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| Name |
Description |
Preferred ID |
Type |
ID |
Score | ||
|---|---|---|---|---|---|---|---|
| Neostriatum direct pathway spiny neuron | The principal projection neuron of the caudate and putamen. | NLX:149135 | term | ILX:0107404 | 23561.348 | Neuron, Nervous system cell, Cell, Anatomical entity, Independent continuant, Continuant | MSN, Medium spiny neuron, Neostriatal spiny neuron, Medium-sized spiny neuron, Striatal spiny neuron, striatal direct pathway spiny neuron, direct pathway medium spiny neuron, direct pathway medium-sized spiny neuron, dMSN, neostriatial direct pathway spiny neuron |
| Striosomal compartment of neostriatum | NLX:146269 | term | ILX:0111105 | 295.19357 | Regional part of brain, Regional part of nervous system, Regional part of body system, Anatomical entity, Independent continuant, Continuant | ||
| Spiny high density | Characterized by a high density of dendritic spines, of sufficient density to give the dendrite a fuzzy coated appearance in light microscopic preparations | NLX:146270 | term | ILX:0110981 | 198.71706 | Quality, Specifically dependent continuant, Dependent continuant, Continuant | spiny |
| Principal neuron role | Neuron whose axon projects out of the region in which the cell soma lies to carry information to another region | ILX:0109349 | term | ILX:0109349 | 158.43867 | Projection role of nerve cell, Functional role of nerve cell, Functional role of cell, Cell role, Role, Realizable entity, Specifically dependent continuant, Dependent continuant, Continuant | Projection neuron role, Principal neuron |
| Enkephalin | Enkephalin is a pentapeptide involved in regulating nociception in the body. | NIFEXT:5096 | term | ILX:0103826 | 42.831398 | Opioid peptide, Peptide, Biomolecule, Anatomical entity, Independent continuant, Continuant | encephalin, Enk |
| Dendrite thickness | ILX:0112767 | annotation | ILX:0112767 | 35.999836 | |||
| Number of primary dendrites | ILX:0112768 | annotation | ILX:0112768 | 33.485737 | |||
| D1 receptor | Dopamine receptor that stimulates adenylyl cyclase activity, and has a high affinity for SKF 38393 and its homologs. It is a protien that is encoded, in humans, by the DRD1 gene. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors are enriched in Caudate-putamen, nucleus accumbens, and olfactory tubercles. These receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. (adapted from Entrez Gene) | NIFEXT:5845 | term | ILX:0102774 | 33.20565 | Protein, Molecular entity, Material entity, Independent continuant, Continuant | D1R, D1, D(1A) dopamine receptor, DRD1, D1 dopamine receptor, dopamine receptor D1 |
| D2 receptor | Dopamine receptor is a G-protien coupled receptor that inhibits adenylyl cyclase activity, potentiate calcium evoked release of arachadonic acid, increase potassium channel opening and in some cells decrease intracellular calcium concentrations. D2 receptors have a high affinity for antipsychotic drugs and have higher levels of expression in mammalian hippocampus and hypothalamus. It is encoded by the DRD2 gene in humans and a missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. (adapted from Entrez Gene). | NIFEXT:5833 | term | ILX:0102775 | 31.016335 | Protein, Molecular entity, Material entity, Independent continuant, Continuant | D2R, D2, D2S, D2L, D2S/D2L, Dopamine D2 receptor, D(2) dopamine receptor, DRD2, D2 dopamine receptor, dopamine receptor D2 |
| Putamen | Subcortical nucleus of telencephalon , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion. | UBERON:0001874 | term | ILX:0109549 | 26.746601 | Regional part of brain, Regional part of nervous system, Regional part of body system, Anatomical entity, Independent continuant, Continuant | Pu, nucleus putamen |
| Caudate nucleus | Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species. | UBERON:0001873 | term | ILX:0101734 | 23.335688 | Regional part of brain, Regional part of nervous system, Regional part of body system, Anatomical entity, Independent continuant, Continuant | Cd, Caudate, caudatus, Ammon horn fields, nucleus caudatus, caudatum |
| Axon myelination | ILX:0112766 | annotation | ILX:0112766 | 22.31113 | |||
| Spine density on dendrites | ILX:0112798 | relationship | ILX:0112798 | 17.433125 | |||
| Multipolar | Three or more primary dendrites in multiple directions | NLX:378 | term | ILX:0107196 | 16.033463 | Soma Shape, Soma Quality, Morphological Quality, Quality, Specifically dependent continuant, Dependent continuant, Continuant | Multipolar soma quality |
| Neurotransmitter receptors | ILX:0112791 | relationship | ILX:0112791 | 15.752406 | |||
| AMPA-type glutamate-gated cationic channel | Cell surface proteins that bind glutamate and directly gate ion channels in cell membranes. AMPA receptors were originally discriminated from other glutamate receptors by their affinity for the agonist AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid). They are probably the most common mediators of fast excitatory synaptic transmission in the central nervous system. Several subtypes have been cloned, and for some types the traditional distinction from kainate receptors may not apply (MSH). | NIFEXT:5251 | term | ILX:0100559 | 15.365065 | Glutamate-gated cationic channel, Tetrameric ion channel, Multimeric ion channel, Macromolecular complex, Biomolecule, Anatomical entity, Independent continuant, Continuant | AMPA receptor, AMPA, ionotropic glutamate AMPA receptor, quisqualate receptor, AMPA-type glutamate-gated cationic channel, AMPAR, ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, ionotropic AMPA receptor |
| Location of local axon arborization | ILX:0112787 | relationship | ILX:0112787 | 14.112141 | |||
| Molecular constituents | ILX:0112790 | relationship | ILX:0112790 | 13.613755 | |||
| Medium soma | A medium sized soma, defined relative to the brain. | NLX:45865 | term | ILX:0106731 | 12.579419 | Soma Size, Soma Quality, Morphological Quality, Quality, Specifically dependent continuant, Dependent continuant, Continuant | |
| Located in | ILX:0112786 | relationship | ILX:0112786 | 10.378107 |
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