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THIS RESOURCE IS NO LONGER IN SERVICE documented on June 4, 2013. Aldente is a tool to identify proteins from peptide mass fingerprinting data. This fast and powerful tool takes advantage of the Hough transform for spectra recalibration and outlier exclusion. The Aldente search form can be used in two modes: for a global view of all the search parameters on one page: click on the section tab All. This global view is useful to have a quick overview before sending the query. to have search parameters grouped into smaller logical sections: click on the corresponding section tab in the tabs banner. Note! Moving from one section to another keeps search parameter selections. For your convenience, you may view / hide the help during your search parameters selection. Use the Help or No help section tab accordingly.

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• SciCrunch
• 17 years ago - by Anonymous

This website is an invitation. an invitation to join scientists and stakeholders in an effort to review the scientific basis of traditional toxicological risk assessment, to provide the toxicological community with the tools it needs to efficiently and transparently judge risks of a diversifying nature and to make toxicology thus fit to meet the challenges of the 21st century. an invitation to participate in the inception and continuous implementation of a new movement in toxicology that aims at adopting an evidence-based approach. an invitation to help bridging the gap between modern toxicological science and risk assessment in order to exploit the wealth of information from new technologies in modern life sciences & toxicological research and to arrive at informed, transparent, judicious and conscientious decisions made on the basis of all evidence available. an invitation to develop a framework that allows combining precious expert insight grown over years of practical experience with structured approaches in basic science, in method assessment and in decision-making. Such evidence-based toxicology might help to make the best possible use of all sources of evidence in an efficient, productive, reliable, acceptable and transparent manner. Why do we need evidence-based toxicology (EBT)? Toxicology and the delivery of effective safety assessment critically relies on concepts and understanding generated by basic scientific research and must therefore adapt constantly to advances in knowledge. However, particularly from the perspective of regulatory toxicology, some of the assessment paradigms and methodologies were established decades ago and have changed little in response to scientific progress. At the same time, changes in our understanding of human disease, changes in the types of product now requiring safety assessment, and changes in the legislative landscape and public expectations pose significant challenges for industry, academia and regulators alike. It is necessary to challenge the status quo and ensure that as a matter of course best scientific practice and technical sophistication is reflected in safety assessment practices such that current and future challenges can be met. It is important therefore to ensure that structures are available that will encourage, facilitate and support a process of critical appraisal and renewal of the toxicological repertoire available for safety assessment. Part of this process is to embrace evidence-based toxicology such that the best possible scientific evidence is applied to judge product safety and likely risks to human health.

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• SciCrunch
• 17 years ago - by Anonymous

Core facility that provides the following services: Flow cytometry equipment and software access, FACS machine training, FACS data analysis, FACS analysis and population isolation, FACS assay consultation. The goals of this Core Facility are to provide flow cytometry services for Howard University?s research investigators, and develop new applications.

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• SciCrunch
• 13 years ago - by Anonymous

The directing and coordinating authority responsible for public health within the United Nations system. The WHO Regional Office for Europe (WHO/Europe) is one of the six regional offices around the world. It serves the WHO European Region, which comprises 53 countries from the Atlantic to the Pacific oceans. WHO/Europe collaborates with a range of public health stakeholders in the Region and globally, to ensure that coordinated action is taken to develop and implement efficient health policies and to strengthen health systems. WHO/Europe is made up of public health, scientific, and technical experts.

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• SciCrunch
• 17 years ago - by Anonymous

