Curator Dashboard

Georgetown University is a private research university in the Georgetown neighborhood of Washington, D.C. The oldest Catholic and Jesuit institution of higher education in the United States.

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• SciCrunch
• 17 years ago - submitted by Eddy Kim

Database of the international consortium working together to mutate all protein-coding genes in the mouse using a combination of gene trapping and gene targeting in C57BL/6 mouse embryonic stem (ES) cells. Detailed information on targeted genes is available. The IKMC includes the following programs: * Knockout Mouse Project (KOMP) (USA) ** CSD, a collaborative team at the Children''''s Hospital Oakland Research Institute (CHORI), the Wellcome Trust Sanger Institute and the University of California at Davis School of Veterinary Medicine , led by Pieter deJong, Ph.D., CHORI, along with K. C. Kent Lloyd, D.V.M., Ph.D., UC Davis; and Allan Bradley, Ph.D. FRS, and William Skarnes, Ph.D., at the Wellcome Trust Sanger Institute. ** Regeneron, a team at the VelociGene division of Regeneron Pharmaceuticals, Inc., led by David Valenzuela, Ph.D. and George D. Yancopoulos, M.D., Ph.D. * European Conditional Mouse Mutagenesis Program (EUCOMM) (Europe) * North American Conditional Mouse Mutagenesis Project (NorCOMM) (Canada) * Texas A&M Institute for Genomic Medicine (TIGM) (USA) Products (vectors, mice, ES cell lines) may be ordered from the above programs.

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• SciCrunch
• 15 years ago - by Anonymous

An online toolbox and workflow management system for a broad range of bioinformatic and systems biology applications. The individual modules, or Bricks, are unified under a standardized interface, with a consistent look-and-feel and can flexibly be put together to comprehensive workflows. The workflow management is intuitively handled through a simple drag-and-drop system. With this system, you can edit the predefined workflows or compose your own workflows from scratch. Your own Bricks can easily be added as scripts or plug-ins and can be used in combination with pre-existing analyses. GeneXplain GmbH provides a number of state-of-the-art bricks; some of them can be obtained free of charge, while others require licensing for small fee in order to guarantee active maintenance and dynamic adaptation to the rapidly developing know-how in this field.

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• SciCrunch
• 15 years ago - by Anonymous

A topographic database for analyzing non-synonymous SNPs (nsSNPs) that can be mapped onto known 3D structures of proteins. These include disease- associated nsSNPs derived from the Online Mendelian Inheritance in Man (OMIM) database and other nsSNPs derived from dbSNP, a resource at the National Center for Biotechnology Information that catalogs SNPs. TopoSNP further classifies each nsSNP site into three categories based on their geometric location: those located in a surface pocket or an interior void of the protein, those on a convex region or a shallow depressed region, and those that are completely buried in the interior of the protein structure. These unique geometric descriptions provide more detailed mapping of nsSNPs to protein structures. It also includes relative entropy of SNPs calculated from multiple sequence alignment as obtained from the Pfam database (a database of protein families and conserved protein motifs) as well as manually adjusted multiple alignments obtained from ClustalW. These structural and conservational data can be useful for studying whether nsSNPs in coding regions are likely to lead to phenotypic changes. TopoSNP includes an interactive structural visualization web interface, as well as downloadable batch data.

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• SciCrunch
• 17 years ago - by Anonymous

Project is providing critical tools for understanding gene function and genetic causes of human diseases. Project KOMP is focused on generating targeted knockout mutations in mouse ES cells. Second phase, KOMP2, relies upon successful generation of strains of knockout mice from these ES cells. Information from JAX about their contributions to KOMP project.

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• SciCrunch
• 15 years ago - by Anonymous

A laboratory that researches neurological diseases, including amyotrophic lateral sclerosis, Alzheimer's disease, glaucoma, retinitis pigmentosa, epilepsy, and hearing disorders. The Laboratory offers courses that train and update neuroscience researchers. It distributes JAX Mice models suitable for neuroscience research. Also available are research tools for neurobiology.

