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This is a web interface for ADDA, an automatic algorithm for domain decomposition and clustering of all protein domain families. We use alignments derived from an all-on-all sequence comparison to define domains within protein sequences based on a global maximum likelihood model. ADDA is downloadable. There are three ways in which you can retrieve a protein sequence and its domains from ADDA. Sequences can be located using sequence identifiers and/or accession numbers, using a identical fragment lookup, or by running BLAST against all sequences in ADDA. ADDA is a protein sequence clustering algorithm. It takes a set of sequences and returns domain families. ADDA has two steps corresponding to the two aspects of the protein sequence clustering domain. First, ADDA splits protein sequences into domains. The idea behind ADDA is in principle the application of Occam''s razor; the goal is to describe the diversity of protein sequences with a minimal set of protein domains. The algorithm behind ADDA approximates this minimal set. In practice ADDA works by looking at where BLAST alignments are located on the sequence and splits the sequences, so that as few as possible alignments are cut by domain boundaries and that as many alignments as possible stretch over complete domains. Secondly, ADDA takes all the domains and then arranges them in a minimum spanning tree, where the similarity between two domains is determined by their relative overlap given a BLAST alignment. Each link in the tree is then checked by a pairwise profile-profile comparison and links below a threshold are removed. The remaining connected components are then taken to represent protein domain families.

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• SciCrunch
• 15 years ago - by Anonymous

A database on nucleotide sequences of 5S rRNAs and their genes. The database contains 1985 primary structures of 5S rRNA and 5S rDNA, and was last updated in 2002, according to the website. They include 60 archaebacterial, 470 eubacterial, 63 plastid, nine mitochondrial and 1383 eukaryotic sequences. The nucleotide sequences of the 5S rRNAs or 5S rDNAs are divided according to the taxonomic position of the source organisms. The sequences for particular organisms can be retrieved as single files using a taxonomic browser or in multiple sequence structural alignments. The multiple sequence alignments of 5S ribosomal RNAs can be downloaded in TAB-delimited and FASTA formats.

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• SciCrunch
• 17 years ago - by Anonymous

The Neuroscience PhD Program at Washington University in St. Louis aims to train the next generation of leaders in neurobiology. The main objectives of the program are to: Provide students with the skills necessary to conduct research including the planning and implementation of a unique research project in the field of neuroscience. Teach students the fundamental concepts within neuroscience and how to apply those concepts in the critical analysis of scientific research. Promote the professional development of students in the areas of scientific writing and oral presentation. Promote interdisciplinary science by encouraging cooperation and collaboration among students in different programs and departments.

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• SciCrunch
• 17 years ago - by Anonymous

The research-oriented program in pharmacology and toxicology prepares students for careers in independent research and teaching in pharmacology, toxicology and related areas.The research interests of the faculty are very broad and active areas of research include cancer biology, pharmacogenomics, pharmacokinetics, immuno-pharmacology and -toxicology and neuroscience. The diversity in faculty research interests provides students with a solid foundation in many areas of molecular and cellular pharmacology and toxicology and gives them a wide variety of research programs from which a dissertation proposal may be selected.<BR/> The curriculum provides exposure of students to virtually all areas of current research in molecular and cellular biochemistry, immunology, molecular biology, pharmacology and toxicology and formal course requirements are flexible to tailor programs to individual needs.Our graduates have been successfully placed in careers in universities and colleges, the pharmaceutical and biotech industries, and in federal and state agencies. The program awards Ph.D. and M.S. degrees.

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• SciCrunch
• 17 years ago - by Anonymous

Modern molecular biology, protein biochemistry, immunology, cell biology, genetics, electrophysiology, and morphology are well represented in the Program in Molecular and Cellular Pharmacology. Students will be instructed thoroughly in these fields as well as in the unique principles of Pharmacology. One major objective of the Program is to teach the students a fundamental understanding of the molecular basis of signal transducing systems and their regulation. The Program brings together an outstanding group of dedicated trainers with a focus on cellular signal transduction. Graduates of the Program will be well prepared for a career in basic biomedical sciences. The Program provides a unique training experience for young scientists who want to elucidate basic principles of cellular signal pathways. Detailed knowledge of these pathways is the most important prerequisite for the discovery of new drugs and the treatment of diseases.

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• 17 years ago - by Anonymous

Research-based medical science department of physiology and pharmacology in the Schulich School of Medicine and Dentistry at the University of Western Ontario that focus on biological processes from the cellular-molecular level to the integrative-systemic level, and on the effects of drugs and environmental agents on these processes. Their areas of research excellence include the physiology and pharmacology of the cardiovascular, neural, reproductive, endocrine and musculoskeletal systems. Several faculty work in the area of developmental biology related to these organ systems. Faculty members in this Department are leaders in nationally-funded collaborative research programs studying skeletal / bone development and biology, heart and vascular biology, cell communication and gap junctions, neural control of vision and movement, and osteoarthritis and pain. Funding from several large infrastructure grants from both national and provincial governments has facilitated the development of state-of-the-art research laboratories and core facilities.

