Curator Dashboard

Voluntary, non-profit organization dedicated to collecting and disseminating statistical data. Resource for gathering and disseminating epidemiologic data on all primary benign and malignant brain and other CNS tumors.

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• SciCrunch
• 15 years ago - by Anonymous

The Centre for Theoretical Neuroscience (CTN) was recently established at the University of Waterloo. The Centre is a growing research initiative of the University. The Centre consists of several labs focused on various areas of theoretical neuroscience (aka computational neuroscience). At present, the Centre consists of faculty members from Applied Mathematics, Biology, Psychology, Engineering, Philosophy, Statistics, Computer Science, and their students. The Centre has established a unique Graduate Program in theoretical neuroscience and hosts a regular academic colloquium series. The Centre also hosts the annual public Waterloo Brain Day lectures. The Centre is currently expanding, running searches for additional core faculty. The distinguished faculty of the Centre include two Canada Research Chairs and a fellow of the Royal Society of Canada. In addition, the Centre has a number of student researchers, both graduate and undergraduate, and hosts postdocs and visiting researchers. The Centre also hosts a graduate program for students wishing to obtain an officially recognized specialization in theoretical neuroscience. Faculty at the Centre pursue work on purely theoretical questions regarding the foundational principles guiding the function of neural systems, as well as constructing detailed neurobiological models of specific brain areas.

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• SciCrunch
• 15 years ago - by Anonymous

An institute whose mission is to translate laboratory discoveries into prevention, treatment and cures for Alzheimer's, ALS, Huntington's, Parkinson's and other neurodegenerative diseases. MIND seeks to accelerate therapies that lessen the toll of disease on patients and families. Researchers of the institute collaborate, strategize, and share technology to find treatment for these diseases. As promising leads are developed in one area, they are tested in the other neurodegenerative disorders.

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• SciCrunch
• 15 years ago - by Anonymous

Biospecimen repository that provides scientists with the opportunity to bank their pluripotent stem cell lines and develops in-house induced pluripotent stem cell (iPSC) lines for distribution. They have developed core capabilities to maintain, characterize, bank, and distribute important stem cell resources. The SCB performs extensive identification and characterization testing for all submitted human induced pluripotent stem cell (iPSC) and mouse embryonic stem cell (mES) lines. The identification and quality control measures include karyotype analysis, microsatellite analysis for parental cell line identity matching, sterility testing, and assessment of viability after cryopreservation. Pluripotency characterizations performed by SCB vary depending upon the distributing repository. * NIGMS iPSCs: Surface antigen expression, Embryoid body formation, Pluritest Gene Expression assay * NINDS iPSCs: Surface antigen expression, Embryoid body formation * NIA mES: Surface antigen expression, Embryoid body formation, Transgene induction Each characterized human iPSC line and mES line released for distribution is provided with a Certificate of Analysis, which includes information regarding characterization and quality of the line, images and links to original publications. The human iPSCs distributed by Coriell are strictly for research purposes and cannot be used in human subjects. All terms described in the Material Transfer Agreement (NIGMS and NINDS Repositories) or Assurance Form (NIA Repository) for the stem cell line must be agreed to prior to using stem cell lines from Coriell.

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• SciCrunch
• 15 years ago - by Anonymous

The WEB ATLAS contains photographs of dissected brains showing important structures. The diagrams folder contains drawings showing functionally important parts of the brain as well as drawings of dissections adapted from C.G. Smith. We are particularly pleased to make Nan Cheney''s medical illustrations of the brain and the head available. The STROKE MODEL portion of the website has syndromes associated with strokes of different vessels of the brain as well as extensive diagrams and tables about the vessels of the brain. The 3D RECONSTRUCTIONS featured on this website were made from MRI scans through the brain - where indicated the source material was from the NIH Visible Human Project. The website will also contain material important for the neuroanatomy labs for med students at UBC. Weekly quizzes will help you keep up with studying the material, the podcasts will help you review material presented in the labs, and the weekly wikis will help you share information with your peers.

