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The Center for Neuroscience at the University of Pittsburgh oversees all neuroscience-related activities on the Pitt campus. CNUP is a multidisciplinary center with members whose primary appointments are in 16 different departments. Their research interests span the breadth of neuroscience, and a number of concentration areas involve diverse groups of scientists. CNUP has a sense of community highlighted by interactive and collaborative aspects in many of our research programs.

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• SciCrunch
• 17 years ago - by Anonymous

The Department of Neuroscience in the School of Arts and Sciences at the University of Pittsburgh provides outstanding undergraduate and graduate education with innovative independent and collaborative research, a well-rounded curriculum, and a seminar series by the world''s most renowned leaders in the field of neuroscience. The Department has become successful and prominent based on the determination, energy, imagination, and skills of its faculty as investigators and as mentors, and on the support of the institution and the funding agencies. Consequently, morale is high and so is our optimism that we will continue to develop and maintain a world-class department.

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• SciCrunch
• 17 years ago - by Anonymous

Pharmacology and Physiology are scientific fields directed toward understanding the molecular, cellular and organ systems that are essential to life itself as well as their alteration by the actions of exogenous agents. Our understanding of these systems is the essential basis for rational clinical diagnosis, treatment of disease and our knowledge of how drugs and toxic agents exert their effects in humans. The interests of the department faculty members cover a broad range of research topics and experimental approaches.

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• SciCrunch
• 17 years ago - by Anonymous

The Department of Neurosciences is composed of 33 ladder-rank faculty members, 23 research and project scientists, and 27 faculty who hold adjunct and joint appointments. Additionally, there are 61 individuals outside the university who participate in our clinical teaching programs. We are proud that Neurosciences at UCSD ranks first out of 90 competitors in overall NIH grant funding. The Department of Neurosciences also supports adult and pediatric residency training programs in neurology utilizing clinical facilities at the UCSD Medical Centers in Hillcrest and La Jolla, VA San Diego Medical Center, and Rady Children''s Hospital of San Diego. Areas of particular interest include the diagnosis, management, and research of neurodegenerative diseases (in particular Alzheimer''s disease and Parkinson''s disease), stroke, epilepsy, neuromuscular disorders, metabolic disorders, and neuro-developmental disorders, including autism. The Department maintains close ties with its neighboring institutions, including the Salk Institute, Scripps Research Institute, and Burnham Institute. The La Jolla Mesa has the greatest concentration of neuroscientists of any single area in the United States .

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• SciCrunch
• 17 years ago - by Anonymous

The Department of Neurobiologys doctoral program provides a strong theoretical and practical foundation in the area of cellular and systems neurobiology with the goal of developing a better understanding of nervous system function and behavior. The graduate program has three major aims to provide basic and advanced instruction in the fundamentals of neurobiology, advanced independent research training in the areas of cellular, structural and systems neurobiology, and teaching experience in undergraduate and professional (dental and medical) courses in neuroscience. The educational program consists of a core series of courses that provide fundamental training in neurobiology. Course subject matter is focused on molecular, cellular, structural, systems and regulatory neurobiology. Advanced topic seminar courses provide training in synaptic and neuronal communication, neuronal plasticity, neuroanatomy, learning and memory, neuroendocrinology, developmental neurobiology, sensory and motor systems, and integrative neurobiology. The educational program is also distinguished by the availability of seminars and journal clubs that provide students with the opportunity for discussion and presentation of contemporary neuroscience literature.

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• SciCrunch
• 17 years ago - by Anonymous

The Department of Neurobiology and Developmental Sciences is structured around three divisions originally intended as academic entities designed to facilitate and support the growth and development of faculty with common interests. Ideally, this will continue to foster the development of programmatic, interdisciplinary funding which would benefit both young and established faculty. The Divisions also provide leadership opportunities for Senior faculty, as they help the Chair with faculty development. In essence, the divisions are sites for mentoring of faculty who need training and skills in specific areas. Many faculty participate in multiple divisions, depending on their needs, interests, and expertise. The three divisions include the Division of Anatomical Education, the Division of Translational Neuroscience, and the Division of Cellular and Molecular Neuroscience.

