Curator Dashboard

An ontology for describing clinical signs and symptoms.

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• SciCrunch
• 13 years ago - by Anonymous

Department offers graduate and postgraduate programs that provide students with intensive education and training in neuroscience, along with opportunity to excel in laboratory. Our program brings together researchers from diverse backgrounds to study brain and its function in health and disease. Educational experiences are provided by faculty members actively involved in research into function of central nervous system through experimentation in molecular neurobiology, neuroanatomy, neurodevelopment, neural systems analysis, biophysics, imaging, and computer-assisted neural system modeling.Ongoing studies in our department range from molecular biophysics of ion channels and receptors, to analysis of neuronal development, signal processing, brain circuitry, and animal behavior all the way to human brain function.

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• SciCrunch
• 17 years ago - by Anonymous

Goal of Department is creation and dissemination of knowledge in psychological sciences, fostering environment conducive to creative scholarship and learning among both students and faculty, and application of knowledge to betterment and service of society. Offers Bachelor of Science and Bachelor of Arts degree in Psychology as well as few undergraduate degree programs in Neuroscience.

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• SciCrunch
• 17 years ago - by Anonymous

Mission of Department of Neuroscience is to do teaching and research on basic functions and diseases of nervous system. Areas of interest include neural plasticity, information processing, and neuronal and synaptic functions, particularly as they relate to development, sensory perception, motor behavior, and cognition. Members of Department also participate in MRI Research Facility, Center for Vision Research, and several NIH and NIMH training grants for graduate and postdoctoral fellows studying neuroscience and vision sciences.Department is also major contributor to Brown''s Institute for Brain Science, multidisciplinary consortium that promotes collaborative theoretical and experimental studies of brain.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on August 20, 2021. Department of Molecular Pharmacology, Physiology, and Biotechnology has closed, effective June 30, 2021. Department of Molecular Pharmacology, Physiology and Biotechnology is basic science department within Brown Medical School, and is full participant in undergraduate based Program in Biology within Division of Biology and Medicine at Brown University.

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• SciCrunch
• 17 years ago - by Anonymous

For more than 75 years, the division of biology has provided many of the major research advances that have made biology the premier science of the 21st century, and has trained many of the world''s most eminent biologists. The division at present has 38 professors of various ranks, who in their classes and laboratories have approximately 100 undergraduates, 100 graduate students, and 160 postdoctoral scholars, as well as more than 250 staff members. We occupy parts or all of seven buildings on the Caltech campus; we also operate a marine laboratory 50 miles from campus. Each building is devoted to state-of-the-art educational facilities and cutting-edge laboratories. We have three major research emphases: Structural, Molecular and Cell Biology; Developmental and Regulatory Biology; and Molecular, Cellular and Integrative Neuroscience. In each area we are trying to solve one of the great problems of modern biology: How do the proteins and other components of cells interact to provide a marvelous nanomachine of more than 100,000 integrated parts, a machine that has numerous extraordinary functions and can reproduce itself? How does a single cell become, by division and formation of new cell types, an entire multicellular organism, which in the case of humans has thousands of different cell types and more than 1 trillion different cells in specific places, communicating to form complex organs? How does the brain, the most complex organ of all, work to allow calculations beyond those of any computer, as well as to demonstrate amazing sensory capabilities, emotions, and consciousness?

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• SciCrunch
• 17 years ago - by Anonymous

Department of Pharmacology research mission is to discover specific mechanisms that control physiological processes at cellular and molecular levels. Department offers broad range of educational opportunities ranging from undergraduate research to classes leading toward Ph.D. and M.D.Training Programs include MOLECULAR THERAPEUTICS TRAINING PROGRAM, BIOMEDICAL SCIENCES TRAINING PROGRAM, MEDICAL SCIENTIST TRAINING PROGRAM, SUMMER UNDERGRADUATE RESEARCH PROGRAM, Cancer Pharmacology Training Program.