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• SciCrunch
• 15 years ago - by Anonymous

Database of negated biomedical sentences in literature consisting of more than 32 million negated sentences. Negated sentences were detected using the algorithm described in - Shashank Agarwal, Hong Yu Biomedical negation scope detection with Conditional Random Fields Journal of the American Medical Informatics Association (JAMIA), 2010; 17:696-701. After entering your query in the search box (for example MeCP2 autism), the search results with the negated sentence and the sentences preceding and following the negated sentences are displayed. A link to the source of the sentence is also provided, which links to the article from which the negated sentence was extracted. BioNOT is no longer updated. Documented 2013.

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• SciCrunch
• 15 years ago - by Anonymous

STEPS is a package for exact stochastic simulation of reaction-diffusion systems in realistic, complex 3D geometries. Our core simulation algorithm is an efficient implementation of a variation on Gillespie''s SSA, extended to deal with diffusion of molecules over the elements of a 3D tetrahedral mesh. While it was mainly developed for simulating detailed models of neuronal signaling pathways in dendrites and around synapses, it is a general tool and can be used for studying any biochemical pathway in which spatial gradients and morphology are thought to play a role. We have implemented STEPS as a set of Python modules, which means STEPS users can use Python scripts to control all aspects of setting up the model, generating a mesh, controlling the simulation and generating and analyzing output. The core computational routines are still implemented as C/C++ extension modules for maximal speed of execution.

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• SciCrunch
• 15 years ago - by Anonymous

Nature Publishing Group (NPG) is a publisher of high impact scientific and medical information in print and online. NPG publishes journals, online databases and services across the life, physical, chemical and applied sciences and clinical medicine. Focusing on the needs of scientists, Nature (founded in 1869) is the leading weekly, international scientific journal. In addition, for this audience, NPG publishes the Nature research journals and Nature Reviews journals, plus a range of prestigious academic journals including society-owned publications. Online, nature.com provides over 6 million visitors per month with access to NPG publications and online databases and services, including news and comment from Nature, NatureJobs plus access to Nature Network and Nature Education''s Scitable.com. Scientific American is at the heart of NPG''s newly-formed consumer media division, meeting the needs of the general public. Founded in 1845, Scientific American is the oldest continuously published magazine in the US and the leading authoritative publication for science in the general media. Together with scientificamerican.com and 16 local language editions around the world it reaches over 3 million consumers and scientists. Other titles include Scientific American Mind and Spektrum der Wissenschaft in Germany. Scientific American is available for site license access on the nature.com platform. Throughout all its businesses NPG is dedicated to serving the scientific and medical communities and the wider scientifically interested general public. Part of Macmillan Publishers Limited, NPG is a global company with principal offices in London, New York and Tokyo, and offices in cities worldwide including Boston, Buenos Aires, Delhi, Hong Kong, Madrid, Barcelona, Munich, Heidelberg, Basingstoke, Melbourne, Paris, San Francisco, Seoul and Washington DC. Read our history for a timeline of NPG and the scientific events which have helped shape the direction of the business.

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• SciCrunch
• 16 years ago - by Anonymous

A gene set analysis algorithm for biomarker identification in the cloud.

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• SciCrunch
• 13 years ago - by Anonymous

A basic screening measure for depression in older adults. They have a FREE iPhone APP and a FREE ANDROID APP that allows you to do the 15-item GDS on your phone and automatically calculate the results. They provide no interpretation of results, but patients with scores higher than 5 should be interviewed carefully. These apps are also available through the Android Marketplace or iTunes stores on your phones. Note: This page is under continuous development but they will try to keep translations of the scale available. Anyone with their own translation can submit it and they''ll post it.