ECVAM was created by a Communication from the Commission to the Council and the Parliament in October 1991*, pointing to a requirement in Directive 86/609/EEC** on the protection of animals used for experimental and other scientific purposes, which requires that the Commission and the Member States should actively support the development, validation and acceptance of methods which could reduce, refine or replace the use of laboratory animals: Article 7.2: An experiment shall not be performed if another scientifically satisfactory method of obtaining the result sought, not entailing the use of an animal, is reasonably and practicably available. Article 23: The Commission and Member States should encourage research into the development and validation of alternative techniques which could provide the same level of information as that obtained in experiments using animals, but which involve fewer animals or which entail less painful procedures, and shall take such other steps as they consider appropriate to encourage research in this field. ECVAM has been established in 1992 as a unit of the Environment Institute, part of the Joint Research Centre, and has been transferred to, at that time, newly formed Institute for Health and Consumer Protection in Ispra, Italy in 1998 of which ECVAM is still part of. Duties of ECVAM As defined in the Communication of the European Commission to Council and the European Parliament in October 1991*: 1. To coordinate the validation of alternative test methods at the European Union level. 2. To act as a focal point for the exchange of information on the development of alternative test methods. 3. To set up, maintain and manage a data base on alternative procedures. 4. To promote dialogue between legislators, industries, biomedical scientists, consumer organisations and animal welfare groups, with a view to the development, validation and international recognition of alternative test methods. Moreover, ECVAM should help to expand the JRC''s role in prenormative research. ECVAM thus seeks to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences, through research, new test development and validation, and the establishment of specialised databases, with the aim of contributing to the replacement, reduction and refinement of laboratory animal precedures (in accordance with the 3Rs concept of Russell & Burch***) Due to the political sensitivity of its duties, ECVAM, uniquely at the JRC, has its own Scientific Advisory Committee (ESAC) with participation from all Member States, relevant industrial associations, academic toxicology, the animal welfare movement, as well as other Commission services with interest in the alternatives topic area. The Validation Process Validation is the process by which the reliability and relevance of a procedure are established for a specific purpose. In 1995, based upon experience gained during several recent large-scale validation studies, and in consultation with various international experts (including members of ERGATT), ECVAM published recommendations concerning the practical and logistical aspects of validating alternative test methods (ECVAM workshop report 5). Five main stages in the evolution of new test methods were identified: test development; prevalidation; validation (involving a formal interlaboratory study with the testing of coded chemicals); independent assessment; and progression toward regulatory acceptance. ECVAM has implemented a prevalidation scheme, which includes three main phases: protocol refinement, protocol transfer, and protocol performance. The objective of the prevalidation process is to ensure that any method included in a formal validation study adequately fulfills the criteria defined for inclusion in such a study, so that financial and human resources are used more efficiently, and so that there is a greater likelihood that the expectations of those in the scientific, regulatory and animal welfare communities, who seek the replacement of current animal tests by relevant and reliable alternative methods, will be met. In 2004, ECVAM has published the Modular Approach to the ECVAM Principles on Test Validity (select from the top-menu bar the sector Publications followed by ECVAM Selected Articles) that makes the validation process more flexible, by breaking down the various steps in validation into indipendent modules, and defining for each module the information needed for assessing test validity. Collaborations ECVAMs activities are undertaken in collaboration with numerous laboratories and organisations in the EU Member States, and all over the world. ECVAM also works in close collaboration with other Commission services, such as DG Environment, DG Enterprise, DG Research and DG Health and Consumer Protection. Sponsor. This is a Five years project funded by DG RTD that aims to develop a testing strategy to improve the prediction of oral acute toxicity using non-animals based systems.

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• SciCrunch
• 17 years ago - by Anonymous

Integration objectives Training and education Standardisation in technology Share of material Web based sharing of information and communication Translational research Spreading excellence objectives Coordinated by Treviso Courses on bone pathology and molecular biology Standard Operation Protocols Web-based discussion forums Research objectives Work packages on: Cartilaginous Tumours (Leiden) Osteogenic Tumours (Munster) Giant Cell Tumours (Oxford) Ewing Sarcoma (Bologna)

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• SciCrunch
• 17 years ago - by Anonymous

