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This demonstration application illustrates how Hierarchical Temporal Memory (HTM) can be applied to video recognition. The HTM network in this demo has been trained to locate people in surveillance video footage. You can see how the HTM operates by experimenting with the sample videos that are bundled with this application. For each video, the application will process it in real time on your machine and track the locations of people and other moving objects, while correctly discriminating between the two. This demonstration application, called Vision4, gives a sense of how Hierarchical Temporal Memory (HTM) performs in recognizing objects in static images. Sponsor. Numenta has fewer than twenty employees and has been privately funded by its founders, board members, and close associates.

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• 17 years ago - by Anonymous

Core facility that provides the following services: Magnetic resonance spectrometer training service, Magnetic Resonance Instrument Access. Welcome to the Magnetic Resonance Facility of the Department of Chemistry and Chemical Biology, Harvard University, in the Laukien-Purcell Instrumentation Center.

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• 13 years ago - by Anonymous

His research interests cover many different questions in population genetics and molecular evolution. He considers himself an evolutionary geneticist, with strengths in computational biology and stochastic models. He has worked on frequency-dependent selection models, spatial genetic models, indel evolution models, sequence alignment, and phylogenetic models. His current research involves estimating indel rates and length distributions, applying population genetic models to phylogeny reconstruction, and finding de novo mutations and SNPs from next-gen sequencing of human genomes. In addition to running De Rerum Natura, Reed also manages the largest group blog on evolution, The Pandas Thumb. In addition he develops plugins and hacks for the Movable Type blogging software. He is an expert on dispatching MT under FastCGI and Lighttpd, as well as integrating it with jQuery. He was editor and designer of The Open Laboratory: The Best Science Writing on Blogs 2007. He is co-creator of Prof. Steve Steve. Partners. Movable Type Site Meter Melody Lulu

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Daylight provides enterprise-level cheminformatics software technologies to life science companies. Our superior chemistry, high performance, and open architecture have earned Daylight a reputation for delivering the state-of-the-art in chemical information processing since 1987. Daylight Chemical Information Systems, Inc. is a privately held company with corporate offices in Aliso Viejo, CA and research offices in Santa Fe, NM and Cambridge, England. Support At Daylight, support means a wide array of services that are designed to empower users to make the most of Daylight software. We offer detailed administration documentation and guides through this website. Our User Group Meetings allow in-depth exploration of our technology. And, of course, our support staff is available to assist you whenever the need occurs. Download - Downloading current releases as well as contributed code, system requirements, installation directions, and release information Reference Guides - List of available documentation such as programming guides and user manuals. Cheminformatics - List of additional general resources including introductory materials, theory manual, tutorials and user meeting archives. Sponsor. Daylight

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• 17 years ago - by Anonymous

EH is a program to test and estimate linkage disequilibrium between different markers or between a disease locus and markers. This is an updated version in which the previous disease (case-control) option has been deleted (but see below how to work with case-control data). The program is written in Free Pascal, which is compatible with (but mch more flexible than) Turbo Pascal. Free Pascal is available for various platforms, e.g. Windows and Linux. The data are taken to consist of a number of individuals collected at random from a population. Based on these sample data, the EH program estimates allele frequencies for each marker. Haplotype frequencies are estimated with allelic association (H1) and without (H0). The EH program also provides log likelihood, chi-square and the number of degrees of freedom under hypotheses H0 and H1. For more information please refer to Terwilliger and Ott (1994). Notes: For sparse data (relatively few observations with large numbers of alleles), the chi-square approximation to the test statistics used by EH is unreliable. Then, more sophisticated programs are recommended. Another program for estimating haplotype frequencies is SNPHAP. It is very flexible although it is restricted to analyzing bi-allelic markers. Also, PHASE is very useful for estimating haplotype frequencies and for inferring haplotypes to individuals. See Marchini et al. (2006). Files in this package (Windows): EH.PAS: Source code of EH program. EH.EXE: Executable code of EH program, which is compiled with a maximum of 30 alleles per locus, 10 loci, 1000 haplotypes, and 3600 genotype patterns (product of numbers of genotypes at each locus). EH.DAT, EH.OUT, etc: Sample input and output files. Input file The EH program does not require additional programs although you need a Pascal compiler (Free Pascal) to recompile the program when you change program constants. There is one input file whose name the user can determine, for example, EH.DAT (this is the default name). It contains the numbers of alleles for each marker and the observations for each genotype. First line: Number of alleles at the first marker, number of alleles at the second marker, and so on. Assuming you have 2 markers, the first marker has 2 alleles and the second marker has 3, you write 2 3 in the first line. The order of markers in the remainder of the input file is determined by the order of markers you entered in the first line. Subsequent lines: Number of observations for given genotypes. These numbers must be arranged as follows: The number of columns is the number of the possible genotypes at the last locus. Let M be the number of alleles at the last locus, then the number of the possible genotypes equals M(M 1)/2. For example, if the last locus has two alleles, then there are 3 possible genotypes which are 1/1, 1/2 and 2/2. Therefore, in each row there are 3 columns corresponding to the genotypes 1/1, 1/2, 2/2. Similarly, if the last marker has three alleles, then there are 6 columns corresponding to 1/1, 1/2, 2/2, 1/3, 2/3, 3/3. The number of rows is the product of the number of the possible genotypes at the first (N - 1) markers, where N is the total number of markers. That is, no. of rows = L1(L1 1)/2 L2(L2 1)/2 ... Li(Li 1)/2 ..., where Li is the number of alleles at the i-th locus. For example, assume you have 3 loci and the first and the second locus each have 2 alleles, and the third locus has 3 alleles. Thus, there are 6 columns and 9 rows (see example 1 below). However, if the first locus has 3 alleles and the second and third have 2 alleles each, there are 18 rows and 3 columns. The output file from the EH program, EH.OUT by default, contains the estimated haplotype frequencies and their corresponding log likelihoods. Sponsor. supported by the Wellcome Trust, the National Institutes of Health (NIH), The SNP Consortium, the Wolfson Foundation, the Nuffield Trust, and the Engineering and Physical Sciences Research Council. M.S. is supported by NIH grant 1RO1HG/LM02585-01. N.P. is a recipient of a K-01 NIH career-transition award. G.R.A. is supported by NIH National Human Genome Research Institute grant HG02651. E.E. is supported by the California Institute for Telecommunications and Information Technology, Calit2. Computational resources for HAP were provided by Calit2 and National Biomedical Computational Resource grant P41 RR08605 (National Center for Research Resources, NIH).

