Searching the Resource Information Network
An animal's current behavior influences its response to sensory stimuli, but the molecular and circuit-level mechanisms of this context-dependent decision-making are not well understood. Caenorhabditis elegans are less likely to respond to a mechanosensory stimulus by reversing if the stimuli is received while the animal turns. Inhibitory feedback from turning associated neurons are needed for this gating. But until now, it has remained unknown precisely where in the circuit gating occurs and which specific neurons and receptors receive inhibition from the turning circuitry. Here, we use genetic manipulations, single-cell rescue experiments, and high-throughput closed-loop optogenetic perturbations during behavior to reveal the specific neuron and receptor responsible for receiving inhibition and altering sensorimotor processing. Our measurements show that an inhibitory acetylcholine-gated chloride channel comprising LGC-47 and ACC-1 expressed in neuron type RIM disrupts mechanosensory evoked reversals during turns, presumably in response to inhibitory signals from turning-associated neuron SAA.
Pubmed ID: 39381742
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Multi paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsThe Simons Foundation is a private foundation based in New York City, incorporated in 1994 by Jim and Marilyn Simons. The Simons Foundation''s mission is to advance the frontiers of research in mathematics and the basic sciences. We sponsor a range of programs that aim to promote a deeper understanding of our world. The primary focus of the foundation''s Mathematics & the Physical Sciences (MPS) program is on the theoretical sciences radiating from mathematics: in particular, the fields of mathematics, theoretical computer science and theoretical physics. Although we have supported basic research in mathematics and physics for years at institutions around the globe, the mode of our support entered an important new phase in fall 2009 with the introduction of grant opportunities with open application procedures. It is intended that this will become our primary mode of operation. In 2010, the MPS program issued its first requests for grant applications. These requests offered grants to establish post-doctoral fellowships, grants to promote collaboration between researchers, grants to create professorships that combine mathematics with other fields, and a grant to endow an institute for theoretical computer science. Other projects are under way, including the Africa Mathematics Project, intended to bolster mathematics scholarship on the African continent, and an oral history project: a series of interviews with renowned mathematicians and scientists which will be made available to the public for viewing. The Simons Foundation''s initial support of life sciences work has tended to focus on research that promotes synergy between biology and mathematics. Such projects have included quantitative biology programs at Cold Spring Harbor Laboratory, the Institut des Hautes ��tudes Scientifiques, the Institute for Advanced Study, and The Rockefeller University. The Life Sciences program is expected to expand in scope over the next two to three years. To date, the Simons Foundation''s single largest initiative has been in autism research. The Simons Foundation Autism Research Initiative (SFARI) program seeks to improve the diagnosis and treatment of autism spectrum disorders by funding, catalyzing, and driving innovative research of the greatest quality and relevance. In 2007, SFARI issued its first Request for Applications, its goal being to attract the best researchers to the field. In the years since, SFARI has given grants to 150 investigators in the United States and abroad. Additionally, to facilitate the field as a whole, SFARI has created the Simons Simplex Collection of extensive genetic and phenotypic data from almost 3,000 families with a child affected by autism. Although SFARI''s immediate priority is to benefit individuals challenged by autism spectrum disorders, the program''s research is expected to yield insights into the neural mechanisms of fundamental human capabilities, complementing the mission of the Simons Foundation to advance research in the basic sciences and mathematics.
View all literature mentionsVector graphics software to create digital graphics, illustrations, and typography for several types of media: print, web, interactive, video, and mobile.
View all literature mentionsAn independent federal agency created by Congress to promote the progress of science; to advance the national health, prosperity, and welfare; to secure the national defense They are the funding source for approximately 20 percent of all federally supported basic research conducted by America''s colleges and universities. In many fields such as mathematics, computer science and the social sciences, NSF is the major source of federal backing. NSF leadership has two major components: a director who oversees NSF staff and management responsible for program creation and administration, merit review, planning, budget and day-to-day operations; and a 24-member National Science Board (NSB) of eminent individuals that meets six times a year to establish the overall policies of the foundation.The director and all Board members serve six year terms. Each of them, as well as the NSF deputy director, is appointed by the President of the United States and confirmed by the U.S. Senate. At present, NSF has a total workforce of about 2,100 at its Arlington, Va., headquarters, including approximately 1,400 career employees, 200 scientists from research institutions on temporary duty, 450 contract workers and the staff of the NSB office and the Office of the Inspector General. NSF is the only federal agency whose mission includes support for all fields of fundamental science and engineering, except for medical sciences. They are tasked with keeping the United States at the leading edge of discovery in areas from astronomy to geology to zoology. So, in addition to funding research in the traditional academic areas, the agency also supports high-risk, high pay-off ideas, novel collaborations and numerous projects that may seem like science fiction today, but which the public will take for granted tomorrow. And in every case, they ensure that research is fully integrated with education so that today''s revolutionary work will also be training tomorrow''s top scientists and engineers NSF''s task of identifying and funding work at the frontiers of science and engineering is not a top-down process.
View all literature mentionsNational institute whose mission is to reduce the burden of neurological disease - a burden borne by every age group, by every segment of society, by people all over the world. To accomplish this goal the NINDS supports and conducts basic, translational, and clinical research on the normal and diseased nervous system. The Institute also fosters the training of investigators in the basic and clinical neurosciences, and seeks better understanding, diagnosis, treatment, and prevention of neurological disorders. NINDS: * Conducts, fosters, coordinates, and guides research on the causes, prevention, diagnosis, and treatment of neurological disorders and stroke, and supports basic research in related scientific areas. * Provides grants-in-aid to public and private institutions and individuals in fields related to its areas of interest, including research project, program project, and research center grants. * Operates a program of contracts for the funding of research and research support efforts in selected areas of institute need. * Provides individual and institutional fellowships to increase scientific expertise in neurological fields. * Conducts a diversified program of intramural and collaborative research in its own laboratories, branches, and clinics. * Collects and disseminates research information related to neurological disorders.
View all literature mentionsWeb tool for graphical illustrations for biological systems by BioRender. Used for articles and presentations. Collection of pre made icons and templates from life science fields for scientific illustrations. Customized icons possible on request.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
