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| Name |
Description |
Preferred ID |
Type |
ID |
Score | ||
|---|---|---|---|---|---|---|---|
| Carbachol | A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors. (PubChem) Pharmacology: Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs). Mechanism of action: Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors. In topical ocular and intraocular administration its principal effects are miosis and increased aqueous humour outflow. Drug type: Approved. Small Molecule. Drug category: Analgesics, Non-Narcotic. Cardiotonic Agents. Cholinergic Agonists. Miotics | CHEBI:3385 | term | ILX:0101647 | 23398.59 | Molecular entity, Material entity, Independent continuant, Continuant | CB, Carbachol USP27, Carbachol chloride, Carbachol hydrochloride, Carbacholin, Carbacholine, Carbacholine chloride, Carbacolina, Carbaminocholine chloride, Carbaminoylcholine chloride, Carbamiotin, Carbamoylcholine chloride, Carbamoylcholine-hydrochloride, Carbamylcholine chloride, Carbastat, Carbastat intraocular, Carbochol, Carbocholin, Carbocholine, Carboptic, Carbyl, Carcholin, Choline carbamate chloride, Choline chloride carbamate, Choline chloride, carbamoyl-, Choline chlorine carbamate, Choline, chloride, carbamate, Coletyl, Doryl, Isopto Carbachol, Jestryl, Karbachol, Karbamoylcholin chlorid, Lentin, Lentine, Miostat, Mistura C, Moryl, P, V, Carbachol, Rilentol |
| Carbachol | A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS. | MESH:M0003323 | term | ILX:0737226 | 23292.395 | ||
| Related to | ILX:0112796 | relationship | ILX:0112796 | 8.194965 | |||
| Alpha 3 Acetylcholine Receptor | Neuronal acetylcholine receptor subunit alpha-3 is encoded by the human CHRNA3 gene. This protein plays a role in ion transport. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. (Adapted from NCBI and Swiss-Prot). | SAO:99825125 | term | ILX:0100486 | 7.8537517 | Protein, Molecular entity, Material entity, Independent continuant, Continuant | Neuronal Acetylcholine Receptor Subunit Alpha-3, CHRNA3, NACHRA3, Cholinergic receptor, nicotinic |
| Has role | ILX:0112784 | relationship | ILX:0112784 | 7.836238 | |||
| Cholinergic system | any molecule, protein, cell, tissue or organ that is related to acetylcholine. | UBERON:0025595 | term | ILX:0102133 | 7.824846 | Molecular system, Body system, Anatomical entity, Independent continuant, Continuant | Acetylcholine system, cholinergic system, ach system |
| Drug | Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances. | CHEBI:23888 | term | ILX:0103576 | 7.68414 | Molecule role, Role, Realizable entity, Specifically dependent continuant, Dependent continuant, Continuant | |
| Bethanechol | A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, cardiac rate changes, and bronchial spasms. (PubChem) Pharmacology: Bethanechol is a parasympathomimetic (cholinergic) used for the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention. Bethanechol, a cholinergic agent, is a synthetic ester which is structurally and pharmacologically related to acetylcholine. It increases the tone of the detrusor urinae muscle, usually producing a contraction sufficiently strong to initiate micturition and empty the bladder. It stimulates gastric motility, increases gastric tone, and often restores impaired rhythmic peristalsis. Bethanechol chloride is not destroyed by cholinesterase and its effects are more prolonged than those of acetytcholine. Mechanism of action: Bethanechol acts by selectively stimulating muscarinic receptors in the parasympathetic nervous system, inducing no affect on nicotinic receptors. Drug type: Approved. Small Molecule. Drug category: Muscarinic Agonists. Parasympathomimetics | ILX:0101259 | term | ILX:0101259 | 6.829201 | Molecular entity, Material entity, Independent continuant, Continuant | Amidopropyldimethylbetaine, BTC, Besacholine, Beta-Methyl Carbachol Chloride, Bethaine Choline Chloride, Bethanechol Chloride, Carbamylmethylcholine Chloride, Duvoid, Mechotane, Mechothane, Mecothane, Mictone, Mictrol, Myocholine, Myotonachol, Myotonine Chloride, Urabeth, Urecholine, Urecholine Chloride |
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