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On page 1 showing 1 ~ 4 papers out of 4 papers

Dopamine D1 + D3 receptor density may correlate with parkinson disease clinical features.

  • Pengfei Yang‎ et al.
  • Annals of clinical and translational neurology‎
  • 2021‎

Dopamine D2-like receptors - mainly dopamine D2 receptors (D2R) and dopamine D3 receptors (D3R) - are believed to be greatly involved in the pathology of Parkinson disease (PD) progression. However, these receptors have not been precisely examined in PD patients. Our aim was to quantitatively calculate the exact densities of dopamine D1 receptors (D1R), D2R, and D3R in control, Alzheimer disease (AD), and Lewy body disease (LBD) patients (including PD, Dementia with Lewy bodies, and Parkinson disease dementia); and analyze the relationship between dopamine receptors and clinical PD manifestations.


Comparison of plasma and CSF biomarkers in predicting cognitive decline.

  • Andrew J Aschenbrenner‎ et al.
  • Annals of clinical and translational neurology‎
  • 2022‎

Concentrations of amyloid-β peptides (Aβ42/Aβ40) and neurofilament light (NfL) can be measured in plasma or cerebrospinal fluid (CSF) and are associated with Alzheimer's disease brain pathology and cognitive impairment. This study directly compared plasma and CSF measures of Aβ42/Aβ40 and NfL as predictors of cognitive decline.


Evaluating brain damage in multiple sclerosis with simultaneous multi-angular-relaxometry of tissue.

  • Biao Xiang‎ et al.
  • Annals of clinical and translational neurology‎
  • 2022‎

Multiple sclerosis (MS) is a common demyelinating central nervous system disease. MRI methods that can quantify myelin loss are needed for trials of putative remyelinating agents. Quantitative magnetization transfer MRI introduced the macromolecule proton fraction (MPF), which correlates with myelin concentration. We developed an alternative approach, Simultaneous-Multi-Angular-Relaxometry-of-Tissue (SMART) MRI, to generate MPF. Our objective was to test SMART-derived MPF metric as a potential imaging biomarker of demyelination.


Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains.

  • Jinbin Xu‎ et al.
  • Annals of clinical and translational neurology‎
  • 2019‎

Increased translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), in glial cells of the brain has been used as a neuroinflammation marker in the early and middle stages of neurodegenerative diseases, such as Alzheimer's disease (AD) and Dementia with Lewy Bodies (DLB). In this study, we investigated the changes in TSPO density with respect to late stage AD and DLB.


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