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| Name |
Description |
Preferred ID |
Type |
ID |
Score | ||
|---|---|---|---|---|---|---|---|
| Skeletal Muscle Cell | SAO:1741889714 | term | ILX:0110658 | 22827.484 | Striated Muscle Cell, Muscle Cell, Cell, Anatomical entity, Independent continuant, Continuant | ||
| Fast twitch skeletal muscle cell | Skeletal muscle cell characterized by a white color due to the absence of myoglobin, and a reliance on glycolytic enzymes. These fibers are efficient for short bursts of speed and power and use both oxidative metabolism and anaerobic metabolism depending on the particular sub-type. | UBERON:0000405 | term | ILX:0104120 | 436.1117 | Skeletal Muscle Cell, Striated Muscle Cell, Muscle Cell, Cell, Anatomical entity, Independent continuant, Continuant | fast twitch muscle fiber, type 2 muscle fiber, type II muscle fiber |
| skeletal muscle endomysium | Reticular tissue which surrounds a skeletal muscle cell. | UBERON:0011898 | term | ILX:0731419 | 388.91943 | ||
| Fast twitch type A skeletal muscle cell | Fast twitch skeletal muscle cell characterized by large amounts of myoglobin an abundance of mitochondria,blood capillaries, a high capacity for generating ATP by oxidation, rapid rate of ATP splitting and hence a high contraction velocity. They are resistant to fatigue but not as much as slow oxidative fibers (adapted from Wikipedia). | NLX:93509 | term | ILX:0104121 | 381.68875 | Fast twitch skeletal muscle cell, Skeletal Muscle Cell, Striated Muscle Cell, Muscle Cell, Cell, Anatomical entity, Independent continuant, Continuant | Type IIa muscle fiber, fast twitch A muscle fiber |
| skeletal muscle cell of the gastrointestinal tract | ILX:0793728 | term | ILX:0793728 | 379.7409 | Skeletal Muscle Cell, Striated Muscle Cell, Muscle Cell, Cell, Anatomical entity, Independent continuant, Continuant | ||
| Muscle Cell | Mature contractile cells, commonly known as myocytes, that form one of three kinds of muscle. The three types of muscle cells are skeletal (muscle fibers), cardiac (myocytes, cardiac), and smooth (myocytes, smooth muscle). They are derived from embryonic (precursor) muscle cells called myoblasts (MSH). | SAO:519252327 | term | ILX:0107217 | 331.59534 | Cell, Anatomical entity, Independent continuant, Continuant | myocyte |
| muscle tissue | Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. | UBERON:0002385 | term | ILX:0724370 | 190.95175 | textus muscularis, portion of muscle tissue, muscular tissue, Muscle tissue | |
| Muscle spindle | The large stretch receptor in skeletal muscles. | ILX:0107219 | term | ILX:0107219 | 190.22038 | Muscle Cell, Cell, Anatomical entity, Independent continuant, Continuant | |
| somatic muscle | A muscle structure of invertebrates whose origin and insertion sites are in basal side of the epidermis or structures derived from it. The simplest somatic muscles consist of a single cell and associated extracellular structures. | UBERON:0014895 | term | ILX:0727927 | 183.52225 | skeletal muscle | |
| skin basal cell carcinoma | The most frequently seen skin cancer. It arises from basal cells of the epidermis and pilosebaceous units. Clinically it is divided into the following types: nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing or morphea-like. More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck and the remaining 15% on the trunk and extremities. Basal cell carcinoma usually grows in a slow and indolent fashion. However, if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and bone. Distant metastases are rare. Excision, curettage and irradiation cure most basal cell carcinomas. | ILX:0754612 | term | ILX:0754612 | 137.51874 | Array | basal cell tumor (morphologic abnormality), malignant basal cell tumor, basal cell neoplasm NOS (morphologic abnormality), basal cell neoplasm (morphologic abnormality), basal cell tumor, malignant basal cell tumor (morphologic abnormality), basal cell carcinoma NOS (morphologic abnormality), epithelioma basal cell, basal cell cancer, malignant basal cell neoplasm, basal cell carcinoma of the skin, BCC, basal cell epithelioma, basal cell skin carcinoma, basal cell carcinoma, skin basal cell carcinoma, Rodent ulcer, skin basal cell cancer, basal cell neoplasm, basal cell carcinoma of skin |
| Spinal cord ventral horn motor neuron alpha | Large lower motor neuron of the brainstem and spinal cord. They innervate extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. Alpha motor neurons are distinct from gamma motor neurons, which innervate intrafusal muscle fibers of muscle spindles. | SAO:1154704263 | term | ILX:0110941 | 17.196266 | Neuron, Nervous system cell, Cell, Anatomical entity, Independent continuant, Continuant | alpha motoneuron, lower motor neuron |
