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As the global aging population rises, finding effective interventions to improve aging health is crucial. Drug repurposing, utilizing existing drugs for new purposes, presents a promising strategy for rapid implementation. We explored naltrexone from the Library of Integrated Network-based Cellular Signatures (LINCS) based on several selection criteria. Low-dose naltrexone (LDN) has gained attention for treating various diseases, yet its impact on longevity remains underexplored. Our study on C. elegans demonstrated that a low dose, but not high dose, of naltrexone extended the healthspan and lifespan. This effect was mediated through SKN-1 (NRF2 in mammals) signaling, influencing innate immune gene expression and upregulating oxidative stress responses. With LDN's low side effects profile, our findings underscore its potential as a geroprotector, suggesting further exploration for promoting healthy aging in humans is warranted.
Pubmed ID: 38799567
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Caenorhabditis elegans with name skn-1(zu67) IV/nT1 [unc-?(n754) let-?] (IV;V). from WB.
View all literature mentionsCaenorhabditis elegans with name atf-4(ok576) X. from WB.
View all literature mentionsCaenorhabditis elegans with name unc-13(n2813) I. from WB.
View all literature mentionsCaenorhabditis elegans with name cdk-5(ok626) III. from WB.
View all literature mentionsCaenorhabditis elegans with name pmk-1(km25) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name ldIs7[skn-1::gfp] from WB.
View all literature mentionsCaenorhabditis elegans with name daf-16(mu86)I from WB.
View all literature mentionsCaenorhabditis elegans with name muIs84 [(pAD76) sod-3p::GFP + rol-6(su1006)]. from WB.
View all literature mentionsCaenorhabditis elegans with name aak-2(ok524) X. from WB.
View all literature mentionsCaenorhabditis elegans with name dvIs19 [(pAF15)gst-4p::GFP::NLS] III. from WB.
View all literature mentionsCaenorhabditis elegans with name C. elegans wild type (ancestral). from WB.
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