Curator Dashboard

A computational pipeline bringing together numerous software packages to perform a full analysis of MeDIP-seq data, including sequence alignment, quality control (QC), and determination and annotation of DMRs.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 19, 2016. Software tool that facilitates the analysis of the 3D structure of spine insertions in dendrites, providing insight on spine distribution patterns. Dispine depends on python 2.6, PyQt4, numpy, python wrappers of VTK and pygame. If you want to test the tool, a test set is provided.

• Resource
• SciCrunch
• 14 years ago - by Anonymous

A structured controlled vocabulary of Caenorhabditis elegans phenotypes.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Service that disambiguates acronyms from Medline in text through your browsers; or use the RESTful Service for integrating it with your applications. Reference: Okazaki, N., Ananiadou, S. and Tsujii, J. (2010). Building a High Quality Sense Inventory for Improved Abbreviation Disambiguation.Bioinformatics, Oxford University Press.

• Resource
• SciCrunch
• 16 years ago - by Anonymous

Software package with an R interface sending requests to AmiGO visualize, retrieving DAG GO trees, parsing GraphViz DOT format files and exporting GML files for Cytoscape. Also uses RCytoscape to interactively display AmiGO trees in Cytoscape.

• Resource
• SciCrunch
• 15 years ago - by Anonymous

A digital image database of serially sectioned human embryos from the Carnegie Collection originally developed as a collaboration between embryologist Dr. Raymond Gasser at Louisiana State University Health Science Center (LSUHSC) and the Human Developmental Anatomy Center (HDAC) in Washington D.C. The aim of the project is to increase understanding of human embryology and to encourage study of human embryonic development by providing students and researchers with reliable resources for human embryo morphology. The VHE project has several components: * DREM: The Digitally Reproduced Embryonic Morphology (DREM) project, with funding from NICHD, project has produced 27 image databases of labeled serial sections from representative human embryos at each of the 23 Carnegie stages. These databases, together with animations and reconstructions of the embryos are available on DVD and CD. * HEIRLOOM: The HEIRLOOM Collection (Human Embryo Imaging and Reconstruction, Library Of Online Media) was funded by the National Library of Medicine to provide greater access to the DREM databases. NLM provided funding to set up this website and to produce additional 3D-reconstructions and animations that are included on the DREM disks. Original website, http://virtualhumanembryo.lsuhsc.edu/HEIRLOOM/heirloom.htm * EHD: Starting in 2011, The Endowment for Human Development (EHD) will also host the VHE databases. They have made the project accessible to everyone and include a comprehensive cataloging of all the terms used to label the embryos. Their website enables users to browse through the complete VHE atlas of human embryology, http://www.ehd.org/virtual-human-embryo/

• Resource
• SciCrunch
• 14 years ago - by Anonymous

It is the most comprehensive child care study conducted to date to determine how variations in child care are related to children''s development. The NICHD SECCYD is a longitudinal study initiated by The National Institute of Child Health and Human Development (NICHD) in 1989 to answer the many questions about the relationship between child care experiences and characteristics and children''s developmental outcomes. After a thorough scientific review, the NICHD selected a research team located at universities across the U.S., and at the NICHD, together providing multiple perspectives on and interests in child care research. The network was led and managed by a Steering Committee which included an independent chairperson, one representative from each of the grantee sites, one representative from the data center and one representative from NICHD. The Steering Committee established policies and procedures that governed the operations of the network, including its publication procedures. The progress of the study was monitored by NICHD and by the Steering Committee with guidance from an Advisory Board which was nominated by the Director of NICHD. This team of researchers worked cooperatively to design and implement the study, and in 1991, enrolled a very diverse sample of children and their families at 10 locations across the U.S. The NICHD SECCYD is characterized by a complex and detailed study design which takes into account many variables, including characteristics of the child care and the family environment. Researchers assessed children''s development using multiple methods (trained observers, interviewers, questionnaires, and testing) and measuring many facets of children''s development (social, emotional, intellectual, language development, behavioral problems and adjustment, and physical health). The 1,364 children and their families enrolled in the study were followed from birth to age 3 years during Phase I of the study from 1991-1994. Phase II of the study was conducted between 1995-2000 to follow the 1226 children and families continuing to participate from age 54 months through their second year in school. Phase III of the study was conducted between 2000 - 2005 to follow over 1100 of the children through their seventh year in school. Phase IV was conducted between 2006 2007 to follow over 1000 of the original families through age 15. The NICHD SECCYD was conducted by a network of investigators, the NICHD Early Child Care Research Network. You may view information regarding data assessments, study publications, as well as a listing of the study researchers and committee members on the study website located at http://secc.rti.org. Qualified researchers are able to become affiliates with the study to utilize data from all phases of the study. As of January 2009, the Inter-University Consortium for Political and Social Research (ICPSR) at the University of Michigan assumed responsibility for the administration of data use agreements for the Phase I IV data. The ICPSR Data Use Agreement can be found at the following location: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/21940/documentation. If you have questions regarding the ICPSR process, please contact Russel Hathaway at rhataway (at) umich.edu.