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• SciCrunch
• 15 years ago - by Anonymous

A tool for mapping and performing quality control on Hi-C data.

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• SciCrunch
• 13 years ago - by Anonymous

A cross-platform graphical DNA trace viewer and editor that displays the chromatogram files from Applied Biosystems automated sequencers and files in the Staden SCF format. Incorrect base calls can be edited and saved. TraceEdit is freely available and designed to operate on Windows and UNIX platforms.

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• SciCrunch
• 13 years ago - by Anonymous

Donate a strain to The Jackson Laboratory Repository. Why donate a strain? * Donating reduces your costs of maintaining strains, lab personnel, shipping and resources. * Each donated strain is cryopreserved, protecting against accidental loss and genetic contamination. * Each donated strain is rederived to a high health status and may be resupplied to donors (up to 3 breeder pairs as long as we have live mice available) * Donating fulfills NIH obligations to share mice. How strain donation works: Strains are submitted by investigators for distribution to the scientific community. All repository strains are cryopreserved. All strains are evaluated monthly by the Genetic Resource Committee (GRC). The GRC is made up of staff scientists and resource managers from The Jackson Laboratory. The GRC recommends which strains are most appropriate to include in the Repository. You will be notified by email after your strain has been reviewed. Donation evaluation criteria * Importance of its current use for research, publication history, and current demand * Importance of its anticipated or potential future use * Difficulty of maintenance relative to scientific value * Existence and reliability of other resources that would ensure its survival * Difficulty of re-creating the strain relative to the time and effort required for its importation and preservation

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• SciCrunch
• 15 years ago - by Anonymous

Repository of Cre Driver lines and related information resources. Their services include analysis of Cre line excision function in both target and non-target tissues using Cre reporter lines and presenting the annotated data in the expression data portion of this website, http://cre.jax.org/data.html.

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• SciCrunch
• 15 years ago - by Anonymous

Central location for voluntary submission of genetic test information by providers including the test''s purpose, methodology, validity, evidence of the test''s usefulness, and laboratory contacts and credentials. GTR aims to advance the public health and research into the genetic basis of health and disease. GTR is accepting registration of clinical tests for Mendelian disorders, complex tests and arrays, and pharmacogenetic tests. These tests may include multiple methods and may include multiple major method categories such as biochemical, cytogenetic, and molecular tests. GTR is not currently accepting registration of tests for somatic disorders, research tests or direct-to-consumer tests.

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• SciCrunch
• 15 years ago - by Anonymous

A scalable web-based system for biological image analysis, management and exploration. The Bisque system incorporates many features useful to imaging researchers from image capture to extensible image analysis and querying. At the core, bisque maintains a flexible database of images and experimental metadata. Image analyses can be incorporated into the system and deployed on clusters and desktops. Search and comparison of datasets by image data and content is supported. Novel semantic analyses are integrated into the system allowing high level semantic queries and comparison of image content. New features and testing of Bisque version: 0.5.1, among many others are: # Parallel execution of datasets # Rich interfaces for autogenerated module UI # Abstracted storage system for local, irods, etc.. They are using Mercurial for their source control system. This should be installed before proceeding. Browse source on-line, http://biodev.ece.ucsb.edu/projects/bisquik/browser Bisque Installation, http://biodev.ece.ucsb.edu/projects/bisquik/wiki/InstallationInstructions05 Bisque DOWNLOAD, http://biodev.ece.ucsb.edu/projects/bisquik/wiki/download, THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 15 years ago - by Anonymous

A blast oriented interface that allows you to retrieve families of polymorphic sequences. It aims to help molecular evolutionary biologists and population geneticists in their research.

