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THIS RESOURCE IS NO LONGER IN SERVICE, documented August 22, 2016. Develop, manufacture and market proprietary, nanocrystalline calcium-phosphate-based biomaterials that promote the repair and regeneration of bone damaged by trauma or disease. ETEX focuses on expanding applications through combinations with cells, biologics, or therapeutic agents delivered in minimally invasive and easy to use systems.

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• SciCrunch
• 16 years ago - by Anonymous

Founded in 1977, California Cryobank (CCB) is a full-service sperm bank providing a comprehensive resource for frozen donor sperm, private semen cryopreservation, and specialized reproductive services (including egg and embryo storage and artificial insemination guidance). We are extremely proud of our 30 years of reproductive success. The demand for expert services has grown exponentially as discussion of reproductive challenges has continued to become more mainstream. At California Cryobank we understand that regardless of how much information and education you bring to the process, there can still be significant apprehension accompanying such big steps as sperm donation and donor insemination. CCB''s commitment to making our clients as comfortable as possible is what sets us apart and makes us so much more than just another sperm bank. Our services are entirely patient-centric; from the education that we provide����??answering questions and providing step-by-step timetables that let patients know what to expect in the weeks and months to come from donor sperm selection through insemination����??to the guidance that we offer. Our team is comprised of physicians, lab technicians, genetic counselors, Client Service Consultants, and Donor Matching Consultants. Every facet of our services is completely and expertly led by one of our experienced and compassionate team members. And while our sperm donor program is the foundation of our service, California Cryobank provides a full range of services for our clients including cord blood banking and access to our CCB Sibling Registry.

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• SciCrunch
• 16 years ago - by Anonymous

An atlas project whose goal is to enerate brainwide maps of inter-regional neural connectivity that specify the inputs and outputs of every brain region, at a "mesoscopic" level of analysis. A 3D injection viewer is used to view the mouse brain. To determine the outputs of a brain region, anterograde tracers are used which are taken up by neurons locally ("the input"), then transported actively down the axons to the "output regions." The whole brain is then sliced thinly, and each slice is digitally imaged. These 2-D images are reconstructed in 3D. The majority of the resulting 3-D brain image is unlabeled. Only the injected region and its output regions have tracer in them, allowing for identification of this small fraction of the connectivity map. This procedure is repeated identically, to account for individual variability. To determine the inputs to the same brain region as above, a retrograde tracer is injected in the same stereotaxic location ("the input"), and the process is repeated. In order to accumulate data from different mice (each of whom has a slightly different brain shape and size), 3-D spatial normalization is performed using registration algorithms. These gigapixel images of whole-brain sections can be zoomed to show individual neurons and their processes, providing a "virtual microscope." Each sampled brain is represented in about 500 images, each image showing an optical section through a 20 micron-thick slice of brain tissue. A multi-resolution viewer permits users to journey through each brain, following the pathways taken through three-dimensional brain space by tracer-labeled neuronal pathways. A key point is that at the mid-range "mesoscopic" scale, the team expects to assemble a picture of connections that are stereotypical and probably genetically determined in a species-specific manner. By dividing the volume of a hemisphere of the mouse brain into 250 equidistant, predefined grid-points, and administering four different kinds of tracer injections at each grid point -- in different animals of the same sex and age a complete wiring diagram that will be stitched together in "shotgun" fashion from the full dataset.

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• SciCrunch
• 15 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented May 10, 2017. A pilot effort that has developed a centralized, web-based biospecimen locator that presents biospecimens collected and stored at participating Arizona hospitals and biospecimen banks, which are available for acquisition and use by researchers. Researchers may use this site to browse, search and request biospecimens to use in qualified studies. The development of the ABL was guided by the Arizona Biospecimen Consortium (ABC), a consortium of hospitals and medical centers in the Phoenix area, and is now being piloted by this Consortium under the direction of ABRC. You may browse by type (cells, fluid, molecular, tissue) or disease. Common data elements decided by the ABC Standards Committee, based on data elements on the National Cancer Institute''s (NCI''s) Common Biorepository Model (CBM), are displayed. These describe the minimum set of data elements that the NCI determined were most important for a researcher to see about a biospecimen. The ABL currently does not display information on whether or not clinical data is available to accompany the biospecimens. However, a requester has the ability to solicit clinical data in the request. Once a request is approved, the biospecimen provider will contact the requester to discuss the request (and the requester''s questions) before finalizing the invoice and shipment. The ABL is available to the public to browse. In order to request biospecimens from the ABL, the researcher will be required to submit the requested required information. Upon submission of the information, shipment of the requested biospecimen(s) will be dependent on the scientific and institutional review approval. Account required. Registration is open to everyone., documented on August 17, 2021.Biospecimens and support services to advance translational research including a wide range of specimen types, including matched sets of normal and diseased tissue, Formalin-Fixed, Paraffin-Embedded (FFPE), blood, and serum, focusing primarily on cancer. They stock a wide range of sample formats to help meet research goals quickly and on budget. Collections are preformed to be ideal for a wide range of studies including genomic, proteomic, molecular and histologic analysis. ILSbio provides tissue and tissue derivatives that are high quality, cost effective and procured in compliance with current and anticipated regulations. The company obtains its clinical specimens under strict IRB approved protocols with informed consent and the utmost attention to issues of patient safety, anonymity and confidentiality. Clinical and pathological data is available for all specimens. Researchers use the tissue products at all levels of scientific study ranging from large pharma and biotech organizations to small labs and university research facilities. They also participate in wholesale distribution to other bio-banking organizations.