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• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 4,2025. These centers support existing and newly developed techniques for bioinformatic analysis aimed at obtaining a deeper understanding of the fundamental biology of a specific set of pathogenic organisms, and efforts to counter the threats posed by these pathogens. The mission of the PathogenPortal is to showcase the collective efforts of the BRCs, and to make the efforts of each BRC more accessible. The PathogenPortal''s content is organized by BRC in both the menus at the top of each page, and the categories in the left column of most pages.. As part of the Pathogen Portal, we have established a Scientific Working Group (SWG) comprised of members with deep expertise in a broad range of domains of relevance to the Pathogen Portal. The SWG provides advice about the management and performance of the resource, and about the needs of the scientific community in relation to the resource. Sponsor. Pathogen Portal is a repository linking to four Bioinformatics Resource Centers (BRCs) sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) and maintained by The Virginia Bioinformatics Institute. The BRCs are providing web-based resources to scientific community conducting basic and applied research on organisms considered potential agents of biowarfare or bioterrorism or causing emerging or re-emerging diseases

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• 14 years ago - by Anonymous

It is an independent, not-for-profit product development partnership working to research and develop new and improved treatments for neglected diseases such as leishmaniasis, human African trypanosomiasis, Chagas disease, and malaria. DNDi was founded in 2003 by the Oswaldo Cruz Foundation from Brazil, the Indian Council for Medical Research, the Kenya Medical Research Institute, the Ministry of Health of Malaysia, Frances Pasteur Institute, Mdecins sans Frontires (MSF) and WHO/TDR which acts as a permanent observer to the initiative.

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• 14 years ago - by Anonymous

DNAWorks automates the design of oligonucleotides for gene synthesis by PCR-based methods. The availability of sequences of entire genomes has dramatically increased the number of protein targets, many of which will need to be overexpressed in cells other than the original source of DNA. Gene synthesis often provides a fast and economically efficient approach. The synthetic gene can be optimized for expression and constructed for easy mutational manipulation without regard to the parent genome. DNAWorks accesses a computer program that automates the design of oligonucleotides for gene synthesis. The website provides forms for simple input information, i.e. amino acid sequence of the target protein and melting temperature (needed for the gene assembly) of synthetic oligonucleotides. The program outputs a series of oligonucleotide sequences with codons optimized for expression in an organism of choice. Those oligonucleotides are characterized by highly homogeneous melting temperatures and a minimized tendency for hairpin formation. The approach presented here simplifies the production of proteins from a wide variety of organisms for genomics-based studies.

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• 17 years ago - by Anonymous

Organism supplier which collects Drosophila stocks from laboratories all over the world, maintains them, and provides them to researchers upon request.