• Resource
• SciCrunch
• 14 years ago - by Anonymous

A package that implements several semantic similarity measures. It is both a library and an end-user application, featuring an intuitive graphical user interface (GUI). It has been implemented with the aim of being fast, expandable, and easy to use. It allows the user to work with the most updated version of GO database and customizable annotation corpora. It provides a set of logically-organized classes that can be easily exploited to both integrate semantic similarity into different analysis pipelines and extend the library with new measures. Platform: Windows compatible, Mac OS X compatible, Linux compatible, Unix compatible

• Resource
• SciCrunch
• 15 years ago - by Anonymous

A brain autopsy program developed to serve the needs of Illinois families and individuals affected by dementing diseases and to advance dementia research by providing tissue to researchers studying dementing diseases. The SIU School of Medicine (SIU-SM) Dementia Brain Autopsy Program facilitates the postmortem process for families wishing to obtain an autopsy for a loved one. A brain autopsy provides family members with accurate information regarding the exact nature of their relative's dementia. This includes information about the possibility of an inherited disorder which may affect other family members. The brain autopsy also helps clinicians improve their clinical skills by identifying the precise cause of the clinical dementia.

• Resource
• SciCrunch
• 15 years ago - by Anonymous

BioCarta Pathways allows users to observe how genes interact in dynamic graphical models. Online maps available within this resource depict molecular relationships from areas of active research. In an open source approach, this community-fed forum constantly integrates emerging proteomic information from the scientific community. It also catalogs and summarizes important resources providing information for over 120,000 genes from multiple species. Find both classical pathways as well as current suggestions for new pathways.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

A clustering tool designed mainly for Metagenomics studies, which clusters 16S rRNA sequences into Operational Taxonomic Units (OTU). By using a Gaussian Mixture model, CROP can automatically determine the best clustering result for 16S rRNA sequences at different phylogenetic levels without setting a hard cutoff threshold as hierarchical clustering does. Yet, at the same time, it is able to manage large datasets and to overcome sequencing errors.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Interactive data set on lead exposure (Blood Lead Concentrations greater than or equal to 25 micrograms per deciliter) of adults in the United States. The data comes from laboratory-reported elevated blood lead levels. Recent research has led to increased concerns about the toxicity of lead at low doses. Reflecting this increased concern, the ABLES program updated its case definition for an elevated BLL to a blood lead concentration greater than or equal to 10 micrograms per deciliter in 2009. This new case definition has also been: (1) recommended by the Council of State and Territorial Epidemiologists in 2009; (2) included in CDC''s list of nationally notifiable conditions in 2010; and (3) adopted as the Healthy People 2020 Occupational Safety and Health Objective 7. Given this new case definition, NIOSH will update the ABLES Charts and Interactive Database to include lead exposures to blood lead level greater than or equal to 10 micrograms per deciliter in the near future.

• Resource
• SciCrunch
• 14 years ago - by Anonymous

A multilingual database that provides large time-series and cross sectional data relating to hunger, food, agriculture, nutrition, fisheries, forestry and food aid by country and region from 1961 to present. Data can be searched, browsed, analyzed and downloaded.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

Data set of postural sway measurements for 15 healthy young (mean age 23, standard deviation 2), and 12 healthy elderly (mean age 73, standard deviation 3) volunteers. Each subject''s postural sway was recorded during a test of 10 minutes for the young subjects, or 5 minutes for the elderly subjects, in all cases with a 2-minute seated break midway through the test. Each test was divided into 30-second trials, and each file of the database contains data for one of these 30-second trials.