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• SciCrunch
• 16 years ago - by Anonymous

An Antibody supplier

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• 14 years ago - by Anonymous

A repository which houses DNA samples prepared from reference cell lines and are available for use in molecular genetic testing. The CF samples contain mutations associated with unique populations, combinations of IVS8 poly-thymidine tract variants, and mutations not previously available. Three DNA samples with homozygous MTHFR-related mutations are available. Hemochromatosis-associated samples include a compound HFE heterozygote and other combinations of HFE alleles. DNA samples with triplet repeats at the intermediate-range are available for HD and Fragile X syndrome. Mutations were confirmed in all cell lines from which the DNA has been prepared by reference testing and multi-laboratory pilot testing. Control DNA samples negative for all mutations are also available. Laboratories are encouraged to contact Coriell Cell Repositories to inquire about obtaining samples or donating samples as possible candidates for transformation.

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• SciCrunch
• 15 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 11, 2023.To guarantee the top level of expertise in modern genetic and biological analyses, we have built an infrastructure that facilitates the collection of genome-wide information on the genetic background of diseases as well as functional information on the molecules that are critical in the disease process. Furthermore we have established the necessary storage, database and computational resources for the expert analyses of the massive amount of collected biological information. Our scientific expertise, technology platforms and large nationwide sample collections facilitate a highly competitive environment for research and education in molecular medicine of the 21st century. The biobanking wet lab effort is concentrated to KTL/Biomedicum Large scale DNA extraction and storage facility. The facility presently houses DNA from more than 200 000 individuals and is co-ordinated by National Public Health Institute. It is equipped with state of the art bar coding system for sample tracking, an automated Gentra DNA extraction equipment, liquid handling robots, storage facilities, and tailor made data management tools for optimal confidentiality and quality control.

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• SciCrunch
• 16 years ago - by Anonymous

Brain Research Trust is a Registered Charity (no. 1137560) and a Company Limited by Guarantee (no. 7345516) promoting and supporting vital research. With the help of our donors, Brain Research Trust supports world-class research at University College London''''s Institute of Neurology (IoN), London. We were able to provide a record 2.3m pounds to research grants in the 09/10 financial year and has been supporting its vital research program for almost 40 years. Brain Research Trust comprises a dedicated fundraising team, a supportive Board of Trustees and a knowledgeable Scientific Advisory Panel who all work together closely to ensure your money goes towards the best neurological research projects. Some of the conditions into which we fund research include: Alzheimer''''s Disease, Ataxia, Brain Tumours, Creutzfeldt-Jakob Disease, Dystonia, Epilepsy, Huntington''''s Disease, Migraine, Motor Neurone Disease, Multiple Sclerosis, Parkinson''''s Disease, Progressive Supranuclear Palsy, Stroke. The Institute of Neurology also carries out research into Autism, Aphasia, Guillain-Barre Syndrome, M��ni��re''''s Disease, Multiple Systems Atrophy (MSA), Myasthenia Gravis, Niemann-Pick Disease, Shy-Drager Syndrome, Tay-Sachs Disease and Tourette Syndrome.

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• SciCrunch
• 15 years ago - by Anonymous

Located in the city of Galway in Ireland.

