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Although Haemophilus influenza type b (Hib) diseases and Hepatitis B (Hep B) infections are preventable with one combined life-saving vaccine, both continue to pose risks to the worlds most vulnerable populations, leading to life-long disabilities or even death. Vaccinating against Hib and Hepatitis B represents an essential step towards reaching Millennium Development Goal 4. The Hib bacterium causes meningitis and pneumonia and is considered the third vaccine-preventable cause of death in children aged under five. It is estimated that there are three million cases of serious Hib infection annually, of which 400,000 result in childhood death. The majority of survivors suffer paralysis, deafness, mental retardation and learning disabilities. Babies and young children are most at risk from Hep B, a viral disease, which attacks the liver and can cause both acute and chronic disease. This can lead to chronic liver disease and puts victims at high risk of death from cirrhosis of the liver and liver cancer in later life. More than two billion people are infected by Hep B worldwide of whom 360 million suffer from chronic Hep B infection; the latter is highly prevalent in all countries that GAVI supports. Children are most vulnerable to infection with 90 percent of infants infected in the first months of their lives developing chronic Hep B infection. Infections in the developing world are mostly from mother to child, or from child to child, mainly through cuts, bites, scrapes and scratches. Vaccinating against Hib and Hep B represents an essential step towards reaching Millennium Development Goal 4, which is to reduce the under-five mortality rate by two thirds by 2015. GAVI uses two mechanisms that draw heavily on private-sector thinking to help overcome historic limitations to development funding for immunisation. These mechanisms are the AMC and the IFFIm. The former reflects the need to meet disproportionately high costs in the early stages of implementing aid programmes; the latter developing countries'' need for sustainable predictable funding., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 14 years ago - by Anonymous

Software for visualization and Analysis of CGH arrays, transcriptome and other Molecular Profiles.

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• SciCrunch
• 13 years ago - by Anonymous

The Institute for Advanced Biosciences, Keio University, is an academic research institute pioneering the new life science field of Systems Biology, using both experimental and computational biology. There are several groups working in collaboration, focusing mainly on genome biology and engineering, genome design and synthetic biology, metabolic engineering, proteomics, metabolomics, RNA biology, bioinformatics and computational biology. Using cutting-edge technologies, intracellular components can be analyzed comprehensively to construct computer simulation models that can find numerous applications in fields such as biomedical, environmental, and agricultural science. Experimental and computational facilities are located in Tsuruoka, Yamagata prefecture, in northern Japan while the SFC campus, in the Tokyo area, hosts the bioinformatics laboratory and most undergraduate curricular activities. IAB has successfully attracted very significant funding for multiple research projects from major funding organizations including the New Energy and Industrial Technology Development Organization (NEDO) (2002-2006), for bioprocesses and cell modeling, the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and its COE network, for biosimulation and systems biology (2003-2008), the Japan Science and Technology Agency (CREST, 2004-2009) for simulation and systems biology, the Ministry of Health, for cancer biology (2005), as well as from Yamagata prefecture and Tsuruoka city, 2001-2006 and 2006-2011). Over the past few years, IAB scientists have accumulated several awards including the 1st prize during the 5th Japan Biotechnology Business Competition (2005), the Minister of State for Science and Technology Policy award in recognition for industry-academia-government collaboration performance (2004), the IBM Shared University Research Award (2003), and the Nihon Kogyo Shimbunsha Award (2003) during the 17th Leading-edge Technology for Originality and Creativity. Sponsor. This study was supported by a grant from the Global COE Program entitled, Human Metabolomic Systems Biology and by a Grant-in-Aid for Scientific Research on Priority Areas Systems Genomes and on Lifesurveyor from the Ministry of Education, Culture, Sports, Science and Technology of Japan as well as research funds from the Yamagata prefectural government and the City of Tsuruoka.

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• SciCrunch
• 17 years ago - by Anonymous

A tool for mapping transcriptome data and for creating a database with an overview of the entire pathway, a web-based resource consisting of a web-application for the visualization of complex omics data onto KEGG pathways to overview all entities in the context of cellular pathways, and databases created with the software to visualize a series of microarray data. The web-application accepts transcriptome, proteome, metabolome, or the combination of these data as input, and because of this scalability it is advantageous for the visualization of cell simulation results. Several databases of transcriptome data obtained at Mori Laboratory, Nara Institute of Science and Technology, Japan, are also presented.

