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A pipeline of scripts to assign ancestry to genomic segments using next-gen sequence data. This method can identify recombination breakpoints in a large number of individuals simultaneously at a resolution sufficient for most mapping purposes, such as quantitative trait locus (QTL) mapping and mapping of induced mutations.

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• SciCrunch
• 13 years ago - by Anonymous

The MRC and Cancer Funders'' Forum (now National Cancer Research Institute, NCRI) established two cancer collaboratives in 2002, ProMPT and the Southern Collaborative. Their purpose was to increase the critical mass of basic and translational cancer researchers working on prostate cancer. The Collaboratives have both been successful in raising external grant income over the past 5 or 6 years and the current funding is very much geared around infrastructure to help with bio-marker development. This includes the establishment of biorepositories and tissue collections together with appropriate epidemiological and clinical information. The ProMPT collaborative is organized by Professor David Neal, Chair of Surgical Oncology in Cambridge. The other institutions include the Universities of Bristol, Manchester, Newcastle upon Tyne, Sheffield and York. The collaborative is very much working on translational aspects of prostate cancer research and has available to it a wide range of models. The Bristol group is working on epidemiological aspects and IGF, the Manchester group is working on stem cells, the Newcastle group is focused on target identification and validation and new drug development. Sheffield is working on model systems, bone metastasis and angiogenesis, York''s expertise is stem cells, structural biology and prostate specific gene targeting., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 16 years ago - by Anonymous

Cre expressing mice under the control of promoters with a design focus on the brain. Each promoter is derived from human sequence, but the resulting expression is assessed in the mouse for the activation of a LacZ reporter gene by the Cre activity. Promoters tested as large MaxiPromoters (BACs inserted into the mouse genome) and MiniPromoters (plasmid-based sequences inserted either into the mouse genome or introduced within AAV viruses). The Cre-related project continues from the Pleiades Promoter Project. Here is the list of genes for which icre/ERT2 mice are currently in development: AGTR1, CARTPT, CLDN5, CLVS2, CRH, GABRA6, HTR1A, HTR1B, KCNA4, KDM5C, MKI67, NEUROD6, NKX6-1, NOV, NPY2R, NR2E1, OLIG2, POU4F2, SLITRK6, SOX1, SOX3, SOX9,, SPRY1, VSX2

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• SciCrunch
• 16 years ago - by Anonymous

Brain Tumour Foundation of Canada is a dedicated team of volunteers, patients, survivors, family members, health care professionals and staff, determined to make the journey with a brain tumor one full of hope and support. We work collaboratively to serve the needs of those Canadians affected by all types of brain tumors. Information, education and support is available and research continues into the cause of and a cure for brain tumors. Every year, thousands of Canadians affected by brain tumors find emotional support and comfort while gaining a better understanding and knowledge of their disease through a range of programs and services available across the country. This includes: up-to-date brain tumor information material, numerous education events and support groups. Important brain tumor research is also supported through annual grants, a fellowship and the brain tumour tissue bank. We welcome donations, large or small. Charitable Registration #BN118816339RR0001

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• SciCrunch
• 16 years ago - by Anonymous

Demystifying Depression is a wiki book on depression that is downloadable as a PDF file. This book may not have been written by a doctor. The recommendations are not referenced to actual research except in a bibliography. This document should in no way serve as a substitute for medical advice. Experts are welcome to add their comments. Depression is a mood disorder, so start many descriptions of the illness. That is a gross understatement. Depression does indeed seriously affect your mood, but that is just the tip of the iceberg. A clinical depression can be an incapacitating illness, affecting your ability to perform tasks that require concentration and rendering you unable to work. By writing this document we hope to provide you with the knowledge everyone should have about their mental well-being. Depression is not an unavoidable fate. It is physical.