Emphron Informatics provides full data management and statistical analysis services across the range of biological research. Our areas of expertise include: Biotechnology - especially drug and diagnostic discovery. We have world class expertise in the management and analysis of data from modern discovery platforms, including gene chips, next generation sequencing, and antibody arrays. Clinical Research - We are experienced in the management and statistical analysis of data from regulatory trials (across a range of theraputic areas and development phases), and we provide low-cost flexible solutions for investigator initiated trials. Environmental Studies. We provide data management, statistical design and statistical analysis services. Emphron Solutions We meet client needs in these areas through a number of solution types: Hosted data management and analysis services. We provide on-line web-enabled data management and analysis systems tailored to our clients needs across our interest areas. These include on-line 21CFR11 compliant clinical databases, gene chip data management and analysis systems, and environmental monitoring databases. These systems are hosted in our enterprise class data centre Full service data management and data analysis. We take over all of your data management and data analysis needs, and provide solutions based on our in-house tools and technologies. System development and integration. We build tailored data management and analysis systems, based on open-source components and install them on your premises. Emphron Professionals Emphron professionals are mostly qualified to Doctoral level, with many years experience of advanced informatics and statistics. They combine cutting-edge technology knowledge, with a sound grasp of business and practical realities.

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• SciCrunch
• 17 years ago - by Anonymous

AMSER is a portal of educational resources and services built specifically for use by those in Community and Technical Colleges but free for anyone to use. AMSER provides links to resources for faculty, staff, librarians, students and others for use in both educational settings or in their pursuit of life long learning. Sponsors: AMSER is funded by the National Science Foundation (NSF) as part of the National Science Digital Library, and is being created by a team of project partners led by Internet Scout.

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• SciCrunch
• 17 years ago - by Anonymous

emergent is a comprehensive, full-featured neural network simulator that allows for the creation and analysis of complex, sophisticated models of the brain in the world. With an emphasis on qualitative analysis and teaching, it also supports the workflow of professional neural network researchers. Its high level drag-and-drop programming interface, built on top of a scripting language that has full introspective access to all aspects of networks and the software itself, allows one to write programs that seamlessly weave together the training of a network and evolution of its environment without ever typing out a line of code. Networks and all of their state variables are visually inspected in 3d, allowing for a quick visual regression of network dynamics and robot behavior. This same 3d world sports a highly accurate Newtonian physics simulation, allowing you to create rich robotics simulations (for example, a car). As a direct descendant of PDP (1986) and PDP (1999), emergent has been in development for decades. In the most recent versions available strive to distill it down to its essential elements. Those that take the time to learn the best practices will be rewarded with the ability to create and understand the most complicated neural models ever published.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. During the embryogenesis of human embryo, the development of each organ may be impaired during specific time periods. As illustrated, such impairment leads to congenital anomalies. After such critical periods, the environmental factors cause either minor congenital anomalies or lead to functional abnormalities. True beginning of gestation starts with the fertilization of the ovum which normally occurs one to several days after ovulation. By convention, however, due the fact that the day of the last menstrual period is easily defined, gestation starts on such day. During the first two weeks of pregnancy the embryo does not exist and endometrium is undergoing its normal menstrual and then proliferative phases. Stage one of the development starts with the fertilization of the ovum and stage 2 is initiated by the cleavage of the fertilized ovum. It is during the 4th and 5th stages of development that blastocyst starts its implantation process. By the end of the second week after fertilization, the stage 6 is initiated. During this stage, the primary chorionic villi and embryonic disc are formed.

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• SciCrunch
• 17 years ago - by Anonymous

You can begin your search immediately using the Quick form on the home page or you can access the other specialized search forms in Embase. You can choose any section from the options on the top menu bar: Search, Emtree, Journals, Authors, or Help. You can start to search without logging in but if you would like to set up an email alert or save a search, then you may Login or Register from the upper-right part of the screen. Note: if you are outside your institution IP range, you will first be directed to the info site before accessing the Embase Home page. For more information on remote access, please see Login section. Search Forms Search is at the core of Embase and all search forms are designed to allow you to look for biomedical and pharmaceutical clinical and research information easily and quickly, whether you are a new or experienced searcher. The Embase search engine allows Boolean searching with wildcard and truncation features, as well as many predefined search limits. Search is divided into five options: Quick, Advanced, Drug, Disease and Article. Quick lets you perform easy yet powerful searches without having to learn a complex search language. It is perfect if you are starting your research and looking for an overview of the literature or good terms to include in your search strategy. Autocomplete will help you to search using the bext terminology. Advanced incorporates options from Emtree term mapping including explosion searching for maximum precision in subject searching (see Emtree) and Drug and Disease provide access to specialized features useful to search these topics, such as ''Adverse Drug Reaction''''Drug Combination''. Generally speaking, drug searches are best carried out in the Drug form, diseases in the Disease form and non-drug and disease searches in the Advanced form. Article allows you to pinpoint individual articles. Embase is owned and operated by Elsevier B.V., Radarweg 29, 1043 NX Amsterdam, The Netherlands, Reg. No. 33156677, BTW No. 002967455B65 (Elsevier).