• Resource
• SciCrunch
• 16 years ago - by Anonymous

LOLA is a web driven database of published and manually curated (public), and user-specific (private) gene lists derived from genome-wide approaches such as expression profiling and proteomics. LOLA allows researchers to measure the similarity of gene lists in order to identify genes that are robustly changed across laboratories, studies, and platforms, and within and between species. Furthermore, LOLA compares lists at a gene-level so that probes mapping to the same gene are not considered different.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

The Department of Pharmacology, a dynamic scholarly environment dedicated to teaching, training, and fundamental discovery, is engaged in numerous collaborations that enhance our research efforts and broaden our training opportunities. To meet the research objectives of our students and faculty, the Department has acquired advanced technologies that enable investigators to take integrative and molecular approaches to their work.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

The collection of chapters in this eBook is written to provide guidance to investigators who are interested in developing assays useful for the evaluation of collections of molecules to identify probes that modulate the activity of biological targets, pathways, and cellular phenotypes. These probes may be candidates for further optimization and investigation in drug discovery and development. Originally written as a guide for therapeutic project teams within a major pharmaceutical company, this manual has been adapted to provide guidelines for scientists in academic, non-profit, government and industrial research laboratories to develop potential assay formats compatible with High Throughput Screening (HTS) and Structure Activity Relationship (SAR) measurements of new and known molecular entities. Topics addressed in this manual include: * Development of optimal assay reagents. * Optimization of assay protocols with respect to sensitivity, dynamic range, signal intensity and stability. * Adopting screening assays from bench scale assays to automation and scale up in microtiter plate formats. * Statistical concepts and tools for validation of assay performance parameters. * Secondary follow up assay development for chemical probe validation and SAR refinement. * Data standards to be followed in reporting screening and SAR assay results. * Glossaries and definitions. This manual will be continuously updated with contributions from experienced scientists from multiple disciplines working in drug discovery & development worldwide. An open submission and review process will be implemented in the near future on this eBook website, hosted by the National Library of Medicine with content management by the National Center for Advancing Translational Sciences (NCATS, http://ncats.nih.gov/), the newest component of the National Institutes of Health (NIH).

• Resource
• SciCrunch
• 15 years ago - by Anonymous

The NCGC Pharmaceutical Collection (NPC) is a comprehensive, publically-accessible collection of approved and investigational drugs for high-throughput screening that provides a valuable resource for both validating new models of disease and better understanding the molecular basis of disease pathology and intervention. The NPC has already generated several useful probes for studying a diverse cross section of biology, including novel targets and pathways. NCGC provides access to its set of approved drugs and bioactives through the Therapeutics for Rare and Neglected Diseases (TRND) program and as part of the compound collection for the Tox21 initiative, a collaborative effort for toxicity screening among several government agencies including the US Environmental Protection Agency (EPA), the National Toxicology Program (NTP), the US Food and Drugs Administration (FDA), and the NCGC. Of the nearly 2750 small molecular entities (MEs) that have been approved for clinical use by US (FDA), EU (EMA), Japanese (NHI), and Canadian (HC) authorities and that are amenable to HTS screening, we currently possess 2,400 as part of our screening collection. The NPC resource currently consists of (i) the physical collection suitable for high throughput screening (HTS) and (ii) the informatics browser and database. Putting together the physical collection has been surprisingly challenging in terms of the time and effort required in the informatics, compound management and synthetic chemistry related activities required for this endeavor. We provide access to the NPC screening library through collaboration. Please contact our Scientific Director Dr. Chris Austin for additional information. The other half of the NPC resource is the NPC browser. This is a self-contained software that is actively developed and maintained by the informatics group to provide electronic access to the NPC content. The latest version of the NPC browser for various platforms can be downloaded.

• Resource
• SciCrunch
• 15 years ago - by Anonymous

A software toolbox based on pattern recognition techniques for the analysis of neuroimaging data. Statistical pattern recognition is a field within the area of machine learning which is concerned with automatic discovery of regularities in data through the use of computer algorithms, and with the use of these regularities to take actions such as classifying the data into different categories. In PRoNTo, brain scans are treated as spatial patterns and statistical learning models are used to identify statistical properties of the data that can be used to discriminate between experimental conditions or groups of subjects (classification models) or to predict a continuous measure (regression models).

• Resource
• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 29,2025. Relational database of all significant published qualitative and quantitative information on cell signaling proteins. The Molecule Pages database was developed with the specific aim of allowing interactions, and indeed whole pathways, to be modeled. The goal is to filter the data to present only validated information. In addition, the Gateway is the home of Signaling Update, which provides a one-stop overview of the latest and hottest research in cell signaling for both the specialist and non-specialist alike.

• Resource
• SciCrunch
• 17 years ago - by Anonymous