Curator Dashboard

Longitudinal twin study to understand individual differences in aging with corresponding data and biological samples. The twin design and the inclusion of twins reared apart makes it possible to study the importance of genetic and environmental factors that may underlie differing aging outcomes. Further, the broad spectrum of biological, psychological, and social domains assessed across the life span makes it possible to study patterns of change within and across domains and how these predict health and diseases of aging. The study is comprised of several longitudinal components including, a comprehensive questionnaire that was sent to all twins in the Swedish Twin Registry who were separated at an early age and reared apart and a control sample of twins reared together. The questionnaires include items concerning rearing, family, adult, and working environment, health status, health related behaviors (e.g. alcohol, tobacco, and dietary habits) as well as relationships, and personality measures. The questionnaires were sent again at 3 year intervals in 1987, 1990, 1993 and after a break again in 2004, 2007, and 2010. Thus far more than 2,000 twins have responded to at least one of the seven questionnaire assessments conducted between 1984 and 2010. Additionally there is information about midlife life style factors from the Swedish Twin Registry that were collected about twenty years before SATSA started. In the second component a subsample of 861 individuals have participated in at least one wave of in-person testing (IPT). The first IPT started in 1986 and since then eight IPTs have been collected and the last wave will be collected during 2012-2013. The IPT includes a health examination, structured interviews, tests of functional capacity, and memory and thinking abilities. To date, over 76% of the sample has participated in 3 or more measurement waves. At IPT9 a third component was added to SATSA, a measure of day-to-day fluctuations in memory and thinking abilities, and emotions. Information about social interactions is also collected. After the visit by the research nurses the twins fill out the day-to-day booklet during the next five days. This procedure will be repeated in IPT10. This will add information about small and short-term changes and more changes are supposed to indicate the beginning of poor health. Data from SATSA can be used to study various aspects of aging. For example, the relative importance of genetic and environmental factors for individual differences in aging especially in cognitive and physical domains has been studied. A further main focus is to study changes within and across domains and which genetic and life style factors predict these changes. Given the wide spectrum of data from measured genes to social relationships collected over more than two decades they dare to say that SATSA is a unique study, with the possibility to answer many questions within gerontology and geriatrics. Types of samples * Serum * DNA Number of sample donors: 674 (June 2010)

• Resource
• SciCrunch
• 15 years ago - by Anonymous

Dr.VIS collects and locates human disease-related viral integration sites. So far, about 600 sites covering 5 virus organisms and 11 human diseases are available. Integration sites in Dr.VIS are located against chromosome, cytoband, gene and refseq position as specific as possible. Viral-cellular junction sequences are extracted from papers and nucleotide databases, and linked to corresponding integration sites Graphic views summarizing distribution of viral integration sites are generated according to chromosome maps. Dr.VIS is built with a hope to facilitate research of human diseases and viruses. Dr.VIS provides curated knowledge of integration sites from chromosome region narrow to genomic position, as well as junction sequences if available. Dr.VIS is an open resource for free.

• Resource
• SciCrunch
• 15 years ago - by Anonymous

On line textbook of basic clinical and functional neuroscience, developed by Rand S. Swenson, D.C., M.D., Ph.D., Dartmouth Medical School Chapter Index * Introduction * Cellular organization * Peripheral nervous system * Development * Spinal cord * Brain stem organization * Sensory systems * Motor systems * Limbic system * Thalamic organization * Cerebral cortical organization * Nutrition of the brain * Conclusions

