Curator Dashboard

Candrive''s aim is to improve the health, safety and quality-of-life of Canada''s older drivers. Candrive''s vision is to establish a national multi-disciplinary collaborative approach to identify, analyze and examine the issues pertaining to the safe operation of vehicles by older persons. One of the goals of the Candrive research program is to find a way to extend the length of time that older drivers can drive. Candrive will examine both the effectiveness of retraining programs and the use of customized or restricted licensing for older drivers who might automatically have had their licence revoked. Unfortunately, even if such measures prove useful, there will still be a small minority of older drivers who are no longer safe to drive. By identifying this minority as early as possible, the program will help protect the reputation, public image and rights of the majority of older drivers who represent the safest and most experienced drivers on the road. Sponsors: This resource is supported by a Team Grant from the Canadian Institutes of Health Research (CIHR). Candrive also receives support from the Ottawa Hospital Research Institute. Keywords: Health, Safety, Analysis, Vehicle, Driver,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

A working guide to the rapidly developing world of Next-Generation DNA sequencing, with an emphasis on bioinformatics.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

COLELMS calculates LMS values, smoothed LMS, and growth reference centiles based in smoothed LMS values. df value is set to when calculating smoothed LMS values. You are responsible for setting an appropriate df for your data. This is version 0.2 of the software. Sponsors: This resource is supported by Boston College. Keywords: Software, LMS, Calculation, Growth, Data, Stata, Module,

• Resource
• SciCrunch
• 16 years ago - by Anonymous

This web site contains information relevant to nomenclature of the avian brain. Its current purpose is to serve as a communication means by which scientists can become more knowledgeable about the avian brain, exchange ideas, and formulate proposals for changing the existing nomenclature. Sponsors: This resource is supported by the Duke University Medical Center. Keywords: Avian, Brain, Rearch, Research, Nomenclature, Atlas,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

This portal shows you the current research projects happening with in the Cancer Genomics Project. Sponsors: This project is supported by Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agenecy. Keywords: Research, Cancer, Genomics, Genetic, Gne, Project,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

This is a database of faces and non-faces, that has been used extensively at the Center for Biological and Computational Learning at MIT. It is freely available for research use. CBCL FACE DATABASE #1: :- Includes complete Readme File :- 19 x 19 Grayscale PGM format images :- Training set: 2,429 faces, 4,548 non-faces :- Test set: 472 faces, 23,573 non-faces :- 27 Megabytes compressed : 110 Megabytes uncompressed :- tar / gz format compression Sponsors: This database is supported by the MIT Center for Biological and Compulational Learning. Keywords: Download, Database, Face, Non-face, Biological, Comuptaitonal, Research,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

The California Institute for Regenerative Medicine is accelerating the development of new therapies for chronic disease and injury by funding stem cell research programs throughout California. T he mission of CIRM is to support and advance stem cell research and regenerative medicine under the highest ethical and medical standards for the discovery and development of cures, therapies, diagnostics and research technologies to relieve human suffering from chronic disease and injury. CIRM was established in 2004 after Californians passed Proposition 71, the California Stem Cell Research and Cures Initiative. The statewide ballot measure, which provided 3 billion in funding for stem cell research at California universities and research institutions, called for the establishment of a new state agency to make grants and provide loans for stem cell research, research facilities and other vital research opportunities. CIRM funds stem cell research at for-profit and not-for-profit institutions throughout California. Grants are awarded as part of Requests for Applications (RFAs). Applications for these RFAs are reviewed by a panel of experts, which makes recommendations to the Governing Board. The board then votes on grants to fund for each RFA. Keywords: Regenerative, Medicine, Development, Therapy, Chronic, Disease, Ilness, Stem cell, Research, Meidcal, Discovery, Cure, Therapy, Diagnostic, Technology, Human, Grant, Funding,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

Software package dedicated to the handling of molecular marker data for multivariate analysis. This package is related to ADE4, a R package for multivariate analysis, graphics, phylogeny and spatial analysis. (entry from Genetic Analysis Software)

• Resource
• SciCrunch
• 14 years ago - by Anonymous

Software tool for carrying out power calculations for large genetic association studies, including two stage genome wide association studies.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

