Curator Dashboard

Consortium to develop evidence supporting the use of imaging Total Kidney Volume (TKV) as a prognostic biomarker that predicts the progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD) to select patients likely to respond to therapy into clinical trials. It aims to replace the currently used measurement of glomerular filtration rate (GFR). Scientists will use the data collected to develop a disease progression model that will evaluate the relationship between TKV and the known complications of ADPKD, including rate of loss of kidney function, hypertension, gross hematuria, kidney stones, urinary tract infections, development of end-stage renal disease, and mortality. These analyses will be used to support the regulatory qualification of TKV as an accepted measure for assessing the progression of ADPKD in clinical trials in which new therapies are tested. PKDOC has the following goals: # Develop standard clinical data elements and definitions that are specific to ADPKD # Create a database of aggregated data from existing multiple, longitudinal, and well-characterized research registries maintained over decades by the leading institutions in ADPKD clinical investigation # Advance and harmonize the missions of regulatory agencies by creating tools that help with the evaluation of new pharmaceutical compounds # Develop a quantitative disease progression model to examine the linkage between TKV and disease outcomes

• Organization
• Consortia-pedia, a FasterCures Project
• 13 years ago - by Anonymous

A 17-item self-administered assessment questionnaire developed by the Psychiatry and Behavioral Sciences Department at Duke University effective in screening for and measuring the severity of social anxiety disorder. Each question is answered with one of 5 responses ranging from Not at All to Extremely. Each response is assigned a score and then totaled at the end. Scoring: * 0-20 Little or No Anxiety * 21-30 Mild Anxiety * 31-40 Moderate Anxiety * 41-50 Severe Anxiety * 51-68 Very Severe Anxiety

• Resource
• SciCrunch
• 13 years ago - by Anonymous

A 17 item self-reported questionnaire to assess the symptoms of posttraumatic stress disorder (PTSD) during the past 2 weeks. The 17 questions all describe symptoms of PTSD which patients rate (by severity) between 0-3, 0 meaning not at all or only once and 3 meaning almost all the time or at least five times a week. The end scores range from 0-51. Scoring: * 0-13 Likelihood of Little to No PTSD * 13-51 Likelihood of PTSD (Higher Score = More Severe)

• Resource
• SciCrunch
• 13 years ago - by Anonymous

A self-administered assessment used to detect possible symptoms of panic disorder and suggest the need for a formal diagnostic assessment. It consists of seven items (which are rated from 0-4). The items assess panic frequency, distress during panic, panic-focused anticipatory anxiety, phobic avoidance of situations, phobic avoidance of physical sensations, impairment in work functioning, and impairment in social functioning. The overall assessment is made by a total score, which is calculated by summing the scores for all seven items. The total scores range from 0 to 28. The PDSS-SR is used for screening and the scores 9 and above suggest the need for a formal diagnostic assessment. (Adapted from Wikipedia)

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Collaborative framework that includes the NIH Office of the Director and the 14 NIH Institutes and Centers that support research on the nervous system. By pooling resources and expertise, the Blueprint identifies cross-cutting areas of research, and confronts challenges too large for any single Institute or Center. The Blueprint makes collaboration a day-to-day part of how the NIH does business in neuroscience, complementing the basic missions of Blueprint partners. During each fiscal year, the partners contribute a small percentage of their funds to a common pool. Since the Blueprint's inception in 2004, this pool has comprised less than 1 percent of the total neuroscience research budget of the partners. In 2009, the Blueprint Grand Challenges were launched to catalyze research with the potential to transform our basic understanding of the brain and our approaches to treating brain disorders. * The Human Connectome Project is an effort to map the connections within the healthy brain. It is expected to help answer questions about how genes influence brain connectivity, and how this in turn relates to mood, personality and behavior. The investigators will collect brain imaging data, plus genetic and behavioral data from 1,200 adults. They are working to optimize brain imaging techniques to see the brain's wiring in unprecedented detail. * The Grand Challenge on Pain supports research to understand the changes in the nervous system that cause acute, temporary pain to become chronic. The initiative is supporting multi-investigator projects to partner researchers in the pain field with researchers in the neuroplasticity field. * The Blueprint Neurotherapeutics Network is helping small labs develop new drugs for nervous system disorders. The Network provides research funding, plus access to millions of dollars worth of services and expertise to assist in every step of the drug development process, from laboratory studies to preparation for clinical trials. Project teams across the U.S. have received funding to pursue drugs for conditions from vision loss to neurodegenerative disease to depression. Since its inception in 2004, the Blueprint has supported the development of new resources, tools and opportunities for neuroscientists. For example, the Blueprint supports several training programs to help students pursue interdisciplinary areas of neuroscience, and to bring students from underrepresented groups into the neurosciences. The Blueprint also funds efforts to develop new approaches to teaching neuroscience through K-12 instruction, museum exhibits and web-based platforms. From fiscal years 2007 to 2009, the Blueprint focused on three major themes of neuroscience - neurodegeneration, neurodevelopment, and neuroplasticity. These efforts enabled unique funding opportunities and training programs, and helped establish new resources including the Blueprint Non-Human Primate Brain Atlas.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

Private research university located in the Boston suburb of Waltham, Massachusetts. Founded in 1948 as a non-sectarian, coeducational institution sponsored by the Jewish community, Brandeis was established on the site of the former Middlesex University.