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• SciCrunch
• 17 years ago - by Anonymous

A database of S. cerevisiae H/ACA and C/D box snoRNAs, useful for research on rRNA nucleotide modifications in the ribosome, especially those created by small nucleolar RNA:protein complexes (snoRNPs). The interactive service enables a user to visualize the positions of pseudouridines, 2'-O-methylations, and base methylations in three-dimensional space in the ribosome and also in linear and secondary structure formats of ribosomal RNA. The tools provide additional perspective on where the modifications occur relative to functional regions within the rRNA and relative to other nearby modifications. This package of tools is presented as a major enhancement of an existing but significantly upgraded yeast snoRNA database. The other key features of the enhanced database include details of the base pairing of snoRNAs with target RNAs, genomic organization of the yeast snoRNA genes, and information on corresponding snoRNAs and modifications in other model organisms.

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• SciCrunch
• 17 years ago - by Anonymous

Public university in the Brazilian state of São Paulo. It is the largest Brazilian public university.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

The Department of Neuroscience is located in the School of Medicine at the University of Pennsylvania. Founded in 1992 to recognize the growing importance of neuroscience as a scientific discipline, the Department laboratories pursue a wide variety of research interests reflecting the entire range of modern neuroscience. The Department lies at the heart of the campus-wide Mahoney Institute of Neurological Sciences, the first research organization to receive NIH funding for training in the neurosciences.

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• SciCrunch
• 17 years ago - by Anonymous

This database contains different yeast strains searchable by ORF and gene name, and serves to support the Yeast Deletion and the Mitochondrial Proteomics Project. The database is hyperlinked with other public databases. The project aims to increase the understanding of mitochondrial function and biogenesis in the context of the cell. In the Deletion Project, strains from the deletion collection were monitored under 9 different media conditions selected for the study of mitochondrial function. 5791 heterozygous diploid and 4706 homozygous diploid deletion strains were monitored in parallel using molecular barcodes on fermentable (YPD, YPDGE) and non-fermentable substrates (YPG, YPE, YPL). The YDPM database contains both the raw data and growth rates calculated for each strain in each media condition. Strains can be searched by ORF or Gene name to access growth measurements and data plots for each strain. Category: Genomics Databases (non-vertebrate) Subcategory: Fungal genome databases Category: Organelle databases Subcategory: Mitochondrial genes and proteins

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 16, 2013. A relational database that contains all the eukaryotic protein-encoding DNA sequences in GenBank. It provides detailed and comprehensive features about both the intron containing and the intron-less genes. In addition to the information found in the GenBank records, which includes properties such as sequence, position, length and description about introns, exons and protein coding regions, Xpro provides annotations on the splice sites motifs and intron phases. Furthermore, Xpro validates intron positions using alignment information between the records sequence and EST sequences found in dbEST. The entries in the XPro are also cross-referenced to SWISS-PROT/TrEMBL and Pfam databases. Unprecedented growth data in GenBank, the primary repository of nucleotide sequences due to the ever increasing number of genome and EST sequencing projects and the poor annotation of exon/intron details required for molecular evolution studies in the primary nucleotide database have made development of Xpro database. It is a specialized database that contains details about genomic features specific to eukaryotic genes and provides various web tools for analyzing/visualizing these features., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on June 08, 2011. The VNTRDB is a database useful for searching common polymorphic tandem repeats or unique tandem repeats in selected bacteria. Additionally, a visualization tool is accompanied with this database to observe sequence differences between bacterial strains and to avoid false positive records result from misestimating copy number and locus length of tandem repeats. Variable number tandem repeats (VNTRs) are one kind of DNA markers that have been widely used in molecular typing of bacteria. For finding potentially polymorphic tandem repeats, more genome sequences of a bacterial species should be compared. Till now, however, only 357 bacterial genome sequences are fully sequenced. Many of these bacterial species merely one strain has been sequenced. Therefore, all fully sequenced bacteria of a same genus are usually compared together to find the polymorphic potency of tandem repeats. It means that the more bacteria or sequences are compared, the more polymorphic tandem repeats will be truly identified. Here, a variable number tandem repeat locus database (VNTRDB) was constructed to microbiologists to meet the requirements of epidemiological studies. All potentially polymorphic tandem repeats in this database are found by comparing homologous tandem repeat loci between different bacteria of a same genus or among different genera. Currently, we provide two kinds of tandem repeats for query in the VNTRDB, i.e., polymorphic TRs and putatively unique TRs. These two query pages contain their own setting parameters for searching common polymorphic tandem repeats or unique tandem repeats in selected bacteria. This VNTRDB is an open resource and can be freely accessed without any restriction. The data in it will be updated or added continuously when new bacterial genome sequences are fully sequenced. Category: Genomics Databases (non-vertebrate) Subcategory: Prokaryotic genome databases