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• SciCrunch
• 17 years ago - by Anonymous

Fungal genomes available from the Sanger Institute. Data are accessible in a number of ways; for each organism there is a BLAST server, allowing search of the sequences. Sequences can also be down-loaded directly by FTP. In addition, for those organisms being sequenced using a cosmid approach, finished and annotated cosmids are submitted to EMBL and other public databases.

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• SciCrunch
• 17 years ago - by Anonymous

C. elegans Gene Knockout Project Containing information about the Gene Knockout consortium, an on-line version of targeted gene database, knockout submission form and oligo prediction software. C. elegans Gene Expression Project Members investigating C. elegans gene expression using promoter GFP fusions and serial analysis of gene expression (SAGE). Serial Analysis of Gene Expression View and download C. elegans SAGE data. Provided are tag to gene mappings, various filters (e.g. sequence quality, minimum tag count), and search by keyword or tag. Also available are supplemental data from publications. Microarray Data Download C. elegans expression data generated from the Affymetrix GeneChipTM or a NimbleGen custom array. These experiments were done in parallel with the SAGE experiments, and there is data available for the six major developmental stages. Expression Patterns for promoter GFP fusions View and search expression patterns of C. elegans promoter GFP fusions. Tools for automated PCR primer design PCR-based screening for deletions in C. elegans genes, including the ''poison primer'' strategy Construction of promoter GFP fusions using PCR stitching (fusion PCR) Fosmid Clone Search We have created a C. elegans fosmid library. Use this site to search for fosmid clones for your gene or region of interest, and request clones.

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• SciCrunch
• 17 years ago - by Anonymous

A computer algorithm that provides a fast and quantitative estimation of the importance of the interactions contributing to the stability of proteins and protein complexes. The predictive power of FOLDEF has been tested on a very large set of point mutants (1088 mutants) spanning most of the structural environments found in proteins . FoldX uses a full atomic description of the structure of the proteins. The different energy terms taken into account in FoldX have been weighted using empirical data obtained from protein engineering experiments.

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• SciCrunch
• 17 years ago - by Anonymous

FlowingData explores how designers, statisticians, and computer scientists are using data to understand ourselves better - mainly through data visualization. Money spent, reps at the gym, time you waste, and personal information you enter online are all forms of data. How can we understand these data flows? Data visualization lets non-experts make sense of it all. About Nathan As for me, I''m a PhD candidate in statistics. I live and breathe data. I also have a background in computer science and design. I do some freelancing from time to time, but mostly I''m just trying to work on my dissertation. You can find more about me here. For the New Readers If you''re new here, welcome to FlowingData. A good place to start is the archives where you''ll find FlowingData''s most popular posts or take a look at the FlowingData beginner''s guide. If you like what you see, subscribe to the feed, follow on Twitter, or fan on Facebook More specifically, I''m most interested in Social data visualization Self-surveillance Data for non-professionals FlowingData readers are data-savvy people who are interested in visualization, statistics, design, analysis, and programming. If you have a product or service that is of interest to them, then FD sponsorship is a great way for you to connect with them. There are two exclusive ways for you or your group to connect with readers. The first is through a banner ad, which appears in the top right of every page. The second is via a bimonthly sponsorship of the FlowingData RSS feed. Both sponsorship types also include a mention in the monthly thank you post.

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• SciCrunch
• 17 years ago - by Anonymous

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

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• SciCrunch
• 17 years ago - by Anonymous

Welcome to Flintbox, an application that revolutionizes the way the innovation community can share technologies, distribute new materials and software, and collaborate on research projects. Hundreds of research institutions are participating in the Flintbox open innovation network. Become a member to contribute and explore We are excited to present the Flintbox Application Programming Interface (API) to provide users with an easy way to upload data from any system to Flintbox. This freely available tool for synchronized information exchange will be a valuable resource to the open innovation community. The Flintbox API gives you the power to: Import existing technology postings directly into Flintbox Avoid duplicate data entry to market your technologies, ideas, and materials Create postings from any database Export project information to other websites For more information about using and implementing the Flintbox API, please see the About the Flintbox API page. Featured Project The New Flintbox offers expanded transactional capabilities: credit cards, purchase orders, purchase authorizations, donations, and much more The global Flintbox community is ideal for marketing new technologies, creative works, course materials, and innovative ideas. Flintbox enables universities to maximize their outreach to a broad spectrum of the innovation community. Plus, Wellspring provides expertise in assisting TTOs, inventors, and industrial liaison offices to promote their technologies, research programs, and partnering opportunities to Flintbox. Flintbox for Corporations Corporations turn to Flintbox to cultivate existing relationships and engage in new opportunities for collaborative research and solution sourcing from universities and other companies. For example, a pharmaceutical firm uses Flintbox to provide researchers and physicians software to assess patient outcomes. Flintbox for Technology Communities Flintbox empowers technology communities to connect effectively in a geographic region, building a Sphere of Innovation to truly recognize and capitalize on the valuable relationships and innovation assets in your community. For example, by creating or joining a community Group of members with common interests, say tissue engineering or artificial intelligence, you can link to other groups and explore common interests and complementary resources, for a dynamic collaborative effort and to efficiently share related technology projects. Flintbox is a registered trademark of Wellspring Worldwide, LLC