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• SciCrunch
• 17 years ago - by Anonymous

A complete online Product Catalog of chemicals, supplies, accessories, and equipment for Electron and Light Microscopy, Histology, Cell Biology, Neuroscience, and all biological related research fields. At the site, you can find technical tips and recommended articles of interest, technical and product data sheets, Material Safety Data Sheets, and many revolutionary new products and exclusive items. A complete product catalog of the entire Diatome collection of Diamond knives, tools, and accessories for Electron and Light microscopy for Biological and Materials Science at room and cryo temperatures. Available on-line as well is information on our services, programs, specials, and policies. The complete handling and use technical manual as well as troubleshooting can also be found at our site. The Summers Optical on-line catalog including a complete line of optical cements and adhesives, decementing agents, hardness testers, ultrasonic baths and UV lights as well as technical and transmission data and problem solving can be found at this site. As well as, our unique bonding manual including troubleshooting and charts for how to choose a cement for specific applications and a complete set of MSDS on all of our products can be seen here. EMS Contract Packaging is a total service contract manufacturer, packager, and formulator with over 40 years experience in drug and cosmetic formulating and packaging. Negafile furniture quality wood filing systems and storage cases for grids, negatives, film and microscope glass slides. And a full line of shipping and packaging solutions for all your traditional or digital media.

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• SciCrunch
• 17 years ago - by Anonymous

Specific short oligonucleotide sequences that enhance pre-mRNA splicing when present in exons, termed exonic splicing enhancers (ESEs), play important roles in constitutive and alternative splicing (ESE References). A hybrid computational/experimental method, RESCUE-ESE, was recently developed for identifying sequences with ESE activity. In this approach, specific hexanucleotide sequences are identified as candidate ESEs on the basis that they have both significantly higher frequency of occurrence in exons than in introns and also significantly higher frequency in exons with weak (non-consensus) splice sites than in exons with strong (consensus) splice sites. Representative hexamers from ten different classes of candidate ESEs, together with 6 or 7 bases of flanking sequence context on each side, were introduced into a weak (poorly spliced) exon in a splicing reporter construct. These reporter minigenes were then transfected into cultured cells, where they are transcribed and spliced, and the relative level of inclusion of the test exon was assayed by quantitative (radio-labeled) RT-PCR. Point mutants of these sequences were also analyzed to confirm the precise motifs responsible for ESE activity. The RESCUE-ESE approach identified 238 hexamers as candidate ESEs using a large database of human genes of known exon-intron structure containing over 30,000 nonredudant exons. In more recent analyses by Yeo et al., the RESCUE-ESE approach was utilized to predict hexamers as candidate ESEs in other vertebrate genes, namely, Fugu rubipes, Zebrafish and Mouse. This allows the identification of motifs that are conserved in vertebrates. This web server allows a sequence to be checked for presence of these candidate ESE hexamers.

