Curator Dashboard

A medical, nonprofit, educational wiki created to support a collective online memory for physicians, nurses, and medical students. Users can publish review articles, clinical notes, pearls, and medical images on the site. Anyone with a medical background can contribute to or edit medical articles. Images include: EKG, x-ray, coronary angiograms, peripheral angiograms, structural angiograms, searchable angiograms, echocardiograms, and radiology. Tutorials include: EKG tutorials, coronary angiography tutorials, and ventriculography tutorials.

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• SciCrunch
• 16 years ago - by Anonymous

National network of research laboratories for genetic testing of eye disease. They offer testing for affected individuals coupled to registry of clinical information available through patient registry. Large data set for investigators to identify additional genetic risk factors and to explore relationship between genetic disease (genotype) and its clinical manifestation (phenotype).

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• SciCrunch
• 14 years ago - by Anonymous

R package using a non-parametric method for estimating distributions of phylogenetic trees, with the goal of identifying trees that are significantly different from the rest of the trees in the sample.

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• SciCrunch
• 12 years ago - by Anonymous

Database providing access to quality controlled Open Access Journals. For a journal to be included it should exercise quality control on submitted papers through an editor, editorial board and/or a peer-review system. It is not be limited to particular languages or subject areas. Offering free online access to high quality full text content, plus excellent search tools, the portal enables researchers to find, use and re-use a vast range of materials with ease. The content of DOAJ will be even more visible and disseminated through this portal. The aim of the Directory is to increase the visibility and ease of use of open access scientific and scholarly journals thereby promoting their increased usage and impact. As of April 2014, DOAJ has 9,709 journals, 5,624 journals searchable at article level, 133 Countries and 1,600,991 articles. The database may be browsed by title or subject, or searched through the interface to for journals or articles.

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• SciCrunch
• 16 years ago - by Anonymous

Open resource of biological samples (DNA, cell lines, and other biospecimens) and corresponding phenotypic data to promote neurological research. Samples from more than 34,000 unique individuals with cerebrovascular disease, dystonia, epilepsy, Huntington's Disease, motor neuron disease, Parkinsonism, and Tourette Syndrome, as well as controls (population control and unaffected relatives) have been collected. The mission of the NINDS Repository is to provide 1) genetics support for scientists investigating pathogenesis in the central and peripheral nervous systems through submissions and distribution; 2) information support for patients, families, and advocates concerned with the living-side of neurological disease and stroke.

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• SciCrunch
• 14 years ago - by Anonymous

The Eye mutant resource lists and describes mouse models for ocular research available from The Jackson Laboratory and provides continuing results from a Jackson Laboratory screening program to identify genes and new mutations that affect vision. It also provides a list of known mouse mutations that affect vision and presents updated information on the cloning of vision-related genes. The primary focus is on the mouse as a model of human inherited vision disorders. The number of known serious or disabling eye diseases in humans is large and affects millions of people each year. Yet research on these diseases frequently is limited by the obvious restrictions on studying pathophysiologic processes in the human eye. Likewise, many human ocular diseases are genetic in origin, but appropriate or available families often are not easy for genetic studies. Mouse models of inherited ocular disease provide powerful tools for quick genetic analysis and characterization. The mouse eye is remarkably similar in structure to the human eye, and many developmental or invasive experiments can be done in mice that are impossible in human beings. Comparative mapping and sequencing between human and mouse genomes shows that knowing the gene location in either man or mouse allows for the same gene to be found more quickly in the other. Finally, the use of inbred strains, where all mice in the strain are alike genetically except for the mutation being studied, is a powerful tool for linkage analysis, and assures phenotypic reproducibility of any model found in a strain. The virutal identity of mice in an inbred strain also allows for fewer numbers of mice to be studied clinically. Mouse models of retinal degeneration have been investigated for many years in the hope of understanding the causes of photoreceptor cell death. 16 naturally occurring mouse mutants that manifest degeneration of photoreceptors in the retina with preservation of all other retinal cell types have been found: retinal degeneration (formerly rd , identical with rodless retina, r, now Pde6b rd1); Purkinje cell degeneration (pcd); nervous (nr); retinal degeneration slow (rds, now Prph Rd2); retinal degeneration 3 (rd3 ); motor neuron degeneration (mnd); retinal degeneration 4 (Rd4 ); retinal degeneration 5 (rd5); vitiligo (vit , now Mitf mi-vit); retinal degeneration 6 (rd6 ); retinal degeneration 7 (rd7); neuronal ceroid lipofuscinosis ( nclf ); retinal degeneration 8 (rd8 ); retinal degeneration 9 ( Rd9 ); retinal degeneration 10 (rd10); and cone photoreceptor function loss (cpfl1).

