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The University of North Carolina at Chapel Hill, also known as UNC-Chapel Hill, Chapel Hill, North Carolina, or simply Carolina is a public research university in Chapel Hill, North Carolina. It is the flagship of the 17 campuses of the University of North Carolina system.

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• SciCrunch
• 16 years ago - submitted by Stephen Larson

A Python package intended to ease statistical learning analyses of large datasets. It offers an extensible framework with a high-level interface to a broad range of algorithms for classification, regression, feature selection, data import and export. While it is not limited to the neuroimaging domain, it is eminently suited for such datasets. PyMVPA is truly free software (in every respect) and additionally requires nothing but free-software to run. Decoding patterns of neural activity onto cognitive states is one of the central goals of functional brain imaging. Standard univariate fMRI analysis methods, which correlate cognitive and perceptual function with the blood oxygenation-level dependent (BOLD) signal, have proven successful in identifying anatomical regions based on signal increases during cognitive and perceptual tasks. Recently, researchers have begun to explore new multivariate techniques that have proven to be more flexible, more reliable, and more sensitive than standard univariate analysis. Drawing on the field of statistical learning theory, these new classifier-based analysis techniques possess explanatory power that could provide new insights into the functional properties of the brain. However, unlike the wealth of software packages for univariate analyses, there are few packages that facilitate multivariate pattern classification analyses of fMRI data. This Python-based, cross-platform, open-source software toolbox software toolbox for the application of classifier-based analysis techniques to fMRI datasets makes use of Python's ability to access libraries written in a large variety of programming languages and computing environments to interface with the wealth of existing machine learning packages.

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• SciCrunch
• 15 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 4th,2023. This Week in Microbiology (TWiM) is a new podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows ''This Week in Virology'' (TWiV) and ''This Week in Parasitism'' (TWiP), Racaniello and guests produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background. As a science Professor at Columbia University, Racaniello has spent his academic career directing a research laboratory focused on viruses. His enthusiasm for teaching inspired him to reach beyond the classroom using new media. TWiM is for everyone who wants to learn about the science of microbiology in a casual way. While there are no exams or pop quizzes, TWiM does encourage interaction with the audience via comments on specific episodes, via email and voicemail at 908-312-0760. Listeners can also use MicrobeWorld to suggest topics for the show by submitting articles or papers to the site and tagging them with TWiM. Each week Racaniello will view the tagged content and select items for discussion. Co-hosts on TWiM include Ronald Atlas, Jo Handelsman, Margaret McFall-Ngai, Stanley Maloy, Elio Schaechter, and Michael Schmidt. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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• SciCrunch
• 15 years ago - by Anonymous

This Week in Virology (TWiV) is a podcast - or netcast, as some prefer to call them, since you don''t need an iPod to listen - about viruses - the kind that make you sick. Professors Vincent Racaniello, Dickson Despommier, Rich Condit and science writer Alan Dove and guests deconstruct viruses, how they cause illness, and how you can prevent infections. It was begun in September 2008 by Vincent Racaniello and Dick Despommier, two science Professors at Columbia University Medical Center. Their goal was to have an informal yet informative conversation about viruses which would be accessible to everyone, no matter what their science background. We wanted to eventually bring other virologists into the conversation, to make it more varied and interesting. Alan Dove, a science writer, joined us late in 2008; Rich Condit, a poxvirologist, joined in 2009, and Kathy Spindler, an adenovirologist, joined in 2012. We''ve had quite a few guests on the show and we''re always trying to get more. Transcripts A few readers have been kind enough to produce transcripts for several TWiV episodes.

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• SciCrunch
• 15 years ago - by Anonymous

Web Platform Docs is a new community-driven site that aims to become a comprehensive and authoritative source for web developer documentation. Anyone can contribute and each person who does makes us stronger. Together we can continue to drive innovation on the Web to serve the greater good. WebPlatform project, supported by various stewards between 2012 and 2015, has been discontinued. Static archived version of github is available.

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• SciCrunch
• 15 years ago - by Anonymous

An ontology for sequence annotations and how to preserve them with reference sequences.

