Carbachol
Description: A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors. (PubChem) Pharmacology: Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs). Mechanism of action: Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors. In topical ocular and intraocular administration its principal effects are miosis and increased aqueous humour outflow. Drug type: Approved. Small Molecule. Drug category: Analgesics, Non-Narcotic. Cardiotonic Agents. Cholinergic Agonists. Miotics
Preferred ID: CHEBI:3385 Type: term ID# ILX:0101647 Score: 23398.777
Carbachol
Description: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Preferred ID: MESH:M0003323 Type: term ID# ILX:0737226 Score: 23292.383
Related to Relationship
Description:
Preferred ID: ILX:0112796 Type: relationship ID# ILX:0112796 Score: 8.195149
Has role Relationship
Description:
Preferred ID: ILX:0112784 Type: relationship ID# ILX:0112784 Score: 7.858898
Alpha 3 Acetylcholine Receptor
Description: Neuronal acetylcholine receptor subunit alpha-3 is encoded by the human CHRNA3 gene. This protein plays a role in ion transport. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. (Adapted from NCBI and Swiss-Prot).
Preferred ID: SAO:99825125 Type: term ID# ILX:0100486 Score: 7.85434
Cholinergic system
Description: any molecule, protein, cell, tissue or organ that is related to acetylcholine.
Preferred ID: UBERON:0025595 Type: term ID# ILX:0102133 Score: 7.8243127
Drug
Description: Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
Preferred ID: CHEBI:23888 Type: term ID# ILX:0103576 Score: 7.6843243
Bethanechol
Description: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, cardiac rate changes, and bronchial spasms. (PubChem) Pharmacology: Bethanechol is a parasympathomimetic (cholinergic) used for the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention. Bethanechol, a cholinergic agent, is a synthetic ester which is structurally and pharmacologically related to acetylcholine. It increases the tone of the detrusor urinae muscle, usually producing a contraction sufficiently strong to initiate micturition and empty the bladder. It stimulates gastric motility, increases gastric tone, and often restores impaired rhythmic peristalsis. Bethanechol chloride is not destroyed by cholinesterase and its effects are more prolonged than those of acetytcholine. Mechanism of action: Bethanechol acts by selectively stimulating muscarinic receptors in the parasympathetic nervous system, inducing no affect on nicotinic receptors. Drug type: Approved. Small Molecule. Drug category: Muscarinic Agonists. Parasympathomimetics
Preferred ID: ILX:0101259 Type: term ID# ILX:0101259 Score: 6.828768
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