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• SciCrunch
• 15 years ago - by Anonymous

A physical repository located in London, UK which banks all types of frozen samples. In particular, samples considered relevant material, such as tissues and cells, that are licensed by the Human Tissue Authority, can be stored long term. Existing holdings of tissues and cells where appropriate can be transferred to the Physical BioBank at the Royal Free. Samples can be stored at -80 or in Liquid nitrogen and will be stored in either 1.2ml or 2ml cryotubes. The UCL-Royal Free BioBank will set up service level agreements with all users which define the responsibilities of the user and the biobank in all aspects of biobanking from consent and collection through to disposal and transfer to third parties. Depositors will remain the owner of the tissues which they deposit (either physically or virtually). Samples are tracked using a specific database (BioVault) and all samples submitted are entered into a secure inter-relational database hosted by UCL. Patient-specific identifiers are removed and held on a separate database. In addition, all holders of samples held in other locations in UCL (including fixed tissues, plasma, sera, DNA and RNA) will be invited to add their holdings to the BioBank Research Database hosted by UCL. The biobank also provides logistical support to more conventional clinical trials and the capacity to store trial samples for additional or future testing.

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• SciCrunch
• 16 years ago - by Anonymous

An information extracting and processing package for biological literature that can be used online or installed locally via a downloadable software package, http://www.textpresso.org/downloads.html Textpresso's two major elements are (1) access to full text, so that entire articles can be searched, and (2) introduction of categories of biological concepts and classes that relate two objects (e.g., association, regulation, etc.) or describe one (e.g., methods, etc). A search engine enables the user to search for one or a combination of these categories and/or keywords within an entire literature. The Textpresso project serves the biological and biomedical research community by providing: * Full text literature searches of model organism research and subject-specific articles at individual sites. Major elements of these search engines are (1) access to full text, so that the entire content of articles can be searched, and (2) search capabilities using categories of biological concepts and classes that relate two objects (e.g., association, regulation, etc.) or identify one (e.g., cell, gene, allele, etc). The search engines are flexible, enabling users to query the entire literature using keywords, one or more categories or a combination of keywords and categories. * Text classification and mining of biomedical literature for database curation. They help database curators to identify and extract biological entities and facts from the full text of research articles. Examples of entity identification and extraction include new allele and gene names and human disease gene orthologs; examples of fact identification and extraction include sentence retrieval for curating gene-gene regulation, Gene Ontology (GO) cellular components and GO molecular function annotations. In addition they classify papers according to curation needs. They employ a variety of methods such as hidden Markov models, support vector machines, conditional random fields and pattern matches. Our collaborators include WormBase, FlyBase, SGD, TAIR, dictyBase and the Neuroscience Information Framework. They are looking forward to collaborating with more model organism databases and projects. * Linking biological entities in PDF and online journal articles to online databases. They have established a journal article mark-up pipeline that links select content of Genetics journal articles to model organism databases such as WormBase and SGD. The entity markup pipeline links over nine classes of objects including genes, proteins, alleles, phenotypes, and anatomical terms to the appropriate page at each database. The first article published with online and PDF-embedded hyperlinks to WormBase appeared in the September 2009 issue of Genetics. As of January 2011, we have processed around 70 articles, to be continued indefinitely. Extension of this pipeline to other journals and model organism databases is planned. Textpresso is useful as a search engine for researchers as well as a curation tool. It was developed as a part of WormBase and is used extensively by C. elegans curators. Textpresso has currently been implemented for 24 different literatures, among them Neuroscience, and can readily be extended to other corpora of text.

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• SciCrunch
• 16 years ago - by Anonymous

A listing of grants and other funding types to support health research, programs and scholarship. Funding sources most frequently listed on ScanGrants include those of private foundations, corporations, businesses, and not-for profit organizations. Finding and listing less traditional funding opportunities is also a priority. Federal and state funding sources are typically not included on ScanGrants because they are readily available on other sites (e.g., www.grants.gov). The funding sources listed on ScanGrants may be of interest to virtually anyone associated with the health field medical researchers, social workers, nurses, students, community-based health educators, academics and others. They include grants, scholarships, fellowships, prizes for scientific achievement or distinguished service, travel awards to professional meetings, abstract, essay and poster awards among other sources of funding. ScanGrants is a free resource that lists funding opportunities for researchers and students at many stages of their research projects or careers. Examples include: poster awards for completed projects; travel grants that could help finance trips to meetings that would enable you to discuss with peers in your field projects you are contemplating undertaking or in the midst of; calls for nominations for science prizes you could nominate colleagues you admire for; and announcements of funding for programs for violence or disease prevention. We invite you to give ScanGrants a try. If you would like your grant or scholarship announcement reviewed for possible posting on ScanGrants, please fill out the form with your name, email address, link to the original online listing of the funding opportunity, the title of the grant or scholarship and as much additional detail as possible.

