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Cleveland Clinic is renowned for its advancements in cardiac care, including pioneering coronary artery bypass surgery, and its focus on research and education. It's also known for its strong performance in numerous other specialties, including neurosurgery, gastroenterology, and oncology
Core provides biomechanical testing of biological structures and biomaterials. Allows investigators to conduct research of mechanical properties of existing biological structures and constructs, as well as to quantify potential for new technologies and clinical advancements. Robotic simulators are built around the simVITRO software platform and are designed for in vitro simulation of major joints including knee, spine, foot, ankle, hip, shoulder, elbow, wrist and more. Provides testing capabilities for range of biomechanical modalities and will offer expert advice and support for development of new test protocols, innovative techniques for instrumentation and data collection. Modalities include tissues, joints, and multi-articular units, such as foot or spine segments.
Software tool to deliver estimated structure parameters of endocrine feedback control systems in vivo from serum or plasma hormone levels. Used for the evaluation of insulin-glucose homeostasis. Allows for calculating the secretory capacity of pancreatic beta cells (SPINA-GBeta), insulin receptor gain (SPINA-GR) and a static disposition index (SPINA-DI) from fasting concentrations of insulin and glucose. Additionally, HOMA, QUICKI and other calculated parameters are delivered as well. Binaries are available for macOS and Windows. For other operating systems, including Linux, Solaris and BSD, SPINA Carb is available as source code. Building from source requires Lazarus/Free Pascal. A special version of the calculation engine is available for modern S implementations, e.g. R.
cloud-based flow cytometry analysis platform bridging machine learning and analytical pipelines with classical analysis
Software Python tool for detecting and counting nematode eggs from microscopy images.
Core provides annotated biospecimens for basic, clinical, and translational research. Helps researchers access, collect, manage, and protect biospecimens using automated processes and quality control. Offers safe and monitored management of biospecimens including temperature-controlled storage, preparation of derivatives from these specimens, aliquoting, distribution, and production of specimen collection kits.
Core offers sample analysis and experiment design, market assessment and FDA regulation, facilitate interactions for intellectual property protection and support submission of translational grant applications within University of Michigan and government agencies.
Core utilizes Akoya PhenoCycler-Fusion to enable high-plex spatial phenotyping of whole tissue slides at single-cell resolution.
Provides expertise through experimental design consultations,cell isolation,single cell analytics (RNA, DNA, protein),biomarker validation,novel statistical and bioinformatics analyses. Services include Single cell targeted gene expression, Single cell RNA Seq, Single cell DNA Seq, Tissue sectioning, Tissue spatial analysis, Spatial transcriptomics and proteomics.
Microscopy Facility supports cancer research, cell and developmental biology, and cross-disciplinary studies spanning molecular mechanisms to translational applications. Houses imaging platforms including widefield, confocal, multi-photon, super-resolution, spinning disk, and light sheet systems. Enables advanced modalities such as TIRF, FRET, STED, SHG/THG, and FLIM for detailed exploration of cell behaviour and microenvironments. Facility staff offer training, expert consultation, image analysis support, and troubleshooting.
Provides access to the latest technologies, with consultation and services available throughout the design and execution of sequencing projects.
Provides genomic services to study genome structure, dynamics and function using Illumina next generation sequencing. Offers expert advice on experimental design and bioinformatics analysis, training and assistance on data storage solutions.
Software tool as second version of Kraken taxonomic sequence classification system.
Software tool as text and source code editor for use with Microsoft Windows.
Software R package for deconvolution of mixed cells from spatial and/or bulk gene expression data. Algorithm for quantifying cell populations defined by single cell sequencing within regions of spatial gene expression studies. Used for mapping cell types in spatial gene expression studies.
Software to evaluate mean absorbed doses to organs and tumors in radionuclide images, providing simple and fast solution for radionuclide imaging and treatment of new drugs in clinical trials. Calculates radiation doses to organs and the whole body based on established human body models.
Source code for pose recognition model for laboratory mice based on yolov8. Real-time spatiotemporal network model for robust mouse pose estimation.
Automated microbial detection system. Instrument for detecting bacteria in biologic and non-biologic samples.
Core provides services and expert advice on routine and specialized molecular biology techniques including plasmid preps, genome editing, mutation detection, digital PCR and spatial transcriptomics.
Digital microscope, combining high-resolution imaging with analysis. Whether running fluorescence imaging or brightfield assays, automated imager features comprehensive preconfigured protocols for cell-based assays to shorten learning curve.