Curator Dashboard

Core provides services including preparation of research tissue specimens for microscopic investigation with imaging capabilities for brighfield and fluorescent microscopy. Offers preparation tissue specimens for Histological sectioning utilizing both frozen and paraffin embedding techniques, preparation of mounted sections on glass slides. Facility maintains microtomes and cryostats for the preparation of tissue sections and houses several high end fluorescent microscopy systems, including the Leica Stellaris 8 tau-STED Super Resolution Microscope, the Nikon A1R+ HD Confocal Microscope,and the Nikon Ti2 HCA Inverted Fluorescence Microscope. Core also provides access to the Spatial Biology Platforms: Akoya PhenoCycler Fusion 2.0, 10x Genomics Visium and 10x Genomics Xenium.

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• 1 month ago - submitted by Luke Fritzky

Software application designed to simplify process of generating and processing data on MIBIScope platform. Scripts for interacting with and generating data from the commercial MIBIScope.

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• 1 month ago - by Anonymous

Software R library facilitates the analysis of the difference between the proprotion of cells in clusters between two scRNA-seq samples. Used to calculate the proportional difference in cell number proportions between clusters in scRNA-seq.

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• 1 month ago - by Anonymous

Software framework constructed in three levels for predicting the peptide and TCR binding recognition. Used to recognize TCR–antigen binding, by combining the concepts of meta-learning and the neural Turing machine.

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• 1 month ago - by Anonymous

Specialized biorepository that collects, creates, and distributes patient specific, de-identified human induced pluripotent stem cell (iPSC) lines to researchers worldwide. SCVI Biobank iPSC lines cover a broad spectrum of cardiac diseases, healthy controls, and non-cardiac disease controls. Used to study cardiovascular diseases, model disease processes, and accelerate the development of personalized medicine.

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• 1 month ago - submitted by Edyta Vieth

Core is a fee-for-use COBRE core that houses multi-photon microscopes and light microscopes that allow high-resolution visualization of cell and tissue structure (mitochondrial networks, collagen structure), metabolic function (optical redox and NADH fluorescence lifetime measurements), and biomolecular composition (autofluorescent metabolic cofactors, lipid deposition).

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• 1 month ago - by Anonymous

Software MHC I ligand prediction package with competitive accuracy and documented implementation. Used for peptide-MHC I binding affinity prediction.

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• 1 month ago - by Anonymous

Facility promotes and facilitates faculty and student research in biomedical bench science. Provides supports for clinical research, expertise and resources to clinical and translational scientists and trainees. Offers services of clinical research coordinators and BSL2 facilities for the processing, storage or molecular experimentation of human biological samples. In addition, equipment and technical assistance for performing ELISAs, cell proliferation assays, autoantibody assays, nitric oxide (NO) measurements, reactive oxygen species (ROS) determination, proteomics, mitochondrial function, flow cytometry, Western immunoblotting, and cell cytokine secretion profiling are available.

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• 1 month ago - by Anonymous

Multi-center facility at Columbia University Irving Medical Center, created to help users take advantage of up-to-date resources in the stem cell field in a timely and cost-efficient way. Offered services include giving access to quality-controlled pluripotent stem cells and stem cell-derivatives prepared using standardized approaches; genome editing services for the generation of custom-designed cell lines; training sessions and informal interactions between scientists from multiple laboratories working on different stem cell models. Some reagents commonly used in stem cell labs, as mTeSR1 media and irradiated mouse embryonic fibroblasts, are also available at discounted prices for our users. We are connected to Stem Cell COREdinates(link is external and opens in a new window), a consortium of pluripotent stem cell-focused core facilities, which allows us to take advantage of the sharing of the most updated and efficient protocols, expertise, and reagents.

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• 1 month ago - by Anonymous

Software R package for enhanced visualization of gene set enrichment analysis in biomedicine. Used to visualize Gene Set Enrichment Analysis (GSEA) results.

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• 1 month ago - by Anonymous

Core provides comprehensive preclinical imaging and radiochemistry services. Expertise covers the entire pipeline from study design to data analysis. Services include preclinical research (mice, rats, CAM assay, zebrafish, slugs) using radionuclide imaging via SPECT/CT and PET/CT, as well as 3T MRI, µCT, radiochemistry, tracer biokinetics, and kinetic modeling.

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• 1 month ago - submitted by Edyta Vieth

Real-time live-cell imaging system designed for long-term time-lapse dynamic observation of living cells, including intracellular calcium flux recording, tumor spheroid, organoid 3D growth tracking, cell migration, apoptosis and pharmacodynamic screening. Equipped with multi-channel fluorescence excitation modules, the system supports continuous non-invasive real-time monitoring under physiological culture environment, used in stem cell research, oncology, cardiovascular pharmacology and cell biology experiments.

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• 1 month ago - submitted by Sui Weikai

Core offers solar cell fabrication, characterization and testing capabilities. Additional services include making modules and performing reliability testing. Core is designed with industrial compatibility in mind. Although fabrication on smaller substrates or even pieces is possible, the native substrate form factor is currently 156 mm silicon. New equipment is being selected to maintain compatibility with evolving solar manufacturing sizes (e.g., M12 = 295 mm diagonal). Supported technology thrusts reinforce industry relevance. Considering solely silicon technology, architectures researched include Al BSF, PERC, SHJ and various tandems, predominantly silicon-based with a perovskite top cell.

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• 1 month ago - submitted by CoreFacilities Admin

test test

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• 1 month ago - submitted by Edyta Vieth

Software R annotation package for Illumina's EPIC v2.0 methylation arrays. The version 2 covers more than 935K CpG sites in the human genome hg38. It is an update of the original EPIC v1.0 array (i.e., the 850K methylation array).

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• 1 month ago - by Anonymous

Software R package provides functions for estimating mitotic age of tissues from corresponding DNA methylation (DNAm) profile. These functions are epigenetic mitotic clocks, providing separate mitotic age estimates on scales unique to each clock. So each estimate should be interpreted as a relative mitotic age, not an absolute one, except for the epiTOC2 clock which does aim to estimate the total number of stem-cell divisions in a tissue.

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• 1 month ago - by Anonymous

iGenSeq platform offers academic researchers and industry tools and services for genomic analysis: medium, high and very high throughput DNA and RNA sequencing, qPCR and ddPCR.

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• 1 month ago - submitted by Edyta Vieth

Thermionic field emission high-resolution scanning electron microscope designed to make high-performance imaging and analytics. Minimizes user intervention and lab management demands with its SmartAlign Technology, an auto-aligning optics system. Additionally, Thermo Scientific FLASH Technology automates image fine-tuning, correcting lens centering, stigmators, and final focus. Capabilities include 1-nanometer resolution at 10 mm analytical working distance, overcoming the typical trade-off between working distance and image quality.

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• 1 month ago - by Anonymous

Atomic Force Microscope (AFM) designed for bioscience and materials research. It is used to capture high-resolution topographical images and perform precise force measurements on both soft biological samples (like live cells and proteins) and advanced materials at the nanoscale.

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• 1 month ago - by Anonymous

Core provides light and electron microscopy services.

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• 1 month ago - by Anonymous