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• SciCrunch
• 17 years ago - by Anonymous

A uniform core set of data elements (whose formal semantics are captured in OWL) for use in a Computer-Based Patient Record (CPR)

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• SciCrunch
• 13 years ago - by Anonymous

The Department of Pharmacology are involved in diverse areas of research with special emphasis on molecular pharmacology, cellular regulation, neuropharmacology, and environmental toxicology. Active areas of research include evaluating the effects of drugs and chemicals on humans and animals; studying the actions of hormones, neurotransmitters, and other physiological regulators on individual cells; examining the detailed molecular structure of cellular constituents; and exploring how the cell regulates it&apos;s vital processes through transcriptional and post-transcriptional mechanisms. Through our research, we&apos;d ultimately like to gain detailed insights into drug action and cellular regulation at many different levels of inquiry: the human patient, the experimental animal, the individual cell, its complement of proteins, and the genetic code.

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• 17 years ago - by Anonymous

The Department of Pharmacology has designed a program of study that involves required and elective graduate courses, laboratory rotations introducing various approaches to the solution of pharmacological problems, journal clubs and seminars.The doctoral training program in Pharmacology exposes our students to the latest scientific thinking and technical developments in the biomedical sciences and to develop their critical thinking and problem solving skills. Upon completion of their graduate training, our students should be able to identify - and to design experiments to test - ideas at the limits of current knowledge in one of the major areas of pharmacology including cancer biology and neuroscience. Students should also learn to analyze, interpret and communicate effectively the results of their thoughts and their experiments to other scientists.

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• SciCrunch
• 17 years ago - by Anonymous

The Department of Pharmacology and Toxicology at the University of Utah is located in Salt Lake City at the foot of the beautiful Wasatch Range of the Rocky Mountains. Our Department focuses on research, graduate and professional training, and service. The faculty of this department place a high priority on the teaching and research training of graduate students for the Ph.D. degree. Our program features close working relationships between individual students and their faculty mentor, rich and diverse research opportunities, and individualized programs of study based on the needs of the students. Doctoral graduates of our program gain employment in research and teaching positions at colleges and universities, engage in research and development in the biotechnology and pharmaceutical industries, and have additional opportunities in research institutes, government agencies, environmental protection organizations, and many other arenas. Our Summer Undergraduate Research Fellowship (SURF) Program provides enriching research experiences for undergraduate students anticipating research careers in the biological sciences.

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• SciCrunch
• 17 years ago - by Anonymous

The Department of Pharmacology is among the oldest and largest in North America, with its official foundations in 1887, at the same time that the Faculty of Medicine was re-established in the University of Toronto. We offer training in pharmacology and toxicology to both undergraduate and graduate students who may subsequently go on to exciting research, regulatory and administrative careers in academic, industrial and healthcare provision settings.Current areas of research investigation in the Department include Receptor Pharmacology, Signal Transduction Pathways, Neuropharmacology, Drug Addiction Studies, Drug Metabolism and Pharmacokinetics, Pharmacogenetics, Cardiovascular Pharmacology, Clinical Pharmacology, Behavioural Pharmacology, Immunopharmacology, Endocrine Pharmacology and Molecular Toxicology. Our research laboratories are located not only in the core Department situated in the Medical Sciences Building on the downtown St. George campus, but also within a number of nearby university Departments, Faculties, university-affiliated research institutes and teaching hospitals. This strategic positioning also enables a wealth of potential opportunities for interdisciplinary collaboration with internationally recognized investigators within one of the largest and densest existing concentrations of biomedical research expertise in North America.

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• SciCrunch
• 17 years ago - by Anonymous

The Graduate Program in Pharmacology and Toxicology has dual aims of (1) advancing scientific knowledge, and (2) preparing students to become independent future scientists. The Program is housed within the Department of Pharmacology and Toxicology, which has a full-time graduate program faculty of 19. An additional 5 faculty from other departments are active members of the Graduate Program, bringing the total number of graduate program faculty to 24. These faculty provide a wide range of research opportunities for addressing pharmacology research questions at a wide variety of experimental levels, ranging from whole animal responses to specific drugs and toxins, to the structural and molecular basis of gene expression of specific receptors.

