Skeletal Muscle Cell
Description:
Preferred ID: SAO:1741889714 Type: term ID# ILX:0110658 Score: 22827.459
Fast twitch skeletal muscle cell
Description: Skeletal muscle cell characterized by a white color due to the absence of myoglobin, and a reliance on glycolytic enzymes. These fibers are efficient for short bursts of speed and power and use both oxidative metabolism and anaerobic metabolism depending on the particular sub-type.
Preferred ID: UBERON:0000405 Type: term ID# ILX:0104120 Score: 436.1117
skeletal muscle endomysium
Description: Reticular tissue which surrounds a skeletal muscle cell.
Preferred ID: UBERON:0011898 Type: term ID# ILX:0731419 Score: 388.9194
Fast twitch type A skeletal muscle cell
Description: Fast twitch skeletal muscle cell characterized by large amounts of myoglobin an abundance of mitochondria,blood capillaries, a high capacity for generating ATP by oxidation, rapid rate of ATP splitting and hence a high contraction velocity. They are resistant to fatigue but not as much as slow oxidative fibers (adapted from Wikipedia).
Preferred ID: NLX:93509 Type: term ID# ILX:0104121 Score: 381.68875
skeletal muscle cell of the gastrointestinal tract
Description:
Preferred ID: ILX:0793728 Type: term ID# ILX:0793728 Score: 379.7409
Muscle Cell
Description: Mature contractile cells, commonly known as myocytes, that form one of three kinds of muscle. The three types of muscle cells are skeletal (muscle fibers), cardiac (myocytes, cardiac), and smooth (myocytes, smooth muscle). They are derived from embryonic (precursor) muscle cells called myoblasts (MSH).
Preferred ID: SAO:519252327 Type: term ID# ILX:0107217 Score: 331.59717
muscle tissue
Description: Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO].
Preferred ID: UBERON:0002385 Type: term ID# ILX:0724370 Score: 190.95164
Muscle spindle
Description: The large stretch receptor in skeletal muscles.
Preferred ID: ILX:0107219 Type: term ID# ILX:0107219 Score: 190.22038
somatic muscle
Description: A muscle structure of invertebrates whose origin and insertion sites are in basal side of the epidermis or structures derived from it. The simplest somatic muscles consist of a single cell and associated extracellular structures.
Preferred ID: UBERON:0014895 Type: term ID# ILX:0727927 Score: 183.52225
skin basal cell carcinoma
Description: The most frequently seen skin cancer. It arises from basal cells of the epidermis and pilosebaceous units. Clinically it is divided into the following types: nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing or morphea-like. More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck and the remaining 15% on the trunk and extremities. Basal cell carcinoma usually grows in a slow and indolent fashion. However, if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and bone. Distant metastases are rare. Excision, curettage and irradiation cure most basal cell carcinomas.
Preferred ID: ILX:0754612 Type: term ID# ILX:0754612 Score: 137.51874
Spinal cord ventral horn motor neuron alpha
Description: Large lower motor neuron of the brainstem and spinal cord. They innervate extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. Alpha motor neurons are distinct from gamma motor neurons, which innervate intrafusal muscle fibers of muscle spindles.
Preferred ID: SAO:1154704263 Type: term ID# ILX:0110941 Score: 17.196266
embryonal rhabdomyosarcoma (disease)
Description: A poorly circumscribed morphologic variant of rhabdomyosarcoma. It is characterized by the presence of primitive skeletal muscle differentiation in any stage of myogenesis.
Preferred ID: MONDO:0009993 Type: term ID# ILX:0766899 Score: 10.861159
SPARC Community (TermSet) TermSet
Description:
Preferred ID: ILX:0793177 Type: TermSet ID# ILX:0793177 Score: 9.232654
Dantrolene
Description: Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin. Pharmacology: Dantrolene is classified as a direct-acting skeletal muscle relaxant. It is currently the only specific and effective treatment for malignant hyperthermia. In isolated nerve-muscle preparation, Dantrium has been shown to produce relaxation by affecting the contractile response of the muscle at a site beyond the myoneural junction. In skeletal muscle, Dantrium dissociates excitation-contraction coupling, probably by interfering with the release of Ca2+ from the sarcoplasmic reticulum. In the anesthetic-induced malignant hyperthermia syndrome, evidence points to an intrinsic abnormality of skeletal muscle tissue. In selected humans, it has been postulated that triggering agents (e.g.,general anesthetics and depolarizing neuromuscular blocking agents) produce a change within the cell which results in an elevated myoplasmic calcium. This elevated myoplasmic calcium activates acute cellular catabolic processes that cascade to the malignant hyperthermia crisis. It is hypothesized that addition of Dantrium to the triggered malignant hyperthermic muscle cell reestablishes a normal level of ionized calcium in the myoplasm. Mechanism of action: Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1, and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction. Drug type: Approved. Small Molecule. Drug category: Muscle Relaxants, Central
Preferred ID: ILX:0102786 Type: term ID# ILX:0102786 Score: 8.345219
hasExactSynonym Annotation
Description:
Preferred ID: ILX:0737161 Type: annotation ID# ILX:0737161 Score: 8.0059185
hasBroadSynonym Annotation
Description:
Preferred ID: ILX:0737164 Type: annotation ID# ILX:0737164 Score: 6.2109
solitary fibrous tumor
Description: Solitary fibrous tumor (SFT) represents a diverse group of ubiquitous rare spindle cell neoplasms that may be benign or malignant and that most frequently arises from the pleura and peritoneum and rarely from other sites such as head and neck, liver and skeletal muscle. SFT may be clinically asymptomatic or may present with enlarging mass, compressive effects depending on the site involved and rarely with paraneoplastic manifestations (osteoarthropathy or hypoglycemia).
Preferred ID: ILX:0754732 Type: term ID# ILX:0754732 Score: 5.9737415
hasNarrowSynonym Annotation
Description:
Preferred ID: ILX:0737163 Type: annotation ID# ILX:0737163 Score: 5.882032
Halazepam
Description: Halazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a trifluoromethyl derivative of nordazepam. While its structure may be similar to chlordiazepoxide and diazepam, it has both less toxicity and less tendency to cause paradoxical hostility and aggression than either of them. (Wikipedia) Pharmacology: Not Available Mechanism of action: Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Drug type: Approved. Illicit. Small Molecule. Drug category: Anti-anxiety Agents. Benzodiazepines. Muscle Relaxants. Sedative
Preferred ID: ILX:0104872 Type: term ID# ILX:0104872 Score: 5.554538
lethal congenital contracture syndrome 2
Description: Lethal congenital contracture syndrome type 2 is a rare arthrogryposis syndrome characterized by multiple congenital contactures (typically extended elbows and flexed knees), micrognathia, anterior horn cell degeneration, skeletal muscle atrophy (mainly in the lower limbs), presence of a markedly distended urinary bladder and absence of hydrops, pterygia and bone fractures. Other craniofacial (e.g. cleft palate, facial palsy) and ocular (e.g. anisocoria, retinal detachment) anomalies may be additionally observed. The disease is usually neonatally lethal however, survival into adolescence has been reported.
Preferred ID: MONDO:0011868 Type: term ID# ILX:0766494 Score: 5.242077
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