• Organization
• SciCrunch
• 17 years ago - submitted by Timothy Tsui

Ontology of master drug data base, 2009_08_05

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Assessment scale to measure the severity of illness in patients with panic disorder (with or without agoraphobia). It is available in both clinician-administered and self-rating formats. It contains 5 sub-scales: panic attacks, agoraphobic avoidance, anticipatory anxiety, disability, and functional avoidance (health concerns). It rates the severity of symptoms over the past week.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

A seven item assessment to measure the severity of a patient's anxiety. The test is self administered and cannot be used to replace a proper clinical assessment and additional evaluations.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Assessment scale commonly used in hospitals to determine the anxiety and depression levels that a patient is experiencing. It contains 14 items, 7 of which are questions about anxiety and the other 7 are about depression.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Assessment scale to assess the severity of symptoms of anxiety in adults, adolescents and children. The scale consists of 14 items, each defined by a series of symptoms, and measures both psychic anxiety (mental agitation and psychological distress) and somatic anxiety (physical complaints related to anxiety). Although the HAM-A remains widely used as an outcome measure in clinical trials, it has been criticized for its sometimes poor ability to discriminate between anxiolytic and antidepressant effects, and somatic anxiety versus somatic side effects. The HAM-A does not provide any standardized probe questions. Despite this, the reported levels of inter-rater reliability for the scale appear to be acceptable. The scale has been translated into: Cantonese for China, French and Spanish. An IVR version of the scale is available from Healthcare Technology Systems.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

A self reporting scale to assess if adult patients are suffering from symptoms of attention deficit-hyperactivity disorder (ADHD). The Symptom Checklist is an instrument consisting of the eighteen DSM-IV-TR criteria. Six of the eighteen questions were found to be the most predictive of symptoms consistent with ADHD. These six questions are the basis for the ASRS v1.1 Screener and are also Part A of the Symptom Checklist. Part B of the Symptom Checklist contains the remaining twelve questions.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

An technology innovator in database and application server software that has been a long time developer of database and semantic repository technologies on both single servers and clusters. This, combined with OpenLink's experience with SQL, gives an all round view of performance across many environments and workload profiles, from transactions to decision support or search. OpenLink also has extensive experience in developing scale-out parallel database technology. The cross-platform product portfolio addresses challenges such as: Universal Data Access, Data Virtualization & Management, Personal & Enterprise Data Spaces, and Implementation & Support.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Data set of a crowd-sourced community effort to extract structured information from Wikipedia and make this information available on the Web. DBpedia allows you to ask sophisticated queries against Wikipedia, and to link the different data sets on the Web to Wikipedia data. It is hoped that this work will make it easier for the huge amount of information in Wikipedia to be used in some new interesting ways. Furthermore, it might inspire new mechanisms for navigating, linking, and improving the encyclopedia itself. The project extracts knowledge from 111 different language editions of Wikipedia. The DBpedia project maps Wikipedia infoboxes from 27 different language editions to a single shared ontology consisting of 320 classes and 1,650 properties. The mappings are created via a world-wide crowd-sourcing effort and enable knowledge from the different Wikipedia editions to be combined. The project publishes regular releases of all DBpedia knowledge bases for download and provides SPARQL query access to 14 out of the 111 language editions via a global network of local DBpedia chapters. In addition to the regular releases, the project maintains a live knowledge base which is updated whenever a page in Wikipedia changes. DBpedia sets 27 million RDF links pointing into over 30 external data sources and thus enables data from these sources to be used together with DBpedia data. Several hundred data sets on the Web publish RDF links pointing to DBpedia themselves and thus make DBpedia one of the central interlinking hubs in the Linked Open Data (LOD) cloud.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

An Antibody supplier

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• SciCrunch
• 14 years ago - by Anonymous

An Antibody supplier

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• SciCrunch
• 14 years ago - by Anonymous

Neuroscience data and knowledge from multiple scales and multiple data sources that has been extracted, linked, and organized to support comprehensive understanding of the brain. The core is the CAS Brain Knowledge base, a very large scale brain knowledge base based on automatic knowledge extraction and integration from various data and knowledge sources. The LND platform provides services for neuron data and knowledge extraction, representation, integration, visualization, semantic search and reasoning over the linked neuron data. Currently, LND extracts and integrates semantic data and knowledge from the following resources: PubMed, INCF-CUMBO, Allen Reference Atlas, NIF, NeuroLex, MeSH, DBPedia/Wikipedia, etc.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Assessment scale to measure the psychiatric symptoms of patients who might have psychiatric symptoms including depression, anxiety, hallucinations, and strange or unusual behaviors. The symptoms of the patient are rated between 1 and 7 and then the 18-24 items/symptoms are scored and combined to create the final score of the patient. This scale is similar to the PANSS, SANS, and SAPS.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE.Documented on October 6th, 2022. Assessment scale that considers psychological, social, and occupational functioning (how well they handle various problems in life) on a hypothetical continuum of mental health-illness. This does not include impairment in functioning due to physical (or environmental) limitations. The score received is usually given as a range (0-100) to patients. Scoring: * 91-100 No Symptoms * 81-90 Absent/Minimal Symptoms * 71-80 Symptoms are Present * 61-70 Mild Symptoms * 51-60 Moderate Symptoms * 41-50 Serious Symptoms * 31-40 Some Impairment * 21-30 Influenced behavior by Delusions or Hallucinations * 11-20 Some Danger of Hurting Self or Others * 1-10 Persistent Danger of Hurting Self or Others * 0 Inadequate Information on Patient

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Curated lists of genes associated to speech / language phenotypes and structural or functional abnormalities observed in patient populations. Entrez ID gene information, as well as gene expression profiles from the Allen Brain Atlas are available. You can also download expression data for a given gene in JSON or XML format.

• Resource
• SciCrunch
• 13 years ago - by Anonymous