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• 14 years ago - by Anonymous

The Lausanne Genomics Technologies Facility (GTF) is a genomic technologies core laboratory serving the Lausanne and Lemanic region research community. It is housed in and administered by the Center for Integrative Genomics. The GTF offers a range of microarrays services, including : providing access to the instrumentation and the consumables that are required for the use of the pre-printed oligonucleotide microarrays available from Affymetrix and Illumina as well as miRNA gene microarrays from Agilent Technologies providing access to and supporting applications using the Illumina Genome Analyzer 2 ultra high throughput DNA sequencing platform providing access to the instrumentation and the consumables that are required for performing quantitative real-time PCR analyses using the Applied Biosystems 7900HT Sequence Detection System. providing bioinformatics support and consultation services at the stages of experimental design, data collection and storage, image analysis and data analysis acting as a center of experience, expertise and training in microarray and quantitative PCR technologies and methodologies. Laboratory space and computer workstations are available to users wanting to perform the experiments and/or analyses in the facility. The GTF also acts as an information clearing house for the user community by providing a forum for the sharing of methods, protocols and experience generated by the GTF and community scientists using microarray and quantitative PCR technology investigating and implementing, when appropriate, microarray-based methods for applications other than gene expression monitoring (e.g. SNP detection) participating in the evaluation of new RNA expression profiling and nucleic hybridization detection technologies as they develop and incorporate the appropriate technologies into the services offered by the facility

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• 17 years ago - by Anonymous

Cytopathology Foundation is a non-profit organization dedicated to the health care for the advancement of art and science of Cytopathology dealing with study of cells for proper disease management especially cancer. Cytopathology is a well established diagnostic sub-specialty of pathology. Instead of using surgically removed tissue to arrive at a diagnosis it attempts to identify diagnostic and prognostic information from dispersed cells obtained by non-invasive or minimally invasive techniques. An example, and its greatest success story thus far, is the role it has played in the battle with cervical cancer. The introduction of the Pap smear has contributed immensely to the early diagnosis and significantly decreased mortality of cervical cancer. Activities of the foundation 1. Support the mission statement in general. 2. Support the editorial and publication expenses of CytoJournal. 3. Future activities may include publication and marketing of cytopathology related literature, to generate funds. 4. Support any other scholarly activities in Cytopathology and related areas.

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• 17 years ago - by Anonymous

Cython is a language that makes writing C extensions for the Python language as easy as Python itself. Cython is based on the well-known Pyrex, but supports more cutting edge functionality and optimizations. The Cython language is very close to the Python language, but Cython additionally supports calling C functions and declaring C types on variables and class attributes. This allows the compiler to generate very efficient C code from Cython code. This makes Cython the ideal language for wrapping external C libraries, and for fast C modules that speed up the execution of Python code. Sponsor. Google and Enthought funded Dag Seljebotn to greatly improve Cython integration with NumPy. Kurt Smith and Danilo Freitas were funded through the Google Summer of Code program to work on improved Fortran and C support respectively.

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• 17 years ago - by Anonymous

An efficient methodology for detecting and delineating gains and losses of chromosomal material in DNA copy-number data.

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• 13 years ago - by Anonymous

The Cystic Fibrosis Foundation has built a dynamic pipeline for the development of more new potential cystic fibrosis (CF) therapies than ever before. To treat a complex disease like CF, therapies must target problems in the airways and the digestive system. In the CF drug development pipeline, there also are promising new therapies designed to rectify the cause of CF a faulty gene and/or its faulty protein product. Cystic fibrosis is an inherited chronic disease that affects the lungs and digestive system of about 30,000 children and adults in the United States (70,000 worldwide). A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that: clogs the lungs and leads to life-threatening lung infections; and obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food. In the 1950s, few children with cystic fibrosis lived to attend elementary school. Today, advances in research and medical treatments have further enhanced and extended life for children and adults with CF. Many people with the disease can now expect to live into their 30s, 40s and beyond.

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• 17 years ago - by Anonymous

In probability theory and statistics, the cumulative distribution function (CDF), or just distribution function, describes the probability that a real-valued random variable X with a given probability distribution will be found at a value less than x. Intuitively, it is the area so far function of the probability distribution. Cumulative distribution functions are also used to specify the distribution of multivariate

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• 17 years ago - by Anonymous

Cryptococcus neoformans is an encapsulated yeast that infects the human host via the respiratory tract where it usually causes an inapparent infection. In the susceptible host, it may disseminate, typically producing a chronic and life-threatening meningitis. The Cryptococcus neoformans serotypes A and D are responsible for the overwhelming majority of pulmonary infections in AIDS patients. Cryptococcus neoformans strain H99 Latest Data Release - May 19, 2004 To date, we have isolated ca. 3750 cDNA clones from Cryptococcus neoformans strain H99 in collaboration with Drs. Juneann Murphy and Dave Dyer at the University of Oklahoma Health Sciences Center''s Department of Microbiology and Immunology in Oklahoma City and Kent Buchanan at the Tulane University Medical School, New Orleans, LA. The Cryptococcus neoformans strain H99 EST''s have been generated by Doris Kupfer, Heather Bell, Sunkyoung So, Yuong Tang, and Jennifer Lewis at the University of Oklahoma''s Advanced Center for Genome Technology, in the Department of Chemistry and Biochemistry. We now have end sequenced all available templates (ca. 7500 reactions) from both ends of the directionally cloned inserts after excision into pBlueScript SK-. . All of our data is available from our ftp site, and we now have added the ability to perform blast searches on this data. A keyword search of a blastx search of GenBank with this data also is available but we have not yet linked this to a unigene database as the number of EST''s sequenced doesn''t warrent this yet.

