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The CMTA is a 501(C)(3)nonprofit organization founded in 1983 whose goals are patient support, public education, promotion of research and ultimately the treatment and cure of CMT. Charcot-Marie-Tooth, or CMT, is the most commonly inherited neurological disorder and is found world-wide in all races and ethnic groups. Discovered in 1886 by three physicians, Jean-Martin-Charcot, Pierre Marie, and Howard Henry Tooth, CMT affects an estimated 2.6 million people. CMT patients slowly lose normal use of their feet/legs and hands/arms as nerves to the extremities degenerate and the muscles in the extremities become weakened because of the loss of stimulation by the affected nerves. Many patients also have some loss of sensory nerve function. CMT is one of the 40 diseases covered by the MDA, but unlike muscular dystrophy, in which the defect is in the muscles, CMT is a disorder in which the defect is in the nerves that control the muscles. CMT usually isnt life-threatening and almost never affects brain function. It is not contagious, but it is hereditary and can be passed down from one generation to the next. CMT... * ...is also known as peroneal muscular atrophy (PMA) and hereditary motor sensory neuropathy (HMSN). * ...is slowly progressive, causing deterioration of peripheral nerves which control sensory information and muscle function of the foot/lower leg and hand/forearm. * ...causes degeneration of peroneal muscles (located on the front of the leg below the knees). * ...causes foot-drop walking gait, foot bone abnormalities, high arches and hammertoes, problems with balance, problems with hand function, occasional lower leg and forearm muscle cramping, loss of some normal reflexes, scoliosis (curvature of the spine) and sometimes, breathing difficulties. * ...does not affect life expectancy, but can, in rare instances, cause severe disability. * ...has no cure, although physical therapy, occupational therapy and moderate physical activity are beneficial. * ...is sometimes surgically treated. * ...is usually inherited in an autosomal dominant pattern, which means if one parent has CMT there is a 50/50 chance of each child inheriting the disorder. * ...may become worse if certain neurotoxic drugs are taken. * ...can vary greatly in severity, even within the same family. * ...can now be diagnosed by a blood test (CMT types: 1A, 1B, 1C, 1D, 1E, 1F, 1X, 2A, 2B, 2E, 2F, 2I, 2J, 2K, 4A, 4C, 4E, 4F, 4J, HNPP, CHN, and DSN).

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• SciCrunch
• 17 years ago - by Anonymous

BrainWeb provides information and links to validated sites about brain diseases and disorders. These include outside resources reviewed by scientific advisers, as well as articles in Dana publications. Sites listed in BrainWeb detail common brain diseases and disorders, and include general neuroscience and health resources. They offer descriptions of conditions, frequently asked questions, organization contacts, and sources for more information. BrainWeb and its links are suitable for lay readers, including students and educators, as well as people with brain disorders, their families, and caregivers.

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• SciCrunch
• 14 years ago - by Anonymous

STRFPak is a Matlab toolbox for estimating the linear and nonlinear stimulus-response mapping function of sensory systems. This mapping function is commonly called the spatio- or spectro-temporal receptive field (STRF). A quantitative estimate of the STRF can be used in subsequent computational modeling studies or to predict future responses of the system. STRFPak implements several general STRF estimation techniques and can be used with any stimuli (including natural scenes and sounds). The theoretical basis for STRF estimation has been known for some time, but estimation software has not been widely available. This project aims to develop appropriate software and make it available to the wider community of sensory neuroscientists. Although STRFPak is based on established methods it incorporates two important innovations. First, STRFPak can be used to characterize a sensory system from its response to arbitrary stimuli including natural signals (e.g., vocalizations, natural scenes). Second, STRFPak incorporates several methods for estimating nonlinear STRFs. STRFPak also includes tutorial examples and documentation.

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• SciCrunch
• 17 years ago - by Anonymous

George Washington University is a pioneer in the field of pharmacogenomics offering the only Bachelor''s degree program in the country. Students are admitted into this full-time program in their Junior year. The program strives to educate a new generation of health science graduates who are acutely aware of the interface between human genetic variability and drug action. Our mission is to offer a world-class education to students and equip future pharmacists, scientists, physicians, policy makers and health care professionals with concrete knowledge and unparalleled experience in pharmacogenomics. Our graduates play integral roles in the resolution of the scientific, policy and ethical issues surrounding personalized medicine. The program will uniquely prepare individuals for a variety of positions in the biopharmaceutical industry and allied health professions as well as continued advanced education in health policy, medicine, pharmacological/genomic research and pharmacy.

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• SciCrunch
• 17 years ago - by Anonymous

A professional organization focused on advancing neurosurgery by providing members with the educational and career development opportunities. They have an annual meeting and offer CME opportunities. The Congress of Neurological Surgeons seeks to improve the quality of healthcare through: * The development of educational programs that convey knowledge, enhance self-directed learning and improve patient outcomes. * Advancing the science of medical education. * Promoting original inquiry and the exchange of clinical and scientific evidence. * Public advocacy for the enhancement of quality, safety and access to neurosurgical care. The Congress of Neurological Surgeons seeks to advance the profession of neurosurgery through: * Refining neurosurgical practice based on evidence. * Promoting volunteerism and leadership development within our specialty. * Development of programs to promote safety, quality and efficiency in practice for domestic and international members.