• Resource
• SciCrunch
• 15 years ago - by Anonymous

Software tool for Bloom-filter-based error correction for next-generation sequencing (NGS) reads. The algorithm produces accurate correction results with much less memory.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Over 22,000 still images of Harold Doc Edgerton materials, 150 restored and digitized films and video, access to approximately 8,000 digitized pages from Doc Edgerton''s hand-written laboratory notebooks, and hundreds of high-speed photographic images constituting the material record of an extraordinary man, great pioneer, inventor, professor emeritus at MIT, who shaped public perception about science and technology. The collections include a social dimension, including you, and the committed community of MIT alumni, faculty, students, staff, and aficionados who share Doc Edgerton''s philosophy of Work hard. Tell everyone everything you know. Close a deal with a handshake. Have fun! The Edgerton Digital Collections (EDC) project is an ambitious and collaborative publishing venture, documenting the history of science and technology. This project celebrates the spirit of a great pioneer and provides the first online access to Harold Edgerton''s research notebooks held by MIT, constituting the material record of an extraordinary man. The collection is a work in progress. Since this project began, we have inventoried, analyzed, cleaned, repaired, cataloged, photographed, titled, annotated, sorted, and organized tens of thousands of Edgerton artifacts, and enabled the public viewing of Doc''s research notebooks, still and moving images.

• Resource
• SciCrunch
• 15 years ago - by Anonymous

Dynamic and interactive view of 222 world wide available mouse resources, classified in 22 categories. The massive generation of data has led to the propagation of mouse resources and databases and the concomitant need for formalized experimental descriptions, data standardization and database interoperability and integration. In this context and with these goals, information is collected through an online questionnaire and/or manual curation. All mouse resource data in MRB are broken up in four sections and presented in four tabs: * The General section/tab contains information such as URL(s), contact information, database description and categorization and related links. * The Ontologies & Standards tab indicates controlled vocabularies and data representation standards adopted by each resource, such as ontologies and minimum information standards. A hyperlink to an index of OBO and non-OBO ontologies can be found here; an index of minimum information standards can be found here. * The Technical tab holds technical information for each resource such as the server technology used, relational database management system(s) utilized, programming language(s) of implementation, schema descriptive documents or actual database dumps and most importantly information on each resource''s programmatic access, the integration and interoperability services. Additionally and through the integration with Molgenis, MRB is capable of generating a SOAP API for hosted resources. * The final section on Database Description Framework (DDF) Criteria, describes the compliance of each resource to the CASIMIR database criteria, which aim to capture key technical data about a database in a formal framework. All data in MRB are freely available to interested users through downloadable weekly database dumps. Programmatic access to some of MRB''s data is feasible via MRB''s SOAP web service. MRB is the front end of a relational, fully normalized PostgreSQL database. The source code is available under the GNU general public license (GPL) as a binary download and via cvs.

• Resource
• SciCrunch
• 15 years ago - by Anonymous

The MIT Edgerton Center carries on the legacy of Doc Edgerton''s research and teaching by providing the Institute with a continuing expertise in high-speed and scientific imaging. Our facilities include a large studio space, a photographic darkroom, and a digital imaging studio equipped with an array of scanners, digital cameras, printers and plotters, and Macintosh computers. In addition, we have several technical digital cameras, including: * Redlake MASD PCI Motionscope, monochrome high-speed video at up to 8,000 images per second. * Concurrent analog data acquisition via a National Instruments A/D card. * Midas 2.0 motion analysis software from Xcitex, Inc. * NAC Model color high-speed camera (in process of donation). * Redlake MASD Ektapro 1012 high-speed video, monochrome, up to 12,000 images per second. * Redlake MASD Megaplus 1.4i scientific still camera These systems are available for use by interested MIT researchers and instructors, and by students pursuing hands-on projects. Each summer we offer a week-long course on high-speed imaging through the MIT Professional Institute. This subject (6.51s) is designed for scientists, engineers, and photographers who need to gather data on rapidly moving subjects and events for study, motion analysis, and trouble-shooting. Mornings are spent in the lecture hall learning the fundamentals for lighting, imaging technologies, and motion analysis. Afternoons are spent making high-speed images in the laboratory. For MIT students, we offer the popular Strobe Project Lab (6.163) to 24 students each term, where students learn the fundamentals of high-speed imaging and apply these techniques to final projects of their own choosing. Two subjects are offered that investigate digital imaging and image manipulation, SP.757 in Fall terms, and SP.747 in Spring terms.

