaching and research training of graduate students. Ten departmental faculty work with an energetic group of graduate students, postdoctoral fellows and research staff in a congenial and collaborative environment. Faculty in the Department of Pharmacology at Creighton University School of Medicine reflect the complex scope of modern pharmacological research as they apply methods of systems and cell physiology, neuroscience, biochemistry, and cellular and molecular biology to better understand drug action. Departmental faculty are engaged in diverse areas of research including, but not limited to, G protein-coupled receptor signal transduction, regulators of G-protein signaling, regulation of receptor gene expression, control of neurotransmitter release, ion channel modulation, molecular pharmacology of excitatory neurotransmission, and cardiovascular and CNS drug discovery. These studies provide insight into the mechanisms of drug action and the means by which drug action is translated into responses in the cardiovascular system, the nervous system, exocrine glands and cancer cells.

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• SciCrunch
• 17 years ago - by Anonymous

Database containing information on Arabidopsis phosphorylation sites which were identified by mass spectrometry in large scale experiments from different research groups. Specific information on the peptide properties as well as on the experimental and analytical context is given. The PhosPhAt service has a built-in plant specific phosphorylation site predictor trained on the experimental dataset for Serine, threonine and tyrosine phosphorylation (pSer, pThr, pTyr). Protein sequences or Arabidopsis AGI gene identifier can be submitted to the predictor. Users and researchers are encouraged to assist in keeping the database current by submitting either published data or unpublished data (MS/MS data required).

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• SciCrunch
• 17 years ago - by Anonymous

Database that catalogs experimentally verified pathogenicity, virulence and effector genes from fungal, Oomycete and bacterial pathogens, which infect animal, plant, fungal and insect hosts. It is an invaluable resource in the discovery of genes in medically and agronomically important pathogens, which may be potential targets for chemical intervention. In collaboration with the FRAC team, it also includes antifungal compounds and their target genes. Each entry is curated by domain experts and is supported by strong experimental evidence (gene disruption experiments, STM etc), as well as literature references in which the original experiments are described. Each gene is presented with its nucleotide and deduced amino acid sequence, as well as a detailed description of the predicted protein's function during the host infection process. To facilitate data interoperability, genes have been annotated using controlled vocabularies and links to external sources (Gene Ontology terms, EC Numbers, NCBI taxonomy, EMBL, PubMed and FRAC).

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• SciCrunch
• 17 years ago - by Anonymous

Gene expression data from published journal articles that test hypotheses relevant to neuroscience of addiction and addictive behavior. Data types include effects of particular drug, strain, or knock out on particular gene, in particular anatomical region. Focuses on gene expression data and exposes data from investigations using DNA microarrays, polymerase chain reaction, immunohistochemistry and in-situ hybridizations. Data are available for query through NIF interface.Data submissions are welcome.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 28,2023. An initiative to develop a molecular classification schema that is both clinically and biologically meaningful, based on gene expression and genomic data from tumors (Gliomas) of patients who will be prospectively followed through natural history and treatment phase of their illness. The study will also explore gene expression profiles to determine the responsiveness of the patients and correlate with discrete chromosomal abnormalities. The initiative was designed to obtain a large amount of molecular data on DNA and RNA of freshly collected tumor samples that were collected, processed and analyzed in a standardized fashion to allow for large-scale cross sample analysis. The sample collection is accompanied by careful and prospective clinical data acquisition, allowing a variety of matched molecular and clinical data permitting a wide variety of analyses. GMDI has accrued fresh frozen tumors in the retrospective phase (all from the Henry Ford Hospital, without germline DNA) and fresh frozen tumors in the prospective phase (from a variety of institutions). In addition to characterizing the samples from patients enrolled in GMDI, the microarray group has generated genomic-scale analyses of the many human and canine glioma initiating cells/glioma stem cells (GIC/GSC) lines, as well as many canine and murine normal neural stem cell (NSC) lines produced in laboratory.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented July 19, 2016. It has been integrated into the National Cancer Informatics Program (NCIP). The National Cancer Institute launched the cancer Biomedical Informatics Grid (caBIG) to create a virtual network of interconnected data, individuals, and organizations that worked together to redefine how cancer research is conducted. caBIG capabilities allowed researchers and clinicians to collaborate more effectively so that complex research questions might be asked and answered faster and more effectively. The mission of caBIG was to develop a truly collaborative information network that accelerated the discovery of new approaches for the detection, diagnosis, treatment, and prevention of cancer, ultimately improving patient outcomes.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 4th, 2023. A database of human data from functional neuroimaging scientific articles containing Talairach coordinates that provides data for novel information retrieval techniques and automated meta-analyses. Each article in this database is identified by a unique number: A WOBIB. Some of the structure of the Brede database is similar to the structure of the BrainMap database (Research Imaging Center, San Antonio). The database is inspired by the hierarchical structure of BrainMap with scientific articles (bib structures) on the highest level containing one or more experiments (exp structure, corresponding to a contrast in general linear model analyses), these in turn comprising one or more locations (loc structures). The information on the bib level (author, title, ...) is setup automatically from PubMed while the rest of the information is entered manually in a Matlab graphical user interface. On the loc level this includes the 3D stereotactic coordinates in either Talairach or MNI space, the brain area (functional, anatomical or cytoarchitectonic area) and magnitude values such as Z-score and P-value. On the exp level information such as modality, scanner and behavioral domain are recorded with external components (such as face recognition or kinetic boundaries) organized in a directed graph and marked up with Medical Subject Headings (MeSH) where possible. The database is distributed as part of the Brede neuroinformatics toolbox (hendrix.imm.dtu.dk/software/brede/) which also provides the functions to manipulate and analyze the data. The Brede Toolbox is a program package primarily written in Matlab. As of 2006/11, 186 papers with 586 experiments.

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• SciCrunch
• 17 years ago - by Anonymous

Software application (entry from Genetic Analysis Software)

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• SciCrunch
• 14 years ago - by Anonymous

Software for a fast, simple way to generate designs for MIP assays targeting hundreds or thousands of genomic loci in parallel. Packaged with MIPgen are scripts that aid in visualization of MIP designs and processing of MIP sequence reads to SAM files that can then be passed through any standard variant calling pipeline.

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• SciCrunch
• 12 years ago - by Anonymous