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• SciCrunch
• 17 years ago - by Anonymous

A computational hosting resource which assissts with lab organization by splitting functions into four modules. “Order requests” is a module where users can view and track order requests. The module “Inventory” allows users to track commercial and lab-made products. “Documents” allows users to organize and share protocols and other documents. “Equipment sign-up” allows users to manage shared equipment. An active help system, video guides, and 1-on-1 demos are available for assistance when setting up.

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• SciCrunch
• 16 years ago - by Anonymous

This is a blog about post genomic knowledge. The website''s goal is to make public datasets from the bioinformatics community available in RDF format via standard SPARQL endpoints.

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• SciCrunch
• 17 years ago - by Anonymous

Resources and tools from a project to automatically extract useful information from texts written by scientists to help overcome the problems caused by information overload. The primary annotated resource created is the GENIA corpus, a collection of biomedical literature which consists of multiple layers of annotation, encompassing both syntactic and semantic annotation. The project also created or coordinated the annotation of multiple other corpus resources. Additionally, a rich set of automatic tools are available for various annotation tasks, most trained on various parts of the GENIA corpus annotations. The GENIA corpus was developed to provide a reference material for the development of bio-TM systems. The corpus currently contains 1,999 Medline abstracts which were collected using the three MeSH terms, human, blood cells, and transcription factors. The corpus has been annotated with various levels of linguistic and semantic information. The GENIA corpus includes the following: * POS annotation * Treebank * Coreference Annotation * Term annotation * Event annotation * Relation annotation * Cellular localization * Disease-Gene association * Pathway corpus The GENIA Project initiated the BioNLP Shared Task series and has organized a number of tasks in three different shared task events, many using resources based on GENIA Corpus annotations. Tools include: * XConc suite: a collection of XML-based tools which are integrated to support the corpus development and annotation.

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• SciCrunch
• 17 years ago - by Anonymous

Gene Expression Atlas is a semantically enriched database of meta-analysis based summary statistics over a curated subset of ArrayExpress Archive, servicing queries for condition-specific gene expression patterns as well as broader exploratory searches for biologically interesting genes/samples. The EBI Gene Expression Atlas Blog discusses ideas, features and problems of creating a large scale meta-analytical atlas of gene expression from publicly available microarray data. Atlas REST API provides all the results available in the main web application in a pragmatic, easy to use form - simple HTTP GET queries as input and either JSON or XML formats as output. Gene Expression Atlas goals: 1. Provision of a statistically robust framework for integration of gene expression experiment results across different platforms at a meta-analytical level 2. A simple interface for identifying strong differential expression candidate genes in conditions of interest 3. Integration of ontologies for high quality annotation of gene and sample attributes 4. Construction of new gene expression summarized views, with a view to analysis of putative signaling pathway targets, discovery of correlated gene expression patterns and the identification of condition/tissue-specific patterns of gene expression.

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• SciCrunch
• 17 years ago - by Anonymous

The Wisconsin Primate Research Center supports one of the largest colonies of common marmosets (Callithrix jacchus) in the United States. Through the Callicam, anyone with web access can observe one of the WPRC''s common marmoset families. The Callicam webcam allows site visitors to pan, zoom, and manipulate the camera themselves for two minutes at a time. Accompanying links to comprehensive information about the species along with sample exercises for use with the Callicam provide the opportunity to learn about this engaging primate while observing it live online.

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• SciCrunch
• 17 years ago - by Anonymous

The UK Crop Plant Bioinformatics Network (UK CropNet) was established in 1996 as part of the BBSRC''s Plant and Animal Genome Analysis special initiative. Our focus is the development, management, and distribution of information relating to comparative mapping and genome research in crop plants. Find out more about our background or read our UK CropNet paper published in Nucleic Acids Research (pdf reader required).This site hosts a wide range of databases and software developed by UK CropNet, as well as hosting many other plant databases developed in the USA. You can perform a keyword text search across all of these databases or use our UK CropNet BLAST server to search against all of the sequences in these databases.

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• SciCrunch
• 17 years ago - by Anonymous

The Center for Neuroscience at the University of Pittsburgh oversees all neuroscience-related activities on the Pitt campus. CNUP is a multidisciplinary center with members whose primary appointments are in 16 different departments. Their research interests span the breadth of neuroscience, and a number of concentration areas involve diverse groups of scientists. CNUP has a sense of community highlighted by interactive and collaborative aspects in many of our research programs.