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• SciCrunch
• 17 years ago - by Anonymous

Ontology for standard measures related to complex diseases, phenotypic traits and environmental exposures

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• SciCrunch
• 13 years ago - by Anonymous

Highly characterized cell lines and high quality DNA for cell and genetic research representing a variety of disease states, chromosomal abnormalities, apparently healthy individuals and many distinct human populations. The NIGMS Repository contains more than 10,600 cell lines, primarily fibroblasts and transformed lymphoblasts, and over 5,500 DNA samples. The NIGMS Repository has a major emphasis on heritable diseases and chromosomally aberrant cell lines. In addition, it contains a large collection dedicated to understanding human variation that includes samples from populations around the world, the CEPH collection, the Polymorphism Discovery Resource, and many apparently healthy controls. Human induced pluripotent stem cell lines, many of which were derived from NIGMS Repository fibroblasts, have recently become available through the NIGMS Repository. Sample donation facilitates all areas of research by making available well-characterized materials to any qualified researcher who might have otherwise been unable to invest the time and resources to collect needed samples independently. Donations to the Repository have created a resource of unparalleled scope. Samples from the collection have been used in more than 5,500 publications and are distributed to scientists in more than 50 countries. This resource is continuously expanding to support new directions in human genetics.

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• SciCrunch
• 16 years ago - by Anonymous

With expertise in the preservation of biological specimens, Swiss Biobank is a biobank of cell therapy products (stem cells, progenitor). Strategically located in Suisse Romande, the center is accessible 7J/7J, 365 days / year. The laboratories and technology platforms are tailored to international standards. Service is prompt, courteous, and responsive to your needs. The first opportunity to harvest adult stem cells, which is the only type at Swiss Biobank, occurs just after the birth of a baby. The umbilical cord blood and placenta are rich in hematopoietic stem cells and can regenerate all cells in the bloodstream. The cord and placenta tissues themselves contain mesenchymal cells that can be used for the regeneration of connective tissue. The standardized procedures for collecting cord blood units are made ����??����??by the medical staff of the hospital / clinic according to international standards. The sample is transported by a courier Swiss Medical Biobank in which it is prepared and cryo-preserved by qualified personnel within 24 hours. In the case of public biobanking, cells, tissues, organs are donated and can be used with consent of the donor, a third person for transplantation, or as part of clinical research. The HLA (Human Leukocyte Antigen) is a group of proteins on the cell surface, and specific to each individual. This allows the immune system to distinguish our own cells for foreign elements (pathogens) that are likely to be attacked. Histocompatibility between the donor and recipient is of primary importance in organ transplantation, tissues and / or cells, to minimize the chances of rejection. There is one chance in four that two siblings have the same HLA code.

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• SciCrunch
• 16 years ago - by Anonymous

Banyan Biomarkers was founded in 2002 by Ron Hayes, PhD , Kevin Wang, PhD, and Nancy Denslow, PhD to create the first Point of Care (POC) Blood Test to diagnose traumatic brain injury (TBI) and to diagnose neurological diseases. Initially inspired by research conducted at the University of Florida and The Evelyn F. and William McKnight Brain Institute, Banyan Biomarkers has made significant progress in developing and clinically validating novel enzyme linked immunosorbent assays (ELISAs) for traumatic brain injury (TBI). Banyan scientists have created an extensive pipeline of potential biomarkers and the company has a robust intellectual property portfolio. Jackson Streeter, Banyan''s CEO, has extensive experience in development of medical devices for acute brain injury. Currently no blood test exists for use by physicians to detect the presence and severity of brain trauma. Banyan Biomarkers'' research has identified unique and proprietary biomarkers present in the patient''s blood following injury to the brain. The detection and quantification of these biomarkers may provide early indications of brain trauma essential for earlier intervention and management. Banyan Biomarkers, Inc. offers preclinical and clinical sample analyses with a proven panel of neurological, psychiatric, neurodegenerative disease, and organ toxicity biomarker assays. The company provides analytical services to a wide range of customers including pharmaceutical companies, biotechnology companies and investigators at academic research institutes.

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• SciCrunch
• 16 years ago - by Anonymous

Controlled vocabulary for soybean field growth stages (Soybean Whole Plant Growth Ontology), plant structure names (Soybean Structure Ontology), development (Soybean Development Ontology) and plant traits (Soybean Trait Ontology). These are only a suggestion. Input from the community will be necessary to update and extend the ontologies. Because of this, these ontologies should also be considered a work in progress. Where applicable, soybean specific terms have been associated with their Plant Ontology (PO) and Gramene Plant Trait Ontology (TO) synonyms to facilitate cross species comparisons. Please feel free to contact them for corrections, additions, and questions.