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• SciCrunch
• 13 years ago - by Anonymous

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• SciCrunch
• 17 years ago - submitted by Stephen Larson

Service that helps users navigate the research journey, connecting people and information from dissertations to governmental and cultural archives to news, in all its forms. Its role is essential to libraries and other organizations whose missions depend on the delivery of complete, trustworthy information. ProQuest''s massive information pool, built through partnerships with content creators, is navigated through technological innovations that enable users to quickly find just the right information. The ProQuest platform moves beyond navigation to empower researchers to use, create, and share contentaccelerating research productivity. The Summon web-scale discovery service is a boon to academic libraries worldwide. ProQuest expanded into corporate and government markets, with the ProQuest Dialog service and acquiring Congressional Information Services and University Publications of America. It acquired ebrary, expanding ProQuest''s content base to include e-books and adding to the technology expertise resident across the enterprise, which also includes such units as Serials Solutions, RefWorks-COS, and Bowker.

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• SciCrunch
• 15 years ago - by Anonymous

The John Templeton Foundation serves as a philanthropic catalyst for discoveries relating to the Big Questions of human purpose and ultimate reality. We support research on subjects ranging from complexity, evolution, and infinity to creativity, forgiveness, love, and free will. We encourage civil, informed dialogue among scientists, philosophers, and theologians and between such experts and the public at large, for the purposes of definitional clarity and new insights. Our vision is derived from the late Sir John Templeton''s optimism about the possibility of acquiring new spiritual information and from his commitment to rigorous scientific research and related scholarship. The Foundation''s motto, How little we know, how eager to learn, exemplifies our support for open-minded inquiry and our hope for advancing human progress through breakthrough discoveries. Our Core Funding Areas cover the full range of the Foundation''s activities and grantmaking. Science and the Big Questions is the largest of these Core Funding Areas and is further divided into several subfields. The descriptions and illustrative grants attached to the Core Funding Areas are not meant to be exhaustive, but they should give potential applicants a general understanding of the sorts of activities that the Foundation does and does not fund. Core Funding Areas: * Science and the Big Questions ** Mathematical and Physical Sciences ** Life Sciences ** Human Sciences ** Philosophy and Theology ** Science in Dialogue * Character Development * Freedom and Free Enterprise * Exceptional Cognitive Talent and Genius * Genetics

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• SciCrunch
• 15 years ago - by Anonymous

XSEDE is a single virtual system that scientists can use to interactively share computing resources, data and expertise. People around the world use these resources and services things like supercomputers, collections of data and new tools to improve our planet. XSEDE resources may be broadly categorized as follows: High Performance Computing, High Throughput Computing, Visualization, Storage, and Data Services. Many resources provide overlapping functionality across categories. Scientists, engineers, social scientists, and humanists around the world - many of them at colleges and universities - use advanced digital resources and services every day. Things like supercomputers, collections of data, and new tools are critical to the success of those researchers, who use them to make our lives healthier, safer, and better. XSEDE integrates these resources and services, makes them easier to use, and helps more people use them. XSEDE supports 16 supercomputers and high-end visualization and data analysis resources across the country. Digital services, meanwhile, provide users with seamless integration to NSF''s high-performance computing and data resources. XSEDE''s integrated, comprehensive suite of advanced digital services will federate with other high-end facilities and with campus-based resources, serving as the foundation for a national cyberinfrastructure ecosystem. Common authentication and trust mechanisms, global namespace and filesystems, remote job submission and monitoring, and file transfer services are examples of XSEDE''s advanced digital services. XSEDE''s standards-based architecture allows open development for future digital services and enhancements. XSEDE also provides the expertise to ensure that researchers can make the most of the supercomputers and tools.

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• SciCrunch
• 15 years ago - by Anonymous

Software toolbox to facilitate quick and easy import, visualization and measurement for Event Related Potential (ERP) data. The toolbox can open and visualise ERP averaged data (Neuroscan, ascii formats), 2D/3D electrode coordinates and 3D cerebral tissue tesselations (meshes). All the features can be explored quickly and easily using the example data provided in the toolbox. The GUI interface is simple and intuitive.