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• SciCrunch
• 17 years ago - by Anonymous

This website is dedicated to the dissemination of information about the European research project FunGenES (Functional Genomics in Embryonic Stem Cells). FunGenES is a research programme carried out on mouse embryonic stem cells with the aim to improve our understanding of cellular self-renewal and differentiation processes into tissue-specific cells. The website contains general knowledge about stem cell research and related issues such as ethics in stem cell related research, and more detailed information about the specific scope and objectives of the FunGenES project. A brochure containing a general project description in PDF format is available for download in the section Publications. FunGenES - Functional Genomics in Embryonic Stem Cells brings together experts in stem cell research from 18 organisations from industry and academic research across Europe. This research initiative is set up as an Integrated Project with a budget of approximately 12 Million Euros, partially funded by the 6th Framework Programme of the European Union. Specialists from Germany, France, Italy, Portugal, Greece and the UK collaborate for a period of 3 years to investigate the functional genomics of mouse embryonic stem (ES) cells. FunGenES aims to achieve a detailed basic understanding of stem cell self-renewal and differentiation. FunGenES investigates the unique ability of mouse embryonic stem cells to develop into any cell of an organ (this ability is also known as pluripotency), creates new tools for functional genomic studies and will thus provide key knowledge to understand the commitment of cells to a particular cell type. This complex process occurs in several steps and controls the development of pluripotent cells into highly specialised cells of an organism. In particular, FunGenES aims to identify genes controlling the development of the pluripotent ES cells into heart cells (cardiomyocytes), nerve cells (neurons), smooth muscle cells, vascular endothelial cells, fat cells (adipocytes), liver cells (hepatocytes) and insulin-producing cells of the pancreas. FunGenES will deliver a gene expression atlas summarising the genetical pathways for cell differentiation. The project aims to contribute to future therapeutic strategies for degenerative diseases such as heart disease, diabetes and Parkinson''s. All these diseases are characterised by the irreversible loss of functional cells. FunGenES was selected from a large number of proposals to be funded as an advanced and promising project in the area of functional genomics in the Life-Science-Health Programme of the European Union. In addition to its ambitious scientific programme, FunGenES aims to inform the general public about stem cell research, its ethical aspects and future therapeutical applications The project is coordinated by Professor Jrgen Hescheler (University of Cologne) Jrgen Hescheler is excited about the potential of the project: By understanding how mammalian genomic information is selectively used in development, we will acquire an essential key to understanding ourselves and our health. Sponsor. The FunGenES Integrated Project was funded by a grant from the European Commission (6th Framework Programme, Thematic Priority: Life sciences, Genomics and Biotechnology for Health, Contract No. : FunGenES LSHG-CT-2003-503494; http://ec.europa.eu/grants/index_en.htm). H.B. and M.T. were also supported by the University Bordeaux 2 (http://www.u-bordeaux2.fr/index.jsp) and CNRS (http://www.cnrs.fr/); A.K.H. received NIH support, grant HL08395 (http://www.nih.gov/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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• SciCrunch
• 17 years ago - by Anonymous

