Curator Dashboard

Center for investigators studying human health and disease, offering the opportunity to assess the causes of disease, and new treatment methods in nonhuman primate models that closely recapitulate humans. Its mission is to provide interdisciplinary programs in biomedical research on significant human health-related problems in which nonhuman primates are the models of choice.

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• SciCrunch
• 17 years ago - by Anonymous

U-CH1 and U-CH2 are sacral-chordoma derived cell lines created by the lab of Dr. Peter Moeller at the University of Ulm, Germany. The Chordoma Foundation maintains a repository of these cell lines and makes them available to academic and industry investigators. Additionally, Notochordal tissue is available from the Congenital Defects Lab at the University of Washington. (Contact us for more information.) The following data is available: * Xenographs: The U-CH1 cell line forms tumors that resemble chordomas in NSG mice. A protocol for creating a xenograft using U-CH1 was developed by Dr. Adrienne Flanagan. * Tissue Microarrays (sacral, spine, skull base, lumbar, cervical, mobile spine, etc.) * Gene Expression Data: EBI Array Express Experiment E-MEXP-353: transcription profiling of human mesenchymal and some possibly neural crest derived neoplasms using the Affymetrix GeneChip? Human Genome HG-U133A. This data set was generated by the University College London Cancer Institute and contains 96 tissue samples including 4 chordomas. * Comparative Genomic Hybridization Data: Gene Expression Omnibus Series GSE9023: DNA copy number analysis of 21 fresh frozen chordoma biopsies, and the respective relapse in four of them, using 32k and 1Mb array CGH. Cases 1-11 were analyzed using 32k array CGH and male genomic DNA (Promega) was used as reference. Cases 17-26, and the respective relapse in four of these tumors, were analyzed with 1 Mb array CGH, using sex matched controls. All cases showed copy number alterations and primarily deletions of chromosomal regions were found. Particularly, the CDKN2A and CDKN2B loci in 9p21 were homo- or heterozygously lost in 70% of the tumors.

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• SciCrunch
• 16 years ago - by Anonymous

ASN Kidney Tube - YouTube are videos hosted at YouTube put out by the American Society of Nephrology (ASN).

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• SciCrunch
• 15 years ago - by Anonymous

High quality ribosomal RNA databases providing comprehensive, quality checked and regularly updated datasets of aligned small (16S/18S, SSU) and large subunit (23S/28S, LSU) ribosomal RNA (rRNA) sequences for all three domains of life (Bacteria, Archaea and Eukarya). Supplementary services include a rRNA gene aligner, online tools for probe and primer evaluation and optimized browsing, searching and downloading on the website. The extensively curated SILVA taxonomy and the new non-redundant SILVA datasets provide an ideal reference for high-throughput classification of data from next-generation sequencing approaches. Alignment tool, SINA, is available for download as well as available for use online.

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• SciCrunch
• 13 years ago - by Anonymous

Develops innovative products to advance proteomic research. We specialize in discovering peptides and proteins with novel biological properties, designing and developing enzyme activity assays for diverse screening applications, and producing innovative protein analysis tools for biomarker identification and characterization.

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• SciCrunch
• 14 years ago - by Anonymous

The LBDA is a Lewy Body Disease (LBD) information resource for lewy body patients, caregivers, and medical professionals. It provides general information on LBD, including diagnosis, symptoms, treatments, etc., as well as providing links to support resources and an LBD online community. For professionals, the site also provides information on patient care, current LBD research and publications, and diagnostics information. LBDA offers many support resources for those affected by LBD and for their loved ones. These resources include local support group meeting information, online support groups, and user forums where users can find information or ask any questions they may have about the disease. A portion of the site is also dedicated to those who wish to help, either through participation in clinical trials, donations, or volunteering. LBDA also offers information on upcoming LBD-related events. LBDA is located Atlanta, GA. :NIF thanks the :<A HREF=http://www.pdf.org TARGET=_blank> :<U>Parkinson''s Disease FoundationU> :A> :<A HREF=http://www.pdf.org TARGET=_blank> A> :for their referral of this resource to us.

