Acetylcholine Receptor
Description: Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology (MSH).
Preferred ID: SAO:1700719022 Type: term ID# ILX:0100242 Score: 23367.809
Acetylcholine (muscarinic) receptor
Description: One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for MUSCARINE over NICOTINE. There are several subtypes (usually M1, M2, M3....) that are characterized by their cellular actions, pharmacology, and molecular biology.Year introduced: 1984(1977) - adapted from MeSH
Preferred ID: SAO:2062447305 Type: term ID# ILX:0100241 Score: 405.0987
acetylcholine receptor kinase
Description:
Preferred ID: MESH:M0107415 Type: term ID# ILX:0567327 Score: 396.64923
Nicotinic Acetylcholine Receptor
Description: Classic ligand-gated ion channel receptor type, where binding of ligand (acetylcholine) to transmembrane protein oligomer causes channel to open, permitting ion (sodium and potassium) flux and depolarization (CSP).
Preferred ID: SAO:1767745398 Type: term ID# ILX:0107579 Score: 391.96686
polyalanyl acetylcholine receptor
Description:
Preferred ID: MESH:M0087256 Type: term ID# ILX:0567334 Score: 385.05655
Alpha 3 Acetylcholine Receptor
Description: Neuronal acetylcholine receptor subunit alpha-3 is encoded by the human CHRNA3 gene. This protein plays a role in ion transport. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. (Adapted from NCBI and Swiss-Prot).
Preferred ID: SAO:99825125 Type: term ID# ILX:0100486 Score: 376.76443
Alpha 7 Acetylcholine Receptor
Description: This receptor it a protein that is a translation product of the CHRNA7 gene or a 1:1 ortholog thereof. NACHRA7 is a type of nicotinic acetylcholine receptor, consisting entirely of α7 subunits. As with other nicotinic acetylcholine receptors, functional α7 receptors are pentameric [i.e., (α7)5 stoichiometry]. It is located in the brain, where activation yields post- and presynaptic excitation, mainly by increased Ca2+ permeability. (Definition provided by PRotein Ontology and Wikipedia).
Preferred ID: SAO:138926812 Type: term ID# ILX:0100487 Score: 376.76443
alpha7 Nicotinic Acetylcholine Receptor
Description: A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric ñ7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.
Preferred ID: MESH:M0089028 Type: term ID# ILX:0491154 Score: 367.52478
alpha6beta2 nicotinic acetylcholine receptor
Description:
Preferred ID: MESH:M0559143 Type: term ID# ILX:0601037 Score: 366.40308
acetylcholine receptor gamma, mouse
Description:
Preferred ID: MESH:M0559177 Type: term ID# ILX:0600648 Score: 350.4075
nicotinic acetylcholine receptor alpha4 subunit
Description:
Preferred ID: MESH:M0275903 Type: term ID# ILX:0394603 Score: 338.00998
alpha6beta2 nicotinic acetylcholine receptor, mouse
Description:
Preferred ID: MESH:M0548298 Type: term ID# ILX:0680617 Score: 338.00998
nicotinic acetylcholine receptor delta, zebrafish
Description:
Preferred ID: MESH:M0499413 Type: term ID# ILX:0544699 Score: 336.24265
alpha6beta2 nicotinic acetylcholine receptor, rat
Description:
Preferred ID: MESH:M0506850 Type: term ID# ILX:0680623 Score: 331.4893
Neuronal acetylcholine receptor subunit alpha-6
Description: A protein that is a translation product of the CHRNA6 gene or a 1:1 ortholog thereof. The ?6 subunit found in certain types of nicotinic acetylcholine receptors found primarily in the brain. Neural nicotinic acetylcholine receptors containing ?6 subunits are expressed on dopamine-releasing neurons in the midbrain, and dopamine release following activation of these neurons is thought to be involved in the addictive properties of nicotine. Due to their selective localisation on dopaminergic neurons, ?6-containing nACh receptors have also been suggested as a possible therapeutic target for the treatment of Parkinson's disease.(Adapted from PRotein Ontology and Wikipedia).
Preferred ID: ILX:0107506 Type: term ID# ILX:0107506 Score: 327.2638
Neuronal acetylcholine receptor subunit alpha-8
Description: This receptor it a protein that is a translation product of the CHRNA8 gene or a 1:1 ortholog thereof. NACHRA8 is a type of nicotinic acetylcholine receptor, consisting entirely of α8 subunits. This is the a type of neuronal-type II receptor subtype and these receptors are most present with in the brain.
Preferred ID: ILX:0107507 Type: term ID# ILX:0107507 Score: 327.2638
Neuronal acetylcholine receptor subunit alpha-9
Description: A protein that is a translation product of the CHRNA9 gene or a 1:1 ortholog thereof. This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells. (Adapted from PRotein Ontology and Entrez Gene).
Preferred ID: ILX:0107508 Type: term ID# ILX:0107508 Score: 327.2638
Neuronal acetylcholine receptor subunit alpha-4
Description: A protein that is a translation product of the CHRNA4 gene or a 1:1 ortholog thereof.
Preferred ID: ILX:0107505 Type: term ID# ILX:0107505 Score: 327.2638
Neuronal acetylcholine receptor subunit beta-4
Description: A protein that is a translation product of the CHRNB4 gene or a 1:1 ortholog thereof. The neuronal acetylcholine receptor is composed of an alpha and a beta subunit. Neuronal acetylcholine receptor beta-4 subunit can be combined with alpha- 2, alpha-3 or alpha-4 to give rise to functional receptor complexes. (Adapted from UniProtKB/Swiss-Prot)
Preferred ID: ILX:0107512 Type: term ID# ILX:0107512 Score: 323.77347
Neuronal acetylcholine receptor subunit beta-3
Description: A protein that is a translation product of the CHRNB3 gene or a 1:1 ortholog thereof. (Adapted from PRotein Ontology).
Preferred ID: ILX:0107511 Type: term ID# ILX:0107511 Score: 323.2219
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