DNA software and consultancy: The DNA Alignment software and Network software is used by biologists, anthropologists, medical researchers and students world wide. We carry out phylogeographic consultancy for US, UK and German clients, including legal medical work. We were involved in the tv projects The Real Eve (Discovery Channel) and Motherland (BBC). Our biotechnological director Dr Peter Forster is on the editorial board of the International Journal of Legal Medicine since 1999. Technology and sales consultancy: Clients include multinational corporations, research institutions, and medium to small businesses. Client quotes: Vorbildlicher Einsatz (Dr Stephan Hitzel, EADS, in CADplus 1/2003 journal, Cover Story). We have had an effective business relationship with Fluxus Technology since 1999, and their experience of the German market has proved to be invaluable as part of our operations supplying high end engineering software and consultancy services right across the engineering supply chain (Andy Chinn, Business Development Manager, ITI TranscenData, February 2006). Abstract. Indo-European is the largest and best-documented language family in the world, yet the reconstruction of the Indo-European tree, first proposed in 1863, has remained controversial. Complications may include ascertainment bias when choosing the linguistic data, and disregard for the wave model of 1872 when attempting to reconstruct the tree. Essentially analogous problems were solved in evolutionary genetics by DNA sequencing and phylogenetic network methods, respectively. We now adapt these tools to linguistics, and analyze Indo-European language data, focusing on Celtic and in particular on the ancient Celtic language of Gaul (modern France), by using bilingual GaulishLatin inscriptions. Our phylogenetic network reveals an early split of Celtic within Indo-European. Interestingly, the next branching event separates Gaulish (Continental Celtic) from the British (Insular Celtic) languages, with Insular Celtic subsequently splitting into Brythonic (Welsh, Breton) and Goidelic (Irish and Scottish Gaelic). Taken together, the network thus suggests that the Celtic language arrived in the British Isles as a single wave (and then differentiated locally), rather than in the traditional two-wave scenario (P-Celtic to Britain and Q-Celtic to Ireland). The phylogenetic network furthermore permits the estimation of time in analogy to genetics, and we obtain tentative dates for Indo-European at 8100 BC 1,900 years, and for the arrival of Celtic in Britain at 3200 BC 1,500 years. The phylogenetic method is easily executed by hand and promises to be an informative approach for many problems in historical linguistics.

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• SciCrunch
• 17 years ago - by Anonymous

Flavornet is a compilation of aroma compounds found in human odor space. A seemingly infinite number of perceptions are invoked by less than 1000 odorants that make up this space. These chemicals with mass less than 300 Daltons bind to proteins on the olfactory receptor neurons (ORNs) at the surface of the olfactory epithelium. Excitation of ORNs generates a topographic map of sensory information in the brain that is a representation of the stimulating chemical features of the external world. The Flavornet lists only those odorants that have been found in a human odor space at supra-threshold levels i.e. at levels likely to stimulate ORNs. In Flavornet odorants are arranged by chromatographic and sensory properties. Except for indexing standards the data have been taken from published research using GCO. They are listed by retention indices both Kovats n-paraffin and ethyl ester on four different substrates. A link to a summary page containing chemical properties, sensory descriptors, bibliographies and pdb (protein data bank) files of MM2 minimized structures is provided for each ligand. To be included in Flavornet an odorant must have been detected in a natural product or real environment by some form of quantitative GCO method e.g. dilution analysis (Aroma Extraction Dilution Analysis or CharmAnalysis) perceived intensity analysis (e.g. Osme) or detection frequency analysis (e.g. SNIFF). Therefore, the Flavornet lists only those volatiles that humans use in their chemical ecology. Once on the list, missing data about an odorant was filled in with estimates (shown in square brackets). These estimates will be replaced with experimental measurements as they become available. In every case data from the first report of a GCO detection will be used unless a more accurate report is subsequently made, then, the new data will be included along with the original. The present data was collected from articles published since 1984 using GCO to detect odorants in natural products. In the summers of 2003 and 2004 Hannah E. Collins, Yale University, read over 100 of these articles and checked the chemical data for the odorants against the Chemical Abstract Service databases. Sponsor. Sponsored by DATU Inc.

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• SciCrunch
• 17 years ago - by Anonymous

A graphical viewer of phylogenetic trees and a program for producing publication-ready figures. It is designed to display summarized and annotated trees produced by BEAST.

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• SciCrunch
• 17 years ago - by Anonymous