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• SciCrunch
• 16 years ago - by Anonymous

The overarching goal of the Post-traumatic Stress Disorder / Traumatic Brain Injury (PTSD / TBI) Clinical Consortium is to combine efforts of the nation''s leading Investigators to bring to the market novel treatments or interventions that will ultimately decrease the impact of military-relevant psychological health problems and TBI. Working together we hope to improve the function, wellness, and overall quality of life for Service members, as well as their families, caregivers, and the American public. Our vision is to design and conduct a series of innovative coordinated clinical trials that are characterized by: * Scientific excellence * State-of-the-art methodology in prevention, detection and treatment * Advanced translational research that will inform future therapies * Dignity and respect for all stakeholders Funding Trials Coming Soon: We anticipate about 10 trials of novel approaches for the treatment of PTSD, TBI, and their combination. Current Trials: * A PILOT SAFETY and FEASABILITY STUDY of HIGH DOSE LEFT PREFRONTAL TRANSCRANIAL MAGNETIC STIMULATION (TMS) to RAPIDLY STABILIZE SUICIDAL PATIENTS with PTSD or TBI, or BOTH. * THE EFFECT of TELEPHONE FOLLOW-UP on OUTCOME for SERVICE MEMBERS with MILD TBI / PTSD * A PROOF-OF-CONCEPT, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLLED STUDY of GANAXOLONE in POSTTRAUMATIC STRESS DISORDER

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• SciCrunch
• 16 years ago - by Anonymous

A permutation-based method (written in Python) for ascertaining genes with a somatic mutation distribution showing evidence of positive selection for non-silent mutations.

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• SciCrunch
• 13 years ago - by Anonymous

CTSpedia is a national effort to collect wisdom, tools, educational materials, and other items useful for clinical and translational researchers and to provide timely and useful advice to clinical and translational researchers with specific problems. The CTSpedia is a collaborative vehicle for the CTSA''s Biostatistics/Epidemiology/Research/Design (BERD) Online Resources and Education taskforce to identify and share resources across the national consortium and community researchers world-wide. With the support of the national BERD consortia, the project obtained funding and support from the National Center for Research Resources (NCRR) to expand the original scope and content of CTSpedia and foster collaboration amongst CTSAs. The main goal of CTSpedia.org is to create a definable academic home on the internet for the discipline of clinical and translational sciences across the country and the world. * While the CTSA consortium serves the onsite physical level of the institutions involved, CTSpedia.org seeks to fill the gaps where the network is lacking, and to augment that network as the central hub for the peer to peer sharing of knowledge and resources. * While the CTSA national scope comes to fruition, the international scope of the consortia is more readily facilitated with an online resource like CTSpedia. * Utilizing the collaborative nature of the wiki-style website, CTSpedia.org allows for researchers anywhere in the world to ask questions and receive answers and related information in a timely and efficient manner, overcoming the logistical issues of distance and scheduling. * The streamlined availability of an online resource and knowledge repository will aid in addressing common issues that arise in clinical research, which will filter out consultation requests for minor questions, allowing for CTSA consultants to address more prevalent consultations.