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• SciCrunch
• 16 years ago - by Anonymous

• Organization
• SciCrunch
• 16 years ago - submitted by Andrea Stagg

Safe and secure environmentally controlled storage for the biotech, pharmaceutical and medical device industries. Masy provides same-day retrieval and shipping of your biomaterials. Our cost-effective repository space is comprised of multiple chamber styles, from walk-in refrigerators / freezers for large containers, to single-shelf storage units for individual vials. Segregated & unsegregated storage is available. Our sophisticated inventory management system utilizes a precise bar-code inventory track-and-trace system with data safely stored on dedicated servers. Critical data access is secured by password protection. Environmental storage condition information and sample access is limited to customer approved personnel only. Our in-house Validation and Calibration teams allow us to offer unique storage conditions. And, we now offer GMP labeling and distribution of clinical samples. Masy is ISO 9001:2009 Certified and NVLAP ISO/IEC 17025:2005 Accredited. Our state-of-the-art facility is conveniently located less than an hour from Metro-Boston, just 15 minutes from the Devens Commerce Park.

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• SciCrunch
• 16 years ago - by Anonymous

A Bioinformatics Resource Center bacterial bioinformatics database and analysis resource that provides researchers with an online resource that stores and integrates a variety of data types (e.g. genomics, transcriptomics, protein-protein interactions (PPIs), three-dimensional protein structures and sequence typing data) and associated metadata. Datatypes are summarized for individual genomes and across taxonomic levels. All genomes, currently more than 10 000, are consistently annotated using RAST, the Rapid Annotations using Subsystems Technology. Summaries of different data types are also provided for individual genes, where comparisons of different annotations are available, and also include available transcriptomic data. PATRIC provides a variety of ways for researchers to find data of interest and a private workspace where they can store both genomic and gene associations, and their own private data. Both private and public data can be analyzed together using a suite of tools to perform comparative genomic or transcriptomic analysis. PATRIC also includes integrated information related to disease and PPIs. The PATRIC project includes three primary collaborators: the University of Chicago, the University of Manchester, and New City Media. The University of Chicago is providing genome annotations and a PATRIC end-user genome annotation service using their Rapid Annotation using Subsystem Technology (RAST) system. The National Centre for Text Mining (NaCTeM) at the University of Manchester is providing literature-based text mining capability and service. New City Media is providing assistance in website interface development. An FTP server and download tool are available.

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• SciCrunch
• 16 years ago - by Anonymous

The UK''s leading MS charity that provides information and support, funding research and fighting for change. We''re a democratic organization: one member, one vote. We fund research, give grants, campaign for change, provide information and support, invest in MS specialists and lend a listening ear to those who need it. The UK''s biggest MS charity. * 38,000 members have a say in how we''re run. * 9000 volunteers give a million hours every year. * 550 staff work in all four nations of the UK. * Over 300 branches support people with MS locally. * One aim: to beat MS. Our national offices in England, Scotland, Wales and Northern Ireland and our network of 300 branches support people affected by MS locally.

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• SciCrunch
• 16 years ago - by Anonymous

COBALT is a multiple sequence alignment tool that finds a collection of pairwise constraints derived from conserved domain database, protein motif database, and sequence similarity, using RPS-BLAST, BLASTP, and PHI-BLAST. Pairwise constraints are then incorporated into a progressive multiple alignment. A Linux executable for COBALT, and CDD and PROSITE data used is available at ftp://ftp.ncbi.nlm.nih.gov/pub/agarwala/cobalt/ COBALT has reasonable runtime performance and alignment accuracy comparable to or exceeding that of other tools for a broad range of problems.