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• SciCrunch
• 17 years ago - by Anonymous

GenePath is a web-enabled intelligent assistant for the analysis of genetic data and for discovery of genetic networks. GenePath uses abductive inference to elucidate network constraints and logic to derive consistent networks. Typically, it starts with a set of genetic experiments, uses a set of embedded rules (patterns) to infer relations between genes and outcome, and based on these relations constructs a genetic network.

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• SciCrunch
• 17 years ago - by Anonymous

Resource for experimentally validated human and mouse noncoding fragments with gene enhancer activity as assessed in transgenic mice. Most of these noncoding elements were selected for testing based on their extreme conservation in other vertebrates or epigenomic evidence (ChIP-Seq) of putative enhancer marks. Central public database of experimentally validated human and mouse noncoding fragments with gene enhancer activity as assessed in transgenic mice. Users can retrieve elements near single genes of interest, search for enhancers that target reporter gene expression to particular tissue, or download entire collections of enhancers with defined tissue specificity or conservation depth.

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• SciCrunch
• 17 years ago - by Anonymous

This interdisciplinary Neuroscience Program is one division of the Biomedical Sciences Graduate Program at the University of New Mexico. Participating faculty are affiliated with the Department of Neurosciences. Students complete a core curriculum in biomedical sciences and then an individualized program of courses and research in neuroscience. Students may choose among neuroscience research laboratories in the Neurosciences Department or at the Los Alamos National Laboratories. Neuroscience graduate students are part of an active neuroscience group that sponsors weekly seminars and journal clubs.

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• SciCrunch
• 17 years ago - by Anonymous

A database containing predicted viral miRNA candidate hairpins. Users may query the putative miRNA hairpins of a specific viral species by the hierarchical menu or by search function using the GenBank Identifier or RefSeq accession number. In addition, users can also search for the putative target genes of a particular viral miRNA hairpins by a RNAhybrid service link. We have previously identified human intronic microRNA as well as zebrafish microRNA. The microRNA hairpin discovery pipeline was also applied to discover viral encoded microRNAs. All viral genomes were obtain from NCBI. The classification of virus is based on the taxonomy table of NCBI (Jun, 2006). Totally, the genomes of 2266 viruses were analyzed. The 3’-UTR regions of human, mouse, rat, zebrafish, arabidopsis and rice genes are available for search.

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• SciCrunch
• 17 years ago - by Anonymous

A database for icosahedral virus capsid structures. The emphasis of the resource is on providing data from structural and computational analyses on these systems, as well as high quality renderings for visual exploration. Users can find links to the PDB coordinates of virus structures, rendered structural images of viral subunits, capsids, and crystal contacts, as well as find basic information such as family, genus, and number of subunits of different viruses. Viperdb includes powerful search utilities, links to other relevant databases, background information on virus capsid structure, and useful database interface tools. It describes various icosahedral virus capsid structures in the Protein Data Bank (PDB) in terms of their complete capsids, detailed structural and computational analysis. Additionally, all virus capsids are placed in a single icosahedral orientation convention, facilitating comparison between different structures. The protomeric (asymmetric unit) coordinates were transformed and stored in a single icosahedral convention (2(Z)-3-5-(X)2). Coordinates (sometimes) were further processed by rearranging the nucleic acid residues, hetero atoms, and water molecules (if present) at the end of the protein chains for the ease of further analysis. Structures are classified in terms of their quasi-symmetry (e.g. T=3, T=4, T=7) and pseudo-symmetry (e.g., P=3).Tools are being developed to study the capsids in terms of structural, energetic and assembly aspects . The derived results are made available throught this website. The site is being developed as part of the training, service and dissemination component of the NIH Research Resource: Multiscale Modeling Tools for Structural Biology (MMTSB).

