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Total 959151 Results
| Label | Description | ILX | Version | Created CID | Modified Time | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Opisthobranchia | ILX:0108062 | 4 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex | |
| Opium | ILX:0108063 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex | |
| Opposite | A positional quality inhering in a bearer by virtue of the bearer's being positioned on opposite sides on the same plane. | ILX:0108064 | 4 | FDI Lab - SciCrunch.org | 08/24/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | troy sincomb |
| Oprelvekin | Oprelvekin, the active ingredient in Neumega is recombinant Interleukin eleven, which is produced in Escherichia coli (E. coli) by recombinant DNA technology. The protein has a molecular mass of approximately 19,000 daltons, and is non-glycosylated. The polypeptide is 177 amino acids in length (the natural IL-11 has 178). This alteration has not resulted in measurable differences in bioactivity either in vitro or in vivo.The primary hematopoietic activity of Neumega is stimulation of megakaryocytopoiesis and thrombopoiesis. In mice and nonhuman primate studies Neumega has shown potent thrombopoietic activity in compromised hematopoiesis, including moderately to severely myelosuppressed animals. In these studies, Neumega improved platelet nadirs and accelerated platelet recoveries compared to controls.In animal studies Oprelvekin also has non-hematopoetic activities. This includes the regulation of intestinal epithelium growth (enhanced healing of gastrointestinal lesions), the inhibition of adipogenesis, the induction of acute phase protein synthesis (e.g., fibrinogen), and inhibition of macrophageal released pro-inflammatory cytokines. Pharmacology: Oprelvekin is indicated for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusions following myelosuppressive chemotherapy in adult patients with nonmyeloid malignancies who are at high risk of severe thrombocytopenia. The primary hematopoietic activity of Oprelvekin is stimulation of megakaryocytopoiesis and thrombopoiesis. Oprelvekin has shown potent thrombopoietic activity in individuals with compromised hematopoiesis Mechanism of action: Oprelvekin binds to the interleukin 11 receptor which leads to a cascade of signal transduction events. IL-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Drug type: Approved. Biotech. Investigational. Drug category: Coagulants. Thrombotics | ILX:0108065 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Opsin-like receptor | ILX:0108066 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex | |
| Opsin-like receptor - unspecified 1 | ILX:0108067 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex | |
| Opsoclonus-Myoclonus Syndrome | A neurological condition that is characterized by uncontrolled rapid irregular movements of the eye ( OPSOCLONUS) and the muscle ( MYOCLONUS) causing unsteady, trembling gait. It is also known as dancing eyes-dancing feet syndrome and is often associated with neoplasms, viral infections, or autoimmune disorders involving the nervous system (MeSH). | ILX:0108068 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Optic chiasm | A location within the visual system of binocular animals where axons of retinal ganglion cells cross contralaterally or remain ipsilatterally towards termination zones in the lateral geniculate nucleus. | ILX:0108069 | 11 | FDI Lab - SciCrunch.org | 01/17/2023 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Optic lobe neuron | Any neuron (FBbt_00005106) that has synaptic terminals in some optic lobe (FBbt_00003701). | ILX:0108070 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Optic Nerve Glioma | Glial cell derived tumors arising from the optic nerve, usually presenting in childhood. Roughly 50% are associated with NEUROFIBROMATOSIS 1. Clinical manifestations include decreased visual acuity; EXOPHTHALMOS; NYSTAGMUS, PATHOLOGIC; STRABISMUS; pallor or swelling of the optic disc; and INTRACRANIAL HYPERTENSION. The tumor may extend into the optic chiasm and hypothalamus (MeSH). | ILX:0108071 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Optic Pathways of CIVM postnatal rat brain atlas | The optic pathways are very easy to segment on coronal T2-weighted MRI. This pathway, comprised of optic nerves, optic chiasm, and optic tracts, is comprised largely of densely packed, myelinated axons, which appear quite dark on T2 MRI. The entire pathway can be segmented by simple seeded thresholding (magic wand) with a seed placed in the optic chiasm. The dorsal and caudal most extent of the optic tracts as the course lateral to the diencephalon can become quite thin, and may be difficult to distinguish depending on image resolution. | ILX:0108072 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Optic recess of third ventricle | Recess in third ventricle lying in front of the optic chiasm at the base of the lamina terminalis | ILX:0108073 | 10 | FDI Lab - SciCrunch.org | 01/17/2023 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Optic tract | Predominantly white matter structure found in diencephalon consisting of fibers originating in the retina. The optic tract is considered to extend from the point of the optic chiasm and terminates largely, although not exclusively, in the lateral geniculate complex. Other fibers end in the superior colliculus and other structures in the diencephalon, midbrain and brainstem (MM). | ILX:0108074 | 11 | FDI Lab - SciCrunch.org | 01/17/2023 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Optic tract of WHS11 | TBA | ILX:0108075 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Optical imaging protocol | An imaging protocol that uses any form of optical microscopy assay to form an image, i.e., an assay that employs light waves as the source of electromagnetic radiation. | ILX:0108076 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Optical microscope | ILX:0108077 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex | |
| Optical quality | An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light. | ILX:0108078 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Optogenetics | Aneuromodulation technique that uses a combination of techniques from optics and genetics to control the activity of individual neurons in living tissue–even within freely-moving animals–and to precisely measure the effects of those manipulations in real-time. It was developed by Karl Deisseroth and his colleagues at Stanford University in 2006 (Adapted from Wikipedia: http://en.wikipedia.org/wiki/Optogenetics) | ILX:0108079 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Oral part of spinal trigeminal nucleus | 'Oral part of spinal trigeminal nucleus' is a gray matter of hindbrain. It is part of the spinal nucleus of trigeminal nerve. | ILX:0108080 | 11 | FDI Lab - SciCrunch.org | 01/17/2023 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
| Oral part of ventral lateral nucleus | 'Oral part of ventral lateral nucleus' is a gray matter of diencephalon. It is part of the ventral lateral nucleus of thalamus. | ILX:0108081 | 11 | FDI Lab - SciCrunch.org | 01/17/2023 | FDI Lab - SciCrunch.org | term | 12/09/2016 | 0 | NeuroLex | NeuroLex |
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