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• SciCrunch
• 17 years ago - by Anonymous

A statistical framework for genomic data fusion is a computational framework for integrating and drawing inferences from a collection of genome-wide measurements. Each dataset is represented via a kernel function, which defines generalized similarity relationships between pairs of entities, such as genes or proteins. The kernel representation is both flexible and efficient, and can be applied to many different types of data. Furthermore, kernel functions derived from different types of data can be combined in a straightforward fashion. Recent advances in the theory of kernel methods have provided efficient algorithms to perform such combinations in a way that minimizes a statistical loss function. These methods exploit semidefinite programming techniques to reduce the problem of finding optimizing kernel combinations to a convex optimization problem. Computational experiments performed using yeast genome-wide datasets, including amino acid sequences, hydropathy profiles, gene expression data and known protein-protein interactions, demonstrate the utility of this approach. A statistical learning algorithm trained from all of these data to recognize particular classes of proteins--membrane proteins and ribosomal proteins--performs significantly better than the same algorithm trained on any single type of data. Matlab code to center a kernel matrix and Matlab code for normalization are available.

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• SciCrunch
• 16 years ago - by Anonymous

Neuroscience research at BU is coordinated through unified community of investigators from multiple research groups of Charles River and MED campuses.Neuroscience faculty support Undergraduate Program in Neuroscience and Graduate Program for Neuroscience. Students can get specialized training in additional disciplines while carrying out neuroscience thesis research (Anatomy & Neurobiology, Biology, and Pharmacology and Experimental Therapeutics).

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 22, 2016. The Next Generation Biology Workbench is a free resource for research and education in Bioinformatics, Genomics, Proteomics, and Phylogenetics. The NGBW is a re-engineering of the Biology Workbench which was designed by Shankar Subramaniam and his group to provide an integrated environment where tools, user data, and public data resources can be easily accessed. The NGBW is designed to be an organic tool that evolves with the needs of the Biomedical research and education communities. The Next Generation Biology Workbench (NGBW) is now available for public use, in its production release.

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• SciCrunch
• 16 years ago - by Anonymous

A web application called Expressed Sequence Tag Information Management and Annotation (ESTIMA) has been created to meet the EST annotation and data management requirements of multiple high-throughput EST sequencing projects. It is anchored on individual ESTs and organized around different properties of ESTs including chromatograms, base-calling quality scores, structure of assembled transcripts, and multiple sources of comparison to infer functional annotation, Gene Ontology associations, and cDNA library information. ESTIMA consists of a relational database schema and a set of interactive query interfaces. These are integrated with a suite of web-based tools that allow a user to query and retrieve information. Further, query results are interconnected among the various EST properties. ESTIMA has several unique features. Users may run their own EST processing pipeline, search against arbitrary reference genomes, and use any clustering and assembly algorithm. The ESTIMA database schema is very flexible and accepts output from any EST processing and assembly pipeline. ESTIMA has been used for management of EST projects of many species, including honeybee (Apis mellifera), cattle (Bos taurus), songbird (Taeniopygia guttata), corn rootworm (Diabrotica vergifera), catfish (Ictalurus punctatus, Ictalurus furcatus), and apple (Malus x domestica). The entire resource may be downloaded and used as is, or readily adapted to fit the unique needs of other cDNA sequencing projects. The scripts used to create the ESTIMA interface are freely available to academic users in an archived format from http://titan.biotec.uiuc.edu/ESTIMA/download/. The entity-relationship (E-R) diagrams and the programs used to generate the Oracle database tables are also available. Presently the chromatograms, EST databases and their annotations have been made available for cattle and honeybee.

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• SciCrunch
• 16 years ago - by Anonymous