This document defines the processes and standards that all FLTK developers must follow when developing and documenting FLTK, and how trouble reports are handled and releases are generated. The purpose of defining formal processes and standards is to organize and focus our development efforts, ensure that all developers communicate and develop software with a common vocabulary/style, and make it possible for us to generate and release a high-quality GUI toolkit which can be used with a high degree of confidence. Much of this file describes the existing practices that have been used up through FLTK 1.1.x, however I have also added some new processes/standards to use for future code and releases. The fltk-dev mailing list and fltk.development newsgroup are the primary means of communication between developers. All major design changes must be discussed prior to implementation. Specific Goals The specific goals of the FLTK are as follows: Develop a C++ GUI toolkit based upon sound object-oriented design principles and experience. (*) Minimize CPU usage (fast). (*) Minimize memory usage (light). (*) Support multiple operating systems and windowing environments, including UNIX/Linux, MacOS X, Microsoft Windows, and X11, using the native graphics interfaces. (*) Support OpenGL rendering in environments that provide it. (*) Provide a graphical development environment for designing GUI interfaces, classes, and simple programs. (*) Support UTF-8 text. Support printer rendering in environments that provide it. Support schemes, styles, themes, skinning, etc. to alter the appearance of widgets in the toolkit easily and efficiently. The purpose is to allow applications to tailor their appearance to the underlying OS or based upon personal/user preferences. Support newer C++ language features, such as templating via the Standard Template Library (STL), and certain Standard C++ library interfaces, such as streams. However, FLTK will not depend upon such features and interfaces to minimize portability issues. Support intelligent layout of widgets. Many of these goals are satisfied by FLTK 1.1.x (*), and many complex applications have been written using FLTK on a wide range of platforms and devices. Development of the remaining features is proceding for FLTK 2.0 with a new, namespace-based API. While 2.0 offers some limited 1.x source compatibility, the changes to the underlying widget classes are significant enough to prevent full compatibility. Software Development Practices Documentation All widgets are documented using the Doxygen software; Doxygen comments are placed in the header file for the class comments and any inline methods, while non-inline methods should have their comments placed in the corresponding source file. The purpose of this separation is to place the comments near the implementation to reduce the possibility of the documentation getting out of sync with the code. All widgets must have a corresponding test program which exercises all widget functionality and can be used to generate image(s) for the documentation. Complex widgets must have a written tutorial, either as full text or an outline for later publication The final manuals are formatted using the HTMLDOC software. Sponsor. Easy Software Products

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• SciCrunch
• 17 years ago - by Anonymous

Family members connect with our Family Tree application. We have over 178,385,793 relatives added and growing! Familybuilder, the top family destination on social networks, today announced that it has been chosen by AlwaysOn as one of the AlwaysOn East Top 100 winners. Inclusion in the AlwaysOn East 100 signifies leadership amongst its peers and game-changing approaches and technologies that are likely to disrupt existing markets and entrenched players. Familybuilder was specially selected by the AlwaysOn editorial team and industry experts spanning the globe based on a set of five criteria: innovation, market potential, commercialization, stakeholder value, and media buzz. Familybuilder and the AlwaysOn East Top 100 companies will be honored at AlwaysOn''s Venture Summit East event on June 21st, 2010, at Harvard Business School in Boston, MCA. This two-day executive event features CEO presentations and high-level debates that highlight the significant economic, political, and technology trends impacting the global growth investor on the East Coast. Now more than ever, staying abreast of market conditions and innovations is crucial to financial success. After examining the companies that are on the AOE100 list, it''s obvious that innovation is not only alive and well on the East Coast, it''s accelerating in economic power and scope. says Tony Perkins, founder and editor of AlwaysOn. The companies certainly represent some of the highest-growth opportunities in the private company marketplace. The AlwaysOn East 100 winners were selected from among hundreds of other technology companies nominated by investors, bankers, journalists, and industry insiders. The AlwaysOn editorial team conducted a rigorous three-month selection process to finalize the 2010 list. Familybuilder is the first company to offer applications for communicating and staying in touch with family members on social networks including Facebook, MySpace, and others. The Company, with over 26 million users and over 160 million family members added, is quickly becoming one of the most used family services online. The Company''s flagship application on Facebook, Family Tree, is one of the top 15 non-gaming applications on the platform. With its substantial base of customers, Familybuilder is now expanding into new lines of businesses including a newsletter http://familybuilder.com/newsletter as well as subscription functionality. About AlwaysOn AlwaysOn is the leading business media brand networking the Global Silicon Valley. AlwaysOn helped ignite the social media revolution in early 2003 when it launched the AlwaysOn network. In 2004, it became the first media brand to socially network its online readers and event attendees. AlwaysOn''s preeminent executive event series includes the Summit at Stanford, OnMedia, OnHollywood, Venture Summit Mid-Atlantic, OnDemand, Venture Summit Silicon Valley, Venture Summit East, GoingGreen Silicon Valley, GoingGreen East, and GoingGreen Europe. The AlwaysOn network and live event series continue to lead the industry by empowering its readers, event participants, sponsors, and advertisers like no other media brand.