This web site has been created to provide a centralized source for CS2 and related vector information. It will be updated (on an irregular basis) with additional information, including new vector designs. CS2 vector: pCS2 is a multipurpose expression vector. Although originally designed for expressing proteins in Xenopus embryos from either injected RNA or DNA, pCS2 is also useful for high-level transient expression in a wide variety of mammalian and avian cells. It is also functional in zebrafish embryos (as DNA or RNA), and it can be used for in vitro transcription/translation (using, for example, the Promega TnT system). A number of derivatives of CS2 have been constructed that allow fusions to epitope tags and other marker proteins, as well as nuclear localization signals or the gal4 DNA binding and activation domains. In almost all cases, the same reading frames are used for the fusion vectors, to facilitate moving genes between multiple CS2 derivatives. pCS2 features: pCS2 contains a strong enhancer/promoter (simian CMV IE94) followed by a polylinker and the SV40 late polyadenlyation site. An SP6 promoter is present in the 5'' untranslated region of the mRNA from the sCMV promoter, allowing in vitro RNA synthesis of sequences cloned into the polylinker. A T7 promoter in reverse orientation between the polylinker and the SV40 polyA site for probe synthesis, as well as a second polylinker after the SV40 polyA site to provide several possible sites to linearize the vector for SP6 RNA transcription. The vector backbone is from pBluescript II KS and includes the amp resistance gene and an f1 origin for producing single stranded DNA. :Sponsors: This resource is supported by the University of Michigan. : Keywords: Vector, Resource, Expression, Protein, Xenopus, Embryo, RNA, DNA, Transient, Zebrafish, Domain, mRNA, Synthesis, Promoter,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

Conversion Software Registry (CSR) has been designed for collecting information about software packages that are capable of file format conversions. The work is motivated by a community need for finding file format conversions inaccessible via current search engines and by the specific need to support systems that could actually perform conversions, such as the NCSA Polyglot. In addition, the value of CSR is in complementing the existing file format registries and introducing software quality information obtained by content-based comparisons of files before and after conversions. The contribution of this work is in the CSR data model design that includes file format extension based conversion, as well as software scripts, software quality measures and test file specific information for evaluating software quality. The CSR system serves as the source of information and a test bed for the system that can execute the conversions automatically by using the third party software, for example, NCSA Polyglot. The CSR system is a database with a web-based interface that provides services related to a) finding a conversion path between formats b) uploading information about the 3rd party software packages and file extensions, c) uploading files for testing, and finally d) uploading scripts in operating system (OS) specific scripting languages (Windows AutoHotKey, AppleScript and Perl) for automated conversions according to the idea of imposed code reuse used by NCSA Polyglot. In order to provide file format conversion services, CSR have included the following components into CSR related to software capable of conversions: input and output file formats (extensions), scripts operating on the software, validated files to be used for information loss measurements, as well as quantitative measures of the information loss for conversions. The CSR focuses: on software and finding the format conversion paths described by a number of software packages and unique input and output formats. The formats themselves are represented by extensions. While not always unique, extensions are often the only accessible information when the 3rd party software is installed (often listed under the File/Open menu in most packages). The CSR also contains information about the software, operating system, software interface and scripts to execute the software. The scripts are important for the automating conversions with the 3rd party software and can be implemented using AutoHotkey scripts (Windows), AppleScript (Mac) or one of a variety of scripting languages for Unix. The information loss due to file format conversions is measured externally by different techniques within the NCSA object-to-object comparison framework called Versus. The comparison is relevant to the software domain, for example for 3D applications surface area or spin images are used and the loss (0-100 range with 100 representing no loss) for a particular software-conversion pair is stored in the database. The information loss also represents edge weights to Input/Output (I/O) Graph, a simple workflow used for finding the shortest conversion path. The CSR is written as a web service. It consists of three main components: Query, Add, Edit. In the Query mode users can a) view list of all software packages with their conversion options, b) select subsets of software in the I/O-Graph, c) search the database by conversions, software, extensions, MIME and PUID. The I/O-Graph contains all information about installed applications and the conversions they allow. The JAVA applet front end is part of the CSR web visualization interface. Section Add allows users to add new software packages with their conversion capabilities and upload the software scripts to automate them. The last section, Edit is designed for adding detailed information about the software, extensions and for uploading the test files. CSR requires users to login for adding and editing. The web fields are auto completed to help search. Sponsors: This research was partially supported by a National Archive and Records Administration (NARA) supplement to NSF PACI cooperative agreement CA #SCI-9619019. Keywords: Software, Registry, Information, Conversion, Database, Tool

