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Chronic temperature stress inhibits reproduction and disrupts endocytosis via chaperone titration in Caenorhabditis elegans.

Rosemary N Plagens | Isiah Mossiah | Karen S Kim Guisbert | Eric Guisbert
BMC biology | 2021

Temperature influences biology at all levels, from altering rates of biochemical reactions to determining sustainability of entire ecosystems. Although extended exposure to elevated temperatures influences organismal phenotypes important for human health, agriculture, and ecology, the molecular mechanisms that drive these responses remain largely unexplored. Prolonged, mild temperature stress (48 h at 28 °C) has been shown to inhibit reproduction in Caenorhabditis elegans without significantly impacting motility or viability.

Pubmed ID: 33858388

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R15 CA227573

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