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• SciCrunch
• 17 years ago - by Anonymous

Core facility that provides the following services: Cell immortalization through retroviral or lentiviral vectors service, Microscopy training, User-based microscopy service. <BR/> <BR/>

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• SciCrunch
• 13 years ago - by Anonymous

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• SciCrunch
• 17 years ago - submitted by Stephen Larson

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. This course emphasizes genetic applications and approaches to drug addiction research through methodological instruction based on literature, data sets and informatics resources drawn from studies of addiction related phenotypes. The course includes plenary sessions on major progress in addiction genetics, and discussion sessions in which students present their work for discussion on applications of genetic methods. Students will leave the course able to design and interpret genetic and genomic studies of addiction as they relate to their specific research question, and will be able to make use of current bioinformatics resources to identify research resources and make use of public data sources in their own research.

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• SciCrunch
• 15 years ago - by Anonymous

Open source database for exchange and exploration of biological images. Used to store, visualize, organize and analyze images in cloud. Centered around database of images and metadata.

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• SciCrunch
• 15 years ago - by Anonymous

The NIH Chemical Genomics Center plays a role within the NIH Molecular Libraries Initiative (MLI), mandated to bring advanced technologies and expertise to researchers who lack the means to perform high-throughput screens and follow-up medicinal chemistry efforts as a means of identifying and optimizing small molecule probes of novel, unexplored cellular targets. These reagents offer the research community much-needed proof-of-concept pharmacological tools that may serve as starting points for therapeutic development into clinical agents. Results from these projects are disseminated to the scientific community through the publicly accessible PubChem database and via peer-reviewed publications. This highly collaborative program merges academic researchers'' wide-ranging expertise within the study of new biochemical targets and pathways with the translational infrastructure of NCATS. To date, NCATS scientists, in collaboration with hundreds of extramural scientists, have developed more than 60 probes that are freely accessible to the scientific community. A number of these probes are highlighted below: * Project: Activators for Human Pyruvate Kinase M2 (hPK) as Leads in Cancer Therapeutics * Project: Inhibitors of Caspase 1 for the Treatment of Numerous Autoimmune and Inflammatory Diseases * Project: Inhibitors of 12-Human Lipoxygenase (12-hLO) for the Treatment of Diabetes and Clotting * Project: Inhibitors of Cruzain as Therapeutic Leads for Chagas Disease * Project: Inhibitors of NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase (HPGD) for the Study of Prostaglandin''s Role in Inflammation * Project: Inhibitors of Cdc2-Like Kinase 4 (Clk4) to Elucidate the Mechanism and Controlling Gene Splicing * Project: Agonists of the Thyroid Stimulating Hormone Receptor for the Treatment of Graves'' Disease * Project: Identification of Inhibitors of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease * Project: Identification of SMN Modulators for Potential SMA Disease Therapeutics * Project: Inhibitors of Platelet Integrin IIb3 * Project: Identification of Novel Small Molecule Antagonists of the Neuropeptide-S Receptor * Project: Inhibitors of Schistosoma mansoni Redox Cascade

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• SciCrunch
• 15 years ago - by Anonymous

The NIH Chemical Genomics Center (NCGC) was created in 2008 as a Comprehensive Screening Center in the Molecular Libraries Probe Production Centers Network, part of the NIH Molecular Libraries Common Fund Program. The goals of NCGC in the NCATS Division of Pre-Clinical Innovation are to translate the discoveries of the Human Genome Project into biological and disease insights and ultimately new therapeutics for human disease through small molecule assay development, high-throughput screening, cheminformatics and chemistry. NCGC programs include Assay Development and High-Throughput Screening, Chemistry Technology and RNAi. In addition, NCGC is one of 12 centers that make up the National Cancer Institute''s Chemical Biology Consortium. These centers use the consortium''s high-throughput screening, informatics and chemistry resources to work on select cancer biology projects and move them through the therapeutics development pipeline, eventually into the clinic. Through such programs, NCGC produces a variety of pre-clinical research tools, from informatics and software tools to an assay guidance manual and more than 200 molecular probes.

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• SciCrunch
• 15 years ago - by Anonymous

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• SciCrunch
• 17 years ago - submitted by Christie Wang