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• SciCrunch
• 17 years ago - by Anonymous

An integrated and comprehensive database of virulence factors for bacterial pathogens (also including Chlamydia and Mycoplasma). VFDB is a platform for further study of comparative pathogenomics. Major features include tabular comparison of pathogenomic composition in terms of virulence, multiple alignments and statistic analysis of homologous virulence genes, and graphical comparison of pathogenomic organization of VFs. Category: Genomics Databases (non-vertebrate) Subcategory: Prokaryotic genome databases

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• SciCrunch
• 17 years ago - by Anonymous

This is a database of microsatellite sequences (short tandem repeats useful in gene comparison and kinship studies) present in 80 genomes. Users can search the database by microsatellite type, repeat unit length (mono- to hexa-nucleotide), repeat number, microsatellite length and repeat sequence class. They can also search by specifying EST, cDNA, CDS identity or by using Gene Index, GenBank, UniGene IDs. Microsatellites, also known as simple sequence repeats (SSRs) or simple tandem repeats (STRs), have extensively been exploited as molecular markers for diverse applications including genome characterization and mapping. Recently, their role in gene regulation and genome evolution has also been discussed widely. We have developed UgMicroSatdb (Unigene MicroSatellite database), a web based relational database of microsatellites present in unigene sequences covering 80 genomes. UgMicroSatdb allows microsatellite search using multiple parameters like microsatellite type simple (perfect) and compound (perfect and imperfect), repeat unit length (mono- to hexa-nucleotide), repeat number, microsatellite length and repeat sequence class. Microsatellites can also be retrieved by specifying EST, cDNA, CDS identity or by using Gene Index, GenBank, UniGene IDs. The database also provides information about trinucleotide repeats encoding various amino acids. Such codon repeats can be searched by specifying characteristics of coded amino acids like charge (basic, acidic or neutral), polarity (polar or non-polar) and their hydrophobic or hydrophilic nature. The nucleotide sequences of the target UniGenes are also provided to facilitate primer designing for PCR amplification of any desired microsatellite.

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• SciCrunch
• 17 years ago - by Anonymous

A Biological Proteome KnowledgeBase linking IPI and SPTR-NR based Proteome analyses with TranScout, TransMem and ProtLoc and offering crosslinks with other relevant information from worldwide highly acknowledged biodatabases such as SWISS-PROT, NCBI Refseq, Ensembl, InterPro or Gene Ontology Annotation. TrSDB is a BioDB (Biological Relational DataBase) that through the same web interface joins several predictive analyses of protein motifs, domains, cellular localization and functional annotation around different compiled sequences, now IPI and SPTR Non-Redundant proteomes.TranScout, TransMem and ProtLoc predictions with crosslinks to InterPro, Gene Ontology Annotation, ENSEMBL, SWISS-PROT/TREMBL, REFSEQ and inter and intraspecies precomputed BLAST Analyses are provided when suitable for each proteome entry. By now, nine eukaryotic organisms proteomes (human, mouse, rat fruit fly, worm, Arabidopis, an alga and two yeasts) may be queried. Periodically compiled proteomes will be updated all at the same time to mantain temporal coherency and new analyses will be provided as well.When one organism has been selected, a funny icon in the upper-right part of the web screen may help you to remind your organism selection.Emphasis is placed upon Transcription Factor prediction supported by TranScout. Complex analyses are performed searching for Transcription Factor evidence from TranScout and InterPro matches as well as existing GO annotation. Mutual transcription factor evidence among homologues is also considered and compiled analyses files are available.

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• SciCrunch
• 17 years ago - by Anonymous