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• SciCrunch
• 17 years ago - by Anonymous

Software tool for computing and annotating genomic ranges.Provides efficient low-level and highly reusable S4 classes for storing ranges of integers, RLE vectors (Run-Length Encoding), and, more generally, data that can be organized sequentially (formally defined as Vector objects), as well as views on these Vector objects. Efficient list-like classes are also provided for storing big collections of instances of the basic classes. All classes in the package use consistent naming and share the same rich and consistent Vector API as much as possible.

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• SciCrunch
• 13 years ago - by Anonymous

A computational pipeline to analyze differential RNA sequencing (dRNA-seq) data to determine transcription start sites genome-wide.

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• SciCrunch
• 13 years ago - by Anonymous

A C++ software program for automatically detecting somatic and germline variants at microsatellite regions. It computes length distributions of microsatellites per site in paired tumor and normal sequence data, subsequently using these to statistically compare observed distributions in both samples.

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• SciCrunch
• 13 years ago - by Anonymous

A computational software toolbox for allele-specific (AS) epigenomics analysis. It incorporates allelic variation data within existing resources, allowing for the identification of significant associations between epigenetic modifications and specific allelic variants in human and mouse cells. It provides a customizable pipeline of command line tools for AS analysis of next-generation sequencing data (ChIP-seq, RNA-seq, etc.) that takes the raw sequencing data and produces separate allelic tracks ready to be viewed on genome browsers. ALEA takes advantage of the available genomic resources for human (The 1000 Genomes Project Consortium) and mouse (The Mouse Genome Project) to reconstruct diploid in-silico genomes for human or hybrid mice under study. Then, for each accompanying ChIP-seq or RNA-seq dataset, it generates two Wiggle track format (WIG) files from short reads aligned differentially to each haplotype.

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• SciCrunch
• 13 years ago - by Anonymous

A community building portal dedicated to understanding Alzheimer's disease and related disorders, it reports on the latest scientific findings from basic research to clinical trials, creates and maintains public databases of essential research data and reagents, and produces discussion forums to promote debate, speed the dissemination of new ideas, and break down barriers across disciplines.

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• SciCrunch
• 17 years ago - by Anonymous

Core facility that provides the following services: 7500 fast Q-PCR service, MALDI MS service, Agilent 2100 bioanalyzer service, NanoDrop 1000 service. <BR/> <BR/>

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• SciCrunch
• 13 years ago - by Anonymous

Service to predict deleterious non-synonymous human Single Nucleotide Polymorphisms (SNPs) using only orthologous protein sequences.

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• SciCrunch
• 13 years ago - by Anonymous

API service for requesting data on topography grid applications.

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• SciCrunch
• 12 years ago - by Anonymous

A web server for constructing multilevel gene regulatory networks using ChIP-seq and gene expression data.

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• SciCrunch
• 13 years ago - by Anonymous

Software for detecting genomic rearrangements in tumors that utilizes only split-read data. It features single nucleotide resolution, high sensitivity, and high specificity in simulated data. It takes advantage of parallelism for efficient use of resources.

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• SciCrunch
• 13 years ago - by Anonymous

Software that facilitates accurate estimation for sampling-induced read duplication in deep sequencing experiments.

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• SciCrunch
• 13 years ago - by Anonymous

Statistical software to estimate tumor purity, ploidy and absolute copy numbers from next generation sequencing data.

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• SciCrunch
• 13 years ago - by Anonymous

Software tools for (automated and manual) quality control of the results of Genome Wide Association Studies.

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• SciCrunch
• 13 years ago - by Anonymous

Software package for the integrative analysis of microarray based gene expression and histone modification data obtained by ChIP-seq. The package provides methods for data preprocessing and matching as well as methods for fitting bayesian mixture models in order to detect genes with differences in both data types.

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• SciCrunch
• 13 years ago - by Anonymous