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NMR Facility provides qualified students and researchers in the Chemistry Department access to state-of-the-art NMR instrumentation. Provides support for variety of NMR studies including structure, conformation, dynamics, kinetics and reaction mechanisms of small organic and inorganic molecules and pharmaceuticals.
Core is unit of Department of Epidemiology at the University of Michigan’s School of Public Health. Offers support for clinical research projects throughout process of gathering samples, storing them, and coordinating the assay of the desired analytes. Offers collection kit designs tailor-made to your research study, with tubes and components labeled clearly with barcoded labels and unique sample IDs. Once collected, samples can be processed and stored in one of our 51 on-site ultra-low freezers or in our liquid nitrogen freezer, where their temperatures will be monitored 24/7. When all of the samples are collected, we can complete any combination of 40 different routine assays on them. We currently offer testing using ELISA plates, open channel chemistry analyzer, and coagulation analyzer.
Facility provides imaging instruments and imaging services for research community. Offers imaging systems including IVIS Spectrum bioluminescent/fluorescent imaging system, Bruker 7 Tesla horizontal bore MRI system, 4DMedical Permetium lung CT system, and Bruker SkyScan CT system.
Core routinely generates patient-specific human induced pluripotent stem cells (hiPSCs) for basic science research purposes. Focus is on cardiovascular cell differentiation of hiPSCs to generate unlimited supplies of patient specific cardiovascular cells for in vitro research. Basic services include:hiPSC derivation, hiPSC characterization, hiPSC expanstion;hiPSC differentiation to: Cardiomyocytes, Endothelial Cells, Vascular Smooth Muscle Cells, Pancreatic Cells;3D organoids: Cardiac, Pancreatic;Cardiotoxicity Screening-Drug Discovery Projects;Arrhythmia Testing;High Content Time Lapse Imaging.
Core is part of the University of Michigan Rogel Cancer Center. Provides Rogel Cancer Center investigators with assistance in all quantitative aspects of cancer research -- including biostatistics, bioinformatics, computational biology, analytics and other emerging data-driven and data-intense endeavors.
Core facility provides nascent RNA sequencing using four techniques: Bru-seq, BruChase-seq, BruUV-seq, and BruDRB-seq. This service is all-inclusive, starting with cells and ending with basic data analysis. In addition, users will have access to our exclusive pipeline to perform further data analysis. Our areas of expertise are RNA isolation, cDNA library preparation, and sequencing data analysis.
Biological and life science product supplier.
Software R package for ploidy and aneuploidy estimation using genotyping platform data. Focused on signal standardization to reduce noise for ploidy estimation and relies heavily on visual inspection of diagnostic plots.
Core is dedicated to protein analysis and applying mass spectrometry-based proteomic approaches to varied biological questions.
Offers microscopy instrumentation and services. Offers support and training on variety of high-end instrumentation and advanced methodologies for both light and electron microscopy, sample preparation services for electron microscopy, training and assistance with image analysis. Provides support across variety of open-source and commercial image analysis software packages.
Offers full-service sample analysis to measure concentrations of small molecules in biological samples. Services include targeted and untargeted metabolomic screening, method development to explore novel metabolic pathways and systems. Staff helps with interpretation and visualization of your data, and the preparation of grants, proposals, and manuscripts.
Core provides resources and services to prepare samples for analysis in epigenetic regulation in both genome-wide and locus-specific manners.
Core facility primary mission is to provide access to advanced NMR spectroscopic methods and tools to students, postdoctoral fellows, and faculty of the University for the advancement of their research.
Facility provides specialized MS services. The major areas of focus of the lab are Analysis of intact proteins, multi-protein complexes, and protein structure; Identification and purification of compounds from complex mixtures coupled with quantitative analysis.; Purification using mass directed autopurification liquid chromatography. Users can be trained on the instruments for walk-up use or samples can be submitted for analysis.
Nanotechnicum is a Biointerfaces Institute core facility providing Nanoparticle Size analysis and Zeta Potential characterization, Chiral materials spectroscopy, Material Pore Size and Porosity characterization, Materials Thermal analysis, and Biomolecular Binding characterization instrumentation and services. The Biointerfaces Institute offers instrumentation to the University of Michigan’s research community, fellow academic institutions, and industry.
Provides full-service consultation, sample processing and results. After running your samples, we will process your data using Mestranova and give you access to the raw data via email or Dropbox.
Core provides training, education, statistics and data management services. Services include: experimental design of new studies, advising on outcomes selection, determining or justifying sample size, designing randomization schemes,designing and writing the statistical analysis/modeling section(s), advising on appropriate database design and implementation methods, advising on the use of national data registries, health system data, grant writing on relevant sections within our specialties, creating custom databases and data entry portals for prospective studies, creating custom datasets or extracts from existing data sources for analysis, merging complex or multi-sourced data in concert with research aims and objectives, implementing blind, double-blind and other randomization schemes and more.
Software R package to access and explore existing scRNA-seq data from various public repositories. Supports downloading scRNA-seq data types, including raw data (SRA and ENA), count matrices (GEO, UCSC Cell Browser, and PanglaoDB), and processed objects (Zenodo, CELLxGENE, and HCA). Can access and explore existing scRNA-seq data, load output/downloaded count matrices and annotations to R (SeuratObject/DESeqDataSet), extract a subset of the SeuratObject based on cell metadata and genes, and merge multiple SeuratObjects if applicable. Provides format conversions between different scRNA-seq objects, including SeuratObject, AnnData, SingleCellExperiment, CellDataSet/cell_data_set, and loom.
Software tools for working with scATAC-seq fragment files.
Software R package for tidying output of statistical models.