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• SciCrunch
• 16 years ago - submitted by Andrea Stagg

Software application using multipoint IBD method for partitioning genetic variance of quantitative traits to specific chromosome regions using data on nuclear families. (entry from Genetic Analysis Software)

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• SciCrunch
• 14 years ago - by Anonymous

The Southeast Tissue Alliance recovers tissues and provides them to leading tissue processing companies. One of the most important aspects of this process is ensuring that donor families understand tissue donation and are fully supported as they make the gifts that change the lives of others. To promote tissue donation, we also work throughout the community to increase awareness, educate health professionals and further donation-related research. The Southeast Tissue Alliance is accredited by the American Association of Tissue Banks, which ensures that our services are of the highest quality and are provided in the most professional manner.

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• SciCrunch
• 16 years ago - by Anonymous

National non-profit patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research. One of the greatest challenges faced by individuals diagnosed with primary immunodeficiency disease is finding the right information and resources when they need it. With knowledge and foresight from their personal experience, the Immune Deficiency Foundation (IDF) was founded by families of children with primary immunodeficiency diseases and their physicians to help meet those needs. It is with the spirit and energy of this keen perspective that IDF exists today, thriving as an organization dedicated to individuals living with primary immunodeficiencies. Since 1980, IDF has provided accurate and timely information for the nearly quarter-million Americans who have been diagnosed with a primary immunodeficiency disease. Governed by a Board of Trustees and supported by a Medical Advisory Committee comprised of some of the world''s leading clinical immunologists, as well as hundreds of grassroots volunteers and a compassionate, professional staff IDF has provided individuals and their families with vital knowledge and made tremendous strides in: * Helping the patient and medical community gain a broader understanding of primary immunodeficiency diseases through education and outreach efforts; * Promoting, participating, and funding research that has helped characterize primary immunodeficiency diseases and given patients and physicians substantially improved treatment options; * Addressing patient needs through public policy programs by focusing on issues such as insurance reimbursement, patient confidentiality, ensuring the safety and availability of immune globulin therapy, and maintaining and enhancing patient access to treatment options. Today, thousands of individuals and families affected by primary immunodeficiency diseases depend on IDF for advocacy, education and empowerment.

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• SciCrunch
• 15 years ago - by Anonymous

An Antibody supplier

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• SciCrunch
• 14 years ago - by Anonymous

Research consortium to advance scientific research in the primary immune deficiency diseases (PIDD) and: * Assemble and maintain a registry of patients with primary immunodeficiency diseases to provide a minimum estimate of the prevalence of each disorder in the United States. Provide a comprehensive clinical picture of each disorder and act as a resource for clinical and laboratory research. * Establish a multifaceted mentoring program to introduce new investigators into the field and stimulate interest and research in primary immune deficiency diseases. * Establish an advisory/review committee to maintain a cell/DNA Repository of biologic material from well-characterized PIDD patients for the advancement of scientific research USIDNET operates a large database of patient information for your use. The purpose and scope of this project is to assemble and maintain a registry of residents with primary immunodeficiency diseases. The project was started with the Registry of U.S. Residents with Chronic Granulomatous Disease. Since then, the registry has been expanded and now collects data on all primary immunodeficiency disorders. The following are just a few of the diseases housed in the registry: Chronic Granulomatous Disease, Common Variable Immunodeficiency Disease, DiGeorge Anomaly, Hyper IgM Syndrome, Leukocyte Adhesion Defect, Severe Combined Immunodeficiency Disease, Wiskott-Aldrich Syndrome, X-Linked Agammaglobulinemia Physicians who would like to register their patients or access the registry are encouraged to contact Onika Davis or Lamar Hamilton, USIDNET team, at odavis (at) primaryimmune.org, or lhamilton (at) primaryimmune.org

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• SciCrunch
• 15 years ago - by Anonymous

The Systems Biology Graphical Notation (SBGN) project aims to develop high quality, standard graphical languages for representing biological processes and interactions. Each SBGN language is based on the consensus of the broad international SBGN community of biologists, curators and software developers. Over the course of its development many individuals, organizations and companies made invaluable contributions to the SBGN through participating in discussions and meetings, providing feedback on the documentation and worked examples, adopting the standard and spreading the word. Circuit diagrams and Unified Modeling Language diagrams are just two examples of standard visual languages that help accelerate work by promoting regularity, removing ambiguity and enabling software tool support for communication of complex information. Ironically, despite having one of the highest ratios of graphical to textual information, biology still lacks standard graphical notations. The recent deluge of biological knowledge makes addressing this deficit a pressing concern. Toward this goal, we present the Systems Biology Graphical Notation (SBGN), a visual language developed by a community of biochemists, modelers and computer scientists. SBGN consists of three complementary languages: process diagram, entity relationship diagram and activity flow diagram. Together they enable scientists to represent networks of biochemical interactions in a standard, unambiguous way. We believe that SBGN will foster efficient and accurate representation, visualization, storage, exchange and reuse of information on all kinds of biological knowledge, from gene regulation, to metabolism, to cellular signaling. A list of software packages known to provide (or have started to develop) support for SBGN notations is available.