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• SciCrunch
• 16 years ago - by Anonymous

Software tool to identify binding sites of known transcription factors on promoter regions. The algorithm is based on one-class support vector machine (One-class SVM). OSCAR uses the sequential composition of known binding sites, and further incorporates the locational preferences of binding events. Nu-OSCAR (Nucleosome-Occupancy Study for Cis-elments Accurate Recognition) is a program that can be used to identify binding sites of known transcription factors, which further incorporates nucleosome occupancy around sites on promoter regions, thereby improving the accuracy of prediction. The derivation of the the algorithm is based on a biophysical view of interactions between protein factors and nucleosome DNA.

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• SciCrunch
• 16 years ago - by Anonymous

EuPathDB integrates numerous database resources and multiple data types. The phylum Apicomplexa comprises veterinary and medically important parasitic protozoa including human pathogenic species of genera Cryptosporidium, Plasmodium and Toxoplasma. ApiDB serves not only as database but unifies access to three major existing individual organism databases, PlasmoDB.org, ToxoDB.org and CryptoDB.org, and integrates these databases with data available from additional sources. Through ApiDB site, users may pose queries and search all available apicomplexan data and tools, or they may visit individual component organism databases. EuPathDB Bioinformatics Resource Center for Biodefense and Emerging/Re-emerging Infectious Diseases is a portal for accessing genomic-scale datasets associated with eukaryotic pathogens.

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• SciCrunch
• 16 years ago - by Anonymous

The WMH Survey Initiative is a project of the Assessment, Classification, and Epidemiology (ACE) Group at the World Health Organization coordinating the implementation and analysis of general population epidemiologic surveys of mental, substance use, and behavioral disorders in countries in all WHO Regions. Reported are the first results of the WHO World Mental Health (WMH) Survey Initiative, a highly ambitious series of cross-national psychiatric epidemiological surveys. The general population surveys in the WMH series span 17 countries in all parts of the world. In many of these countries the WMH surveys provide the first community epidemiological data ever available on mental disorders in the population. The detailed information on lifetime prevalence, age of onset, course, correlates, and treatment of mental disorders in this volume provides mental health professionals and healthcare policy planners with an unprecedented reference on the cross-national descriptive epidemiology of mental disorders. The WHO Global Burden of Disease Study estimates that mental and addictive disorders are among the most burdensome in the world and their burden will increase over next decades. However, these estimates and projections are based largely on literature reviews and limited and isolated studies rather than on cross-national epidemiologic surveys. In order to move forward with public health initiatives aimed at addressing the global burden of mental disorders the WMH Survey Initiative carried out rigorously implemented general population surveys that estimate the prevalences of mental disorders, evaluate risk factors for purposes of targeting interventions, study patterns of and barriers to service use, and validate estimates of disease burden world-wide. The WMH Survey Initiative aims to obtain accurate cross-national information about the prevalences and correlates of mental, substance, and behavioral disorders. Included in studies of correlates will be analyses of impairments, other adverse social consequences, and patterns of help-seeking. The WMH Survey Consortium includes nationally or regionally representative surveys in 28 countries, representing all regions of the world, and with a total eventual sample size in excess of 154,000. ISBN:9780521884198

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• SciCrunch
• 16 years ago - by Anonymous

KORA-gen is infrastructure to provide phenotypes, genotypes and biosamples for collaborative genetic epidemiological research. From all four surveys that have been conducted so far, the following biological material is on hand: genomic DNA, blood serum, blood plasma and EBV immortalized cell lines (form KORA S4 only). These have been extracted from blood samples and are stored in nitrogen tanks and -80 degrees C refrigerators. Genomic DNA from more than 18.000 adult subjects from Augsburg and the surrounding counties is available at present. So far, EBV immortalized cell lines from 1.600 participants are cultivated. To meet the manifold demands of researchers with genetic and molecular questions KORA-gen fulfills the following prerequisites for successful genetic-epidemiological research: * representative samples from the general population, * well characterized disease phenotypes and intermediate phenotypes, * information on environmental factors, * availability of genomic DNA, serum, plasma and urine, as well as EBV immortalized cell lines. In total, four population based health surveys have been conducted between 1984 and 2000 with 18000 participants in the age range of 25 to 74 years, and a biological specimen bank was established in order to enable scientists to perform epidemiologic research with respect to molecular and genetic questions. The KORA study center conducts regular follow-up investigations and has collected a wealth of information on sociodemography, general medical history, environmental factors, smoking, nutrition, alcohol consumption, and various laboratory parameters. This unique resource will be increased further by follow-up studies of the cohort. The assessment of statistical questions covers the definition of the study design and the calculation of statistical power. Furthermore, we offer assistance in data analysis. Kora-gen can be used by external partners. Interested parties can inform themselves interactively via internet about the available data and rules of access. The genotypic data base is a common resource to all partners.