| embryonal rhabdomyosarcoma (disease) | A poorly circumscribed morphologic variant of rhabdomyosarcoma. It is characterized by the presence of primitive skeletal muscle differentiation in any stage of myogenesis. | MONDO:0009993 | term | ILX:0766899 | 10.869396 | rhabdomyosarcoma, embryonal, 1; RMSE1, rhabdomyosarcoma embryonal, RMSE1, rhabdomyosarcoma chromosomal region, botryoid rhabdomyosarcoma (type of ERMS), spindle cell rhabdomyosarcomas (type of ERMS), rhabdomyosarcoma, embryonal, 1, rhabdomyosarcoma 1, ERMS, rhabdomyosarcoma, embryonal, type 1, embryonal rhabdomyosarcoma | |
| SPARC Community (TermSet) | ILX:0793177 | TermSet | ILX:0793177 | 9.232969 | |||
| Dantrolene | Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin. Pharmacology: Dantrolene is classified as a direct-acting skeletal muscle relaxant. It is currently the only specific and effective treatment for malignant hyperthermia. In isolated nerve-muscle preparation, Dantrium has been shown to produce relaxation by affecting the contractile response of the muscle at a site beyond the myoneural junction. In skeletal muscle, Dantrium dissociates excitation-contraction coupling, probably by interfering with the release of Ca2+ from the sarcoplasmic reticulum. In the anesthetic-induced malignant hyperthermia syndrome, evidence points to an intrinsic abnormality of skeletal muscle tissue. In selected humans, it has been postulated that triggering agents (e.g.,general anesthetics and depolarizing neuromuscular blocking agents) produce a change within the cell which results in an elevated myoplasmic calcium. This elevated myoplasmic calcium activates acute cellular catabolic processes that cascade to the malignant hyperthermia crisis. It is hypothesized that addition of Dantrium to the triggered malignant hyperthermic muscle cell reestablishes a normal level of ionized calcium in the myoplasm. Mechanism of action: Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1, and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction. Drug type: Approved. Small Molecule. Drug category: Muscle Relaxants, Central | ILX:0102786 | term | ILX:0102786 | 8.344593 | Molecular entity, Material entity, Independent continuant, Continuant | Dantrolene Sodium, Dantroleno (INN-Spanish), Dantrolenum (INN-Latin), Dantrium |
| hasExactSynonym | ILX:0737161 | annotation | ILX:0737161 | 8.005941 | |||
| hasBroadSynonym | ILX:0737164 | annotation | ILX:0737164 | 6.231251 | |||
| solitary fibrous tumor | Solitary fibrous tumor (SFT) represents a diverse group of ubiquitous rare spindle cell neoplasms that may be benign or malignant and that most frequently arises from the pleura and peritoneum and rarely from other sites such as head and neck, liver and skeletal muscle. SFT may be clinically asymptomatic or may present with enlarging mass, compressive effects depending on the site involved and rarely with paraneoplastic manifestations (osteoarthropathy or hypoglycemia). | ILX:0754732 | term | ILX:0754732 | 5.9737415 | Array | solitary fibrous tumor/hemangiopericytoma, localized fibrous mesothelioma, localized fibrous tumor, solitary fibrous tumor, hemangiopericytoma, SFT, submesothelial fibroma |
| hasNarrowSynonym | ILX:0737163 | annotation | ILX:0737163 | 5.882032 | |||
| Halazepam | Halazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a trifluoromethyl derivative of nordazepam. While its structure may be similar to chlordiazepoxide and diazepam, it has both less toxicity and less tendency to cause paradoxical hostility and aggression than either of them. (Wikipedia) Pharmacology: Not Available Mechanism of action: Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Drug type: Approved. Illicit. Small Molecule. Drug category: Anti-anxiety Agents. Benzodiazepines. Muscle Relaxants. Sedative | ILX:0104872 | term | ILX:0104872 | 5.5540648 | Molecular entity, Material entity, Independent continuant, Continuant | Halazepamum (INN-Latin), Pacinone |
| lethal congenital contracture syndrome 2 | Lethal congenital contracture syndrome type 2 is a rare arthrogryposis syndrome characterized by multiple congenital contactures (typically extended elbows and flexed knees), micrognathia, anterior horn cell degeneration, skeletal muscle atrophy (mainly in the lower limbs), presence of a markedly distended urinary bladder and absence of hydrops, pterygia and bone fractures. Other craniofacial (e.g. cleft palate, facial palsy) and ocular (e.g. anisocoria, retinal detachment) anomalies may be additionally observed. The disease is usually neonatally lethal however, survival into adolescence has been reported. | MONDO:0011868 | term | ILX:0766494 | 5.242077 | multiple contracture syndrome, Israeli Bedouin type, multiple contracture syndrome, Israeli Bedouin type a, lethal congenital contracture syndrome 2; LCCS2, ERBB3 lethal congenital contracture syndrome, lethal congenital contracture syndrome type 2, multiple contracture syndrome, Israeli-Bedouin type, LCCS2, lethal congenital contracture syndrome 2, lethal congenital contracture syndrome caused by mutation in ERBB3 |
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