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• SciCrunch
• 16 years ago - by Anonymous

One of the medical schools in the U.S., consistently ranked among the top in the nation.

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• SciCrunch
• 15 years ago - submitted by Andrea Stagg

A tool for taxonomic classification of DNA fragments, as they are typically obtained in metagenome projects. The classification is based on taxon-specific DNA base composition characteristics (genomic signatures). Classification of query sequences is achieved by mapping the query sequences to the genomic signatures of sequences with known taxonomic affiliations. The mapping is done via the Self-Organizing Map (SOM) algorithm. TaxSOM offers two modes of operation: * mapping query sequences to a pre-calculated SOM * mapping query sequences to a custom SOM

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• SciCrunch
• 13 years ago - by Anonymous

The PXE International BioBank and Clinical Data Registry is the centralized sample repository and registry for pseudoxanthoma elasticum (PXE). It enables translational research and treatment discovery. PXE International, Inc. holds the world''''s largest collection of blood and tissue from people affected by PXE and their families. It is the only centralized repository for PXE samples in the world. The PXE International BioBank has tens of thousands of samples, including DNA, tissue from every organ in the body, full body donations postmortem, and many special samples such as eyes, urine, breast tumor tissue and so on. The PXE International Clinical Data Registry ties the biological samples to the clinical record and stores self reported data (surveys and questionnaires), medical records (from any specialist), images (CT scans, MRIs and so on) and anything else that can be scanned or typed in. We are using these samples for genetic research ������?? examining the many mutations, the effect of the mutations on the cell and the future of possible interventions. PXE International established the PXE International Blood and Tissue Bank to make certain that your privacy and confidentiality are protected and your samples are available to any approved research project. Researchers interested in either donating PXE DNA, tissue and cell lines or in applying to use material from the bank should call 202.362.9599 or email Sharon Terry.

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• SciCrunch
• 16 years ago - by Anonymous

The goal of this project is the creation of an extensive biomaterials bank. Materials (blood, serum, plasma, DNA) from all patients who participate in studies in the network will be collected for this purpose. The objective is a consistently high quality standard for the processing, storage and management of all samples. The biomaterials bank is an investment in the future by the network. It enables the competence network and the research community in general to acquire new scientific knowledge about the development, progression and prognosis of the different forms of heart failure. Each time a patient is documented in a study in the competence network, blood (EDTA whole blood and serum) is drawn from the patient, sent by post to the central biomaterials bank and processed there in the central incoming sample laboratory according to specified standards. In the first two subsidization periods, a total of 100,000 samples from approximately 10,000 patients was documented and processed (aliquoting, DNA extraction). These samples are stored in climate-controlled rooms used especially for this purpose at the biomaterial bank of the Experimental and Clinical Research Center (ECRC) in Berlin-Buch at temperatures between -20 and -80 degrees C. As the central infrastructure project for all samples, the biomaterials bank is deeply involved in the networking. There are also intensive collaborations with other competence networks (e.g. the Competence Network for Congenital Heart Defects) and biobanks. The biomaterial bank of the Heart Failure Competence Network also participates in domestic and European pilot projects for networking biomaterial banks (BBMRI, ESFRI, etc.). The goal of these projects is to develop uniform methods for sample processing and use.

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• SciCrunch
• 16 years ago - by Anonymous

BioBank is a new Beaumont research center that is focused on developing innovative methods for early detection of disease and personalized treatment plans through leading edge analysis techniques and state of the art technologies. Biomarkers from tissue, blood or fluids, are used to develop the next generation of care management, taking it from bench to bedside. Beaumont BioBank will work to: * collect high-quality biological specimens from any specialty at Beaumont * store, analyze and record specimens in an efficient, organized and accessible manner using leading-edge technologies * connect specialties and specialists with each other across traditional hospital or laboratory departments to provide a multidisciplinary research structure * facilitate translational research that links molecular laboratory techniques that enable us to apply biomarker discoveries to clinical outcome studies in a speedy and direct manner

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• SciCrunch
• 16 years ago - by Anonymous