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• SciCrunch
• 16 years ago - by Anonymous

A multifunctional workbench for species identification using insertion/deletion variants. The SPInDel workbench provides a step-by-step environment for the alignment of target sequences, selection of informative hypervariable regions, design of PCR primers and the statistical validation of the species-identification process. It includes a large dataset comprising nearly 1,800 numeric profiles for the identification of eukaryotic, prokaryotic and viral species.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 11,2024. Tissue Culture Facility provides mycoplasma testing, baculovirus titer measurements, growing of cultured cells and cell storage, to University of Virginia researchers. The Facility also supplies cell culture reagents and supplies. Training and access to facilities is also available. Products and services are only available to users at the University of Virginia.

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• SciCrunch
• 16 years ago - by Anonymous

A free tool for displaying pairwise comparisons between two or more DNA sequences. It can be used to identify and analyze regions of similarity and difference between genomes and to explore conservation of synteny, in the context of the entire sequences and their annotation. It is based on the software for Artemis, the genome viewer and annotation tool. ACT runs on UNIX, GNU/Linux, Macintosh and MS Windows systems. It can read complete EMBL and GENBANK entries or sequences in FASTA or raw format. Other sequence features can be in EMBL, GENBANK or GFF format.

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• SciCrunch
• 16 years ago - by Anonymous

The NSABP (National Surgical Adjuvant Breast and Bowel Project) Tissue Bank is the central repository of tissue samples (stained and unstained slides, tissue blocks, and frozen tissue specimens) collected from clinical trials conducted by the NSABP. The main scientific aim of the NSABP Division of Pathology is to develop clinical context-specific prognostic markers and predictive markers that predict response to or benefit from specific therapeutic modality. To achieve this aim, the laboratory collects the tumor and adjacent normal tissues from cancer patients enrolled into the NSABP trials through its membership institutions, and maintain these valuable materials with clinical follow-up information and distribute them to qualified approved investigators. Currently, specimens from more than 90,000 cases of breast and colon cancer are stored and maintained at the bank. Paraffin embedded tumor specimens are available from NSABP trials. We currently do not bank frozen tissues. All blocks are from patients enrolled in prospective NSABP treatment protocols and complete clinical follow up information as well as demographic information is available. Depending on the project, unstained tissue sections of 4-micrometer thickness, tissue microarrays, or stained slides are provided to the investigators in a blinded study format. Any investigators with novel projects that conform to the research goals of NSABP may apply for the tissue. Please refer to the NSABP Tissue Bank Policy to determine if your project conforms to these goals. Priority is given to NSABP membership institutions who regularly submit tissue blocks.

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• SciCrunch
• 16 years ago - by Anonymous

The Defense and Veterans Brain Injury Center (DVBIC) is a congressionally mandated collaboration of the Department of Defense (DoD) and Veterans Affairs (VA) health centers serving patients with traumatic brain injury (TBI). Its mission is to serve active duty military, their beneficiaries, and veterans with traumatic brain injuries (TBIs) through state-of-the-art clinical care, innovative clinical research initiatives and educational programs. DVBIC fulfills this mission through ongoing collaboration with military, VA and civilian health partners, local communities, families and individuals with TBI. In 2008, DVBIC''s mission expanded to include Force Health Protection and Management. This encompasses the following Department of Defense (DoD) programs: * TBI Surveillance * TBI Registry * Pre-deployment neurocognitive testing * Family Caregiver Curriculum * 15 year longitudinal study of TBI * Independent study of automated neurocognitive tests DVBIC has been named the Office of Responsibility or Executive Agency for these programs. The DVBIC multi-site network includes a growing number of DoD and VA hospitals as well as civilian TBI rehabilitation programs. Each DVBIC site works collaboratively to provide and improve TBI care for active duty military, veterans and their eligible beneficiaries. DVBIC''s multi-center network design and collaborations with forward medical commands allows for clinical innovation along the entire continuum of care: from initial injury in the war zone through to medical evacuation, acute care, rehabilitation and ultimately a return to community, family, and work or continued duty when possible. WHAT WE DO * Develop and provide advanced TBI-specific evaluation, treatment and follow-up care for military personnel, their beneficiaries, and veterans with mild to severe TBIs * Conduct clinical research that defines optimal care and treatment for individuals with TBI * Develop and deliver effective educational materials and programming for the prevention, assessment and treatment of TBI including the management of its continuing effects. DVBIC is specifically committed to the effort to prevent, treat, and provide education on TBI for US military members currently on active duty, National Guard and reservists recently injured in the line of duty, their beneficiaries, and retired military personnel. * Oversee congressionally-mandated DoD TBI programs All of the above are done through innovative collaborations among the Armed Forces, VA, federal agencies, and coordinating academic institutions.

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• SciCrunch
• 16 years ago - by Anonymous