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• SciCrunch
• 17 years ago - by Anonymous

The Department of Neuroscience in the School of Arts and Sciences at the University of Pittsburgh provides outstanding undergraduate and graduate education with innovative independent and collaborative research, a well-rounded curriculum, and a seminar series by the world''s most renowned leaders in the field of neuroscience. The Department has become successful and prominent based on the determination, energy, imagination, and skills of its faculty as investigators and as mentors, and on the support of the institution and the funding agencies. Consequently, morale is high and so is our optimism that we will continue to develop and maintain a world-class department.

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• SciCrunch
• 17 years ago - by Anonymous

Pharmacology and Physiology are scientific fields directed toward understanding the molecular, cellular and organ systems that are essential to life itself as well as their alteration by the actions of exogenous agents. Our understanding of these systems is the essential basis for rational clinical diagnosis, treatment of disease and our knowledge of how drugs and toxic agents exert their effects in humans. The interests of the department faculty members cover a broad range of research topics and experimental approaches.

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• SciCrunch
• 17 years ago - by Anonymous

The Department of Neurosciences is composed of 33 ladder-rank faculty members, 23 research and project scientists, and 27 faculty who hold adjunct and joint appointments. Additionally, there are 61 individuals outside the university who participate in our clinical teaching programs. We are proud that Neurosciences at UCSD ranks first out of 90 competitors in overall NIH grant funding. The Department of Neurosciences also supports adult and pediatric residency training programs in neurology utilizing clinical facilities at the UCSD Medical Centers in Hillcrest and La Jolla, VA San Diego Medical Center, and Rady Children''s Hospital of San Diego. Areas of particular interest include the diagnosis, management, and research of neurodegenerative diseases (in particular Alzheimer''s disease and Parkinson''s disease), stroke, epilepsy, neuromuscular disorders, metabolic disorders, and neuro-developmental disorders, including autism. The Department maintains close ties with its neighboring institutions, including the Salk Institute, Scripps Research Institute, and Burnham Institute. The La Jolla Mesa has the greatest concentration of neuroscientists of any single area in the United States .

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• SciCrunch
• 17 years ago - by Anonymous

The Department of Neurobiologys doctoral program provides a strong theoretical and practical foundation in the area of cellular and systems neurobiology with the goal of developing a better understanding of nervous system function and behavior. The graduate program has three major aims to provide basic and advanced instruction in the fundamentals of neurobiology, advanced independent research training in the areas of cellular, structural and systems neurobiology, and teaching experience in undergraduate and professional (dental and medical) courses in neuroscience. The educational program consists of a core series of courses that provide fundamental training in neurobiology. Course subject matter is focused on molecular, cellular, structural, systems and regulatory neurobiology. Advanced topic seminar courses provide training in synaptic and neuronal communication, neuronal plasticity, neuroanatomy, learning and memory, neuroendocrinology, developmental neurobiology, sensory and motor systems, and integrative neurobiology. The educational program is also distinguished by the availability of seminars and journal clubs that provide students with the opportunity for discussion and presentation of contemporary neuroscience literature.

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• SciCrunch
• 17 years ago - by Anonymous

The Department of Neurobiology and Developmental Sciences is structured around three divisions originally intended as academic entities designed to facilitate and support the growth and development of faculty with common interests. Ideally, this will continue to foster the development of programmatic, interdisciplinary funding which would benefit both young and established faculty. The Divisions also provide leadership opportunities for Senior faculty, as they help the Chair with faculty development. In essence, the divisions are sites for mentoring of faculty who need training and skills in specific areas. Many faculty participate in multiple divisions, depending on their needs, interests, and expertise. The three divisions include the Division of Anatomical Education, the Division of Translational Neuroscience, and the Division of Cellular and Molecular Neuroscience.

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• SciCrunch
• 17 years ago - by Anonymous

A database of S. cerevisiae H/ACA and C/D box snoRNAs, useful for research on rRNA nucleotide modifications in the ribosome, especially those created by small nucleolar RNA:protein complexes (snoRNPs). The interactive service enables a user to visualize the positions of pseudouridines, 2'-O-methylations, and base methylations in three-dimensional space in the ribosome and also in linear and secondary structure formats of ribosomal RNA. The tools provide additional perspective on where the modifications occur relative to functional regions within the rRNA and relative to other nearby modifications. This package of tools is presented as a major enhancement of an existing but significantly upgraded yeast snoRNA database. The other key features of the enhanced database include details of the base pairing of snoRNAs with target RNAs, genomic organization of the yeast snoRNA genes, and information on corresponding snoRNAs and modifications in other model organisms.

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• SciCrunch
• 17 years ago - by Anonymous

Public university in the Brazilian state of São Paulo. It is the largest Brazilian public university.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

The Department of Neuroscience is located in the School of Medicine at the University of Pennsylvania. Founded in 1992 to recognize the growing importance of neuroscience as a scientific discipline, the Department laboratories pursue a wide variety of research interests reflecting the entire range of modern neuroscience. The Department lies at the heart of the campus-wide Mahoney Institute of Neurological Sciences, the first research organization to receive NIH funding for training in the neurosciences.

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• SciCrunch
• 17 years ago - by Anonymous