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• SciCrunch
• 17 years ago - by Anonymous

It ranks amino acid residues in a protein sequence by their relative evolutionary importance, and when a structure is available for that protein, it also can display a structural map of where top-ranked residues fall. This can be useful for rational function re-design and protein engineering because biologist can then efficiently target mutations to the most relevant parts of a protein. For example, one may selectively block, separate, rewire, or mimic functions. ET-based functional annotations may also be useful to suggest protein function (see the ET Annotation Server). ET rank essentially captures the extent of evolutionary pressure at a given sequence position. It is obtained by correlating the sequence variations in an alignment of a protein family with its evolutionary divergences. Top-ranked residues are associated with variations that correlate with large divergences near the root of the evolutionary tree, and presumably linked to significant functional changes. Poorly-ranked residues in contrast are associated with variations near the leaves of the tree, presumably linked to modest functional differences, if any at all. We provide two means of generating and visualizing the ET ranks of importance: the ET Viewer and the ET report_maker. 0. The ET Viewer runs real-value ET or integer ET and displays results. Its ET Wizard takes a PDB identifier, or file, for input, and it outputs ranks of evolutionary importance for every sequence position in the protein. All trace parameters may be adjusted; custom alignments and phylogenetic trees may be used. The ET Viewer then displays a color map of the structure showing which residues are ranked among the top nth percentile, where n is adjustable, and whether they cluster (a z-score indicates whether these top-ranked residues cluster in a statistically significant manner). A multiple sequence alignment viewer and phylogenetic tree viewer display the underlying data. 0. (06/19/2009)A special note for Mac users: 0. The latest Java update for Mac, Java for Mac OS X 10.5 Update 4, moves the Java Web Start application to a new location, causing problems launching ET viewer and other Java Web Start programs. In order to fix this, you need to show your computer where the new location is for Java Web Start. In Finder, select the ET_Viewer_2_pub.jnlp file (which is probably in your downloads folder). Under the File menu, select Get Info. In the resulting window, there''s a section called Open With: Click the drop-down menu and select Other.... A new window will open. Navigate to your hard drive, select System, then Library, then CoreServices, and then select Java Web Start.app. Then click the Change All... button in the Open With: section to make this change permanent. Sponsor. A.D.W., S.E. and R.M.W. were also supported by train- ing fellowships from the National Library of Medicine to the Keck Center for Interdisciplinary Bioscience Training of the Gulf Coast Consortia.

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• SciCrunch
• 14 years ago - by Anonymous

Welcome to the EMQN website. EMQN is a not-for-profit organisation promoting quality in molecular genetic testing through the provision of external quality assessment (proficiency testing schemes) and the organisation of best practice meetings and publication of guidelines. The European Molecular Genetics Quality Network (EMQN) started in October 1998 after a successful pilot trial. From January 1999 to March 2002, the network was supported by a grant from the European Commission under the Standards Measurement and Testing Programme (contract number SMT4-CT98-7515). From April 2002, the network is supported by subscriptions from it users. External Quality Assessment (EQA): There are 26 EQA schemes being offered in 2010. To participate you must be a registered member of the network. For more information on EQA schemes, click the link here. Best Practice: EMQN is actively promoting ''best practice'' meetings on individual diseases. To assist in this process, EMQN will be organising best practice meetings. To participate you must be a registered member of the network. Following the meeting, draft best practice guidelines are produced and publised on this and other related websites, for example, the web site of the UK Clinical Molecular Genetics Society (CMGS). To find out more about best practice click here. Administration: The EMQN is based at the National Genetics Reference Laboratory (Manchester), St Mary''s Hospital, Manchester, The United Kingdom. The Network is co-ordinated and administered by Dr''s Rob Elles and Simon Patton. A management group is responsible for the activities and direction of the network. National partners in different countries help to disseminate information about the network. Quality Policy The EMQN provides a comprehensive range of quality assurance programs for molecular genetics to laboratories and industry worldwide. The European Molecular Genetics Quality Network (EMQN) is committed to helping ensure diagnostic molecular genetic laboratory test results are accurate, reliable and comparable wherever they are produced. The EMQN will provide a high quality and timely service which takes into account the needs and requirements of its users. Objectives To help to raise and maintain the standards of diagnostic clinical molecular genetic testing. To undertake and promote educational activities. To be a leading authority in quality assurance . To design and provide the best possible materials and data management. To design and provide quality reports that are timely and valid. To provide professional support and consultation. To develop new programs as required. To participate in peer review. To strive for continual improvement of the quality system. Sponsor. the network was supported by a grant from the European Commission under the Standards Measurement and Testing Programme (contract number SMT4-CT98-7515