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• SciCrunch
• 16 years ago - by Anonymous

A cross-national data archive located in Luxembourg that contains two primary databases: the Luxembourg Income Study Database (LIS Database) includes income microdata from a large number of countries at multiple points in time. The newer Luxembourg Wealth Study Database(LWS Database) includes wealth microdata from a smaller selection of countries. Both databases include labor market and demographic data as well. Our mission is to enable, facilitate, promote, and conduct cross-national comparative research on socio-economic outcomes and on the institutional factors that shape those outcomes. Since its beginning in 1983, the LIS has grown into a cooperative research project with a membership that includes countries in Europe, North America, and Australia. The database now contains information for more than 30 countries with datasets that span up to three decades. The LIS databank has a total of over 140 datasets covering the period 1968 to 2005. The primary objectives of the LIS are as follows: * Test the feasibility for creating a database containing social and economic data collected in household surveys from different countries; * Provide a method which allows researchers to use the data under restrictions required by the countries providing the data; * Create a system that allows research requests to be received from and returned to users at remote locations; and * Promote comparative research on the social and economic status of various populations and subgroups in different countries. Data Availability: The dataset is accessed globally via electronic mail networks. Extensive documentation concerning technical aspects of the survey data, variables list, and the social institutions of income provision in member countries are also available to users through the project Website. * Dates of Study: 1968-present * Study Features: International * Sample Size: 30+ Countries Link: * ICPSR: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/00150

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• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented September 6, 2016. CarePath was founded for inducing change and delivering evidence based care in America that can lead to better medical outcomes for seriously ill and reduction in cost of care. The initial focus of CarePath is on traumatic brain injury CarePath is now working with several states and many of the leading trauma hospitals on the implementation of evidence-based treatment guidelines on behalf of traumatic brain injured patients in order to dramatically improve patient outcomes and reduce the need for long term care.

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• SciCrunch
• 16 years ago - by Anonymous

H. Lee Moffitt Cancer Center & Research Institute has made a lasting commitment to the prevention and cure of cancer, working tirelessly in the areas of patient care, research and education to advance one step further in fighting this disease. As part of an elite group of National Cancer Institute (NCI) Comprehensive Cancer Centers, Moffitt focuses on the development of early stage translational research aimed at the rapid translation of scientific discoveries to benefit patient care. Since the first patient admission in October 1986, Moffitt physicians, scientists and staff members have worked together to establish a tradition of excellence offered in an atmosphere characterized by kindness, caring and hope. The Cancer Center''s future growth in clinical care and research rests firmly on this tradition and makes possible the changes ahead. The mission of Moffitt Cancer Center is to contribute to the prevention and cure of cancer. Moffitt''s vision is to be the leader in scientific discovery and translation into compassionate care, cures, and prevention of cancer for our community and the world. As it grows to fulfill its mission, the Cancer Center will continue to be distinguished by its compassionate and effective patient care. Moffitt Cancer Center is a not-for-profit institution. It includes private patient rooms, the Southeast''s largest Blood and Marrow Transplant Program, outpatient treatment programs that record more than 320,500 visits a year, the Moffitt Research Center, Moffitt Cancer Center at International Plaza and the Lifetime Cancer Screening & Prevention Center.

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• SciCrunch
• 16 years ago - by Anonymous

Established in 2002, Angioma Alliance is a patient-driven, non-profit patient advocacy organization. Our mission is to inform and support individuals affected by cerebral cavernous malformations while facilitating improved diagnosis and management of the illness through education and research. We are dedicated to improving the lives of those affected by cavernous angioma. There are many needs that we have been addressing together. First and foremost, people diagnosed with cavernous angiomas have needed more information and a way to talk to others who have the illness. Physicians are frequently unfamiliar with the disease. Internet information has been scarce and technical, and until Angioma Alliance there had been no active internet forums. Many of us have never known anyone else with the illness. Angioma Alliance''s website, peer support program, patient literature, family conferences, and medical convention exhibits have been providing vital information and opportunities for support to those of us affected by cavernous angioma and to the physicians who care for us. Second, we have needed to increase if the public awareness of cavernous angioma. Third, we have needed a way to connect with the research community. Angioma Alliance can be as active and effective as those who choose to volunteer. If you or a family member or friend is affected by cavernous angioma, please consider joining us in our effort.

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• SciCrunch
• 16 years ago - by Anonymous