• Resource
• SciCrunch
• 15 years ago - by Anonymous

The dbRBC database provides an open, publicly accessible platform for DNA and clinical data related to the human Red Blood Cells (RBC). A new bioinformatics resource, dbRBC, has been installed at the National Center of Biotechnology Information (NCBI). This resource combines the well established Blood Group Antigen Gene Mutation Database (BGMUT) with tools and interlinked resources developed at the NCBI. The main task of dbRBC is to provide access to publicly available genomic, protein and structural information linked to the red blood cell antigens. The site offers a number of resources: * BGMUT Database * Alignment Viewer * SBT Tool * Probe/Primer Resource * Typing Kit Interface * Obstacle

• Resource
• SciCrunch
• 15 years ago - by Anonymous

DOMMINO is a comprehensive structural database on macromolecular interactions. As of June, 2011, it contains more than 407,000 binary interactions. The distinctive features of DOMMINO are: # Automated updates: DOMMINO is fully automated and is designed to update itself on a weekly basis, one day after a PDB weekly update. Thus, the community will be able to study macromolecular interactions almost immediately after they are released by PDB. # Coverage of non-domain mediated interactions: In addition to domain-domain and domain-peptide interactions the database characterizes the interaction between domains and unstructured protein regions that are not parts of a domain, such as inter-domain linkers and N- and C-termini. The interactions that involve the latter unstructured parts of proteins have been included to the database for the first time providing additional ~186,000 interactions (~45% of the total number of interactions, as of June, 2011). # Coverage of new structural domains: DOMMINO employs one of the most accurate structural classifications of proteins, SCOP. In addition to the existing SCOP-annotated domains, we employ a state-of-the-art machine learning approach to classify newer protein structures into existing SCOP families. With the progress of structural genomics, we do not expect a significant growth of the number of structurally novel folds or protein families and therefore our method allows covering almost all new protein structures. In total, using this predictive approach has allowed us to add more than 261,000 new interactions, almost twice as many as existing SCOP-annotated interactions. # The web-interface is designed to give the user a possibility of a flexible search as well as the capability to study macromolecular interactions in a PDB structure at the interaction network level and at the individual interface level. The web interface of the DOMMINO database includes a comprehensive list of help topics linked to the specific actions. In addition, we have designed a step-by-step tutorial that covers all aspects of working with the data from DOMMINO using the web interface.

• Resource
• SciCrunch
• 15 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 6th, 2022. The biobank comprises paraffin blocks of surgical and autopsy tissue samples and corresponding histological slides as well as cytological material consisting of slides of vaginal smears, fine needle aspiration biopsies and exfoliative cytological material. The tissue samples date back until 1944 and most of the cytological samples until 1970. A subunit of the bank constitutes the National Tissue Microarray Centre. This center is supported by SWEGENE with the purpose to organize and construct tissue microarrays (TMA:s) for high throughput molecular pathology research on various kinds of tumors and other diseases. By linking the TMA.s to long-term and complete clinical follow-up data, prognostic and predictive studies will be facilitated. Biobank content: * Approximately 2,4 million paraffin blocks of surgical tissue specimens, * 1,1 million paraffin blocks of tissue samples from autopsies, * 3,8 million histological slides and * 1,6 million cytology slides. At present, the Tissue Microarray Centre includes: * A consecutive series of all invasive breast cancers (n=600) diagnosed in Malmo between 1988 and 1992. * All incident breast cancers within the Malmo Diet and Cancer cohort (n=400). * A subgroup of 600 pre-menopausal primary breast cancers within the nationwide, population-based randomized tamoxifen trial SBII:2. * 180 primary breast cancers from post-menopausal women included in a similar study. * A set of 120 extremely well characterized primary breast cancer samples with a clinical follow-up of 10 years. More than 40 relevant tumor biological parameters have been recorded in this material and it is therefore useful for a first screening of a marker in order to identify associations to other gene products. * 350 renal cell carcinomas (In collaboration with NUS). We provide researchers with state-of-the-art population based tissue microarrays with long-term and complete follow-up data on survival and treatment. With the TMA-technology, valuable biobank material will be preserved, allowing high throughput in-situ analyses of various tumors and other diseases with a minimal waste of tissue.

