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| Name |
Description |
Preferred ID |
Type |
ID |
Score | ||
|---|---|---|---|---|---|---|---|
| Triflupromazine | A phenothiazine used as an antipsychotic agent and as an antiemetic. (PubChem) Pharmacology: Triflupromazine is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists. Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. It reduces anxiety, emotional withdrawal, hallucinations, disorganized thoughts, blunted mood, and suspiciousness. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can also be used to control severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Triflupromazine acts on the central nervous system. Mechanism of action: Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Triflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT2B). Drug type: Approved. Small Molecule. Drug category: Antiemetics. Antipsychotic Agents. Antipsychotics. Dopamine Antagonists | CHEBI:9711 | term | ILX:0111962 | 24040.654 | Molecular entity, Material entity, Independent continuant, Continuant | Adazine, Fluopromazine, Psyquil, Siquil |
| Triflupromazine | A phenothiazine used as an antipsychotic agent and as an antiemetic. | MESH:M0021962 | term | ILX:0737624 | 23400.744 | ||
| Cholinergic system | any molecule, protein, cell, tissue or organ that is related to acetylcholine. | UBERON:0025595 | term | ILX:0102133 | 7.824846 | Molecular system, Body system, Anatomical entity, Independent continuant, Continuant | Acetylcholine system, cholinergic system, ach system |
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