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The AWC OFF neuron is important for attraction to 1-butanol in Caenorhabditis elegans.

Vaughn E Brown | Ella Bradley | Tymmaa A Asaed | Sokhna B Lo | Zach S Bellini | Dylan J Blackett | Jeremy J Callaway | Jacob Hallesy | Zoey E Joshlin | Taryn L Kaneko | Catie H Kaneshiro | Kae R Kidd | Jacinda Lee | Kaitlyn M Leung | Janelle S Li | Ben P Luo | Charlene C Mbaeri | Alanna O'Neill | Precious Omomofe | James D Schmidt | Minh Truong | Elizabeth E Glater
microPublication biology | 2025

C. elegans uses chemosensation to recognize a variety of odors, many of which are released by bacteria, the major food source of C. elegans . Specific amphid sensory neurons are known to detect different odorants. Here we show that the AWC OFF neuron detects the attractive odorant 1-butanol. Because few odorants that are specifically recognized by the AWC OFF neuron have been identified, we hope that the identification of this additional odorant will facilitate studies of the role of the AWC OFF neuron in odor detection and discrimination.

Pubmed ID: 39882098

Associated grants

  • Agency: NIH HHS, United States
    Id: P40 OD010440

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This is a list of tools and resources that we have found mentioned in this publication.


Caenorhabditis Genetics Center (tool)

RRID:SCR_007341

Center that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.

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N2 (organism)

RRID:WB-STRAIN:WBStrain00000001

Caenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.

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CX10 (organism)

RRID:WB-STRAIN:WBStrain00005214

Caenorhabditis elegans with name osm-9(ky10) from WB.

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PR680 (organism)

RRID:WB-STRAIN:WBStrain00030787

Caenorhabditis elegans with name che-1(p680) I. from WB.

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CX4 (organism)

RRID:WB-STRAIN:WBStrain00005213

Caenorhabditis elegans with name odr-7(ky4) X. from WB.

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CX3937 (organism)

RRID:WB-STRAIN:WBStrain00005258

Caenorhabditis elegans with name lim-4(ky403) X. from WB.

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