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented May 10, 2017. A pilot effort that has developed a centralized, web-based biospecimen locator that presents biospecimens collected and stored at participating Arizona hospitals and biospecimen banks, which are available for acquisition and use by researchers. Researchers may use this site to browse, search and request biospecimens to use in qualified studies. The development of the ABL was guided by the Arizona Biospecimen Consortium (ABC), a consortium of hospitals and medical centers in the Phoenix area, and is now being piloted by this Consortium under the direction of ABRC. You may browse by type (cells, fluid, molecular, tissue) or disease. Common data elements decided by the ABC Standards Committee, based on data elements on the National Cancer Institute''s (NCI''s) Common Biorepository Model (CBM), are displayed. These describe the minimum set of data elements that the NCI determined were most important for a researcher to see about a biospecimen. The ABL currently does not display information on whether or not clinical data is available to accompany the biospecimens. However, a requester has the ability to solicit clinical data in the request. Once a request is approved, the biospecimen provider will contact the requester to discuss the request (and the requester''s questions) before finalizing the invoice and shipment. The ABL is available to the public to browse. In order to request biospecimens from the ABL, the researcher will be required to submit the requested required information. Upon submission of the information, shipment of the requested biospecimen(s) will be dependent on the scientific and institutional review approval. Account required. Registration is open to everyone.

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• SciCrunch
• 16 years ago - by Anonymous

Japanese national university located in Fukuoka, in the island of Kyushu.

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• SciCrunch
• 12 years ago - submitted by Stephen Larson

A non-profit organization dedicated to saving lives through organ and tissue donation in the seven-county greater Los Angeles area. With more than 200 hospitals, 12 transplant centers and a diverse population of 19 million, OneLegacy is the largest organ and tissue recovery organization in the world. OneLegacy saves and heals lives through organ, eye and tissue donation, comforts the families we serve, and inspires our communities to Donate Life. With each day comes a chance for people to say yes to donation and help those on the other side of the bridge, one legacy at a time.

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• SciCrunch
• 16 years ago - by Anonymous

Sasakawa Memorial Health Foundation (SMHF) was established in 1974, with Mr. Ryoichi Sasakawa, founder and first chairman of the Nippon Foundation (TNF) as President, and Professor Morizo Ishidate, father of chemotherapy of Hansen''s Disease (HD) in Japan, as chair. The principal objective of SMHF is to eliminate HD, a disease which has struck fear into human beings for millennia and stigmatized those it touched. SMHF approaches HD not only as a public health problem but also as a social and human issue. Apart from HD, the work of SMHF covers many of issues within the realm of basic health needs. In doing so SMHF has always respected the ownership by the people, of their own health related needs. SMHF believes in sharing resources and knowledge, rather than creating a situation in which the ''haves'' give to the ''have-nots''. Through this we would like to share with you the joy of working together across national borders for the benefit of people in need. Sasakawa Memorial Health Foundation provides grants to projects implemented by non-profit organizations based outside of Japan. Funding Areas: Hansen''s disease (HD), Neglected Tropical Diseases (NTDs), and Palliative Care (For Japan based Applicants Only)

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• SciCrunch
• 16 years ago - by Anonymous

The International Anesthesia Research Society is a nonpolitical, not-for-profit medical society founded in 1922 to advance and support scientific research and education related to anesthesia, and to improve patient care through basic research. The IARS contributes nearly $1 million annually to fund anesthesia research; provides a forum for anesthesiology leaders to share information and ideas; maintains a worldwide membership of more than 15,000 physicians, physician residents, and others with doctoral degrees, as well as health professionals in anesthesia-related practice; sponsors the SmartTots initiative in partnership with the FDA; and publishes the monthly Anesthesia & Analgesia journal in print and online. The IARS mission is to encourage, stimulate, and fund ongoing anesthesia-related research projects that will enhance and advance the specialty, and to disseminate current, state-of-the art, basic and clinical research data in all areas of clinical anesthesia, including perioperative medicine, critical care, and pain management. The IARS is focused solely on the advancement and support of education and scientific research related to anesthesiology. To fulfill this mission the Society publishes a monthly scientific journal, Anesthesia & Analgesia, conducts an annual clinical and scientific meeting, funds anesthesia-related research, and sponsors the SmartTots research initiative.