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• SciCrunch
• 17 years ago - by Anonymous

MIALAB, headed by Dr. Vince Calhoun, focuses on developing and optimizing methods and software for quantitative analysis of structure and function in medical images with particular focus on the study of psychiatric illness. We work with many types of data, including functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), electroencephalography (EEG), structural imaging and genetic data. Much of our time is spent working on new methods for flexible analysis of brain imaging data. The use of data driven approaches is very useful for extracting potentially unpredictable patterns within these data. However such methods can be further improved by incorporating additional prior information as constraints, in order to benefit from what we know. To this end, we draw heavily from the areas of image processing, adaptive signal processing, estimation theory, neural networks, statistical signal processing, and pattern recognition.

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• SciCrunch
• 15 years ago - by Anonymous

The Hereditary Disease Foundation (HDF) aims to cure genetic illness by supporting basic biomedical research. The HDF was started by Dr. Milton Wexler in 1968 when his wife was diagnosed with Huntington''s disease (HD). The Foundation uses a variety of strategies - workshops, grants, fellowships, and targeted research contracts - to solve the mysteries of genetic disease and develop new treatments and cures. Huntington''s disease is a fatal, dominantly inherited, genetic, neurological disorder causing involuntary movements, severe emotional disturbance and progressive cognitive loss over ten to twenty years. Each child of an affected parent has a 50% risk of inheriting HD, usually in the third or fourth decade of life, though children as young as two years and adults in their eighties may also develop symptoms. The Hereditary Disease Foundation uses Huntington''s disease as a model for hereditary disease research because it is triggered by a mutation of one single gene. Progress toward treatment or a cure could be instrumental in finding ways to treat other illnesses with more complex genetics, including Parkinson''s, Alzheimer''s, Lou Gehrig''s disease (ALS), depression, schizophrenia, and cancer. The Hereditary Disease Foundation has given over $50 million to support pioneering research in genetics, gene therapy, molecular and cell biology, cell survival and death, animal models, neurophysiology, neuropharmacology and other areas relevant to understanding inherited diseases. * Milton Wexler Workshop Program: A centerpiece of the Foundation is the interdisciplinary Workshop Program which sponsors Workshops held many times during the year. Milton Wexler began the Program to bring scientists together from different academic disciplines to brainstorm - without prepared lectures or slides - and explore new directions for research. They often share unpublished data. * Funding Opportunities ** The Basic Research Grants Program supports projects that contribute to identifying and understanding the fundamental defects in Huntington''s disease and related disorders. ** The John J. Wasmuth Postdoctoral Fellowships are named in honor of the late John Jacob Wasmuth, an essential member of the Huntington''s Disease Collaborative Research Group. Our hope is that those granted fellowships bearing his name will seek John''s level of imagination, rigor, creativity and spirit. ** The Lieberman Award is presented annually to a worthy scientist, thanks to the generosity of Harry Lieberman, a trustee of the Hereditary Disease Foundation. ** The Milton Wexler Postdoctoral Fellowship Award is named after the founder of the Hereditary Disease Foundation. The Hereditary Disease Foundation restricts this annual award to research highly relevant to curing Huntington''s disease. * Giving to the Hereditary Disease Foundation - Donations are accepted by check, credit card, etc.

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• SciCrunch
• 15 years ago - by Anonymous

A primary clinical trial registry which houses proposed, ongoing, and completed clinical research studies. An ISRCTN is a simple numeric system for the unique identification of randomized controlled trials worldwide. The registry provides content validation and curation and the unique identification number necessary for publication. Submitted studies range from cancer to urological diseases.

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• SciCrunch
• 15 years ago - by Anonymous

Software program for phylogenetic analyses of large datasets under maximum likelihood.

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• SciCrunch
• 13 years ago - by Anonymous

A free, open source authoring and publishing platform that is designed to make it easy for authors to write long-form, born-digital scholarship online. Scalar enables users to assemble media from multiple sources and juxtapose them with their own writing in a variety of ways, with minimal technical expertise required. This semantic web authoring tool brings a considered balance between standardization and structural flexibility to all kinds of material including a built-in reading interface as well as an API that enables Scalar content to be used to drive custom-designed applications. Scalar also gives authors tools to structure essay- and book-length works in ways that take advantage of the unique capabilities of digital writing, including nested, recursive, and non-linear formats. The platform also supports collaborative authoring and reader commentary.