• Resource
• SciCrunch
• 17 years ago - by Anonymous

This is a trial for a large randomised placebo controlled trial among trauma patients with, or at risk of, significant haemorrhage, of the effects of antifibrinolytic treatment on death and transfusion requirement. Sponsors: This resource is supported by UK NIHR Health Technology Assessment programme, Pfizer, BUPA Foundation, and J P Moulton Charitable Foundation. Keyowrds: Trial, Placebo, Drug, Trauma, Haemorrhage, Antifibrinolytic, Treatment, Death, Transfusion,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

CMC Microsystems enables and supports the creation and application of micro- and nano-system knowledge by providing a national infrastructure for excellence in research and a path to commercialization of related devices, components and systems. CMC Microsystems provides the tools, technologies and services that make microsystems research and development possible in universities across Canada. CMC delivers innovative and cost-effective services to a growing community of microsystems researchers that connect 43 universities and one college across Canada, and presently involves over 3,100 faculty and graduate students. A 4th Pillar organization stimulating synergistic collaboration among universities, companies and government agencies, CMC is a pioneer in developing creative solutions including Canada-wide Internet-based access to advanced microsystems testing facilities-at a fraction of the cost of conventional methods. Over the last five years, CMC delivered a value of 342 million to Canadian universities. Throughout the last 25 years CMC has successfully demonstrated the ability to specify, acquire and distribute all the necessary tools and technologies to design, make and test microsystems devices, components and systems and in the last five years has significantly expanded its skill base and partnerships. CMC has also developed a series of key relationships with suppliers which have enabled smooth and uninterrupted access to the latest tools and technologies. The governance structure is widely viewed as one of the soundest among organizations of this type and the management team of five people has a total experience of well over 100 years in the microsystems field.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

Cerep offers a panel of over 630 validated in vitro pharmacological assays that cover a broad range of targets including receptors, ion channels, transporters, enzymes and second messengers. These assays are used to identify lead compounds, to define mechanism of action, and to identify off-target activities. All assays are available on an ad hoc basis. At any time, clients can select one or more assays to be tested against one or more compounds at one or more concentrations. In addition to ad hoc access, client specific and Cerep profiles are available. Client specific profiles can be adapted using any of the over 630 Cerep assays. Standard Profiles are designed by Cerep and available to all clients. The Standard Profiles are a rapid and cost effective way of prioritizing the most promising compounds in the lead selection process. Benefiting from increased efficiency generated from optimized processes, Cerep is happy to expand custom made profiles clients can design at set prices. While offering more flexibility, clients are able to select among predefined lists of functional GPCR, kinase and binding assays. Keywords: In vitro, Pharmacology, Assay, Target, Receptor, Ion channel, Transporter, Enzyme, Mechanism, Hoc, Compound, Kinase, GPCR, Secondary messenger,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

Ontology designed for supporting the COG enrichment study by using Fisher''s exact test

• Resource
• SciCrunch
• 13 years ago - by Anonymous

The Cancer Genome Project is using current high throughput techniques to characterise a series of approximately 800 cancer cell lines including those most frequently used in biological and pharmaceutical research and drug discovery. These screens include sequencing of known cancer genes, copy number and genotyping analysis using SNP arrays and identification of microsatellite instability. Pair-wise comparison of the SNP array data for the entire series of cell lines under study has been performed identifying those lines which, in our set, are either identical or derived from a parental line. These lines are termed synonymous cell lines. Sponsors: This study was supported by the Wellcome Trust and Glaxo Smith Kline. :K eywords: Cancer, Genome, Technique, Research, Pharmaceutical, Drug, Discovery, Gene, Number, Genotype, SNP, Array, Microsatellite, Instability, Biological, Cell line, SNP, Data,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