• Resource
• SciCrunch
• 15 years ago - by Anonymous

Database of European clinical trials containing information on interventional clinical trials on medicines. The information available dates from 1 May 2004 when national medicine regulatory authorities began populating the EudraCT database, the application that is used by national medicine regulatory authorities to enter clinical trial data. The EU Clinical Trials Register website launched on 22 March 2011 enables users to search for information which has been included in the EudraCT database. Users are able to: * view the description of a phase II-IV adult clinical trial where the investigator sites are in European Union member states and the European Economic Area; * view the description of any pediatric clinical trial with investigator sites in the European Union and any trials which form part of a pediatric investigation plan (PIP) including those where the investigator sites are outside the European Union. * download up to 20 results (per request) in a text file (.txt). The details in the clinical trial description include: * the design of the trial; * the sponsor; * the investigational medicine (trade name or active substance identification); * the therapeutic areas; * the status (authorized, ongoing, complete).

• Resource
• SciCrunch
• 15 years ago - by Anonymous

A database which collects virus data from miRBase and ICTV, VirGne, VBRC., etc, including known viral miRNAs and supporting predicted host miRNA targets by miRanda and TargetScan. ViTa also provides effective annotations, including human miRNA expression, virus infected tissues, annotation of virus and comparisons. Additionally, multiple functions and graphical web interface are designed and implemented to help users to investigate the microRNA roles in viral existence., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

DataVer is the premier data management verification service for scientific data. DataVer''s data management plan (DMP) Compliance Review and the companion Star Ratings will bring transparency to the investigator''s compliance with data management and sharing guidelines on a grant by grant basis. DataVer will accomplish this through 1) open publication of its review standards and procedures that it applies to all submitted grants and 2) openly report the results of its findings through its web portal so anyone can look up the compliance history of an investigator or lab. The Data Management Plan. The NIH and the NSF typically require a DMP detailing data types and quantity, its storage duration, and plans for making the data accessible to fellow scientists. The DMP is supposed to meet their published guidelines outlining the data management and sharing requirements to which the PI must agree as a condition of funding. The compliance record to date is less than ideal.. Institutional funders may not require a specific DMP as such but many have specific requirements for data management and post-grant data availability. While a specific DMP as such may not be produced for these grants, the data management and sharing is expected to comport with the funders'' guidelines. To date, there are no standardized or uniform means to track or assess the compliance of the investigator with the DMP or published guidelines. While individual institutions have tasked program managers with monitoring the compliance, the process is not uniform and the data stays within the specific institute, unavailable for other granting institutes or foundations. What DataVer does. DataVer offers two services with variations. First, it offers a DMP (or funder guideline) compliance review. For this DataVer compares the actual data management and data sharing of the grant funded data to the approved DMP and with the guidelines its funding agency(s). Second, DataVer rates the actual usability and accessibility of the data based on its own published standards on a three star rating scale. This indicates at a glance how well the data is organized and whether it''s available for reuse by an outside investigator. These procedures give the funders and the scientific community accurate, standardized and timely reports on an investigators'' data storage and data sharing in a publicly available database. We at DataVer believe this light, cast on actual data openness, will further encourage increased care in data management and archiving as well as increased data sharing. This openness and transparency will be a positive means to increase data management plan and guideline compliance, and will stimulate increased attention to the accessibility and usability of the data, so important to its reuse. We will offer a means by which universities, investigators, research facilities, and data repositories can obtain a compliance certification for consistently setting a high standard of data accessibility and usability across multiple grants. This certification is a means by which these stakeholders can demonstrate their achievement in support of data sharing. Grantors will be able to see an institution or facility''s pattern of compliance when deciding where to spend their limited resources.