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• 17 years ago - by Anonymous

This Blast server offers searches against all D. rerio finished and unfinished clones in the Sanger sequencing pipeline. You can now also search the de novo assemblies generated from sequencing of one doubled haploid homozygous individual of each the AB and Tuebingen strain. Both fish were sequenced to ~40x coverage using Illumina GA sequencing technology and the sequences were assembled using Phusion2, resulting in a 1,33 Gb AB and a 1.48 Gb Tuebingen assembly. Due to the short reads and short inserts and no integration of physical or genetic map data, both assemblies are highly fragmented - with an N50 contig size of about 5kb. Mis-assembly errors may also be present in the contigs. Please note these assemblies are independent additions to the assemblies released by the zebrafish genome project and are intended to aid identification of polymorphisms between these two strains. Charity. Genome Research Limited is a charity registered in England with number 1021457

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• 17 years ago - by Anonymous

Criterion Ventures is launching a new venture that will adapt existing financial services and connect them with consumers through affinity groups to address the needs of the cash market of healthcare. Currently, the healthcare industry is dominated by an insurance market. But sitting next to the insurance market is a $300 billion/year cash market for health care. This cash market lacks the rational pricing, products, services and intermediaries needed to deliver health care affordably and in a way that maximizes access. In the end, consumers are not getting the best value per dollar spent. By introducing and bringing to scale innovative products and services, and connecting them to consumers through existing affinity groups whose members are struggling with the impact of the cash portion of healthcare, we will be able to rationalize the market. By creating a rational market we will bring greater value to consumers for their healthcare dollars and increase access to care. The business will draw revenues from four sources: Charging transaction fees to consumers who use our products Charging interest to consumers who take advantage of our lines of credit offerings Interest earned on deposits that we or our partners will hold for consumers Charging management fees to affinity groups for setting up their customized set of products and services. Partners. Thomas H. Cochran, Managing Director, CivilCredit Advisors Catherine (Cathy) Dunham, Director, Access Project Richard Eskow, CEO, Health Knowledge Systems Tim Freundlich, Founder and Managing Principal, Good Capital; Director of Strategic Initiatives, Calvert Foundation Ben Geyerhahn, Principal, Hudson TG Kevin Jones, Founding Principal, Good Capital Claudia Machaver, Consultant Robert Mittman, Founder, Facilitation, Foresight, Strategy Sara Olsen, Founding Partner, SVT Group Mark Rukavina, Executive Director, Access Project Michael Tobman, Principal, Hudson TG Dana Wright, Founder, Take Action, Inc.

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• 17 years ago - by Anonymous

The annual Cosyne meeting provides an inclusive forum for the exchange of experimental and theoretical/computational approaches to problems in systems neuroscience. The first Cosyne meeting, held in 2004 at Cold Spring Harbor Laboratory, drew over 350 participants. Since 2005, the meeting has been held in Salt Lake City, Utah. It has attracted a growing number of participants, from nearly 400 in 2005 to over 500 in 2010. To encourage interdisciplinary interactions, the main meeting is arranged in a single track. A set of invited talks are selected by the Executive Committee, and additional talks and posters are selected by the Program Committee, based on submitted abstracts. Cosyne topics include but are not limited to: neural coding, natural scene statistics, dendritic computation, neural basis of persistent activity, nonlinear receptive field mapping, representations of time and sequence, reward systems, decision-making, synaptic plasticity, map formation and plasticity, population coding, attention, computation with spiking networks. Sponsor. Thanks to the generosity of The Gatsby Charitable Foundation, of Qualcomm Incorporated and of Brain Corporation, up to 40 travel grants will be available to support student and postdoc participation in the main Cosyne meeting.

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• 17 years ago - by Anonymous

DNA Direct was founded in 2005 to address the growing need for genetic expertise and guidance across the healthcare continuum. Genetic technology is rapidly advancing and new associations between common genes and disease are being discovered every day. With more than 2000 molecular diagnostic and genetic tests available today, the impact of genetics has never been greater and is becoming an integral part of medicine and patient care To bring the power of personalized medicine to patients, providers and payors reducing health risks, preventing disease, and better targeting therapies. DNA Direct''s Precision Health Services include: * Utilization Management * Clinical Decision Support Programs * Clinical Management * Online and Telephone Support Resources for Providers and Patients * Lab Network

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• 17 years ago - by Anonymous