BACPAC Resources (a BAC Clones Distribution Center) is the distribution arm of their academic laboratory. They operate on a cost-recovery mechanism in order to make the resources generated in their laboratory available to the academic scientific community. While clones and screening services are widely available, library arrays are primarily available to researchers with a scientific need to analyze most clones in the library. This site contains information on currently available BAC and PAC genomic DNA libraries, BAC Clones, PAC Clones, Fosmid Clones, cDNA collections, high-density colony hybridization filters, and BAC and PAC cloning vectors. Protocols used in our laboratory for the hybridization-based screening of colony filters, purification of BAC and PAC DNA, and end-sequencing methodologies, are also provided. BPRC does not list clones, for two reasons: 1)most clones have not been characterized and lack specific data. 2)all clones are part of libraries and all clones from a particular library share common characteristics. Hence, to find out if BPRC has a particular clone, one needs either use Automatic Clone Validation or else find out if the clone is compatible with the range of clone names for a corresponding clone library. Typically (although not always), clone names are derived from the library name. BPRC uses the NCBI-recommended clone nomenclature & library nomenclature. Most arrayed libraries are available in frozen microtiter dish format to academic and non-academic users provided that there is a scientific need for complete-library access. (for instance to annotate, modify or analyze all BAC clones as part of a genome project). Keywords: BAC, Distribution, SUplier, Laboratory, Scientifc, Clone, Screen, Library, Array, Researcher, Research, PAC, Genomic, DNA, Fosmid, cDNA, Hybridization, Filter, Vector, Cloning, Purification, Microtiter,

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• SciCrunch
• 17 years ago - by Anonymous

Frontiers community is a web portal for both open access Frontiers journals and a community portal for jobs, books, and scholarly events. Frontiers is more than just an open-access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity of seeking, sharing and generating knowledge. As a first active measure in this direction, Frontiers provides immediate and permanent online open access to all of its publications, but this alone is not enough to realize our grand goals. The Frontiers solution develops around two main concepts, mutually integrating each other within the innovative Frontiers'' platform: * the Frontiers Journal Series, and * the Frontiers Community. As an open-access Journal Series, Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. As an interdisciplinary Community system, Frontiers is reshaping research management with a state-of-the-art platform, designed as a collaborative architecture and aimed at all research communities, whether academicians or research enthusiasts, investors or grantmakers. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new 21st century generation.

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• SciCrunch
• 17 years ago - by Anonymous

WAViS generates pictures of your alignment files. These tools should help you with preparation of publication-quality pictures of your alignment. Sponsors: This resource is supported by Institute of Molecular Genetics. Keywords: Software, Server, Picture, Alignment,

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• SciCrunch
• 17 years ago - by Anonymous

A website dedicated to advancing non-animal methods of toxicity testing, both to better protect the health of humans, animals, and the environment and to reduce the numbers and suffering of animals used in current toxicology assessments. The website is designed to encourage the exchange of technical and policy information on in vitro and in silico methods for all types of toxicity tests. The AltTox Forum is a message board for the AltTox community to use for posting news, information, and perspectives as well as encouraging feedback and commentary. This online community is intended to foster progress internationally in the development, validation, and acceptance of in vitro methods, with the goal of decreasing our reliance on animal-based safety testing. The Forum is moderated by a group of internationally-recognized subject matter experts. The Way Forward invited commentaries, which are posted in the TTRC, are opinion pieces written by experts in each relevant subfield. These essays are meant to help chart the course for future developments by advancing opportunities to overcome challenges and barriers to progress. Stakeholders are invited to comment on these essays in The AltTox Forum. AltTox users are encouraged to contribute to the website and interact with other users in several ways, including: :- Participating in the online forum :- Providing invited expert commentaries :- Suggesting or submitting content, events, monthly features, data, and graphics :- Providing feedback through the Website Feedback surve To encourage objectivity, the website content is overseen by an editorial board of distinguished subject matter experts.

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• SciCrunch
• 17 years ago - by Anonymous

