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Proper Citation: RRID:BCBC_1262
Description: NOD-scid IL2rgnull mice are deficient in mature lymphocytes and NK cells, survive beyond 16-month of age, and even after sublethal irradiation resist lymphoma development. Moreover, cytokine-mobilized human peripheral blood stem cells engraft at high levels in NOD-scid IL2rgnull mice and develop into human CD3+CD4+ and CD3+CD8+ T cells, Ig+B cells, myeloid cells, NK cells and plasmacytoid dentritic cells.
Species: Mus musculus
Notes: NOD-scid IL2rgnull mice are deficient in mature lymphocytes and NK cells, survive beyond 16-month of age, and even after sublethal irradiation resist lymphoma development. Moreover, cytokine-mobilized human peripheral blood stem cells engraft at high levels in NOD-scid IL2rgnull mice and develop into human CD3+CD4+ and CD3+CD8+ T cells, Ig+B cells, myeloid cells, NK cells and plasmacytoid dentritic cells.
Phenotype: Diabetes mellitus
Affected Gene: interleukin 2 receptor, gamma chain
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No rating or validation information has been found for NOD-scidIL2gnull (NOD.Cg-PrkdcscidIl2rgtm1Wjl/Sz).
No alerts have been found for NOD-scidIL2gnull (NOD.Cg-PrkdcscidIl2rgtm1Wjl/Sz).
Source: Integrated Animals
Source Database: BCBC, Beta Cell Biology Consortium
