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Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice.

Aaron M Marshall | Rebecca J McClaine | Devikala Gurusamy | Jerilyn K Gray | Kara E Lewnard | Sohaib A Khan | Susan E Waltz
Molecular cancer | 2012

The receptor tyrosine kinase family includes many transmembrane proteins with diverse physiological and pathophysiological functions. The involvement of tyrosine kinase signaling in promoting a more aggressive tumor phenotype within the context of chemotherapeutic evasion is gaining recognition. The Ron receptor is a tyrosine kinase receptor that has been implicated in the progression of breast cancer and evasion of tamoxifen therapy.

Pubmed ID: 22226043

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Associated grants

  • Agency: BLRD VA, United States
    Id: I01 BX000803
  • Agency: NCI NIH HHS, United States
    Id: T32 CA117846
  • Agency: NCI NIH HHS, United States
    Id: T32CA117846
  • Agency: NCI NIH HHS, United States
    Id: CA100002

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FVB/NJ (tool)

RRID:IMSR_JAX:001800

Mus musculus with name FVB/NJ from IMSR.

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C57BL/6J (tool)

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Mus musculus with name C57BL/6J from IMSR.

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Crl:NU(NCr)-Foxn1nu (tool)

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Mus musculus with name Crl:NU(NCr)-Foxn1nu from IMSR.

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