This is the HQSNP DB (high-quality SNP database) developed by CHG bioinformatics group. The high-quality SNP is defined as a SNP having allele frequency or genotyping data. The majority of the HQSNPs come from HapMap, others come from JSNP (Japanese SNP database), TSC (The SNP Consortium), Affymetrix 120K SNP, and Perlegen SNP. There are four kinds of SNP search you can do: * Get SNPs by dbSNP rs#: Choose this search if you have already selected a list of SNPs and you just want to get the SNP information. The program will generate a Excel file containing the SNP flanking sequence, variation, quality, function, etc. In the Excel file, there are 10 highlighted fields. You can send only those highlighted information to Illumina to get SNP pre-score. (The same fields are presented in other types of searches as well.) * Get gene SNPs by gene names: Choose this search if you have a list of gene names and you want to get the SNP information in these genes. The gene name can be official gene symbol, Ensembl gene ID, RefSeq accession ID, LocusLink number, etc. * Get gene SNPs by genome regions: Choose this search if you have a list of genome regions and you want to get all gene SNP information in these regions. The software will find all the Ensembl genes in the regions and find SNPs associated to each Ensembl gene. * Get genome scan SNPs by genome regions: Choose this search if you have a list of genome regions and you want to get evenly spaced SNPs in these regions. A SNP selection tool (SNPselector) was built upon HQSNP. It took snp ID list, gene name list, or genome region list as input and searched SNPs for genome scan or gene assoctiation study. It could take an optional ABI SNP file (exported from ABI SNP search web page) as input for checking whether the candidate SNP is available from ABI. It could also take an optional Illumina SNP pre-score file as input to select SNP for Illumina SNP assay. It generated results sorted by tag SNP in LD block, SNP quality, SNP function, SNP regulatory potential, and SNP mutation risk. SNPselector is now retired from public use (as of September 30, 2010).

• Resource
• SciCrunch
• 16 years ago - by Anonymous

It is a database of keys facts about proteins, families, and complexes involved in cell migration. This ongoing project provides a large amount of automated and curated data, collected from numerous online resources that are updated monthly. These data include names, synonyms, sequence information, summaries, CMC research data, reagents, structures, as well as protein family and complex details. CMKB''s ultimate goal is to create a database that will enable the cell migration community to conveniently access significant information about molecules of interest. This will also serve as a stepping stone to pathway analysis and demonstrate how these molecules coordinate with one another during cell adhesion and movement. Sponsors: This resource is supported by the Cell Migration Consortium.

• Resource
• SciCrunch
• 14 years ago - by Anonymous

The REasons for Geographic and Racial Differences in Stroke (REGARDS) project, sponsored by the National Institutes of Health (NIH), is a national study focusing on learning more about the factors that increase a person''s risk of having a stroke. REGARDS is an observational study of risk factors for stroke in adults 45 years or older. 30,239 participants were recruited between January 2003 and October 2007. They completed a telephone interview followed by an in-home physical exam. Measurements included traditional risk factors such as blood pressure and cholesterol levels, and an echocardiogram of the heart. At six month intervals, participants are contacted by phone to ask about stroke symptoms, hospitalizations and general health status. The study is ongoing and will follow participants for many years. The purpose of the REGARDS project is to understand why people in some parts of the country develop more strokes than people in other parts of the country, and why blacks develop more strokes than whites. We hope to learn how to reduce the number of people having strokes.

• Resource
• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on August 20,2021. Center for Neuropharmacology & Neuroscience (CNN) is composed of faculty and students with research interests that are focused on the nervous system. One major purpose of the CNN is to facilitate and strengthen collaborations in neuroscience research; it also provides a unique interface for interactions among clinical and basic scientists. Neuropharmacology and Neuroscience are large and diverse fields that encompass physiology, pharmacology, anatomy, behavior, development, neural disorders and diseases.

• Resource
• SciCrunch
• 16 years ago - by Anonymous