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• SciCrunch
• 17 years ago - by Anonymous

Neuroscience department portal characterized by collaborative interactions between faculty and students working at many different levels of analysis, including research on cell-molecular neurobiology, systems-level analysis of neural circuits, neural engineering, and cognitive and computational neuroscience. When combined with a varied curriculum, weekly seminars, an annual graduate student symposium, and an extremely active neuroscience graduate student forum, the USC Neuroscience Graduate Program provides a highly inter-disciplinary and supportive training experience designed to prepare students for a variety of successful careers. More than 60 USC Neuroscience faculty conduct externally funded research programs in areas ranging from the molecules that determine neuronal function to the principles of human cognition and emotion. Find out more about ongoing Neuroscience research at USC in each of the following major topic areas: - Behavioral, Systems, &amp; Cognitive Neuroscience - Cellular &amp; Molecular Neurobiology - Development, Plasticity &amp; Repair - Computational Neuroscience &amp; Neural Engineering - Aging, Neurobiology of Disease, &amp; Translational Research Sponsors: Funded by the University of Southern California

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• SciCrunch
• 17 years ago - by Anonymous

University of Virginia&apos;s Biomedical Sciences Program provides students with the requisite knowledge and skills with which to pioneer major advances in our understanding of the complex biology of cells and tissues, and to lead efforts to cure and/or better treat human disease in the 21st Century. To help meet the challenges of modern biological/biomedical research training, the University of Virginia faculty have adopted an interdepartmental structure for graduate training that optimizes the research training opportunities available to you, and the flexibility to chose a mentor and advanced graduate specialty training area ideally suited for your professional interests and aspirations. To ensure personalized attention, entering students are asked to identify one of seven graduate program groups within the Biomedical Sciences Graduate Program that best suits their initial professional interests. However, students are free to change their program selection as their interests evolve during their first year, and have access to a plethora of research interests from over 200 biological/biomedical science faculty in the School of Medicine and College of Arts and Sciences on the main University of Virginia campus.

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• SciCrunch
• 17 years ago - by Anonymous

The Department of Pharmacology is a program that combines an interdisciplinary core curriculum, advanced coursework and original research, and is designed to give students a broad interdisciplinary base and flexibility. Research training is offered in each of six formal advanced programs organized around traditional disciplines basic to medicine: Biochemistry and Molecular Biology, Cell Biology and Neuroscience, Microbiology and Immunology, Molecular and Cellular Pharmacology, or Physiology, and in the interdisciplinary Cancer Biology Program. There are also a number of research focus areas shared among the graduate faculty in the College of Medicine.

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• SciCrunch
• 17 years ago - by Anonymous

Offers graduate program and training. Areas include mechanisms of DNA repair, oligodendrocyte development and maturation, functional neuroanatomy, neurophysiology, cellular responses to oxidative stress, kinesin motor proteins and motility, regulation of nuclear transcription, and hormonal regulation of fertility. Program emphasizes understanding of biological principles at the cellular level and training in the anatomical disciplines to ensure success during career development. To achieve these objectives the department participates extensively in the Interdisciplinary Graduate Curriculum which teaches fundamental biological principles during the first year. After the first year, students select a mentor and begin to focus on a significant research topic.

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• SciCrunch
• 17 years ago - by Anonymous

Department that includes over 60 faculty members in ten different departments from both the School of Medicine and Dentistry and The College of Arts and Sciences. Several graduate and undergraduate degree programs exist on campus that are designed to meet the diverse needs and interests of students engaged in the study of the nervous system. The tight physical proximity of the medical and main campuses generates a highly collaborative and interactive Neuroscience community, and provides students with broad and flexible opportunities in their training.

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• SciCrunch
• 17 years ago - by Anonymous

The University of Rhode Island College of Pharmacy is a professional school, but it is also an integral part of University of Rhode Island. The College of Pharmacy fosters a learning-centered, research-oriented educational environment that encourages individuals to make positive life-long contributions to global health. We prepare professional degree students to provide compassionate pharmacist-delivered patient care, and inspire our students through innovative problem-based learning, rich experiential curricula and inter-professional collaboration. We foster a community of scholars who will further the body of knowledge in pharmaceutical, biomedical, and clinical sciences. We strive to improve quality of life: locally, nationally and globally.

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• SciCrunch
• 17 years ago - by Anonymous

The Institute of Neurobiology is an interdisciplinary, interdepartmental research center of the Medical Sciences Campus of the University of Puerto Rico. Its members carry out basic research in Neuroscience, with particular emphasis on the use of simple systems to understand basic mechanisms of nervous system function and development. There are currently 14 full-time faculty members who carry out research and graduate teaching at the Institute. Their research interests range from the development of insect synapses to the anatomy of retinal projections in mammals. Graduate students carrying out research at the Institute are enrolled in Ph.D. and M.Sc. programs in the Medical Sciences Campus and in the Department of Biology, UPR. The Institute houses laboratories equipped for electrophysiology, biochemistry, molecular biology and histology, including confocal and electron microscopy.Located in Old San Juan, the Institute overlooks the Atlantic Ocean and El Morro, the fortress which guards San Juan bay.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 22, 2016. A Java program for analyzing the pairwise linkage disequilibrium.

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• SciCrunch
• 14 years ago - by Anonymous