Neostriatum direct pathway spiny neuron
Description: The principal projection neuron of the caudate and putamen.
Preferred ID: NLX:149135 Type: term ID# ILX:0107404 Score: 23561.348
Striosomal compartment of neostriatum
Description:
Preferred ID: NLX:146269 Type: term ID# ILX:0111105 Score: 295.19357
Spiny high density
Description: Characterized by a high density of dendritic spines, of sufficient density to give the dendrite a fuzzy coated appearance in light microscopic preparations
Preferred ID: NLX:146270 Type: term ID# ILX:0110981 Score: 198.71706
Principal neuron role
Description: Neuron whose axon projects out of the region in which the cell soma lies to carry information to another region
Preferred ID: ILX:0109349 Type: term ID# ILX:0109349 Score: 158.43953
Enkephalin
Description: Enkephalin is a pentapeptide involved in regulating nociception in the body.
Preferred ID: NIFEXT:5096 Type: term ID# ILX:0103826 Score: 42.831398
Dendrite thickness Annotation
Description:
Preferred ID: ILX:0112767 Type: annotation ID# ILX:0112767 Score: 35.999836
D1 receptor
Description: Dopamine receptor that stimulates adenylyl cyclase activity, and has a high affinity for SKF 38393 and its homologs. It is a protien that is encoded, in humans, by the DRD1 gene. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors are enriched in Caudate-putamen, nucleus accumbens, and olfactory tubercles. These receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. (adapted from Entrez Gene)
Preferred ID: NIFEXT:5845 Type: term ID# ILX:0102774 Score: 33.814938
Number of primary dendrites Annotation
Description:
Preferred ID: ILX:0112768 Type: annotation ID# ILX:0112768 Score: 33.485653
D2 receptor
Description: Dopamine receptor is a G-protien coupled receptor that inhibits adenylyl cyclase activity, potentiate calcium evoked release of arachadonic acid, increase potassium channel opening and in some cells decrease intracellular calcium concentrations. D2 receptors have a high affinity for antipsychotic drugs and have higher levels of expression in mammalian hippocampus and hypothalamus. It is encoded by the DRD2 gene in humans and a missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. (adapted from Entrez Gene).
Preferred ID: NIFEXT:5833 Type: term ID# ILX:0102775 Score: 31.637735
Putamen
Description: Subcortical nucleus of telencephalon , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion.
Preferred ID: UBERON:0001874 Type: term ID# ILX:0109549 Score: 26.746601
Caudate nucleus
Description: Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species.
Preferred ID: UBERON:0001873 Type: term ID# ILX:0101734 Score: 23.335688
Axon myelination Annotation
Description:
Preferred ID: ILX:0112766 Type: annotation ID# ILX:0112766 Score: 22.310877
Spine density on dendrites Relationship
Description:
Preferred ID: ILX:0112798 Type: relationship ID# ILX:0112798 Score: 17.433527
Multipolar
Description: Three or more primary dendrites in multiple directions
Preferred ID: NLX:378 Type: term ID# ILX:0107196 Score: 16.561243
Neurotransmitter receptors Relationship
Description:
Preferred ID: ILX:0112791 Type: relationship ID# ILX:0112791 Score: 15.752406
AMPA-type glutamate-gated cationic channel
Description: Cell surface proteins that bind glutamate and directly gate ion channels in cell membranes. AMPA receptors were originally discriminated from other glutamate receptors by their affinity for the agonist AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid). They are probably the most common mediators of fast excitatory synaptic transmission in the central nervous system. Several subtypes have been cloned, and for some types the traditional distinction from kainate receptors may not apply (MSH).
Preferred ID: NIFEXT:5251 Type: term ID# ILX:0100559 Score: 15.365065
Location of local axon arborization Relationship
Description:
Preferred ID: ILX:0112787 Type: relationship ID# ILX:0112787 Score: 14.112141
Molecular constituents Relationship
Description:
Preferred ID: ILX:0112790 Type: relationship ID# ILX:0112790 Score: 13.613755
Medium soma
Description: A medium sized soma, defined relative to the brain.
Preferred ID: NLX:45865 Type: term ID# ILX:0106731 Score: 13.005727
Located in Relationship
Description:
Preferred ID: ILX:0112786 Type: relationship ID# ILX:0112786 Score: 10.378107
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