• Resource
• SciCrunch
• 15 years ago - by Anonymous

A searchable, keyword-indexed bibliography on conditioned taste aversion learning, the avoidance of fluids and foods previously associated with the aversive effects of a variety of drugs. The database includes articles as early as 1951, and papers just published given that the database is ongoing and constantly updated. In the mid 1950''s, John Garcia and his colleagues at the Radiological Defense Laboratory at Hunters Point in San Francisco assessed the effects of ionizing radiation on a myriad of behaviors in the laboratory rat. One of their behavioral findings was that radiated rats avoided consumption of solutions that had been present during radiation, presumably due to the association of the taste of the solution with the aversive effects of the radiation. These results were published in Science and introduced to the literature the phenomenon of conditioned taste aversion learning (or the Garcia Effect). Subsequently, Garcia and his colleagues demonstrated that such learning appeared unique in a number of respects, including the fact that these aversions were acquired often in a single conditioning trial, selectively to gustatory stimuli and even when long delays were imposed between access to the solution and administration of the aversive agent. Together, these unique characteristics appeared to violate the basic tenets of traditional learning theory and along with a number of other behavioral phenomena (e.g., bird song learning, species-specific defense reactions, tonic immobility and schedule-induced polydipsia) introduced the concept of biological constraints on learning that forced a reconceptualization of the role evolution played in the acquisition of behavior (Garcia and Ervin, 1968; Revusky and Garcia, 1970; Rozin and Kalat, 1971). Although the initial investigations into conditioned taste aversion learning focused on these biological and evolutionary issues and their relation to learning, research in this area soon assessed the basic generality of the phenomenon, specifically, under what conditions such learning did or did not occur. With such research, a wide variety of gustatory stimuli were reported as effective conditioned stimuli and an extensive list of drugs with diverse consequences were reported as effective aversion-inducing agents. Aversions were established in a range of strains and species and under many experimental conditions. Research in this area continues to extend the conditions under which such learning occurs and to demonstrate its biological, neurochemical and anatomical substrates. Although the conditions under which aversion learning are reported to occur appear to generalize from the specific conditions under which they were originally reported, a number of factors including sex, age, training and testing procedures, deprivation level and drug history, all affect the rate of its acquisition and its terminal strength (Riley, 1998). In addition to these experimental demonstrations and assessments of generality, research on conditioned taste aversions has expanded to include investigations into its research and clinical applications (Braveman and Bronstein, 1985). In so doing, taste aversion learning has been applied to the characterization and classification of drug toxicity, the demonstration of the stimulus properties of abused drugs, the management of wildlife predation, the assessment of the etiology and treatment of cancer anorexia, the study of the biochemistry and molecular biology of learning, the etiology and control of alcohol use and abuse, the receptor characterization of the motivational effects of drugs, the occurrence of drug interactions, the characterization of drug withdrawal, the determination of taste psychophysics, the treatment of autoimmune diseases and the evaluation of the role of malaise in drug-induced satiety and drug-induced behavioral deficits. The speed with which aversions are acquired and the relative robustness of this preparation have made conditioned taste aversion learning a widely used, highly replicable and sensitive tool. In 1976, we published the first of three bibliographies on conditioned taste aversion learning. In this initial publication (see Riley and Baril, 1976), we listed and annotated 403 papers in this field. Subsequent lists published in 1977 (Riley and Clarke, 1977) and 1985 (Riley and Tuck, 1985) listed 632 and 1373 papers, respectively. Since that time, we have maintained a bibliography on taste aversion learning utilizing a variety of journal and on-line searches as well as benefiting from the generous contribution of preprints, reprints and pdf files from many colleagues. To date, the number of papers on conditioned taste aversion learning is approaching 3000. The present database lists these papers and provides a mechanism for searching the articles according to a number of search functions. Specifically, it was constructed to provide the reader access to these articles via a variety of search terms, including Author(s), Key Words, Date, Article Title and Journal. One can search for single or multiple items within any specific category. Further, one can search a single or combination of categories. The database is constantly being updated, and any feedback and suggestions are welcome and can be sent to CTALearning (at) american.edu.