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• SciCrunch
• 15 years ago - by Anonymous

Videos from the National Center for Biotechnology Information including presentations and tutorials about NCBI biomolecular and biomedical literature databases and tools.

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• SciCrunch
• 15 years ago - by Anonymous

nature.com blogs is the new home for blogs written by Nature Publishing Group editors, staff and occasional guest bloggers. If you''re looking for the nature.com blogs catalogue of science blogs, this has been temporarily taken offline. In the meantime, the data in the catalogue is still accessible via the blogs API. If you''d like to submit your blog to the catalogue or suggest someone else''s, please email blogs (at) nature.com All nature.com blogs * Nature News Blog * Of Schemes and Memes Blog * Spoonful of Medicine * The Sceptical Chymist * Nature Jobs Blog * Trade Secrets * Stepwise * Soapbox Science * London Blog * Boston Blog * New York Blog * House of Wisdom * Indigenus * Methagora * Action Potential * Free Association * The Seven Stones Archived blogs * Climate Feedback * In The Field * Inherently Responsive * Nascent * Nature''s Journal Club * Nautilus * Peer-to-Peer * The Niche

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• SciCrunch
• 15 years ago - by Anonymous

ZiFDB is a database of zinc finger arrays and zinc finger proteins organized for use by molecular biologists. ZiFDB organizes information on both individual zinc finger modules and engineered ZFAs. There are currently four sets of zinc finger modules available: 1) Sangamo BioScience researchers have identified fingers recognizing all 5''-GNN-3'' and a few of 5''-ANN-3'', 5''-CNN-3'' and 5''-TNN-3'' triplets using phage display, targeted mutagenesis and SELECT methods (Liu et al., 2002); 2) the Barbas group constructed another set of models, which recognize all 5''-GNN-3'', most 5''-ANN-3'', 5''-CNN-3'' and a few 5''-TNN-3'' triplets (Dreier et al., 2001; Dreier et al., 2005; Dreier et al., 2000;); 3) Toolgen, Inc. isolated a set of naturally-occurring zinc finger modules from human transcription factors (Bae et al., 2003); 4) the Joung lab has made a large number of ZFAs by OPEN, and the constituent zinc fingers are included in the database. For the engineered ZFAs, we have collected information on 3-finger ZFAs, since this is the architecture advocated by the Zinc Finger Consortium (http://www.zincfingers.org), a group of academic laboratories dedicated to the development of improved methods to engineer zinc finger proteins. Currently, all ZFAs in ZiFDB are described in the published literature. In the future, unpublished ZFAs will also be included. It is hoped that the information in this database will help molecular biologists develop zinc finger reagents that meet their needs for genome modification. Further, we hope the analysis of the collected information will aid in improving modular design.

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• SciCrunch
• 17 years ago - by Anonymous

The Foundation is dedicated to advancing environmental conservation, scientific research, and patient care, as well as helping to improve quality of life in the San Francisco Bay Area--Gordon and Betty Moore''s home for more than 70 years. The Foundation is devoted to the inspirational vision articulated by our founders: creating positive outcomes for future generations. This vision guides our mission: to achieve significant, lasting and measurable results in environmental conservation, science, patient care, and the San Francisco Bay Area. A set of core valuesimpact, integrity, disciplined approach, and collaborationdirects our work. The Foundation carries out its work through the following frameworks: * Programs. The enduring management unit designed to achieve transformational change in a selected field of interest through a portfolio of integrated interventions. * Initiatives. Initiatives are built around well-developed strategies for concentrated investments, focused on the long-term and achieving significant impact. Initiatives are characterized by a portfolio approach to grantmaking, and other engagements of the Foundation, to pursue ambitious, large-scale outcomes. * Program grants. The Foundation devotes some of its grantmaking to experimentation, focused innovation, and agile response to time-sensitive, high-impact opportunities in its areas of focus. Across all initiatives and program grants, the Foundation''s grantees and partners seek to make positive changes in the world. The Foundation''s headquarters are in Palo Alto, in a building renovated with an emphasis on the environment and sustainability.

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• SciCrunch
• 15 years ago - by Anonymous