Doris Kupfer, Sara Downard, and Laura Hern in our Genome Center at the University of Oklahoma, have sequenced the 3'' and/or 5'' ends of double stranded cDNAs constructed from the salivary glands of the lone star tick, Amblyomma americanum constructed by Richard Essenberg and Majd Aljamali, Department of Biochemistry and Molecular Biology at Oklahoma State University, Stillwater OK. Four libraries are included in this August 27, 2003 release. Lib1:TSG Lib1, female, salivary gland, 50-200 mg feeding adults Lib2:TSG Lib2, female, salivary gland, unfed adults, feeding adults, replete adults Lib3:TSG Lib3, female, salivary gland, 3 day feeding adults Lib4:TSG Lib4, female, salivary gland, 50-200 mg feeding adults, was constructed from TSG Lib1 by normalization following procedure of, Bonaldo et al (Genome Res. 1996 Sep;6(9):791-806). Amblyomma americanum lone star tick Latest Data Release - August 27, 2003 1757 total ESTs that were assembled into 810 entries and 608,477 nucleotides in the four separately libraries and combined into one searchable database. - The Amblyomma americanum lone star tick salivary gland cDNA libraries Lib1, Lib2 and Lib4 were constructed from multiple feeding stages in Clonetech pTriplEx2 vector by directionally cloning into the 5'' EcoRI and 3'' SfiIb sites. Lib3 was constructed from 3 day feeding adults by Stratagene, Inc. into pBlueScript SK- . - Ribosomal RNA, mitochondrial RNA, vector and small (less than 100bp) inserts, will be removed prior to assembly of a UniGene database using Phred (Phil Green, University of Washington) . All of our data is available from our ftp site, and we now have added the ability to perform blast searches on this data. A keyword search of a blastx search of GenBank with this data also is available. Sponsors: This resource is supported by University of Oklahoma. Keywords: CDNA, Dataset, Library, RNA, Mitochondrial, Ribosomal,

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• SciCrunch
• 17 years ago - by Anonymous

The American Heart Association (AHA) publishes medical scientific statements on various cardiovascular disease and stroke topics. AHA volunteer scientists and healthcare professionals write the papers. The statements are supported by scientific studies published in recognized journals and have a rigorous review and approval process. Scientific statements generally include a review of data available on a specific subject, an evaluation on its relationship to overall cardiovascular disease science, and often an American Heart Association position on the basis of that evaluation. The American Heart Association sponsors accredited scientific conferences and professional development seminars to disseminate new and emerging scientific knowledge and stimulate discussion on future research and the application of knowledge. Keywords: Heart, Cardiovascular, Disease, Stroke, Volunteer, Scientist, Healthcare, Development, Knowledge,

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• SciCrunch
• 17 years ago - by Anonymous

The National Institute of Neurological Disorders and Stroke (NINDS) conducts and supports research on brain and nervous system disorders. Created by the U.S. Congress in 1950, NINDS is one of the more than two dozen research institutes and centers that comprise the National Institutes of Health (NIH). NINDS has occupied a central position in the world of neuroscience for more than 50 years. It provides access to different research programs both extramural and intramural. Research Topics: Epilepsy, Parkinson''s Disease, Traumatic Brain Injury, Anticonvulsant Screening, CounterACT, Bioengineering, Neural Interfaces, Stem Cell Research. Offices and Programs: *Channels, Synapses and Neural Circuits *Neural Environment *Neurodegeneration *Neurogenetics *Office of Clinical Research *Office of International Activities *Office of Minority Health and Research *Office of Translational Research *Office of Training and Career Development *Repair and Plasticity *Systems and Cognitive Neuroscience

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• SciCrunch
• 17 years ago - by Anonymous

As fascinating as diversity is, it''s not the sort of thing that computational scientists usually get excited about. Uncovering how diversity came to be has captured the attention of a team of researchers at Alliance partner University of New Mexico and the University of Texas, though. Using the 512-processor LosLobos Linux Pentium III supercomputing cluster at the Albuquerque High Performance Computing Center, the team has created a phylogeny reconstruction - or evolutionary history - of 12 bluebell species, predicting all of the steps that take these species back to a single common ancestor. To meet the challenge, they created a whole new piece of software known as GRAPPA. GRAPPA is is free software available as a gzipped tar file containing all source files needed to compile an executable version.

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• SciCrunch
• 16 years ago - by Anonymous

The Power Atlas is a web-based resource to assist investigators in the planning and design of microarray and expression based experiments. This software is currently aimed at estimating the power and sample size for a two group comparison based upon pilot data. The methods underlying the web site are reported in Gadbury et al (2004) and the software is described in further detail at Page et al (2006). There are two ways to use the Power Atlas: 1. We have downloaded the datasets currently in the Gene Expression Omnibus (GEO) and processed each of them with our power analysis software. Investigators may search among the datasets for the experiment that most closely resembles their proposed project and get sample size and power estimates. 2. Investigators may upload their own preliminary data and the program will extrapolate power from this dataset.

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• SciCrunch
• 17 years ago - by Anonymous