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. Part of the Surgery Program, The Moncton Hospital''s Tissue Bank is a support service that recovers, processes, stores and distributes bone for transplantation. Approximately 175 surgical bone donors and 25 cadaver donors are received by The Moncton Hospital Tissue Bank each year. The Tissue Bank consolidates the recovery, processing, testing, storage and distribution of tissues for transplantation to: * Improve the health of individuals; * Provide the required tissue to surgeons for their patients; * Provide the highest quality tissue for transplantation; * Ensure the safety, efficacy and economy in all aspects of tissue banking practice; * Ensure that the quantity and range of tissue meets the clinical demand; * Develop and use outcome measures to ensure quality and safety of tissue provided; * Contribute to the development and implementation of national standards; and * Provide a clinical support service to clinicians in order for them to help the patients achieve their optimum level of functioning. While South-East Regional Health Authority has led the province of New Brunswick in organ donation for decades, only in 2002 did the health authority officially embark on working towards achieving accreditation. In October, 2006, the American Association of Tissue Banks awarded the prestigious accreditation to the Dr. Donald MacLellan Tissue Bank, making this the sixth tissue bank in Canada to hold this achievement. This service will enable SERHA to provide better care to New Brunswicker''s in the event of a trauma or the need for reconstructive surgery.

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• SciCrunch
• 16 years ago - by Anonymous

A reference ontology of classical physics as applied to the dynamics of biological systems. It is designed to encompass the multiple structural scales (multiscale atoms to organisms) and multiple physical domains (multidomain fluid dynamics, chemical kinetics, particle diffusion, etc.) that are encountered in the study and analysis of biological organisms.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented May 10, 2017. It has been incorporated with the LBIH Biobank. The Liverpool Tissue Bank (LTB) collects biological samples (tissue surplus to diagnostic requirement and blood) from patients undergoing surgery or biopsy procedure for the treatment and diagnosis of a wide variety of medical conditions. The main focus of the LTB is collecting samples from patients where cancer is a confirmed or likely diagnosis. These samples are banked to provide an invaluable resource for research groups investigating the molecular mechanisms involved in a range of medical conditions with the aim of devising new treatments and therapies. The Liverpool Tissue Bank (LTB) was formerly known as the Cancer Tissue Bank Research Centre (CTBRC) and changed to the LTB in late 2009. The Tissue Bank was established in 1991 from a charitable donation by the Candis Club, the charitable arm of Candis Magazine. It is a University of Liverpool resource located within the Department of Pathology, School of Cancer Studies. The LTB operates a cost recovery scheme where a charge is made to researchers to cover the costs involved in the collection, storage and processing of biosamples.

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• SciCrunch
• 16 years ago - by Anonymous

The Parkinson's Disease Mouse Model Resource (PDMMR) is funded by the Michael J Fox Foundation to provide genetically engineered mice and information useful for their selection and use. The resource also serves as an archive of genetically stable mouse models. The Repository distributes Parkinson's disease models that are useful for the study of the basic pathophysiology of PD, and for testing new therapies. Also available are research tool strains including transgenics that express marker genes in affected brain regions, and strains with systems for regulating gene expression (e.g. Cre recombinase and tet-inducible promoters) in specific types of neurons.

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 31, 2016. Stem cell research, particularly human embryonic stem cell (hESC) research, holds tremendous promise to discover therapeutic options and perhaps cures for insidious diseases such as cancer, juvenile diabetes, Alzheimer's and Parkinson's. The Massachusetts Human Stem Cell Bank provides the biomedical research community with expertly maintained human ES (hES) and reprogrammed (iPS) cell lines to facilitate studies into the properties and potential therapeutic applications of pluripotent stem cells. The Bank cultures, characterizes and distributes quality controlled hES and iPS cell lines derived in Massachusetts and beyond. The Bank is a 15,000 square foot facility that contains research and training space for visiting investigators. In addition, the Education and Training division provides technical training and programs to educate the community.

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• SciCrunch
• 16 years ago - by Anonymous